{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:41:21Z","timestamp":1792856481603,"version":"4.5.0"},"reference-count":80,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Associazione Italiana Ricerca sul Cancro (AIRC)","award":["23006"],"award-info":[{"award-number":["23006"]}]},{"name":"Italian Ministry of Health","award":["23006"],"award-info":[{"award-number":["23006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cancer cachexia is a complex multifactorial syndrome whose hallmarks are weight loss due to the wasting of muscle tissue with or without the loss of adipose tissue, anorexia, systemic inflammation, and multi-organ metabolic alterations, which negatively impact patients\u2019 response to anticancer treatments, quality of life, and overall survival. Despite its clinical relevance, cancer cachexia often remains an underestimated complication due to the lack of rigorous diagnostic and therapeutic pathways. A number of studies have shown alterations in gut microbiota diversity and composition in association with cancer cachexia markers and symptoms, thus supporting a central role for dysbiosis in the pathogenesis of this syndrome. Different tools of microbiota manipulation, including probiotics, prebiotics, synbiotics, and fecal microbiota transplantation, have been investigated, demonstrating encouraging improvements in cachexia outcomes. Albeit pioneering, these studies pave the way for future research with the aim of exploring the role of gut microbiota in cancer cachexia more deeply and setting up effective microbiota-targeting interventions to be translated into clinical practice.<\/jats:p>","DOI":"10.3390\/ijms24031849","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T01:57:57Z","timestamp":1674007077000},"page":"1849","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Targeting Gut Microbiota in Cancer Cachexia: Towards New Treatment Options"],"prefix":"10.3390","volume":"24","author":[{"given":"Concetta","family":"Panebianco","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Fondazione IRCCS Casa Sollievo della Sofferenza, Hospital, Viale dei Cappuccini, 1, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annacandida","family":"Villani","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Fondazione IRCCS Casa Sollievo della Sofferenza, Hospital, Viale dei Cappuccini, 1, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Potenza","sequence":"additional","affiliation":[{"name":"Dietetic and Clinical Nutrition Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, Viale dei Cappuccini, 1, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Favaro","sequence":"additional","affiliation":[{"name":"Department of Medical Science, University of Turin, 10124 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Finocchiaro","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Citt\u00e0 della Salute e della Scienza, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8314-8016","authenticated-orcid":false,"given":"Francesco","family":"Perri","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Fondazione IRCCS Casa Sollievo della Sofferenza, Hospital, Viale dei Cappuccini, 1, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3492-1153","authenticated-orcid":false,"given":"Valerio","family":"Pazienza","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Fondazione IRCCS Casa Sollievo della Sofferenza, Hospital, Viale dei Cappuccini, 1, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nrc3829","article-title":"Cancer cachexia: Understanding the molecular basis","volume":"14","author":"Argiles","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5597","DOI":"10.2147\/CMAR.S261585","article-title":"Cancer Cachexia: Definition, Staging, and Emerging Treatments","volume":"12","author":"Ni","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Braha, A., Albai, A., Timar, B., Negru, S., Sorin, S., Roman, D., and Popovici, D. (2022). Nutritional Interventions to Improve Cachexia Outcomes in Cancer-A Systematic Review. Medicina, 58.","DOI":"10.3390\/medicina58070966"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: An international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.trecan.2018.10.001","article-title":"Cancer Cachexia: More Than Skeletal Muscle Wasting","volume":"4","author":"Schmidt","year":"2018","journal-title":"Trends Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/jcsm.12910","article-title":"Addressing unmet needs for people with cancer cachexia: Recommendations from a multistakeholder workshop","volume":"13","author":"Garcia","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.1007\/s00520-020-05346-8","article-title":"Incidence and frequency of cancer cachexia during chemotherapy for advanced pancreatic ductal adenocarcinoma","volume":"28","author":"Mitsunaga","year":"2020","journal-title":"Support. Care Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.1038\/oncsis.2016.3","article-title":"Understanding cachexia as a cancer metabolism syndrome","volume":"5","author":"Porporato","year":"2016","journal-title":"Oncogenesis"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1042\/BCJ20170032","article-title":"Novel targeted therapies for cancer cachexia","volume":"474","author":"Argiles","year":"2017","journal-title":"Biochem. