{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:54:08Z","timestamp":1787316848474,"version":"build-2736575974"},"reference-count":75,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T00:00:00Z","timestamp":1674864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft","award":["1636\/2-1 (MAAA)"],"award-info":[{"award-number":["1636\/2-1 (MAAA)"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["1636\/5-1 (MAAA)"],"award-info":[{"award-number":["1636\/5-1 (MAAA)"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["SCHU 2494\/15-1"],"award-info":[{"award-number":["SCHU 2494\/15-1"]}]},{"name":"Marga und Walter Boll Stiftung (MAAA)","award":["1636\/2-1 (MAAA)"],"award-info":[{"award-number":["1636\/2-1 (MAAA)"]}]},{"name":"Marga und Walter Boll Stiftung (MAAA)","award":["1636\/5-1 (MAAA)"],"award-info":[{"award-number":["1636\/5-1 (MAAA)"]}]},{"name":"Marga und Walter Boll Stiftung (MAAA)","award":["SCHU 2494\/15-1"],"award-info":[{"award-number":["SCHU 2494\/15-1"]}]},{"name":"Stiftung Oskar Helene Heim","award":["1636\/2-1 (MAAA)"],"award-info":[{"award-number":["1636\/2-1 (MAAA)"]}]},{"name":"Stiftung Oskar Helene Heim","award":["1636\/5-1 (MAAA)"],"award-info":[{"award-number":["1636\/5-1 (MAAA)"]}]},{"name":"Stiftung Oskar Helene Heim","award":["SCHU 2494\/15-1"],"award-info":[{"award-number":["SCHU 2494\/15-1"]}]},{"name":"Center for Molecular Medicine Cologne (CMMC; MAAA)","award":["1636\/2-1 (MAAA)"],"award-info":[{"award-number":["1636\/2-1 (MAAA)"]}]},{"name":"Center for Molecular Medicine Cologne (CMMC; MAAA)","award":["1636\/5-1 (MAAA)"],"award-info":[{"award-number":["1636\/5-1 (MAAA)"]}]},{"name":"Center for Molecular Medicine Cologne (CMMC; MAAA)","award":["SCHU 2494\/15-1"],"award-info":[{"award-number":["SCHU 2494\/15-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chronic Kidney Disease (CKD), a global health burden, is strongly associated with age-related renal function decline, hypertension, and diabetes, which are all frequent consequences of obesity. Despite extensive studies, the mechanisms determining susceptibility to CKD remain insufficiently understood. Clinical evidence together with prior studies from our group showed that perinatal metabolic disorders after intrauterine growth restriction or maternal obesity adversely affect kidney structure and function throughout life. Since obesity and aging processes converge in similar pathways we tested if perinatal obesity caused by high-fat diet (HFD)-fed dams sensitizes aging-associated mechanisms in kidneys of newborn mice. The results showed a marked increase of \u03b3H2AX-positive cells with elevated 8-Oxo-dG (RNA\/DNA damage), both indicative of DNA damage response and oxidative stress. Using unbiased comprehensive transcriptomics we identified compartment-specific differentially-regulated signaling pathways in kidneys after perinatal obesity. Comparison of these data to transcriptomic data of naturally aged kidneys and prematurely aged kidneys of genetic modified mice with a hypomorphic allele of Ercc1, revealed similar signatures, e.g., inflammatory signaling. In a biochemical approach we validated pathways of inflammaging in the kidneys after perinatal obesity. Collectively, our initial findings demonstrate premature aging-associated processes as a consequence of perinatal obesity that could determine the susceptibility for CKD early in life.<\/jats:p>","DOI":"10.3390\/ijms24032508","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T04:58:25Z","timestamp":1675054705000},"page":"2508","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Perinatal Obesity Sensitizes for Premature Kidney Aging Signaling"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4981-0931","authenticated-orcid":false,"given":"Jaco","family":"Selle","sequence":"first","affiliation":[{"name":"Translational Experimental Pediatrics\u2014Experimental Pulmonology, Department of Pediatric and Adolescent Medicine, University Hospital Cologne, 50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3746-4047","authenticated-orcid":false,"given":"Katrin","family":"Bohl","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Nephrology Research Laboratory, University Hospital of Cologne, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne, 50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1287-7830","authenticated-orcid":false,"given":"Katja","family":"H\u00f6pker","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Nephrology Research Laboratory, University Hospital of Cologne, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany"},{"name":"Department of Pediatric and Adolescent Medicine, University Hospital Cologne, 50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Wilke","sequence":"additional","affiliation":[{"name":"Translational Experimental Pediatrics\u2014Experimental Pulmonology, Department of Pediatric and Adolescent Medicine, University Hospital Cologne, 50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Dinger","sequence":"additional","affiliation":[{"name":"Translational Experimental Pediatrics\u2014Experimental Pulmonology, Department of Pediatric and Adolescent Medicine, University Hospital Cologne, 50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6218-2239","authenticated-orcid":false,"given":"Philipp","family":"Kasper","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Cologne, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastian","family":"Abend","sequence":"additional","affiliation":[{"name":"Translational Experimental Pediatrics\u2014Experimental Pulmonology, Department of Pediatric and Adolescent Medicine, University Hospital Cologne, 50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5194-9000","authenticated-orcid":false,"given":"Bernhard","family":"Schermer","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Nephrology Research Laboratory, University Hospital of Cologne, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne, 50931 Cologne, Germany"},{"name":"Center for Molecular Medicine Cologne (CMMC), University Hospital Cologne, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6910-0745","authenticated-orcid":false,"given":"Roman-Ulrich","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Nephrology Research Laboratory, University Hospital of Cologne, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne, 50931 Cologne, Germany"},{"name":"Center for Molecular Medicine Cologne (CMMC), University Hospital Cologne, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3646-9471","authenticated-orcid":false,"given":"Christine","family":"Kurschat","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Nephrology Research Laboratory, University Hospital of Cologne, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne, 50931 Cologne, Germany"},{"name":"Center for Molecular Medicine Cologne (CMMC), University Hospital Cologne, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5749-7183","authenticated-orcid":false,"given":"Kai-Dietrich","family":"N\u00fcsken","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, University Hospital Cologne, 50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0674-804X","authenticated-orcid":false,"given":"Eva","family":"N\u00fcsken","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, University Hospital Cologne, 50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5667-4720","authenticated-orcid":false,"given":"David","family":"Meyer","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne, 50931 Cologne, Germany"},{"name":"Institute for Genome Stability in Aging and Disease, Medical Faculty, University Hospital Cologne, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0440-8831","authenticated-orcid":false,"given":"Soni","family":"Savai Pullamsetti","sequence":"additional","affiliation":[{"name":"Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), 61231 Bad Nauheim, Germany"},{"name":"Institute for Lung Health (ILH), Universities of Gie\u00dfen and Marburg Lung Centre (UGMLC), Cardiopulmonary Institute (CPI), Member of the German Center of Lung Research (DZL), 35392 Gie\u00dfen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6097-5238","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne, 50931 Cologne, Germany"},{"name":"Institute for Genome Stability in Aging and Disease, Medical Faculty, University Hospital Cologne, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"D\u00f6tsch","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, University Hospital Cologne, 50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A. 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