{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:18:47Z","timestamp":1792804727547,"version":"4.5.0"},"reference-count":177,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and ICT (MIST), Republic of Korea","award":["2020R1A2C2012721"],"award-info":[{"award-number":["2020R1A2C2012721"]}],"id":[{"id":"https:\/\/ror.org\/01wpjm123","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Activating the immune system plays an important role in maintaining physiological homeostasis and defending the body against harmful infections. However, abnormalities in the immune response can lead to various immunopathological responses and severe inflammation. The activation of dendritic cells (DCs) can influence immunological responses by promoting the differentiation of T cells into various functional subtypes crucial for the eradication of pathogens. CD83 is a molecule known to be expressed on mature DCs, activated B cells, and T cells. Two isotypes of CD83, a membrane-bound form and a soluble form, are subjects of extensive scientific research. It has been suggested that CD83 is not only a ubiquitous co-stimulatory molecule but also a crucial player in monitoring and resolving inflammatory reactions. Although CD83 has been involved in immunological responses, its functions in autoimmune diseases and effects on pathogen immune evasion remain unclear. Herein, we outline current immunological findings and the proposed function of CD83 in inflammatory disorders.<\/jats:p>","DOI":"10.3390\/ijms24032831","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T02:21:12Z","timestamp":1675304472000},"page":"2831","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["CD83 Regulates the Immune Responses in Inflammatory Disorders"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5754-1324","authenticated-orcid":false,"given":"Bushra","family":"Riaz","sequence":"first","affiliation":[{"name":"Department of Biomedical Science, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0617-1698","authenticated-orcid":false,"given":"S.","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0349-9815","authenticated-orcid":false,"given":"Hye","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonghyang","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Ajou University School of Medicine, Suwon 16499, Republic of Korea"},{"name":"Department of Microbiology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/ni.1894","article-title":"Programming dendritic cells to induce T(H)2 and tolerogenic responses","volume":"11","author":"Pulendran","year":"2010","journal-title":"Nat. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41577-018-0088-1","article-title":"Dendritic cell subsets in T cell programming: Location dictates function","volume":"19","author":"Eisenbarth","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nri2379","article-title":"T-cell activation by dendritic cells in the lymph node: Lessons from the movies","volume":"8","author":"Bousso","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.3389\/fimmu.2019.01325","article-title":"Costimulatory Molecules and Immune Checkpoints Are Differentially Expressed on Different Subsets of Dendritic Cells","volume":"10","author":"Carenza","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1084\/jem.20092203","article-title":"CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation","volume":"208","author":"Tze","year":"2011","journal-title":"J. Exp. Med."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Peckert-Maier, K., Royzman, D., Langguth, P., Marosan, A., Strack, A., Sadeghi Shermeh, A., Steinkasserer, A., Zinser, E., and Wild, A.B. (2022). Tilting the Balance: Therapeutic Prospects of CD83 as a Checkpoint Molecule Controlling Resolution of Inflammation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020732"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.4049\/jimmunol.154.8.3821","article-title":"Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily","volume":"154","author":"Zhou","year":"1995","journal-title":"J. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1038\/s41423-021-00726-4","article-title":"Dendritic cell migration in inflammation and immunity","volume":"18","author":"Liu","year":"2021","journal-title":"Cell Mol. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.it.2008.01.009","article-title":"CD83 regulates lymphocyte maturation, activation and homeostasis","volume":"29","author":"Breloer","year":"2008","journal-title":"Trends Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.3389\/fimmu.2019.01312","article-title":"CD83: Activation Marker for Antigen Presenting Cells and Its Therapeutic Potential","volume":"10","author":"Li","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/10428199409052677","article-title":"New CD from the B cell section of the Fifth International Workshop on Human Leukocyte Differentiation Antigens","volume":"13","author":"Engel","year":"1994","journal-title":"Leuk. Lymphoma"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1073\/pnas.92.3.826","article-title":"Three populations of cells with dendritic morphology exist in peripheral blood, only one of which is infectable with human immunodeficiency virus type 1","volume":"92","author":"Weissman","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s002510050449","article-title":"The mouse Cd83 gene: Structure, domain organization, and chromosome localization","volume":"48","author":"Twist","year":"1998","journal-title":"Immunogenetics"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bbrc.2005.01.114","article-title":"CD83 is a dimer: Comparative analysis of monomeric and dimeric isoforms","volume":"329","author":"Lechmann","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.jmb.2017.03.009","article-title":"Crystal Structure of the Extracellular Domain of the Human Dendritic Cell Surface Marker CD83","volume":"429","author":"Heilingloh","year":"2017","journal-title":"J. Mol. