{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:32:47Z","timestamp":1787160767221,"version":"build-2736575974"},"reference-count":158,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T00:00:00Z","timestamp":1675555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Curtis Joseph and Harold Groves Chair in Anesthesia and Pain Medicine (JTM)"},{"name":"Department of Anesthesiology and Pain Medicine, University of Toronto"},{"name":"Labatt Family Heart Centre, The Hospital for Sick Children, Toronto (MP and JGC)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Even with modern therapy, patients with heart failure only have a 50% five-year survival rate. To improve the development of new therapeutic strategies, preclinical models of disease are needed to properly emulate the human condition. Determining the most appropriate model represents the first key step for reliable and translatable experimental research. Rodent models of heart failure provide a strategic compromise between human in vivo similarity and the ability to perform a larger number of experiments and explore many therapeutic candidates. We herein review the currently available rodent models of heart failure, summarizing their physiopathological basis, the timeline of the development of ventricular failure, and their specific clinical features. In order to facilitate the future planning of investigations in the field of heart failure, a detailed overview of the advantages and possible drawbacks of each model is provided.<\/jats:p>","DOI":"10.3390\/ijms24043162","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T03:34:30Z","timestamp":1675654470000},"page":"3162","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Rodent Models of Dilated Cardiomyopathy and Heart Failure for Translational Investigations and Therapeutic Discovery"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4472-6287","authenticated-orcid":false,"given":"Matteo","family":"Ponzoni","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Surgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada"},{"name":"Program in Translational Medicine, SickKids Research Institute, Toronto, ON M5G 0A4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Coles","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada"},{"name":"Program in Translational Medicine, SickKids Research Institute, Toronto, ON M5G 0A4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2050-3620","authenticated-orcid":false,"given":"Jason T.","family":"Maynes","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada"},{"name":"Program in Molecular Medicine, SickKids Research Institute, Toronto, ON M5G 0A4, Canada"},{"name":"Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON M5G 1E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jchf.2020.01.014","article-title":"Advanced Heart Failure: Epidemiology, Diagnosis, and Therapeutic Approaches","volume":"8","author":"Truby","year":"2020","journal-title":"JACC. Heart Fail."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/HHF.0b013e318291329a","article-title":"Forecasting the Impact of Heart Failure in the United States: A Policy Statement from the American Heart Association","volume":"6","author":"Heidenreich","year":"2013","journal-title":"Circ. Heart Fail."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ijcard.2016.05.035","article-title":"The Fontan Epidemic: Population Projections from the Australia and New Zealand Fontan Registry","volume":"219","author":"Schilling","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1161\/CIRCULATIONAHA.110.946343","article-title":"Temporal Trends in Survival to Adulthood among Patients Born with Congenital Heart Disease from 1970 to 1992 in Belgium","volume":"122","author":"Moons","year":"2010","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.healun.2018.07.018","article-title":"The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-First Pediatric Heart Transplantation Report-2018; Focus Theme: Multiorgan Transplantation","volume":"37","author":"Rossano","year":"2018","journal-title":"J. Hear. Lung Transplant. Off. Publ. Int. Soc. Hear. Transplant."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/HCO.0000000000000351","article-title":"Five Decades of Pediatric Heart Transplantation: Challenges Overcome, Challenges Remaining","volume":"32","author":"Zangwill","year":"2017","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.healun.2020.01.1345","article-title":"ISHLT Consensus Statement on Donor Organ Acceptability and Management in Pediatric Heart Transplantation","volume":"39","author":"Kirk","year":"2020","journal-title":"J. Hear. lung Transplant. Off. Publ. Int. Soc. Hear. Transplant."