{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:58:51Z","timestamp":1791583131828,"version":"4.3.4"},"reference-count":51,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Core Program at IFIN-HH","award":["PN 19 06 02 03\/2019"],"award-info":[{"award-number":["PN 19 06 02 03\/2019"]}]},{"name":"Core Program at IFIN-HH","award":["PN19 35 02 03"],"award-info":[{"award-number":["PN19 35 02 03"]}]},{"name":"Core Program at IFIN-HH","award":["C1.2"],"award-info":[{"award-number":["C1.2"]}]},{"name":"Core Program at IFIN-HH","award":["41PFE\/2021"],"award-info":[{"award-number":["41PFE\/2021"]}]},{"name":"Romanian Ministry of Research, Innovation and Digitalization","award":["PN 19 06 02 03\/2019"],"award-info":[{"award-number":["PN 19 06 02 03\/2019"]}]},{"name":"Romanian Ministry of Research, Innovation and Digitalization","award":["PN19 35 02 03"],"award-info":[{"award-number":["PN19 35 02 03"]}]},{"name":"Romanian Ministry of Research, Innovation and Digitalization","award":["C1.2"],"award-info":[{"award-number":["C1.2"]}]},{"name":"Romanian Ministry of Research, Innovation and Digitalization","award":["41PFE\/2021"],"award-info":[{"award-number":["41PFE\/2021"]}]},{"name":"M.C.C.","award":["PN 19 06 02 03\/2019"],"award-info":[{"award-number":["PN 19 06 02 03\/2019"]}]},{"name":"M.C.C.","award":["PN19 35 02 03"],"award-info":[{"award-number":["PN19 35 02 03"]}]},{"name":"M.C.C.","award":["C1.2"],"award-info":[{"award-number":["C1.2"]}]},{"name":"M.C.C.","award":["41PFE\/2021"],"award-info":[{"award-number":["41PFE\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>To improve their biological activity, complexes [Cu(bipy)(dmtp)2(OH2)](ClO4)2\u00b7dmtp (1) and [Cu(phen)(dmtp)2(OH2)](ClO4)2\u00b7dmtp (2) (bipy 2,2\u2032-bipyridine, phen: 1,10-phenantroline, and dmtp: 5,7-dimethyl-1,2,4-triazolo [1,5-a]pyrimidine) were included in \u03b2-cyclodextrins (\u03b2-CD). During the inclusion, the co-crystalized dmtp molecule was lost, and UV-Vis spectra together with the docking studies indicated the synthesis of new materials with 1:1 and 1:2 molar ratios between complexes and \u03b2-CD. The association between Cu(II) compounds and \u03b2-CD has been proven by the identification of the components\u2019 patterns in the IR spectra and powder XRD diffractograms, while solid-state UV-Vis and EPR spectra analysis highlighted a slight modification of the square-pyramidal stereochemistry around Cu(II) in comparison with precursors. The inclusion species are stable in solution and exhibit the ability to scavenge or trap ROS species (O2\u00b7\u2212 and HO\u00b7) as indicated by the EPR experiments. Moreover, the two inclusion species exhibit anti-proliferative activity against murine melanoma B16 cells, which has been more significant for (2)@\u03b2-CD in comparison with (2). This behavior is associated with a cell cycle arrest in the G0\/G1 phase. Compared with precursors, (1a)@\u03b2-CD and (2a)@\u03b2-CD exhibit 17 and 26 times more intense activity against planktonic Escherichia coli, respectively, while (2a)@\u03b2-CD is 3 times more active against the Staphylococcus aureus strain.<\/jats:p>","DOI":"10.3390\/ijms24032688","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T02:29:03Z","timestamp":1675218543000},"page":"2688","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Copper (II) Species with Improved Anti-Melanoma and Antibacterial Activity by Inclusion in \u03b2-Cyclodextrin"],"prefix":"10.3390","volume":"24","author":[{"given":"Alina","family":"Tirsoaga","sequence":"first","affiliation":[{"name":"Department of Analytical and Physical Chemistry, Faculty of Chemistry, University of Bucharest, 4-12 Regina Elisabeta Av., District 3, 030018 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Cojocaru","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., District 5, 050663 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4018-7610","authenticated-orcid":false,"given":"Mihaela","family":"Badea","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., District 5, 050663 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irinel Adriana","family":"Badea","sequence":"additional","affiliation":[{"name":"Department of Analytical and Physical Chemistry, Faculty of Chemistry, University of Bucharest, 4-12 Regina Elisabeta Av., District 3, 030018 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8190-9512","authenticated-orcid":false,"given":"Arpad Mihai","family":"Rostas","sequence":"additional","affiliation":[{"name":"National Institute for Research and Development of Isotopic and Molecular Technologies, Department of Physics of Nanostructured Systems, 67-103 Donat Str., 400293 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Stoica","sequence":"additional","affiliation":[{"name":"Horia Hulubei National Institute for Physics and Nuclear Engineering, Department of Life and Environmental Physics, 30 Reactorului Str., 077125 Magurele-Ilfov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7309-6002","authenticated-orcid":false,"given":"Mihaela","family":"Bacalum","sequence":"additional","affiliation":[{"name":"Horia Hulubei National Institute for Physics and Nuclear Engineering, Department of Life and Environmental Physics, 30 Reactorului Str., 077125 Magurele-Ilfov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-1857","authenticated-orcid":false,"given":"Mariana Carmen","family":"Chifiriuc","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor Str., District 5, 060101 Bucharest, Romania"},{"name":"Romanian Academy of Scientists, 54 Spl. Independen\u021bei Str., District 5, 050085 Bucharest, Romania"},{"name":"Biological Sciences Division, The Romanian Academy, 25 Calea Victoriei, Sector 1, District 1, 010071 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4208-0972","authenticated-orcid":false,"given":"Rodica","family":"Olar","sequence":"additional","affiliation":[{"name":"Department of Analytical and Physical Chemistry, Faculty of Chemistry, University of Bucharest, 4-12 Regina Elisabeta Av., District 3, 030018 Bucharest, Romania"},{"name":"Department of Inorganic and Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., District 5, 050663 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"214506","DOI":"10.1016\/j.ccr.2022.214506","article-title":"Revisiting metallodrugs for the treatment of skin cancers","volume":"462","author":"Manzano","year":"2022","journal-title":"Coord. 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