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41416-022-01826-2","article-title":"Cancer cachexia: A nutritional or a systemic inflammatory syndrome?","volume":"127","author":"McGovern","year":"2022","journal-title":"Br. J. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e47258","DOI":"10.15252\/embr.201847258","article-title":"Energy metabolism in cachexia","volume":"20","author":"Rohm","year":"2019","journal-title":"EMBO Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0749-0690(02)00032-0","article-title":"Distinguishing starvation from cachexia","volume":"18","author":"Thomas","year":"2002","journal-title":"Clin. Geriatr. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/rco2.30","article-title":"Mediators and clinical treatment for cancer cachexia: A systematic review","volume":"4","author":"Cao","year":"2021","journal-title":"JCSM Rapid Commun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.2147\/TCRM.S196802","article-title":"Emerging Treatment Options For Cancer-Associated Cachexia: A Literature Review","volume":"15","author":"Naito","year":"2019","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1002\/mco2.164","article-title":"Targeting cancer cachexia: Molecular mechanisms and clinical study","volume":"3","author":"Wang","year":"2022","journal-title":"MedComm"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1615\/CritRevOncog.v17.i3.80","article-title":"Multitargeted treatment of cancer cachexia","volume":"17","author":"Madeddu","year":"2012","journal-title":"Crit. Rev. Oncog."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1200\/JCO.1993.11.4.762","article-title":"Phase III evaluation of four doses of megestrol acetate as therapy for patients with cancer anorexia and\/or cachexia","volume":"11","author":"Loprinzi","year":"1993","journal-title":"J. Clin. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"960341","DOI":"10.3389\/fcell.2022.960341","article-title":"Cancer cachexia as a multiorgan failure: Reconstruction of the crime scene","volume":"10","author":"Ferrara","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Herremans, K.M., Riner, A.N., Cameron, M.E., and Trevino, J.G. (2019). The Microbiota and Cancer Cachexia. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20246267"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1007\/s00213-018-5159-2","article-title":"The gut microbiome in anorexia nervosa: Relevance for nutritional rehabilitation","volume":"236","author":"Ruusunen","year":"2019","journal-title":"Psychopharmacology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1038\/s41598-021-84031-0","article-title":"Alterations in intestinal microbiota diversity, composition, and function in patients with sarcopenia","volume":"11","author":"Kang","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.jcmgh.2021.02.007","article-title":"Regulation of Intestinal Barrier Function by Microbial Metabolites","volume":"11","author":"Ghosh","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1002\/jcsm.12964","article-title":"Gut microbes and muscle function: Can probiotics make our muscles stronger?","volume":"13","author":"Giron","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Przewlocka, K., Folwarski, M., Kazmierczak-Siedlecka, K., Skonieczna-Zydecka, K., and Kaczor, J.J. (2020). Gut-Muscle AxisExists and May Affect Skeletal Muscle Adaptation to Training. Nutrients, 12.","DOI":"10.3390\/nu12051451"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3389\/fcimb.2019.00305","article-title":"Targeting the Gut Microbiota to Treat Cachexia","volume":"9","author":"Genton","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1007\/s00726-017-2493-3","article-title":"A review of the relationship between the gut microbiota and amino acid metabolism","volume":"49","author":"Lin","year":"2017","journal-title":"Amino Acids"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"101508","DOI":"10.1016\/j.beem.2021.101508","article-title":"Gut microbiota and metabolic aspects of cancer