{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T18:36:43Z","timestamp":1780943803102,"version":"3.54.1"},"reference-count":78,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Due to their chemical, mechanical, and optical properties, 2D ultrathin nanomaterials have significant potential in biomedicine. However, the cytotoxicity of such materials, including their mutual increase or decrease, is still not well understood. We studied the effects that graphene oxide (GO) nanolayers (with dimensions 0.1\u20133 \u03bcm and average individual flake thickness less than 1 nm) and ZrS3 nanoribbons (length more than 10 \u03bcm, width 0.4\u20133 \u03bcm, and thickness 50\u2013120 nm) have on the viability, cell cycle, and cell death of HCT116 colon carcinoma cells. We found that ZrS3 exhibited strong cytotoxicity by causing apoptotic cell death, which was in contrast to GO. When adding GO to ZrS3, ZrS3 was significantly less toxic, which may be because GO inhibits the effects of cytotoxic hydrogen sulfide produced by ZrS3. Thus, using zirconium trisulfide nanoribbons as an example, we have demonstrated the ability of graphene oxide to reduce the cytotoxicity of another nanomaterial, which may be of practical importance in biomedicine, including the development of biocompatible nanocoatings for scaffolds, theranostic nanostructures, and others.<\/jats:p>","DOI":"10.3390\/ijms24032783","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T06:49:36Z","timestamp":1675234176000},"page":"2783","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Graphene Oxide Nanosurface Reduces Apoptotic Death of HCT116 Colon Carcinoma Cells Induced by Zirconium Trisulfide Nanoribbons"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9080-5683","authenticated-orcid":false,"given":"Victor V.","family":"Tatarskiy","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Oncobiology, Institute of Gene Biology RAS, 119334 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga V.","family":"Zakharova","sequence":"additional","affiliation":[{"name":"Institute for Environmental Science and Biotechnology, Derzhavin Tambov State University, 392020 Tambov, Russia"},{"name":"Department of Functional Nanosystems and High-Temperature Materials, National University of Science and Technology \u00abMISIS\u00bb, 119991 Moscow, Russia"},{"name":"Engineering Center, Plekhanov Russian University of Economics, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Baranchikov","sequence":"additional","affiliation":[{"name":"Institute for Environmental Science and Biotechnology, Derzhavin Tambov State University, 392020 Tambov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2027-4311","authenticated-orcid":false,"given":"Dmitry S.","family":"Muratov","sequence":"additional","affiliation":[{"name":"Department of Functional Nanosystems and High-Temperature Materials, National University of Science and Technology \u00abMISIS\u00bb, 119991 Moscow, Russia"},{"name":"Scientific School \u201cChemistry and Technology of Polymer Materials\u201d, Plekhanov Russian University of Economics, Stremyanny Lane 36, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis V.","family":"Kuznetsov","sequence":"additional","affiliation":[{"name":"Department of Functional Nanosystems and High-Temperature Materials, National University of Science and Technology \u00abMISIS\u00bb, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8699-9112","authenticated-orcid":false,"given":"Alexander A.","family":"Gusev","sequence":"additional","affiliation":[{"name":"Institute for Environmental Science and Biotechnology, Derzhavin Tambov State University, 392020 Tambov, Russia"},{"name":"Department of Functional Nanosystems and High-Temperature Materials, National University of Science and Technology \u00abMISIS\u00bb, 119991 Moscow, Russia"},{"name":"Engineering Center, Plekhanov Russian University of Economics, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6225","DOI":"10.1021\/acs.chemrev.6b00558","article-title":"Recent Advances in Ultrathin Two-Dimensional Nanomaterials","volume":"117","author":"Tan","year":"2017","journal-title":"Chem. 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