{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:37:49Z","timestamp":1789213069532,"version":"build-2803163510"},"reference-count":30,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"scholarship of the President of the Russian Federation for young scientists and graduate students","award":["SP-1641.2021.4"],"award-info":[{"award-number":["SP-1641.2021.4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A series of novel organotin(IV) complexes on the base of 2-(N-3\u2032,5\u2032-di-tert-butyl-4\u2032-hydroxyphenyl)-iminomethylphenol (L) of formulae Me2SnBr2(L)2 (1), Bu2SnCl2(L)2(2), Ph2SnCl2(L) (3), Ph2SnCl2(L)2 (4) Ph3SnBr(L)2 (5) were synthesized and characterized by 1H, 13C, 119Sn NMR, IR, ESI-MS and elemental analysis. The crystal structures of initial L and complex 2 were determined by XRD method. It was found that L crystallizes in the orthorhombic syngony. The distorted octahedron geometry around Sn center is observed in the structure of complex 2. Intra- and inter-molecular hydrogen bonds were found in both structures. The antioxidant activity of new complexes as reducing agents, radical scavengers and lipoxygenase inhibitors was estimated spectrophotometrically in CUPRAC and DPPH tests (compounds 1 and 5 were found to be the most active in both methods), and in the process of enzymatic oxidation in vitro of linoleic acid under the action of lipoxygenase LOX 1-B (EC50 &gt; 33.3 \u03bcM for complex 2). Furthermore, compounds 1\u20135 have been investigated for their antiproliferative activity in vitro towards HCT-116, MCF-7 and A-549 and non-malignant WI-38 human cell lines. Complexes 2 and 5 demonstrated the highest activity. The plausible mechanisms of the antiproliferative activity of compounds, including the influence on the polymerization of Tb+MAP, are discussed. Some of the synthesized compounds have also actively induced apoptosis and blocked proliferation in the cell cycle G2\/M phase.<\/jats:p>","DOI":"10.3390\/ijms24032024","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T02:35:55Z","timestamp":1674182155000},"page":"2024","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Biological Activity of Novel Organotin Compounds with a Schiff Base Containing an Antioxidant Fragment"],"prefix":"10.3390","volume":"24","author":[{"given":"Taisiya A.","family":"Antonenko","sequence":"first","affiliation":[{"name":"Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory 1\/3, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia A.","family":"Gracheva","sequence":"additional","affiliation":[{"name":"Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory 1\/3, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry B.","family":"Shpakovsky","sequence":"additional","affiliation":[{"name":"Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory 1\/3, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mstislav A.","family":"Vorobyev","sequence":"additional","affiliation":[{"name":"Institute of Geography of the Russian Academy of Sciences, Department of Glaciology, 117312 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9780-1490","authenticated-orcid":false,"given":"Dmitrii M.","family":"Mazur","sequence":"additional","affiliation":[{"name":"Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory 1\/3, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor A.","family":"Tafeenko","sequence":"additional","affiliation":[{"name":"Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory 1\/3, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yury F.","family":"Oprunenko","sequence":"additional","affiliation":[{"name":"Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory 1\/3, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2887-1185","authenticated-orcid":false,"given":"Elena F.","family":"Shevtsova","sequence":"additional","affiliation":[{"name":"Institute of Physiologically Active Compounds of Russian Academy of Sciences, 142432 Chernogolovka, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel N.","family":"Shevtsov","sequence":"additional","affiliation":[{"name":"Institute of Physiologically Active Compounds of Russian Academy of Sciences, 142432 Chernogolovka, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-1658","authenticated-orcid":false,"given":"Alexey A.","family":"Nazarov","sequence":"additional","affiliation":[{"name":"Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory 1\/3, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena R.","family":"Milaeva","sequence":"additional","affiliation":[{"name":"Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory 1\/3, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1515\/pac-2016-1130","article-title":"Hybrid metal complexes with opposed biological modes of action\u2014Promising selective drug candidates","volume":"89","author":"Milaeva","year":"2017","journal-title":"Pure Appl. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1515\/pac-2019-1209","article-title":"Novel selective anticancer agents based on Sn and Au complexes. 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