cachexia","volume":"35","author":"Ziemons","year":"2021","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1038\/s41396-021-00998-8","article-title":"Distinct composition and metabolic functions of human gut microbiota are associated with cachexia in lung cancer patients","volume":"15","author":"Ni","year":"2021","journal-title":"ISME J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/jcsm.12684","article-title":"Multi-compartment metabolomics and metagenomics reveal major hepatic and intestinal disturbances in cancer cachectic mice","volume":"12","author":"Potgens","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1002\/jcsm.12804","article-title":"Gut microbiota and short-chain fatty acid alterations in cachectic cancer patients","volume":"12","author":"Ubachs","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"101427","DOI":"10.1016\/j.molmet.2021.101427","article-title":"Microbiota and body weight control: Weight watchers within?","volume":"57","author":"Boscaini","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"eaan5662","DOI":"10.1126\/scitranslmed.aan5662","article-title":"The gut microbiota influences skeletal muscle mass and function in mice","volume":"11","author":"Lahiri","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1080\/07853890.2021.1900593","article-title":"Depletion of gut microbiota induces skeletal muscle atrophy by FXR-FGF15\/19 signalling","volume":"53","author":"Qiu","year":"2021","journal-title":"Ann. Med."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Bindels, L.B., Beck, R., Schakman, O., Martin, J.C., De Backer, F., Sohet, F.M., Dewulf, E.M., Pachikian, B.D., Neyrinck, A.M., and Thissen, J.P. (2012). Restoring specific lactobacilli levels decreases inflammation and muscle atrophy markers in an acute leukemia mouse model. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0037971"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1038\/ismej.2015.209","article-title":"Synbiotic approach restores intestinal homeostasis and prolongs survival in leukaemic mice with cachexia","volume":"10","author":"Bindels","year":"2016","journal-title":"ISME J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"12321","DOI":"10.1038\/s41598-018-30569-5","article-title":"Klebsiella oxytoca expands in cancer cachexia and acts as a gut pathobiont contributing to intestinal dysfunction","volume":"8","author":"Potgens","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/jcsm.12798","article-title":"Bile acid metabolism dysregulation associates with cancer cachexia: Roles of liver and gut microbiome","volume":"12","author":"Feng","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e26425","DOI":"10.1002\/pbc.26425","article-title":"Neuroblastoma causes alterations of the intestinal microbiome, gut hormones, inflammatory cytokines, and bile acid composition","volume":"64","author":"Castellani","year":"2017","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_39","first-page":"001088","article-title":"Analysis of mouse faecal dysbiosis, during the development of cachexia, induced by transplantation with Lewis lung carcinoma cells","volume":"167","author":"Menegidio","year":"2021","journal-title":"Microbiology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e00144","DOI":"10.1002\/phy2.144","article-title":"Concurrent muscle and bone deterioration in a murine model of cancer cachexia","volume":"1","author":"Choi","year":"2013","journal-title":"Physiol. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1517\/17460440903300842","article-title":"Animal models of anorexia and cachexia","volume":"4","author":"Deboer","year":"2009","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Jabes, D.L., de Maria, Y., Aciole Barbosa, D., Santos, K., Carvalho, L.M., Humberto, A.C., Alencar, V.C., Costa de Oliveira, R., Batista, M.L., and Menegidio, F.B. (2020). Fungal Dysbiosis Correlates with the Development of Tumor-Induced Cachexia in Mice. J. Fungi, 6.","DOI":"10.1101\/2020.06.29.171397"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Hakozaki, T., Nolin-Lapalme, A., Kogawa, M., Okuma, Y., Nakamura, S., Moreau-Amaru, D., Tamura, T., Hosomi, Y., Takeyama, H., and Richard, C. (2022). Cancer Cachexia among Patients with Advanced Non-Small-Cell Lung Cancer on Immunotherapy: An Observational Study with Exploratory Gut Microbiota Analysis. Cancers, 14.","DOI":"10.3390\/cancers14215405"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature18646","article-title":"Human gut microbes impact host serum metabolome and insulin sensitivity","volume":"535","author":"Pedersen","year":"2016","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3389\/fphys.2017.00127","article-title":"Transcriptional Signature of an Altered Purine Metabolism in the Skeletal Muscle of a Huntington\u2019s Disease Mouse Model","volume":"8","author":"Mielcarek","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Miller, S.G., Hafen, P.S., and Brault, J.J. (2020). Increased Adenine Nucleotide Degradation in Skeletal Muscle Atrophy. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010088"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e00006","DOI":"10.1002\/edm2.6","article-title":"A role for methanogens and methane in the regulation of GLP-1","volume":"1","author":"Laverdure","year":"2018","journal-title":"Endocrinol. Diabetes Metab."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"616506","DOI":"10.3389\/fendo.2021.616506","article-title":"Impaired Intestinal Barrier and Tissue Bacteria: Pathomechanisms for Metabolic Diseases","volume":"12","author":"Massier","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3164\/jcbn.19-10","article-title":"Dietary intake of probiotic kimchi ameliorated IL-6-driven cancer cachexia","volume":"65","author":"An","year":"2019","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Bindels, L.B., Neyrinck, A.M., Salazar, N., Taminiau, B., Druart, C., Muccioli, G.G., Francois, E., Blecker, C., Richel, A., and Daube, G. (2015). Non Digestible Oligosaccharides Modulate the Gut Microbiota to Control the Development of Leukemia and Associated Cachexia in Mice. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0131009"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"12552","DOI":"10.1038\/s41598-017-12644-5","article-title":"Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in Apc(Min\/+) mice","volume":"7","author":"Huang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1111\/cas.15306","article-title":"Water-soluble dietary fiber alleviates cancer-induced muscle wasting through changes in gut microenvironment in mice","volume":"113","author":"Sakakida","year":"2022","journal-title":"Cancer Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"11803","DOI":"10.18632\/oncotarget.7730","article-title":"Beneficial bacteria inhibit cachexia","volume":"7","author":"Varian","year":"2016","journal-title":"Oncotarget"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1111\/j.1365-2672.2011.05157.x","article-title":"B-group vitamin production by lactic acid bacteria--current knowledge and potential applications","volume":"111","author":"LeBlanc","year":"2011","journal-title":"J. Appl. Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"110240","DOI":"10.1016\/j.pnpbp.2020.110240","article-title":"Gut microbiota-derived vitamins-underrated powers of a multipotent ally in psychiatric health and disease","volume":"107","author":"Rudzki","year":"2021","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cofs.2020.01.003","article-title":"Sources, formulations, advanced delivery and health benefits of probiotics","volume":"32","author":"Roobab","year":"2020","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"104080","DOI":"10.1016\/j.jff.2020.104080","article-title":"Probiotics as an alternative antimicrobial therapy: Current reality and future directions","volume":"73","author":"Silva","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1016\/j.biotechadv.2018.09.003","article-title":"How to select a probiotic? A review and update of methods and criteria","volume":"36","author":"Soccol","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","article-title":"Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics","volume":"14","author":"Gibson","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"109682","DOI":"10.1016\/j.foodres.2020.109682","article-title":"Encapsulated probiotic cells: Relevant techniques, natural sources as encapsulating materials and food applications-A narrative review","volume":"137","author":"Rodrigues","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41575-020-0344-2","article-title":"The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics","volume":"17","author":"Swanson","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"257","DOI":"10.5946\/ce.2015.117","article-title":"Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives","volume":"49","author":"Choi","year":"2016","journal-title":"Clin. Endosc."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cofs.2018.02.011","article-title":"Polyphenol-based prebiotics and synbiotics: Potential for cancer chemoprevention","volume":"20","author":"Thilakarathna","year":"2018","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5946\/ce.2019.009","article-title":"Fecal Microbiota Transplantation: An Update on Clinical Practice","volume":"52","author":"Kim","year":"2019","journal-title":"Clin. Endosc."