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Guo, Y., Li, R., Song, X., Zhong, Y., Wang, C., Jia, H., Wu, L., Wang, D., Fang, F., and Ma, J. (2014). The expression and characterization of functionally active soluble CD83 by Pichia pastoris using high-density fermentation. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0089264"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3389\/fimmu.2020.00721","article-title":"The CD83 Molecule\u2014An Important Immune Checkpoint","volume":"11","author":"Grosche","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1006\/prep.2001.1594","article-title":"Overexpression, purification, and biochemical characterization of the extracellular human CD83 domain and generation of monoclonal antibodies","volume":"24","author":"Lechmann","year":"2002","journal-title":"Protein Expr. Purif."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1084\/jem.20160316","article-title":"Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83","volume":"213","author":"Petrozziello","year":"2016","journal-title":"J. Exp. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1084\/jem.20160312","article-title":"Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection","volume":"213","author":"Liu","year":"2016","journal-title":"J. Exp. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.imbio.2014.08.005","article-title":"Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo","volume":"220","author":"Kreiser","year":"2015","journal-title":"Immunobiology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.3892\/mmr.2015.3796","article-title":"Continuous expression of CD83 on activated human CD4\u207a T cells is correlated with their differentiation into induced regulatory T cells","volume":"12","author":"Chen","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e99712","DOI":"10.1172\/jci.insight.99712","article-title":"CD83 expression is essential for Treg cell differentiation and stability","volume":"3","author":"Doebbeler","year":"2018","journal-title":"JCI Insight"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5890","DOI":"10.4049\/jimmunol.180.9.5890","article-title":"CD83 expression in CD4+ T cells modulates inflammation and autoimmunity","volume":"180","author":"Reinwald","year":"2008","journal-title":"J. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.imlet.2011.01.013","article-title":"Activated T cells induce rapid CD83 expression on B cells by engagement of CD40","volume":"136","author":"Kretschmer","year":"2011","journal-title":"Immunol. Lett."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.4049\/jimmunol.179.7.4550","article-title":"CD83 expression is a sensitive marker of activation required for B cell and CD4+ T cell longevity in vivo","volume":"179","author":"Prazma","year":"2007","journal-title":"J. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1182\/blood.V81.2.454.454","article-title":"Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed at high levels in activated B lymphocytes","volume":"81","author":"Kozlow","year":"1993","journal-title":"Blood"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/srep00345","article-title":"Functionally Distinct Subpopulations of CpG-Activated Memory B Cells","volume":"2","author":"Henn","year":"2012","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1034\/j.1600-0765.2002.00664.x","article-title":"Upregulation of co-stimulatory molecule expression and dendritic cell marker (CD83) on B cells in periodontal disease","volume":"37","author":"Mahanonda","year":"2002","journal-title":"J. Periodontal Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Kretschmer, B., L\u00fcthje, K., Guse, A.H., Ehrlich, S., Koch-Nolte, F., Haag, F., Fleischer, B., and Breloer, M. (2007). CD83 modulates B cell function in vitro: Increased IL-10 and reduced Ig secretion by CD83Tg B cells. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0000755"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/eji.200636535","article-title":"CD83 expression on dendritic cells and T cells: Correlation with effective immune responses","volume":"37","author":"Heirman","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.4049\/jimmunol.173.5.2995","article-title":"A novel mutation in CD83 results in the development of a unique population of CD4+ T cells","volume":"173","author":"Appleby","year":"2004","journal-title":"J. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/mi.2014.79","article-title":"Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis","volume":"8","author":"Bates","year":"2015","journal-title":"Mucosal. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/intimm\/dxm067","article-title":"CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells","volume":"19","author":"Kuwano","year":"2007","journal-title":"Int. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1073\/pnas.0708874105","article-title":"MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation","volume":"105","author":"Camosseto","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e126246","DOI":"10.1172\/jci.insight.126246","article-title":"CD83 orchestrates immunity toward self and non-self in dendritic cells","volume":"4","author":"Wild","year":"2019","journal-title":"JCI Insight"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/intimm\/13.7.959","article-title":"A soluble form of CD83 is released from activated dendritic cells and B lymphocytes, and is detectable in normal human sera","volume":"13","author":"Hock","year":"2001","journal-title":"Int. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1093\/intimm\/12.9.1347","article-title":"Activation-induced expression of murine CD83 on T cells and identification of a specific CD83 ligand on murine B cells","volume":"12","author":"Cramer","year":"2000","journal-title":"Int. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1084\/jem.194.12.1813","article-title":"The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells","volume":"194","author":"Lechmann","year":"2001","journal-title":"J. Exp. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1182\/blood-2005-05-2073","article-title":"Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity","volume":"107","author":"Hirano","year":"2006","journal-title":"Blood"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.4049\/jimmunol.166.6.3865","article-title":"CD83 is an I-type lectin adhesion receptor that binds monocytes and a subset of activated CD8+ T cells [corrected]","volume":"166","author":"Scholler","year":"2001","journal-title":"J. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.4049\/jimmunol.1600802","article-title":"Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4\/MD-2 Complex on CD14+ Monocytes","volume":"198","author":"Horvatinovich","year":"2017","journal-title":"J. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.4049\/jimmunol.1201531","article-title":"Topical application of soluble CD83 induces IDO-mediated immune modulation, increases Foxp3+ T cells, and prolongs allogeneic corneal graft survival","volume":"191","author":"Bock","year":"2013","journal-title":"J. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"24914","DOI":"10.1074\/jbc.M109.000059","article-title":"Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(\u2212) T cells and T regulatory cells","volume":"284","author":"Cao","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"605713","DOI":"10.3389\/fcell.2020.605713","article-title":"Soluble CD83 Regulates Dendritic Cell-T Cell Immunological Synapse Formation by Disrupting Rab1a-Mediated F-Actin Rearrangement","volume":"8","author":"Lin","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"216","DOI":"10.7150\/ijbs.38722","article-title":"Soluble CD83 alleviates experimental allergic rhinitis through modulating antigen-specific Th2 cell property","volume":"16","author":"Wu","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"18778","DOI":"10.1073\/pnas.1018994108","article-title":"CD83-stimulated monocytes suppress T-cell immune responses through production of prostaglandin E2","volume":"108","author":"Chen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.mib.2010.06.002","article-title":"Manipulation of dendritic cell function by viruses","volume":"13","author":"Cunningham","year":"2010","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5958","DOI":"10.1128\/JVI.75.13.5958-5964.2001","article-title":"Immature monocyte-derived dendritic cells are productively infected with herpes simplex virus type 1","volume":"75","author":"Mikloska","year":"2001","journal-title":"J. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1002\/(SICI)1521-4141(199910)29:10<3245::AID-IMMU3245>3.0.CO;2-X","article-title":"Inhibition of dendritic cell maturation by herpes simplex virus","volume":"29","author":"Salio","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1099\/vir.0.2008\/003129-0","article-title":"Dendritic cells mediate herpes simplex virus infection and transmission through the C-type lectin DC-SIGN","volume":"89","author":"Bolmstedt","year":"2008","journal-title":"J. Gen. Virol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1128\/JVI.77.6.3768-3776.2003","article-title":"Deletion of the virion host shutoff protein (vhs) from herpes simplex virus (HSV) relieves the viral block to dendritic cell activation: Potential of vhs- HSV vectors for dendritic cell-mediated immunotherapy","volume":"77","author":"Samady","year":"2003","journal-title":"J. Virol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"6326","DOI":"10.1128\/JVI.02327-06","article-title":"Herpes simplex virus type 1 induces CD83 degradation in mature dendritic cells with immediate-early kinetics via the cellular proteasome","volume":"81","author":"Kummer","year":"2007","journal-title":"J. Virol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"7127","DOI":"10.1128\/JVI.74.15.7127-7136.2000","article-title":"Mature dendritic cells infected with herpes simplex virus type 1 exhibit inhibited T-cell stimulatory capacity","volume":"74","author":"Kruse","year":"2000","journal-title":"J. Virol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"11046","DOI":"10.1128\/JVI.01517-15","article-title":"Particles Transmit Viral Proteins from Herpes Simplex Virus 1-Infected Mature Dendritic Cells to Uninfected Bystander Cells, Inducing CD83 Downmodulation","volume":"89","author":"Heilingloh","year":"2015","journal-title":"J. Virol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.3389\/fmicb.2020.01997","article-title":"Mass Spectrometric Characterization of HSV-1 L-Particles From Human Dendritic Cells and BHK21 Cells and Analysis of Their Functional Role","volume":"11","author":"Birzer","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.3389\/fmicb.2017.02565","article-title":"Role of L-Particles during Herpes Simplex Virus Infection","volume":"8","author":"Heilingloh","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1182\/blood-2004-12-4899","article-title":"Immunomodulatory effects of HSV-2 infection on immature macaque dendritic cells modify innate and adaptive responses","volume":"106","author":"Peretti","year":"2005","journal-title":"Blood"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1128\/JVI.01302-12","article-title":"Herpes simplex virus 2 (HSV-2) prevents dendritic cell maturation, induces apoptosis, and