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Unfortunately, the underlying molecular mechanisms that lead to this disorder are not fully understood. Moreover, current biomarkers for DIC, including biological and clinical parameters, generally provide a poor diagnosis and prognosis. In recent years, non-coding RNAs have been studied as promising and robust biomarkers for a variety of diseases. Thus, their potential in the diagnosis and prognosis of DIC should be further studied. Specifically, the relationship between the coagulation cascade and non-coding RNAs should be established. In this review, microRNAs, long non-coding RNAs, and circular RNAs are studied in relation to DIC. Specifically, the axis between these non-coding RNAs and the corresponding affected pathway has been identified, including inflammation, alteration of the coagulation cascade, and endothelial damage. The main affected pathway identified is PI3K\/AKT\/mTOR axis, where several ncRNAs participate in its regulation, including miR-122-5p which is sponged by circ_0005963, ciRS-122, and circPTN, and miR-19a-3p which is modulated by circ_0000096 and circ_0063425. Additionally, both miR-223 and miR-24 were found to affect the PI3K\/AKT pathway and were regulated by lncGAS5 and lncKCNQ1OT1, respectively. Thus, this work provides a useful pipeline of inter-connected ncRNAs that future research on their impact on DIC can further explore.<\/jats:p>","DOI":"10.3390\/ijms24032582","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T04:58:25Z","timestamp":1675054705000},"page":"2582","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Intricate Role of Non-Coding RNAs in Sepsis-Associated Disseminated Intravascular Coagulation"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-235X","authenticated-orcid":false,"given":"Irene","family":"C\u00e1novas-Cervera","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain"},{"name":"Health Research Institute INCLIVA, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Nacher-Sendra","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain"},{"name":"Health Research Institute INCLIVA, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca","family":"Osca-Verdegal","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain"},{"name":"Health Research Institute INCLIVA, 46010 Valencia, Spain"},{"name":"Center for Biomedical Research Network on Rare Diseases (CIBERER), Carlos III Health Institute, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enric","family":"Dolz-Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4292-5509","authenticated-orcid":false,"given":"Jes\u00fas","family":"Beltr\u00e1n-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain"},{"name":"Health Research Institute INCLIVA, 46010 Valencia, Spain"},{"name":"Center for Biomedical Research Network on Rare Diseases (CIBERER), Carlos III Health Institute, 46010 Valencia, Spain"},{"name":"Department of Medicine, Division of Regenerative Medicine, University of California, San Diego, CA 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3766-1948","authenticated-orcid":false,"given":"Mar\u00eda","family":"Rodr\u00edguez-Gimillo","sequence":"additional","affiliation":[{"name":"Health Research Institute INCLIVA, 46010 Valencia, Spain"},{"name":"Intensive Care Unit, Clinical University Hospital of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Ferrando-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Health Research Institute INCLIVA, 46010 Valencia, Spain"},{"name":"Intensive Care Unit, Clinical University Hospital of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9149-0310","authenticated-orcid":false,"given":"Nieves","family":"Carbonell","sequence":"additional","affiliation":[{"name":"Health Research Institute INCLIVA, 46010 Valencia, Spain"},{"name":"Intensive Care Unit, Clinical University Hospital of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7547-7872","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Garc\u00eda-Gim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain"},{"name":"Health Research Institute INCLIVA, 46010 Valencia, Spain"},{"name":"Center for Biomedical Research Network on Rare Diseases (CIBERER), Carlos III Health Institute, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, Regional, and National Sepsis Incidence and Mortality, 1990\u20132017: 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