{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:02:41Z","timestamp":1792789361379,"version":"4.5.0"},"reference-count":46,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cCarol Davila\u201d University of Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Eosinophilic fasciitis (EF), defined as diffuse fasciitis with eosinophilia by Shulman in 1974, is a disease with unknown etiology and whose pathogenesis is still being researched. The diagnosis is based on the clinical aspects (skin induration with an \u201corange peel\u201d appearance), the lab results (eosinophilia, increased inflammatory markers), the skin biopsy with the pathognomonic histopathological result, as well as the typical MRI changes. The treatment includes glucocorticoids and immunosuppressive drugs. Due to severe refractory cases, the treatment remains a challenge. EF is still a disease with potential for further research.<\/jats:p>","DOI":"10.3390\/ijms24031982","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T04:19:40Z","timestamp":1674101980000},"page":"1982","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Eosinophilic Fasciitis: Current and Remaining Challenges"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1342-3243","authenticated-orcid":false,"given":"Diana","family":"Mazilu","sequence":"first","affiliation":[{"name":"\u201cSfanta Maria\u201d Clinical Hospital, Ion Mihalache blvd, 37-39, 011172 Bucharest, Romania"},{"name":"\u201cCarol Davila\u201d University of Medicine, Dionisie Lupu Street, nr 37, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Alina","family":"Bolta\u0219iu (T\u0103taru)","sequence":"additional","affiliation":[{"name":"\u201cSfanta Maria\u201d Clinical Hospital, Ion Mihalache blvd, 37-39, 011172 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-667X","authenticated-orcid":false,"given":"Denise-Ani","family":"Mardale","sequence":"additional","affiliation":[{"name":"\u201cSfanta Maria\u201d Clinical Hospital, Ion Mihalache blvd, 37-39, 011172 Bucharest, Romania"},{"name":"\u201cCarol Davila\u201d University of Medicine, Dionisie Lupu Street, nr 37, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Silviana","family":"Bij\u0103","sequence":"additional","affiliation":[{"name":"\u201cSfanta Maria\u201d Clinical Hospital, Ion Mihalache blvd, 37-39, 011172 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sermina","family":"Ismail","sequence":"additional","affiliation":[{"name":"\u201cSfanta Maria\u201d Clinical Hospital, Ion Mihalache blvd, 37-39, 011172 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Zanfir","sequence":"additional","affiliation":[{"name":"\u201cSfanta Maria\u201d Clinical Hospital, Ion Mihalache blvd, 37-39, 011172 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florentina","family":"Negoi","sequence":"additional","affiliation":[{"name":"\u201cSfanta Maria\u201d Clinical Hospital, Ion Mihalache blvd, 37-39, 011172 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andra Rodica","family":"Balanescu","sequence":"additional","affiliation":[{"name":"\u201cSfanta Maria\u201d Clinical Hospital, Ion Mihalache blvd, 37-39, 011172 Bucharest, Romania"},{"name":"\u201cCarol Davila\u201d University of Medicine, Dionisie Lupu Street, nr 37, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/1756-185X.14284","article-title":"Eosinophilic fasciitis induced by a game of drumming probably via type 2 innate immunity","volume":"25","author":"Watanabe","year":"2022","journal-title":"Int. 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