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1055\/a-1150-2016","article-title":"Acquired von Willebrand Syndrome and Platelet Function Defects during Extracorporeal Life Support (Mechanical Circulatory Support)","volume":"40","author":"Schlagenhauf","year":"2020","journal-title":"Hamostaseologie"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1111\/jth.13497","article-title":"Mechanical Circulatory Support Is Associated with Loss of Platelet Receptors Glycoprotein Ib\u03b1 and Glycoprotein VI","volume":"14","author":"Lukito","year":"2016","journal-title":"J. Thromb. Haemost."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1161\/CIRCRESAHA.116.310253","article-title":"Intracoronary Cardiac Progenitor Cells in Single Ventricle Physiology: The PERSEUS (Cardiac Progenitor Cell Infusion to Treat Univentricular Heart Disease) Randomized Phase 2 Trial","volume":"120","author":"Ishigami","year":"2017","journal-title":"Circ. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1093\/eurheartj\/ehaa541","article-title":"Intracoronary ALLogeneic Heart STem Cells to Achieve Myocardial Regeneration (ALLSTAR): A Randomized, Placebo-Controlled, Double-Blinded Trial","volume":"41","author":"Makkar","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1016\/j.jtcvs.2014.07.050","article-title":"Losartan Ameliorates \u201cUpstream\u201d Pulmonary Vein Vasculopathy in a Piglet Model of Pulmonary Vein Stenosis","volume":"148","author":"Zhu","year":"2014","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1111\/aor.14057","article-title":"Surgical Strategies for the Management of End-Stage Heart Failure in Infants and Children: A 15-Year Experience with a Patient-Tailored Approach","volume":"45","author":"Ponzoni","year":"2021","journal-title":"Artif. Organs"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Ponzoni, M., Castaldi, B., and Padalino, M.A. (2022). Pulmonary Artery Banding for Dilated Cardiomyopathy in Children: Returning to the Bench from Bedside. Children, 9.","DOI":"10.3390\/children9091392"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Traister, A., Patel, R., Huang, A., Patel, S., Plakhotnik, J., Lee, J.E., Medina, M.G., Welsh, C., Ruparel, P., and Zhang, L. (2018). Cardiac Regenerative Capacity Is Age- and Disease-Dependent in Childhood Heart Disease. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0200342"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"100050","DOI":"10.1016\/j.jacadv.2022.100050","article-title":"Mesenchymal Stromal Cells Isolated From Patients With Congenital Heart Disease Reveal an Age-Dependent Proinflammatory Phenotype","volume":"1","author":"Zhang","year":"2022","journal-title":"JACC Adv."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.omtm.2022.11.010","article-title":"Correction of DMD in Human IPSC-Derived Cardiomyocytes by Base-Editing-Induced Exon Skipping","volume":"28","author":"Wang","year":"2023","journal-title":"Mol. Ther.\u2014Methods Clin. Dev."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Nishiyama, T., Zhang, Y., Cui, M., Li, H., Sanchez-Ortiz, E., McAnally, J.R., Tan, W., Kim, J., Chen, K., and Xu, L. (2022). Precise Genomic Editing of Pathogenic Mutations in RBM20 Rescues Dilated Cardiomyopathy. Sci. Transl. Med., 14.","DOI":"10.1126\/scitranslmed.ade1633"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/CIRCHEARTFAILURE.108.839761","article-title":"Small Animal Models of Heart Failure: Development of Novel Therapies, Past and Present","volume":"2","author":"Patten","year":"2009","journal-title":"Circ. Heart Fail."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1161\/RES.0b013e3182582523","article-title":"Animal Models of Heart Failure: A Scientific Statement from the American Heart Association","volume":"111","author":"Houser","year":"2012","journal-title":"Circ. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1093\/cvr\/cvz161","article-title":"Small Animal Models of Heart Failure","volume":"115","author":"Riehle","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"660959","DOI":"10.3389\/fmolb.2021.660959","article-title":"Alternative Animal Models of Aging Research","volume":"8","author":"Holtze","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1586\/erc.09.126","article-title":"Cardiovascular MRI in Small Animals","volume":"8","author":"Makowski","year":"2010","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fcvm.2016.00034","article-title":"Rat Heterotopic Heart Transplantation Model to Investigate Unloading-Induced Myocardial