{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:50:40Z","timestamp":1760147440360,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["320030_182690"],"award-info":[{"award-number":["320030_182690"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Walter-Bruckerhoff Stiftung","award":["320030_182690"],"award-info":[{"award-number":["320030_182690"]}]},{"name":"Stiftung f\u00fcr Angewandte Krebsforchung","award":["320030_182690"],"award-info":[{"award-number":["320030_182690"]}]},{"name":"Inserm, the Ligue Contre le Cancer (Ile de France committee)","award":["320030_182690"],"award-info":[{"award-number":["320030_182690"]}]},{"name":"the Chancellerie des Universit\u00e9s de Paris (Legs POIX)","award":["320030_182690"],"award-info":[{"award-number":["320030_182690"]}]},{"name":"Canc\u00e9rop\u00f4le \u00cele-de-France (Emergence)","award":["320030_182690"],"award-info":[{"award-number":["320030_182690"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Pleural mesothelioma (PM) is a cancer where epithelioid, biphasic and sarcomatoid histotypes are observed. Sarcomatoid PM is characterized by mesenchymal features. Multi-omics have been used to characterize the epithelial-to-mesenchymal (EMT) phenotype at the molecular level. We contribute to this effort by including the analysis of RNA editing. We extracted samples with the highest vs. lowest Epithelial score from two PM cohorts and observed increased RNA editing in introns and decreased RNA editing in 3\u2032UTR upon EMT. The same was observed in primary PM primary cultures stratified by transcriptomics analysis into two groups, one of them enriched with mesenchymal features. Our data demonstrate that, as has been observed in other cancer types, RNA editing associates to EMT phenotype in PM.<\/jats:p>","DOI":"10.3390\/ijms24032874","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T02:57:24Z","timestamp":1675306644000},"page":"2874","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Pattern of RNA Editing Changes in Pleural Mesothelioma upon Epithelial-Mesenchymal Transition"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-0294","authenticated-orcid":false,"given":"Emanuela","family":"Felley-Bosco","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Zurich, Sternwartstrasse 14, 8091 Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihong","family":"Qi","sequence":"additional","affiliation":[{"name":"Functional Genomics Center Zurich, ETH Zurich and University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5823-7404","authenticated-orcid":false,"given":"Didier","family":"Jean","sequence":"additional","affiliation":[{"name":"Functional Genomics of Solid Tumors, Centre de Recherche des Cordeliers, Inserm, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9ment","family":"Meiller","sequence":"additional","affiliation":[{"name":"Functional Genomics of Solid Tumors, Centre de Recherche des Cordeliers, Inserm, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7612-9394","authenticated-orcid":false,"given":"Hubert","family":"Rehrauer","sequence":"additional","affiliation":[{"name":"Functional Genomics Center Zurich, ETH Zurich and University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3322\/caac.21572","article-title":"Mesothelioma: Scientific clues for prevention, diagnosis, and therapy","volume":"69","author":"Carbone","year":"2019","journal-title":"CA Cancer J. 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