},{"key":"ref_66","first-page":"634","article-title":"Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome","volume":"67","author":"Zuo","year":"2017","journal-title":"Gut"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s41591-018-0324-z","article-title":"Healthy infants harbor intestinal bacteria that protect against food allergy","volume":"25","author":"Feehley","year":"2019","journal-title":"Nat. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.ebiom.2019.03.070","article-title":"Adjunctive fecal microbiota transplantation in supportive oncology: Emerging indications and considerations in immunocompromised patients","volume":"44","author":"Wardill","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/ajg.2014.133","article-title":"Fecal microbiota transplant for treatment of Clostridium difficile infection in immunocompromised patients","volume":"109","author":"Kelly","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1007\/s10620-021-07347-x","article-title":"Fecal Microbiota Transplant for Clostridioides Difficile Infection Is Safe and Efficacious in an Immunocompromised Cohort","volume":"67","author":"Suchman","year":"2022","journal-title":"Dig. Dis. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/MCG.0000000000000410","article-title":"The Long-term Efficacy and Safety of Fecal Microbiota Transplant for Recurrent, Severe, and Complicated Clostridium difficile Infection in 146 Elderly Individuals","volume":"50","author":"Agrawal","year":"2016","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"961569","DOI":"10.3389\/fmedt.2022.961569","article-title":"Orchestrating the fecal microbiota transplantation: Current technological advancements and potential biomedical application","volume":"4","author":"Nigam","year":"2022","journal-title":"Front. Med. Technol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.biologicals.2022.01.004","article-title":"Evolution of FMT-From early clinical to standardized treatments","volume":"76","author":"Servetas","year":"2022","journal-title":"Biologicals"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"18224","DOI":"10.18632\/oncotarget.24804","article-title":"Increased gut permeability in cancer cachexia: Mechanisms and clinical relevance","volume":"9","author":"Bindels","year":"2018","journal-title":"Oncotarget"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Martin, R., Miquel, S., Chain, F., Natividad, J.M., Jury, J., Lu, J., Sokol, H., Theodorou, V., Bercik, P., and Verdu, E.F. (2015). Faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model. BMC Microbiol., 15.","DOI":"10.1186\/s12866-015-0400-1"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.3109\/00365521.2013.828773","article-title":"Faecalibacterium prausnitzii supernatant improves intestinal barrier function in mice DSS colitis","volume":"48","author":"Carlsson","year":"2013","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"31226","DOI":"10.18632\/oncotarget.8886","article-title":"Triterpenoid herbal saponins enhance beneficial bacteria, decrease sulfate-reducing bacteria, modulate inflammatory intestinal microenvironment and exert cancer preventive effects in ApcMin\/+ mice","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Obermuller, B., Singer, G., Kienesberger, B., Klymiuk, I., Sperl, D., Stadlbauer, V., Horvath, A., Miekisch, W., Gierschner, P., and Grabherr, R. (2020). The Effects of Prebiotic Supplementation with OMNi-LOGiC((R)) FIBRE on Fecal Microbiome, Fecal Volatile Organic Compounds, and Gut Permeability in Murine Neuroblastoma-Induced Tumor-Associated Cachexia. Nutrients, 12.","DOI":"10.3390\/nu12072029"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1056\/NEJMoa2106516","article-title":"SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection","volume":"386","author":"Feuerstadt","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1158\/1078-0432.CCR-20-4918","article-title":"Fecal Microbiota Transplantation from Overweight or Obese Donors in Cachectic Patients with Advanced Gastroesophageal Cancer: A Randomized, Double-blind, Placebo-Controlled, Phase II Study","volume":"27","author":"Prodan","year":"2021","journal-title":"Clin. Cancer Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/3\/1849\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:08:30Z","timestamp":1760119710000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/3\/1849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,17]]},"references-count":80,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["ijms24031849"],"URL":"https:\/\/doi.org\/10.3390\/ijms24031849","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,17]]}}}