Remodeling","volume":"3","author":"Fu","year":"2016","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1046\/j.1440-1681.2003.03876.x","article-title":"On Being the Right Size: Heart Design, Mitochondrial Efficiency and Lifespan Potential","volume":"30","author":"Dobson","year":"2003","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"497841","DOI":"10.1155\/2011\/497841","article-title":"Animal Models of Cardiovascular Diseases","volume":"2011","author":"Zaragoza","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/0735-1097(88)92616-2","article-title":"Increased Afterload Aggravates Infarct Expansion after Acute Myocardial Infarction","volume":"12","author":"Nolan","year":"1988","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1253\/circj.66.219","article-title":"Dilated Cardiomyopathy: Concepts Derived from Gene Deficient and Transgenic Animal Models","volume":"66","author":"Ross","year":"2002","journal-title":"Circ. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.yjmcc.2009.10.031","article-title":"Mutations in Troponin That Cause HCM, DCM AND RCM: What Can We Learn about Thin Filament Function?","volume":"48","author":"Willott","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13287-016-0401-5","article-title":"Recent Advances in Animal and Human Pluripotent Stem Cell Modeling of Cardiac Laminopathy","volume":"7","author":"Lee","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00424-019-02257-4","article-title":"Hereditary Heart Disease: Pathophysiology, Clinical Presentation, and Animal Models of HCM, RCM, and DCM Associated with Mutations in Cardiac Myosin Light Chains","volume":"471","author":"Yadav","year":"2019","journal-title":"Pflug. Arch."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41572-019-0084-1","article-title":"Dilated Cardiomyopathy","volume":"5","author":"Schultheiss","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.pharmthera.2013.10.007","article-title":"Small and Large Animal Models in Cardiac Contraction Research: Advantages and Disadvantages","volume":"141","author":"Janssen","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Bozkurt, B., Colvin, M., Cook, J., Cooper, L.T., Deswal, A., Fonarow, G.C., Francis, G.S., Lenihan, D., Lewis, E.F., and McNamara, D.M. (2016). Current Diagnostic and Treatment Strategies for Specific Dilated Cardiomyopathies: A Scientific Statement From the American Heart Association. Circulation, 134.","DOI":"10.1161\/CIR.0000000000000455"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.3390\/jcm10235518","article-title":"Echocardiographic Advances in Dilated Cardiomyopathy","volume":"10","author":"Faggiano","year":"2021","journal-title":"J. Clin. Med."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"(2014). 2014 ESC Guidelines on Diagnosis and Management of Hypertrophic Cardiomyopathy. Eur. Heart J., 35, 2733\u20132779.","DOI":"10.1093\/eurheartj\/ehu284"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1093\/eurheartj\/ehac543","article-title":"Restrictive Cardiomyopathy: Definition and Diagnosis","volume":"43","author":"Rapezzi","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e301","DOI":"10.1016\/j.hrthm.2019.05.007","article-title":"2019 HRS Expert Consensus Statement on Evaluation, Risk Stratification, and Management of Arrhythmogenic Cardiomyopathy","volume":"16","author":"Towbin","year":"2019","journal-title":"Hear. Rhythm"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"165774","DOI":"10.1016\/j.bbadis.2020.165774","article-title":"Mutation-Specific Pathology and Treatment of Hypertrophic Cardiomyopathy in Patients, Mouse Models and Human Engineered Heart Tissue","volume":"1866","author":"Wijnker","year":"2020","journal-title":"Biochim. Biophys. Acta\u2014Mol. Basis Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.tcm.2019.11.009","article-title":"Phenotypic Variation and Targeted Therapy of Hypertrophic Cardiomyopathy Using Genetic Animal Models","volume":"31","author":"Gannon","year":"2021","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Liu, X., Zhang, L., Pacciulli, D., Zhao, J., Nan, C., Shen, W., Quan, J., Tian, J., and Huang, X. (2016). Restrictive Cardiomyopathy Caused by Troponin Mutations: Application of Disease Animal Models in Translational Studies. Front. Physiol., 7.","DOI":"10.3389\/fphys.2016.00629"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"0108","DOI":"10.31083\/j.rcm2303108","article-title":"Restrictive Cardiomyopathy: From Genetics and Clinical Overview to Animal Modeling","volume":"23","author":"Chintanaphol","year":"2022","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Gerull, B., and Brodehl, A. (2020). Genetic Animal Models for Arrhythmogenic Cardiomyopathy. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.00624"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s00395-017-0640-3","article-title":"Animal Models of Arrhythmogenic Right Ventricular Cardiomyopathy: What Have We Learned and Where Do We Go? Insight for Therapeutics","volume":"112","year":"2017","journal-title":"Basic Res. Cardiol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Pilati, M., Rebonato, M., Formigari, R., and Butera, G. (2022). Endomyocardial Biopsy in Pediatric Myocarditis and Dilated Cardiomyopathy: A Tool in Search for a Role. J. Cardiovasc. Dev. Dis., 9.","DOI":"10.3390\/jcdd9010024"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ponzoni, M., Azzolina, D., Vedovelli, L., Gregori, D., Di Salvo, G., D\u2019Udekem, Y., Vida, V., and Padalino, M.A. (2022). Ventricular Morphology of Single Ventricle Hearts Has a Significant Impact on Outcomes after Fontan Palliation. A Meta-Analysis. Eur. J. Cardio-Thorac. Surg.","DOI":"10.1093\/ejcts\/ezac535"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0021-5198(19)43389-1","article-title":"Effect of Isoproterenol on Renal Uric Acid Excretion in Rats","volume":"45","author":"Sugino","year":"1987","journal-title":"Jpn. J. Pharmacol."},{"key":"ref_49","first-page":"443","article-title":"An Infarct-like Myocardial Lesion and Other Toxic Manifestations Produced by Isoproterenol in the Rat","volume":"67","author":"RONA","year":"1959","journal-title":"AMA. Arch. Pathol."},{"key":"ref_50","first-page":"203","article-title":"Rat Model for Acute Myocardial Infarction: Application to Technetium-Labeled Glucoheptonate, Tetracycline, and Polyphosphate","volume":"17","author":"Adler","year":"1976","journal-title":"J. Nucl. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.biomaterials.2004.02.058","article-title":"Implantation of Bone Marrow Mononuclear Cells Using Injectable Fibrin Matrix Enhances Neovascularization in Infarcted Myocardium","volume":"26","author":"Ryu","year":"2005","journal-title":"Biomaterials"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"8309","DOI":"10.4238\/2014.October.20.7","article-title":"Intermedin Protects against Myocardial Ischemia-Reperfusion Injury in Hyperlipidemia Rats","volume":"13","author":"Yang","year":"2014","journal-title":"Genet. Mol. Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Kolk, M.V.V., Meyberg, D., Deuse, T., Tang-Quan, K.R., Robbins, R.C., Reichenspurner, H., and Schrepfer, S. (2009). LAD-Ligation: A Murine Model of Myocardial Infarction. J. Vis. Exp.","DOI":"10.3791\/1438-v"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Reichert, K., Colantuono, B., McCormack, I., Rodrigues, F., Pavlov, V., and Abid, M.R. (2017). Murine Left Anterior Descending (LAD) Coronary Artery Ligation: An Improved and Simplified Model for Myocardial Infarction. J. Vis. Exp.","DOI":"10.3791\/55353-v"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/01.RES.44.4.503","article-title":"Myocardial Infarct Size and Ventricular Function in Rats","volume":"44","author":"Pfeffer","year":"1979","journal-title":"Circ. Res."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Kainuma, S., Miyagawa, S., Fukushima, S., Tsuchimochi, H., Sonobe, T., Fujii, Y., Pearson, J.T., Saito, A., Harada, A., and Toda, K. (2017). Influence of Coronary Architecture on the Variability in Myocardial Infarction Induced by Coronary Ligation in Rats. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0183323"},{"key":"ref_57","first-page":"H2147","article-title":"Myocardial Ischemia and Reperfusion: A Murine Model","volume":"269","author":"Michael","year":"1995","journal-title":"Am. J. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1177\/10742484211031327","article-title":"Remote Ischemic Perconditioning Ameliorates Myocardial Ischemia and Reperfusion-Induced Coronary Endothelial Dysfunction and Aortic Stiffness in Rats","volume":"26","author":"Dostal","year":"2021","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/icvts\/ivu187","article-title":"An Experimental Model of Myocardial Infarction and Controlled Reperfusion Using a Miniaturized Cardiopulmonary Bypass in Rats","volume":"19","author":"Peterss","year":"2014","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_60","first-page":"H2468","article-title":"ANG II Receptor Blockade Prevents Ventricular Hypertrophy and ANF Gene Expression with Pressure Overload in Mice","volume":"266","author":"Rockman","year":"1994","journal-title":"Am. J. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41598-021-04096-9","article-title":"O-Ring-Induced Transverse Aortic Constriction (OTAC) Is a New Simple Method to Develop Cardiac Hypertrophy and Heart Failure in Mice","volume":"12","author":"Nakao","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/01.RES.73.1.184","article-title":"Selective Changes in Cardiac Gene Expression during Compensated Hypertrophy and the Transition to Cardiac Decompensation in Rats with Chronic Aortic Banding","volume":"73","author":"Feldman","year":"1993","journal-title":"Circ. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1038\/s41598-019-39581-9","article-title":"Characterization of Biventricular Alterations in Myocardial (Reverse) Remodelling in Aortic Banding-Induced Chronic Pressure Overload","volume":"9","author":"Hamdani","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"R894","DOI":"10.1152\/ajpregu.00370.2019","article-title":"Rats Are Protected from the Stress of Chronic Pressure Overload Compared with Mice","volume":"318","author":"Nishimura","year":"2020","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1161\/01.CIR.91.10.2642","article-title":"Serial Echocardiographic-Doppler Assessment of Left Ventricular Geometry and Function in Rats with Pressure-Overload Hypertrophy. Chronic Angiotensin-Converting Enzyme Inhibition Attenuates the Transition to Heart Failure","volume":"91","author":"Litwin","year":"1995","journal-title":"Circulation"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"H994","DOI":"10.1152\/ajpheart.00245.2011","article-title":"A New Model of Congestive Heart Failure in Rats","volume":"301","author":"Chen","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3904\/kjim.2019.120","article-title":"The Relationship between MiRNA-26b and Connective Tissue Growth Factor in Rat Models of Aortic Banding and Debanding","volume":"36","author":"Cho","year":"2021","journal-title":"Korean J. Intern. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1139\/Y10-049","article-title":"Effect of Sodium Houttuyfonate on Inhibiting Ventricular Remodeling Induced by Abdominal Aortic Banding in Rats","volume":"88","author":"Gao","year":"2010","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"753210","DOI":"10.1155\/2015\/753210","article-title":"Novel Model of Pulmonary Artery Banding Leading to Right Heart Failure in Rats","volume":"2015","author":"Hirata","year":"2015","journal-title":"Biomed Res. Int."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Andersen, S., Schultz, J.G., Holmboe, S., Axelsen, J.B., Hansen, M.S., Lyhne, M.D., Nielsen-Kudsk, J.E., and Andersen, A. (2018). A Pulmonary Trunk Banding Model of Pressure Overload Induced Right Ventricular Hypertrophy and Failure. J. Vis. Exp.","DOI":"10.3791\/58050"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"H994","DOI":"10.1152\/ajpheart.00071.2022","article-title":"Female Rats Are Less Prone to Clinical Heart Failure than Male Rats in a Juvenile Rat Model of Right Ventricular Pressure Load","volume":"322","author":"Bossers","year":"2022","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"H85","DOI":"10.1152\/ajpheart.00089.2016","article-title":"Distinct Right Ventricle Remodeling in Response to Pressure Overload in the Rat","volume":"311","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"H204","DOI":"10.1152\/ajpheart.00654.2021","article-title":"Sex Similarities and Differences in the Reverse and Anti-Remodeling Effect of Pressure Unloading Therapy in a Rat Model of Aortic Banding and Debanding","volume":"323","author":"Ruppert","year":"2022","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e006170","DOI":"10.1161\/CIRCHEARTFAILURE.119.006170","article-title":"Mitochondrial Reversible Changes Determine Diastolic Function Adaptations During Myocardial (Reverse) Remodeling","volume":"13","author":"Rodrigues","year":"2020","journal-title":"Circ. Heart Fail."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"6354","DOI":"10.1038\/s41598-019-42936-x","article-title":"The TIR\/BB-Loop Mimetic AS-1 Prevents Ang II-Induced Hypertensive Cardiac Hypertrophy via NF-\u039aB Dependent Downregulation of MiRNA-143","volume":"9","author":"Song","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1540-8191.2001.tb00482.x","article-title":"A Rat Model of Dilated Cardiomyopathy to Investigate Partial Left Ventriculectomy","volume":"16","author":"Yuasa","year":"2001","journal-title":"J. Card. Surg."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1253\/jcj.27.282","article-title":"Development of a Strain of Spontaneously Hypertensive Rats","volume":"27","author":"OKAMOTO","year":"1963","journal-title":"Jpn. Circ. J."