triggers release of proinflammatory cytokines: Potential links to HSV-HIV synergy","volume":"87","author":"Stefanidou","year":"2013","journal-title":"J. Virol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Grosche, L., M\u00fchl-Z\u00fcrbes, P., Ciblis, B., Krawczyk, A., Kuhnt, C., Kamm, L., Steinkasserer, A., and Heilingloh, C.S. (2020). Herpes Simplex Virus Type-2 Paralyzes the Function of Monocyte-Derived Dendritic Cells. Viruses, 12.","DOI":"10.3390\/v12010112"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.3389\/fimmu.2017.01523","article-title":"US6 Gene Deletion in Herpes Simplex Virus Type 2 Enhances Dendritic Cell Function and T Cell Activation","volume":"8","author":"Weiss","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.cell.2010.01.023","article-title":"Homeostasis and inflammation in the intestine","volume":"140","author":"Garrett","year":"2010","journal-title":"Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1172\/JCI30587","article-title":"The fundamental basis of inflammatory bowel disease","volume":"117","author":"Strober","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1159\/000515332","article-title":"Intestinal Epithelial Cell-Derived CD83 Contributes to Regulatory T-Cell Generation and Inhibition of Food Allergy","volume":"13","author":"Yu","year":"2021","journal-title":"J. Innate Immun."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.3748\/wjg.v22.i7.2195","article-title":"Role of regulatory T cell in the pathogenesis of inflammatory bowel disease","volume":"22","author":"Yamada","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/ard.2003.018382","article-title":"Colon mucosa of patients both with spondyloarthritis and Crohn\u2019s disease is enriched with macrophages expressing the scavenger receptor CD163","volume":"64","author":"Demetter","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1756284818815334","DOI":"10.1177\/1756284818815334","article-title":"Role of indoleamine 2,3-dioxygenase in pathology of the gastrointestinal tract","volume":"11","author":"Acovic","year":"2018","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1136\/gut.2009.185108","article-title":"Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory\/T effector cell balance and oral tolerance induction","volume":"59","author":"Matteoli","year":"2010","journal-title":"Gut"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-3-319-67577-0_9","article-title":"Tryptophan Catabolism and Cancer Immunotherapy Targeting IDO Mediated Immune Suppression","volume":"1036","author":"Amobi","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/mi.2013.119","article-title":"Soluble CD83 ameliorates experimental colitis in mice","volume":"7","author":"Eckhardt","year":"2014","journal-title":"Mucosal. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Islam, S.M.S., Ryu, H.M., and Sohn, S. (2022). Tetragenococcus halophilus Alleviates Intestinal Inflammation in Mice by Altering Gut Microbiota and Regulating Dendritic Cell Activation via CD83. Cells, 11.","DOI":"10.3390\/cells11121903"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s10753-016-0470-8","article-title":"Foxp3, Regulatory T Cell, and Autoimmune Diseases","volume":"40","author":"Tao","year":"2017","journal-title":"Inflammation"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/imm.13317","article-title":"Epithelial cell-derived CD83 restores immune tolerance in the airway mucosa by inducing regulatory T-cell differentiation","volume":"163","author":"Mo","year":"2021","journal-title":"Immunology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cyto.2014.12.027","article-title":"Th1\/Th2\/Th17\/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: Correlation with disease activity","volume":"72","author":"Talaat","year":"2015","journal-title":"Cytokine"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/rheumatology\/kem327","article-title":"Role of pathogenic auto-antibody production by Toll-like receptor 9 of B cells in active systemic lupus erythematosus","volume":"47","author":"Nakano","year":"2008","journal-title":"Rheumatolog"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s12016-019-08744-x","article-title":"Platelets and IgE: Shaping the Innate Immune Response in Systemic Lupus Erythematosus","volume":"58","author":"Brilland","year":"2020","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.4049\/jimmunol.177.9.5878","article-title":"Aberrant phenotype and function of myeloid dendritic cells in systemic lupus erythematosus","volume":"177","author":"Ding","year":"2006","journal-title":"J. Immunol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1177\/0961203308089410","article-title":"Systemic lupus erythematosus patients have increased number of circulating plasmacytoid dendritic cells, but decreased myeloid dendritic cells with deficient CD83 expression","volume":"17","author":"Jin","year":"2008","journal-title":"Lupus"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1136\/ard.2009.111021","article-title":"Blood dendritic cells in systemic lupus erythematosus exhibit altered activation state and chemokine receptor function","volume":"69","author":"Gerl","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nri3155","article-title":"Selection of regulatory T cells in the thymus","volume":"12","author":"Hsieh","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1007\/s00018-011-0689-3","article-title":"Membrane vesicles, current state-of-the-art: Emerging role of extracellular vesicles","volume":"68","author":"Aradi","year":"2011","journal-title":"Cell Mol. Life Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/art.34381","article-title":"Increased IgG on cell-derived plasma microparticles in systemic lupus erythematosus is associated with autoantibodies and complement activation","volume":"64","author":"Nielsen","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/art.39417","article-title":"Circulating Apoptotic Microparticles in Systemic Lupus Erythematosus Patients Drive the Activation of Dendritic Cell Subsets and Prime Neutrophils for NETosis","volume":"68","author":"Dieker","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1084\/jem.20081165","article-title":"Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: Implications for the pathogenesis of SLE","volume":"205","author":"Urbonaviciute","year":"2008","journal-title":"J. Exp. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1038\/s41467-019-10491-8","article-title":"Mesenchymal stem cell therapy induces FLT3L and CD1c(+) dendritic cells in systemic lupus erythematosus patients","volume":"10","author":"Yuan","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1399-0039.2008.01037.x","article-title":"HLA-G genotype and HLA-G expression in systemic lupus erythematosus: HLA-G as a putative susceptibility gene in systemic lupus erythematosus","volume":"71","author":"Rizzo","year":"2008","journal-title":"Tissue Antigens"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"796054","DOI":"10.3389\/fimmu.2022.796054","article-title":"HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune Disease","volume":"13","author":"Juarez","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10875-010-9496-0","article-title":"Expression and functional role of HLA-G in immune cells from patients with systemic lupus erythematosus","volume":"31","author":"Baranda","year":"2011","journal-title":"J. Clin. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"583853","DOI":"10.3389\/fimmu.2020.583853","article-title":"SLE: Novel Postulates for Therapeutic Options","volume":"11","author":"Hosszu","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3389\/fimmu.2014.00278","article-title":"Monocyte Expressed Macromolecular C1 and C1q Receptors as Molecular Sensors of Danger: Implications in SLE","volume":"5","author":"Ghebrehiwet","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1136\/annrheumdis-2022-222345","article-title":"Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study","volume":"81","author":"Yin","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.imbio.2013.06.002","article-title":"Soluble human CD83 ameliorates lupus in NZB\/W F1 mice","volume":"218","author":"Starke","year":"2013","journal-title":"Immunobiology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.bbrc.2008.07.051","article-title":"Curcumin prevents human dendritic cell response to immune stimulants","volume":"374","author":"Shirley","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/gut.2004.063008","article-title":"Increased number of mature dendritic cells in Crohn\u2019s disease: Evidence for a chemokine mediated retention mechanism","volume":"55","author":"Middel","year":"2006","journal-title":"Gut"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"10055","DOI":"10.1038\/s41598-020-67149-5","article-title":"Difference in Presence and Number of CD83(+) Dendritic Cells in Patients with Ulcerative Colitis and Crohn\u2019s Disease","volume":"10","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/ni805","article-title":"Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP","volume":"3","author":"Soumelis","year":"2002","journal-title":"Nat. Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.jaci.2007.03.006","article-title":"Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis","volume":"119","author":"Lowes","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jid.2019.07.703","article-title":"Transglutaminase 3 Promotes Skin Inflammation in Atopic Dermatitis by Activating Monocyte-Derived Dendritic Cells via DC-SIGN","volume":"140","author":"Su","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jaci.2020.05.048","article-title":"Tape strips detect distinct immune and barrier profiles in atopic dermatitis and psoriasis","volume":"147","author":"He","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"5761392","DOI":"10.1155\/2019\/5761392","article-title":"Inhibition of CD83 Alleviates Systemic Inflammation in Herpes Simplex Virus Type 1-Induced Beh\u00e7et\u2019s Disease Model Mouse","volume":"2019","author":"Islam","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"607768","DOI":"10.3389\/fimmu.2021.607768","article-title":"Interrelationship of Stress, Environment, and Herpes Simplex Virus Type-1 on Beh\u00e7et\u2019s Disease: Using a Mouse Model","volume":"12","author":"Islam","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/eji.201141835","article-title":"Stable antigen-specific T-cell hyporesponsiveness induced by tolerogenic dendritic cells from multiple sclerosis patients","volume":"42","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Romme Christensen, J., B\u00f6rnsen, L., Ratzer, R., Piehl, F., Khademi, M., Olsson, T., S\u00f8rensen, P.S., and Sellebjerg, F. (2013). Systemic inflammation in progressive multiple sclerosis involves follicular T-helper, Th17- and activated B-cells and correlates with progression. PLoS ONE, 8.","DOI":"10.1371\/annotation\/b4e623eb-4950-48d9-8d85-8d70426d95a3"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jneuroim.2018.04.005","article-title":"The levels of soluble forms of CD21 and CD83 in multiple sclerosis","volume":"320","author":"Karampoor","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.3389\/fimmu.2019.01442","article-title":"Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells","volume":"10","author":"Zinser","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1582-4934.2002.tb00520.x","article-title":"Co-stimulatory and adhesion molecules of dendritic cells in rheumatoid arthritis","volume":"6","author":"Balanescu","year":"2002","journal-title":"J. Cell Mol. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1399-0039.2005.00524.x","article-title":"Levels of the soluble forms of CD80, CD86, and CD83 are elevated in the synovial fluid of rheumatoid arthritis patients","volume":"67","author":"Hock","year":"2006","journal-title":"Tissue Antigens"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"940","DOI":"10.2353\/ajpath.2008.070703","article-title":"Rheumatoid arthritis synovium contains two subsets of CD83-DC-LAMP- dendritic cells with distinct cytokine profiles","volume":"172","author":"Lebre","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2017.02.017","article-title":"Expression of soluble CD83 in plasma from early-stage rheumatoid arthritis patients is not modified by anti-TNF-\u03b1 therapy","volume":"96","author":"Kristensen","year":"2017","journal-title":"Cytokine"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.40393","article-title":"CD4+ and B Lymphocyte Expression Quantitative Traits at Rheumatoid Arthritis Risk Loci in Patients With Untreated Early Arthritis: Implications for Causal Gene Identification","volume":"70","author":"Thalayasingam","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1002\/art.40652","article-title":"Reduction of CD83 Expression on B Cells and the Genetic Basis for Rheumatoid Arthritis: Comment on the Article by Thalayasingam et al","volume":"70","author":"Tsuchida","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3389\/fimmu.2019.00633","article-title":"Soluble CD83 Triggers Resolution of Arthritis and Sustained Inflammation Control in IDO Dependent Manner","volume":"10","author":"Royzman","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13075-020-2137-y","article-title":"Identification of molecules associated with response to abatacept in patients with rheumatoid arthritis","volume":"22","author":"Yamazaki","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000370220","article-title":"Atopic dermatitis: Global epidemiology and risk factors","volume":"66","author":"Nutten","year":"2015","journal-title":"Ann. Nutr. Metab."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2500\/aap.2019.40.4202","article-title":"Pathophysiology of atopic dermatitis: Clinical implications","volume":"40","author":"Kim","year":"2019","journal-title":"Allergy Asthma Proc."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jaad.2018.09.035","article-title":"A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics","volume":"80","author":"Yew","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Pellefigues, C. (2020). IgE Autoreactivity in Atopic Dermatitis: Paving the Road for Autoimmune Diseases?. Antibodies, 9.","DOI":"10.3390\/antib9030047"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.jaci.2012.02.002","article-title":"Does \u201cautoreactivity\u201d play a role in atopic dermatitis?","volume":"129","author":"Tang","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s12016-010-8224-0","article-title":"Role of dendritic cells in atopic dermatitis: An update","volume":"41","author":"Bieber","year":"2011","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/j.1365-2222.2012.03964.x","article-title":"Cutaneous dendritic cells in allergic inflammation","volume":"42","author":"Gros","year":"2012","journal-title":"Clin. Exp. Allergy."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jaci.2009.11.019","article-title":"Dendritic cells: Bridging innate and adaptive immunity in atopic dermatitis","volume":"125","author":"Novak","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/all.12145","article-title":"TLR2 down-regulates Fc\u03b5RI and its transcription factor PU.1 in human Langerhans cells","volume":"68","author":"Herrmann","year":"2013","journal-title":"Allergy"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/1523-1747.ep12343596","article-title":"Immunomorphological and ultrastructural characterization of Langerhans cells and a novel, inflammatory dendritic epidermal cell (IDEC) population in lesional skin of atopic eczema","volume":"106","author":"Wollenberg","year":"1996","journal-title":"J. Investig. Dermatol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1111\/all.13460","article-title":"Langerhans and inflammatory dendritic epidermal cells in atopic dermatitis are tolerized toward TLR2 activation","volume":"73","author":"Iwamoto","year":"2018","journal-title":"Allergy"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.immuni.2007.01.017","article-title":"Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania","volume":"26","year":"2007","journal-title":"Immunity"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1034\/j.1600-0625.2003.120111.x","article-title":"Alteration in the production of IL-10 and IL-12 and aberrant expression of CD23, CD83 and CD86 by monocytes or monocyte-derived dendritic cells from atopic dermatitis patients","volume":"12","author":"Aiba","year":"2003","journal-title":"Exp. Dermatol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.0022-202X.2005.23627.x","article-title":"Transglutaminase function in epidermis","volume":"124","author":"Eckert","year":"2005","journal-title":"J. Investig. Dermatol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jaci.2010.10.043","article-title":"Peroxisome proliferator-activated receptor \u03b3-mediated suppression of dendritic cell function prevents the onset of atopic dermatitis in NC\/Tnd mice","volume":"127","author":"Jung","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ophtha.2007.04.056","article-title":"Clinical features of chinese patients with Beh\u00e7et\u2019s disease","volume":"115","author":"Yang","year":"2008","journal-title":"Ophthalmology"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"625710","DOI":"10.3389\/fmed.2021.625710","article-title":"Genetics of Beh\u00e7et\u2019s Disease: Functional Genetic Analysis and Estimating Disease Heritability","volume":"8","author":"Sawalha","year":"2021","journal-title":"Front. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3389\/fimmu.2019.00665","article-title":"Immunopathogenesis of Behcet\u2019s Disease","volume":"10","author":"Tong","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000065883","article-title":"Role of CD83 in the immunomodulation of dendritic cells","volume":"129","author":"Lechmann","year":"2002","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","article-title":"Immunobiology of dendritic cells","volume":"18","author":"Banchereau","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.autrev.2014.11.009","article-title":"Beh\u00e7et\u2019s syndrome patients exhibit specific microbiome signature","volume":"14","author":"Consolandi","year":"2015","journal-title":"Autoimmun. Rev."},{"key":"ref_135","first-page":"979","article-title":"Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut","volume":"7","author":"Selak","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"712312","DOI":"10.3389\/fimmu.2021.712312","article-title":"Eubacterium rectale Attenuates HSV-1 Induced Systemic Inflammation in Mice by Inhibiting CD83","volume":"12","author":"Islam","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.4049\/jimmunol.1101621","article-title":"Local activation of dendritic cells alters the pathogenesis of autoimmune disease in the retina","volume":"188","author":"Heuss","year":"2012","journal-title":"J. Immunol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"5578","DOI":"10.4049\/jimmunol.178.9.5578","article-title":"Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: Initial encounter with autoantigen defines disease phenotype","volume":"178","author":"Tang","year":"2007","journal-title":"J. Immunol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"12895","DOI":"10.1038\/s41598-017-13412-1","article-title":"NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis","volume":"7","author":"Lin","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"113645","DOI":"10.1016\/j.bcp.2019.113645","article-title":"Teriflunomide suppresses T helper cells and dendritic cells to alleviate experimental autoimmune uveitis","volume":"170","author":"Li","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nri2889","article-title":"Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases","volume":"10","author":"Buckner","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/icb.2010.137","article-title":"Human FoxP3(+)CD4(+) regulatory T cells: Their knowns and unknowns","volume":"89","author":"Miyara","year":"2011","journal-title":"Immunol. Cell Biol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"844300","DOI":"10.3389\/fimmu.2022.844300","article-title":"Regulatory T Cells in Autoimmune Vasculitis","volume":"13","author":"Jin","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jneuroim.2011.01.012","article-title":"RORC and Foxp3 axis in cerebrospinal fluid of patients with neuro-Beh\u00e7et\u2019s disease","volume":"233","author":"Hamzaoui","year":"2011","journal-title":"J. Neuroimmunol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jaci.2011.05.029","article-title":"Critical role of IL-21 in modulating TH17 and regulatory T cells in Beh\u00e7et disease","volume":"128","author":"Geri","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.4049\/jimmunol.177.9.6415","article-title":"Characterization of the divergent wound-healing responses occurring in the pathergy reaction and normal healthy volunteers","volume":"177","author":"Melikoglu","year":"2006","journal-title":"J. Immunol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"505","DOI":"10.4103\/1947-2714.118923","article-title":"Langerhans cells and their role in oral mucosal diseases","volume":"5","author":"Upadhyay","year":"2013","journal-title":"N. Am. J. Med. Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0092-8674(02)00673-6","article-title":"CD83 expression influences CD4+ T cell development in the thymus","volume":"108","author":"Fujimoto","year":"2002","journal-title":"Cell"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"877","DOI":"10.30773\/pi.2019.0106","article-title":"Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art","volume":"16","author":"Silveira","year":"2019","journal-title":"Psychiatry Investig."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1177\/1352458517694432","article-title":"New insights into the burden and costs of multiple sclerosis in Europe","volume":"23","author":"Kobelt","year":"2017","journal-title":"Mult. Scler."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ene.13819","article-title":"Multiple sclerosis\u2014A review","volume":"26","author":"Dobson","year":"2019","journal-title":"Eur. J. Neurol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1212\/WNL.0b013e3182a08ce8","article-title":"Contribution of cortical lesion subtypes at 7T MRI to physical and cognitive performance in MS","volume":"81","author":"Nielsen","year":"2013","journal-title":"Neurology"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.0105-2896.2005.00240.x","article-title":"Multiple sclerosis","volume":"204","author":"Hafler","year":"2005","journal-title":"Immunol. Rev."