{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:38:42Z","timestamp":1779399522143,"version":"3.53.1"},"reference-count":76,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council","doi-asserted-by":"publisher","award":["123456"],"award-info":[{"award-number":["123456"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Lithium chloride (LiCl) has been widely researched and utilized as a therapeutic option for bipolar disorder (BD). Several pathways, including cell signaling and signal transduction pathways in mammalian cells, are shown to be regulated by LiCl. LiCl can negatively control the expression and activity of PGM2, a phosphoglucomutase that influences sugar metabolism in yeast. In the presence of galactose, when yeast cells are challenged by LiCl, the phosphoglucomutase activity of PGM2p is decreased, causing an increase in the concentration of toxic galactose metabolism intermediates that result in cell sensitivity. Here, we report that the null yeast mutant strains DBP7\u2206 and YRF1-6\u2206 exhibit increased LiCl sensitivity on galactose-containing media. Additionally, we demonstrate that DBP7 and YRF1-6 modulate the translational level of PGM2 mRNA, and the observed alteration in translation seems to be associated with the 5\u2032-untranslated region (UTR) of PGM2 mRNA. Furthermore, we observe that DBP7 and YRF1-6 influence, to varying degrees, the translation of other mRNAs that carry different 5\u2032-UTR secondary structures.<\/jats:p>","DOI":"10.3390\/ijms24021785","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T06:52:10Z","timestamp":1673851930000},"page":"1785","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["DBP7 and YRF1-6 Are Involved in Cell Sensitivity to LiCl by Regulating the Translation of PGM2 mRNA"],"prefix":"10.3390","volume":"24","author":[{"given":"Sasi Kumar","family":"Jagadeesan","sequence":"first","affiliation":[{"name":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada"},{"name":"Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Al-gafari","sequence":"additional","affiliation":[{"name":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada"},{"name":"Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashu","family":"Wang","sequence":"additional","affiliation":[{"name":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada"},{"name":"Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Takallou","sequence":"additional","affiliation":[{"name":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada"},{"name":"Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Allard","sequence":"additional","affiliation":[{"name":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada"},{"name":"Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0762-3465","authenticated-orcid":false,"given":"Maryam","family":"Hajikarimlou","sequence":"additional","affiliation":[{"name":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada"},{"name":"Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas David Daniel","family":"Kazmirchuk","sequence":"additional","affiliation":[{"name":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada"},{"name":"Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houman","family":"Moteshareie","sequence":"additional","affiliation":[{"name":"Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada"},{"name":"Biotechnology Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON K1A 0K9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3749-6754","authenticated-orcid":false,"given":"Kamaledin B.","family":"Said","sequence":"additional","affiliation":[{"name":"Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada"},{"name":"Department of Pathology and Microbiology, College of Medicine, University of Hail, Hail 55476, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Nokhbeh","sequence":"additional","affiliation":[{"name":"Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6625-2153","authenticated-orcid":false,"given":"Bahram","family":"Samanfar","sequence":"additional","affiliation":[{"name":"Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada"},{"name":"Agriculture and Agri-Food Canada, Ottawa Research and Development Centre (ORDC), Ottawa, ON K1A 0C6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan","family":"Golshani","sequence":"additional","affiliation":[{"name":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada"},{"name":"Department of Biology, Carleton University, Ottawa, ON K1S 5B6, 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