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"H1775","DOI":"10.1152\/ajpheart.00305.2002","article-title":"Structural, Functional, and Molecular Characterization of the SHHF Model of Heart Failure","volume":"283","author":"Heyen","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.21037\/cdt-20-400","article-title":"Animal Models of Right Heart Failure","volume":"10","author":"Andersen","year":"2020","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1161\/CIRCULATIONAHA.109.883843","article-title":"Chronic Pulmonary Artery Pressure Elevation Is Insufficient to Explain Right Heart Failure","volume":"120","author":"Bogaard","year":"2009","journal-title":"Circulation"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Yamazaki, H., Tajima, H., Yamamoto, Y., Munesue, S., Okazaki, M., Ohbatake, Y., Nakanuma, S., Makino, I., Miyashita, T., and Takamura, H. (2022). Thrombopoietin Accumulation in Hepatocytes Induces a Decrease in Its Serum Levels in a Sinusoidal Obstruction Syndrome Model. Mol. Med. Rep., 25.","DOI":"10.3892\/mmr.2022.12717"},{"key":"ref_82","first-page":"1864107","article-title":"Glucagon-Like Peptide-1 Mediates the Protective Effect of the Dipeptidyl Peptidase IV Inhibitor on Renal Fibrosis via Reducing the Phenotypic Conversion of Renal Microvascular Cells in Monocrotaline-Treated Rats","volume":"2018","author":"Xu","year":"2018","journal-title":"Biomed Res. Int."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.3390\/cells11071073","article-title":"Neutralization of GDF15 Prevents Anorexia and Weight Loss in the Monocrotaline-Induced Cardiac Cachexia Rat Model","volume":"11","author":"Albuquerque","year":"2022","journal-title":"Cells"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1165\/rcmb.2014-0045TR","article-title":"The Role of Vascular Endothelial Growth Factor in Pulmonary Arterial Hypertension. The Angiogenesis Paradox","volume":"51","author":"Voelkel","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2045894019897513","article-title":"Understanding Longitudinal Biventricular Structural and Functional Changes in a Pulmonary Hypertension Sugen\u2013Hypoxia Rat Model by Cardiac Magnetic Resonance Imaging","volume":"10","author":"Jayasekera","year":"2020","journal-title":"Pulm. Circ."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1161\/HYPERTENSIONAHA.122.19300","article-title":"Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics","volume":"79","author":"Zelt","year":"2022","journal-title":"Hypertension"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"17136","DOI":"10.1038\/s41598-021-96618-8","article-title":"Right versus Left Ventricular Remodeling in Heart Failure Due to Chronic Volume Overload","volume":"11","author":"Havlenova","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"H674","DOI":"10.1152\/ajpheart.2001.280.2.H674","article-title":"Contribution of Ventricular Remodeling to Pathogenesis of Heart Failure in Rats","volume":"280","author":"Brower","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1248\/bpb.b22-00031","article-title":"Chronic Volume Overload Caused by Abdominal Aorto-Venocaval Shunt Provides Arrhythmogenic Substrates in the Rat Atrium","volume":"45","author":"Aimoto","year":"2022","journal-title":"Biol. Pharm. Bull."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s11010-009-0361-5","article-title":"Early Predictors of Cardiac Decompensation in Experimental Volume Overload","volume":"338","author":"Ascah","year":"2010","journal-title":"Mol. Cell. Biochem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"6809","DOI":"10.3390\/ijms23126809","article-title":"Derangements and Reversibility of Energy Metabolism in Failing Hearts Resulting from Volume Overload: Transcriptomics and Metabolomics Analyses","volume":"23","author":"Tung","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.jtcvs.2020.08.119","article-title":"Hemodynamic and Transcriptomic Studies Suggest Early Left Ventricular Dysfunction in a Preclinical Model of Severe Mitral Regurgitation","volume":"161","author":"Corporan","year":"2021","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"714774","DOI":"10.3389\/fcvm.2021.714774","article-title":"Ultrastructural Adaptation of the Cardiomyocyte to Chronic Mitral Regurgitation","volume":"8","author":"Corporan","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1016\/j.jtcvs.2019.06.109","article-title":"Mitral Regurgitation Worsens Cardiac Remodeling in Ischemic Cardiomyopathy in an Experimental Model","volume":"160","author":"Onohara","year":"2020","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Kono, T., Onohara, D., Amedi, A., Corporan, D., and Padala, M. (2021). Effect of Early versus Late Onset Mitral Regurgitation on Left Ventricular Remodeling in Ischemic Cardiomyopathy in an Animal Model. J. Thorac. Cardiovasc. Surg.","DOI":"10.1016\/j.jtcvs.2021.11.024"},{"key":"ref_96","first-page":"128","article-title":"Experimental Aortic Regurgitation in Rats under Echocardiographic Guidance","volume":"11","author":"Arsenault","year":"2002","journal-title":"J. Heart Valve Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.hlc.2021.11.016","article-title":"The Role of Extracellular Matrix in the Experimental Acute Aortic Regurgitation Model in Rats","volume":"31","author":"Bussoni","year":"2022","journal-title":"Heart. Lung Circ."