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1002\/eji.200737400","article-title":"Dendritic cells: Understanding immunogenicity","volume":"37","author":"Steinman","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3389\/fimmu.2018.01169","article-title":"Tolerogenic Dendritic Cells as a Promising Antigen-Specific Therapy in the Treatment of Multiple Sclerosis and Neuromyelitis Optica From Preclinical to Clinical Trials","volume":"9","author":"Zubizarreta","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1084\/jem.20030973","article-title":"Prevention and treatment of experimental autoimmune encephalomyelitis by soluble CD83","volume":"200","author":"Zinser","year":"2004","journal-title":"J. Exp. Med."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"5953","DOI":"10.4049\/jimmunol.1001628","article-title":"IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis","volume":"185","author":"Yan","year":"2010","journal-title":"J. Immunol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/glia.22734","article-title":"Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway","volume":"63","author":"Ott","year":"2015","journal-title":"Glia"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.3389\/fimmu.2018.01363","article-title":"An Expanded Neuroimmunomodulation Axis: sCD83-Indoleamine 2,3-Dioxygenase-Kynurenine Pathway and Updates of Kynurenine Pathway in Neurologic Diseases","volume":"9","author":"Bo","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"738","DOI":"10.3109\/08820139.2012.676122","article-title":"Indoleamine 2,3-dioxygenase and dendritic cell tolerogenicity","volume":"41","author":"Harden","year":"2012","journal-title":"Immunol. Investig."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nrneurol.2012.203","article-title":"B cells and antibodies in multiple sclerosis pathogenesis and therapy","volume":"8","author":"Krumbholz","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1177\/1352458510379611","article-title":"Immunomodulatory effects of vitamin D on monocyte-derived dendritic cells in multiple sclerosis","volume":"16","author":"Tabarkiewicz","year":"2010","journal-title":"Mult. Scler."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.4049\/jimmunol.1402302","article-title":"A comparative analysis of multiple sclerosis-relevant anti-inflammatory properties of ethyl pyruvate and dimethyl fumarate","volume":"194","year":"2015","journal-title":"J. Immunol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3389\/fimmu.2019.00157","article-title":"Ethyl Pyruvate Induces Tolerogenic Dendritic Cells","volume":"10","author":"Djedovic","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41590-020-00816-x","article-title":"The immunology of rheumatoid arthritis","volume":"22","author":"Weyand","year":"2021","journal-title":"Nat. Immunol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41584-018-0109-2","article-title":"Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis","volume":"15","author":"Chen","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nrrheum.2009.185","article-title":"Dendritic cells as targets for therapy in rheumatoid arthritis","volume":"5","author":"Khan","year":"2009","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.4049\/jimmunol.0903841","article-title":"Regulatory T cells protect from local and systemic bone destruction in arthritis","volume":"184","author":"Zaiss","year":"2010","journal-title":"J. Immunol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/ni.2088","article-title":"IDO: More than an enzyme","volume":"12","author":"Chen","year":"2011","journal-title":"Nat. Immunol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.4049\/jimmunol.1502125","article-title":"IDO1 and TGF-\u03b2 Mediate Protective Effects of IFN-\u03b1 in Antigen-Induced Arthritis","volume":"197","author":"Chalise","year":"2016","journal-title":"J. Immunol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/ni.2077","article-title":"Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells","volume":"12","author":"Pallotta","year":"2011","journal-title":"Nat. Immunol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1136\/ard.55.11.816","article-title":"Human osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis","volume":"55","author":"Fujikawa","year":"1996","journal-title":"Ann. Rheum. Dis."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.4049\/jimmunol.169.3.1516","article-title":"Stimulation by toll-like receptors inhibits osteoclast differentiation","volume":"169","author":"Takami","year":"2002","journal-title":"J. Immunol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"936995","DOI":"10.3389\/fimmu.2022.936995","article-title":"The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis","volume":"13","author":"Royzman","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/imm.12888","article-title":"Human dendritic cell subsets: An update","volume":"154","author":"Collin","year":"2018","journal-title":"Immunology"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.humimm.2016.07.005","article-title":"Maturation and cytokine production potential of dendritic cells isolated from rheumatoid arthritis patients peripheral blood and induced in vitro","volume":"77","author":"Sennikov","year":"2016","journal-title":"Hum. Immunol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"784528","DOI":"10.3389\/fimmu.2022.784528","article-title":"Anti-Mouse CD83 Monoclonal Antibody Targeting Mature Dendritic Cells Provides Protection Against Collagen Induced Arthritis","volume":"13","author":"Silveira","year":"2022","journal-title":"Front. Immunol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/3\/2831\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:21:33Z","timestamp":1760120493000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/3\/2831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,1]]},"references-count":177,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["ijms24032831"],"URL":"https:\/\/doi.org\/10.3390\/ijms24032831","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,1]]}}}