{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:19:42Z","timestamp":1787959182503,"version":"build-2784847793"},"reference-count":62,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cFondation pour la Recherche M\u00e9dicale\u201d postdoctoral fellowship","award":["SPF20151234951"],"award-info":[{"award-number":["SPF20151234951"]}]},{"name":"\u201cFondation pour la Recherche M\u00e9dicale\u201d postdoctoral fellowship","award":["10-IAHU-03"],"award-info":[{"award-number":["10-IAHU-03"]}]},{"name":"Fondation M\u00e9diterran\u00e9e Infection","award":["SPF20151234951"],"award-info":[{"award-number":["SPF20151234951"]}]},{"name":"Fondation M\u00e9diterran\u00e9e Infection","award":["10-IAHU-03"],"award-info":[{"award-number":["10-IAHU-03"]}]},{"name":"French Government","award":["SPF20151234951"],"award-info":[{"award-number":["SPF20151234951"]}]},{"name":"French Government","award":["10-IAHU-03"],"award-info":[{"award-number":["10-IAHU-03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Circadian rhythms have been described in numerous tissues of living organisms and are necessary for homeostasis. The understanding of their role in normal and pathological pregnancy is only just emerging. It has been established that clock genes are expressed in the placenta of animals and humans, but the rhythmicity of placenta immune cells is not known. Macrophages from healthy placenta of women at term were isolated and the expression of clock genes BMAL1, CLOCK, PER2, CRY2, and NR1D1 was assessed by qRT-PCR every 4 h over 24 h. Raw data were treated with cosinor analysis to evaluate the significance of the oscillations. Placental macrophages exhibited significant circadian expression of clock genes but one third of placental macrophages lost clock gene rhythmicity; the clock gene oscillations were restored by co-culture with trophoblasts. We wondered if melatonin, a key hormone regulating circadian rhythm, was involved in the oscillations of placental cells. We showed that macrophages and trophoblasts produced melatonin and expressed MT2 receptor. In women who developed preeclampsia during pregnancy, circadian oscillations of placental macrophages were lost and could not be rescued by coculture with trophoblasts from healthy women. Moreover, production and oscillations of melatonin were altered in preeclamptic macrophages. For the first time to our knowledge, this study shows circadian rhythms and melatonin production by placental macrophages. It also shows that preeclampsia is associated with a disruption of the circadian rhythm of placental cells. These results represent a new scientific breakthrough that may contribute to the prevention and treatment of obstetrical pathologies.<\/jats:p>","DOI":"10.3390\/ijms24032363","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T01:57:07Z","timestamp":1674698227000},"page":"2363","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Disruption of the Expression of the Placental Clock and Melatonin Genes in Preeclampsia"],"prefix":"10.3390","volume":"24","author":[{"given":"A\u00efssatou Bailo","family":"Diallo","sequence":"first","affiliation":[{"name":"MEPHI, IRD, APHM, Aix-Marseille Univ, 13005 Marseille, France"},{"name":"Institut Hospitalo-Universitaire M\u00e9diterran\u00e9e-Infection, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-5346","authenticated-orcid":false,"given":"Benjamin","family":"Coiffard","sequence":"additional","affiliation":[{"name":"MEPHI, IRD, APHM, Aix-Marseille Univ, 13005 Marseille, France"},{"name":"Institut Hospitalo-Universitaire M\u00e9diterran\u00e9e-Infection, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Desbriere","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, H\u00f4pital Saint Joseph, 13008 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1002-7261","authenticated-orcid":false,"given":"Maria","family":"Katsogiannou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, H\u00f4pital Saint Joseph, 13008 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6345-4929","authenticated-orcid":false,"given":"Xavier","family":"Donato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, H\u00f4pital Saint Joseph, 13008 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Bretelle","sequence":"additional","affiliation":[{"name":"MEPHI, IRD, APHM, Aix-Marseille Univ, 13005 Marseille, France"},{"name":"Institut Hospitalo-Universitaire M\u00e9diterran\u00e9e-Infection, 13005 Marseille, France"},{"name":"Department of Obstetrics and Gynecology, APHM, H\u00f4pital de la Conception, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2285-7051","authenticated-orcid":false,"given":"Soraya","family":"Mezouar","sequence":"additional","affiliation":[{"name":"MEPHI, IRD, APHM, Aix-Marseille Univ, 13005 Marseille, France"},{"name":"Institut Hospitalo-Universitaire M\u00e9diterran\u00e9e-Infection, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Mege","sequence":"additional","affiliation":[{"name":"MEPHI, IRD, APHM, Aix-Marseille Univ, 13005 Marseille, France"},{"name":"Institut Hospitalo-Universitaire M\u00e9diterran\u00e9e-Infection, 13005 Marseille, France"},{"name":"Department of Immunology, APHM, H\u00f4pital de la Conception, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.3389\/fimmu.2020.01457","article-title":"For Whom the Clock Ticks: Clinical Chronobiology for Infectious Diseases","volume":"11","author":"Diallo","year":"2020","journal-title":"Front. 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