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Walsh-Wilkinson, E., Drolet, M.-C., Arsenault, M., and Couet, J. (2020). Sex Differences in the Evolution of Left Ventricle Remodeling in Rats with Severe Volume Overload. BMC Cardiovasc. Disord., 20.","DOI":"10.1186\/s12872-020-01360-0"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"H38","DOI":"10.1152\/ajpheart.00467.2020","article-title":"Impaired Right and Left Ventricular Function and Relaxation Induced by Pulmonary Regurgitation Are Not Reversed by Tardive Antifibrosis Treatment","volume":"321","author":"Akazawa","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1093\/eurheartj\/ehm263","article-title":"In Vivo Model of Drug-Induced Valvular Heart Disease in Rats: Pergolide-Induced Valvular Heart Disease Demonstrated with Echocardiography and Correlation with Pathology","volume":"28","author":"Droogmans","year":"2007","journal-title":"Eur. Heart J."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Khosroshahi, A.J., Mokhtari, B., and Badalzadeh, R. (2022). Combination of Nicotinamide Mononucleotide and Troxerutin Induces Full Protection against Doxorubicin-Induced Cardiotoxicity by Modulating Mitochondrial Biogenesis and Inflammatory Response. Mol. Biol. Rep.","DOI":"10.1007\/s11033-022-07390-5"},{"key":"ref_102","first-page":"213","article-title":"Short-Term and Long-Term Models of Doxorubicin-Induced Cardiomyopathy in Rats: A Comparison of Functional and Histopathological Changes","volume":"69","author":"Romano","year":"2017","journal-title":"Exp. Toxicol. Pathol. Off. J. Ges. Fur Toxikol. Pathol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"8130","DOI":"10.7150\/thno.47407","article-title":"Screening for In-Vivo Regional Contractile Defaults to Predict the Delayed Doxorubicin Cardiotoxicity in Juvenile Rat","volume":"10","author":"Chakouri","year":"2020","journal-title":"Theranostics"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1007\/s12012-021-09685-8","article-title":"The Protective Effects of Coenzyme Q10 and Lisinopril Against Doxorubicin-Induced Cardiotoxicity in Rats: A Stereological and Electrocardiogram Study","volume":"21","author":"Rahmanifard","year":"2021","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"103308","DOI":"10.1016\/j.sjbs.2022.103308","article-title":"Doxorubicin-Induced Hepatic Toxicity in Rats: Mechanistic Protective Role of Omega-3 Fatty Acids through Nrf2\/HO-1 Activation and PI3K\/Akt\/GSK-3\u03b2 Axis Modulation","volume":"29","author":"Saleh","year":"2022","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_106","first-page":"1243","article-title":"Kidney Dysfunction and Oxidative Stress in Doxorubicin-Induced Nephrotic Rat: Protective Role of Sesame Oil","volume":"32","author":"Mahzari","year":"2021","journal-title":"Saudi J. Kidney Dis. Transplant. Off. Publ. Saudi Cent. Organ Transplant. Saudi Arab."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e13747","DOI":"10.1111\/jfbc.13747","article-title":"Immunomodulatory Effects of Bee Pollen on Doxorubicin-Induced Bone Marrow\/Spleen Immunosuppression in Rat","volume":"45","author":"Shaldoum","year":"2021","journal-title":"J. Food Biochem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"H679","DOI":"10.1152\/ajpheart.00145.2003","article-title":"Hyperhomocysteinemia Leads to Pathological Ventricular Hypertrophy in Normotensive Rats","volume":"285","author":"Joseph","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_109","first-page":"117","article-title":"A Novel Rat Model of Heart Failure Induced by High Methionine Diet Showing Evidence of Association between Hyperhomocysteinemia and Activation of NF-KappaB","volume":"8","author":"Liu","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/01.RES.71.2.346","article-title":"Myocardial Mechanical, Biochemical, and Structural Alterations Induced by Chronic Ethanol Ingestion in Rats","volume":"71","author":"Capasso","year":"1992","journal-title":"Circ. Res."