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The genes can be modulated by both the central circadian system and some extrinsic factors, such as light and thyroid hormones. These circadian genes participate in the regulation of several physiological processes of HFs, including hair growth and pigmentation. On the other hand, because peripheral circadian genes are synchronized with the central clock, HFs could provide a noninvasive and practical method for monitoring and evaluating multiple circadian-rhythm-related conditions and disorders among humans, including day and night shifts, sleep\u2013wake disorders, physical activities, energy metabolism, and aging. However, due to the complexity of circadian biology, understanding how intrinsic oscillation operates using peripheral tissues only may be insufficient. Combining HF sampling with multidimensional assays such as detection of body temperature, blood samples, or certain validated questionnaires may be helpful in improving HF applications. Thus, HFs can serve as a critical model for monitoring the circadian clock and can help provide an understanding of the potential mechanisms of circadian-rhythm-related conditions; furthermore, chronotherapy could support personalized treatment scheduling based on the gene expression profile expressed in HFs.<\/jats:p>","DOI":"10.3390\/ijms24032407","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T01:57:07Z","timestamp":1674698227000},"page":"2407","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Hair Follicles as a Critical Model for Monitoring the Circadian Clock"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4445-8403","authenticated-orcid":false,"given":"Li-Ping","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China"},{"name":"Institute of Regenerative Medicine, Jiangsu University, Zhenjiang 212001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9140-7118","authenticated-orcid":false,"given":"Meng-Huan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China"},{"name":"Institute of Regenerative Medicine, Jiangsu University, Zhenjiang 212001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9002-3190","authenticated-orcid":false,"given":"Yun-Wen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Regenerative Medicine, Jiangsu University, Zhenjiang 212001, China"},{"name":"Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China"},{"name":"Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda 278-8510, Japan"},{"name":"Department of Regenerative Medicine, Yokohama City University School of Medicine, Yokohama 234-0006, Japan"},{"name":"Division of Regenerative Medicine, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1001\/jamadermatol.2021.2196","article-title":"Health-Related Quality of Life, Depression, and Self-esteem in Patients With Androgenetic Alopecia: A Systematic Review and Meta-analysis","volume":"157","author":"Huang","year":"2021","journal-title":"JAMA Dermatol."},{"key":"ref_2","first-page":"411","article-title":"Psychology of Hair Loss Patients and Importance of Counseling","volume":"54","author":"Dhami","year":"2021","journal-title":"Indian J. 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