{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:39:18Z","timestamp":1762609158618,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Public Welfare Research Project of Zhejiang Province","award":["LGF22H300005","Y202147485","2020R01015","2022C02059"],"award-info":[{"award-number":["LGF22H300005","Y202147485","2020R01015","2022C02059"]}]},{"name":"General Research Project of Education Department of Zhejiang Province","award":["LGF22H300005","Y202147485","2020R01015","2022C02059"],"award-info":[{"award-number":["LGF22H300005","Y202147485","2020R01015","2022C02059"]}]},{"name":"Zhejiang Provincial Leading Innovation and Entrepreneurship Team Project","award":["LGF22H300005","Y202147485","2020R01015","2022C02059"],"award-info":[{"award-number":["LGF22H300005","Y202147485","2020R01015","2022C02059"]}]},{"name":"the Key Research and development Program of \u201cLeading Goose\u201d of Zhejiang Province","award":["LGF22H300005","Y202147485","2020R01015","2022C02059"],"award-info":[{"award-number":["LGF22H300005","Y202147485","2020R01015","2022C02059"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Lipid-lowering is one of the most effective methods of prevention and treatment for cardiovascular diseases. However, most clinical lipid-lowering drugs have adverse effects and cannot achieve the desired efficacy in some complex hyperlipidemia patients, so it is of great significance to develop safe and effective novel lipid-lowering drugs. In the course of our project aimed at discovering the chemical novelty and bioactive natural products of marine-derived actinomycetes, we found that the organic crude extracts (OCEs) of Nocardiopsis sp. ZHD001 exhibited strong in vivo efficacies in reducing weight gain, lowering LDL-C, TC, and TG levels, and improving HDL-C levels in high-fat-diet-fed mice models. Chemical investigations of the active OCEs led to identifying two new sphydrofuran-derived compounds (1\u20132) and one known 2-methyl-4-(1-glycerol)-furan (3). Their structures were elucidated by the analysis of HRESIMS, 1D and 2D NMR spectroscopic data, and ECD calculations. Among these compounds, compound 1 represents a novel rearranged sphydrofuran-derived derivative. Bioactivity evaluations of these pure compounds showed that all the compounds exhibited significant lipid-lowering activity with lower cytotoxicity in vitro compared to simvastatin. Our results demonstrate that sphydrofuran-derived derivatives might be promising candidates for lipid-lowering drugs.<\/jats:p>","DOI":"10.3390\/ijms24032822","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T02:21:12Z","timestamp":1675304472000},"page":"2822","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Identification of Novel Sphydrofuran-Derived Derivatives with Lipid-Lowering Activity from the Active Crude Extracts of Nocardiopsis sp. ZHD001"],"prefix":"10.3390","volume":"24","author":[{"given":"Yuhong","family":"Tian","sequence":"first","affiliation":[{"name":"School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5419-7345","authenticated-orcid":false,"given":"Yongjun","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengshun","family":"Wen","sequence":"additional","affiliation":[{"name":"School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Guan","sequence":"additional","affiliation":[{"name":"School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-0279","authenticated-orcid":false,"given":"Xiaokun","family":"Ouyang","sequence":"additional","affiliation":[{"name":"School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanjing","family":"Ding","sequence":"additional","affiliation":[{"name":"Institute of Marine Biology and Pharmacology, Ocean College, Zhejiang University, Zhoushan 316021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongjun","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Marine Biology and Pharmacology, Ocean College, Zhejiang University, Zhoushan 316021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart Disease and Stroke Statistics\u20142021 Update A Report From the American Heart Association","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41569-018-0119-4","article-title":"Epidemiology of cardiovascular disease in China: Current features and implications","volume":"16","author":"Zhao","year":"2019","journal-title":"Nat. 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