},{"key":"ref_111","first-page":"H212","article-title":"Left Ventricular Dysfunction Induced by Chronic Alcohol Ingestion in Rats","volume":"261","author":"Capasso","year":"1991","journal-title":"Am. J. Physiol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Marchini, G.S., Cestari, I.N., Salemi, V.M.C., Irigoyen, M.C., Arnold, A., Kakoi, A., Rocon, C., Aiello, V.D., and Cestari, I.A. (2020). Early Changes in Myocyte Contractility and Cardiac Function in Streptozotocin-Induced Type 1 Diabetes in Rats. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0237305"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s10517-021-05321-1","article-title":"Systolic Dysfunction of the Heart in Type 1 Diabetes Mellitus","volume":"172","author":"Lakomkin","year":"2021","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s10517-021-05272-7","article-title":"Expression of Bax and Bcl-2 Proteins in Left-Ventricular Cardiomyocytes in Wistar-Kyoto and SHR Rats with Insulin-Dependent Diabetes Mellitus","volume":"171","author":"Sklifasovskaya","year":"2021","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/10641963.2020.1860077","article-title":"Echocardiographic Follow-up to Right Ventricular Modifications in Secondary Pulmonary Hypertension to Diabetes in Rats","volume":"43","year":"2021","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12933-017-0645-0","article-title":"Comparison of Speckle-Tracking Echocardiography with Invasive Hemodynamics for the Detection of Characteristic Cardiac Dysfunction in Type-1 and Type-2 Diabetic Rat Models","volume":"17","author":"Braun","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/1074248418784287","article-title":"Cardiosphere-Derived Cells Attenuate Inflammation, Preserve Systolic Function, and Prevent Adverse Remodeling in Rat Hearts With Experimental Autoimmune Myocarditis","volume":"24","author":"Nana","year":"2019","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"696362","DOI":"10.3389\/fcvm.2021.696362","article-title":"RIP1\/RIP3\/MLKL Mediates Myocardial Function Through Necroptosis in Experimental Autoimmune Myocarditis","volume":"8","author":"Wu","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.21037\/qims-20-122","article-title":"Non-Invasive Assessment of Early and Acute Myocarditis in a Rat Model Using Cardiac Magnetic Resonance Tissue Tracking Analysis of Myocardial Strain","volume":"10","author":"Zhu","year":"2020","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1007\/s00330-009-1454-y","article-title":"Acute Myocarditis in a Rat Model: Late Gadolinium Enhancement with Histopathological Correlation","volume":"19","author":"Korkusuz","year":"2009","journal-title":"Eur. Radiol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.yjmcc.2013.07.013","article-title":"Role of CaMKII and ROS in Rapid Pacing-Induced Apoptosis","volume":"63","author":"Gonano","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_122","first-page":"4917","article-title":"MiRNA-182 Regulates the Cardiomyocyte Apoptosis in Heart Failure","volume":"23","author":"Zhou","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1161\/01.RES.0000244087.36230.bf","article-title":"Pacing-Induced Heterogeneities in Intracellular Ca2+ Signaling, Cardiac Alternans, and Ventricular Arrhythmias in Intact Rat Heart","volume":"99","author":"Aistrup","year":"2006","journal-title":"Circ. Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.yjmcc.2008.02.272","article-title":"Mutation That Dramatically Alters Rat Titin Isoform Expression and Cardiomyocyte Passive Tension","volume":"44","author":"Greaser","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nm.2693","article-title":"RBM20, a Gene for Hereditary Cardiomyopathy, Regulates Titin Splicing","volume":"18","author":"Guo","year":"2012","journal-title":"Nat. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e15011","DOI":"10.14814\/phy2.15011","article-title":"The Ryanodine Receptor Stabilizer S107 Ameliorates Contractility of Adult Rbm20 Knockout Rat Cardiomyocytes","volume":"9","author":"Guo","year":"2021","journal-title":"Physiol. Rep."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1536\/ihj.20-372","article-title":"Age-Dependent Echocardiographic and Pathologic Findings in a Rat Model with Duchenne Muscular Dystrophy Generated by CRISPR\/Cas9 Genome Editing","volume":"61","author":"Sugihara","year":"2020","journal-title":"Int. Heart J."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"11580","DOI":"10.1038\/s41598-022-15934-9","article-title":"A Medium-Chain Triglyceride Containing Ketogenic Diet Exacerbates Cardiomyopathy in a CRISPR\/Cas9 Gene-Edited Rat Model with Duchenne Muscular Dystrophy","volume":"12","author":"Fujikura","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/ame2.12193","article-title":"Novel Rat Model of Multiple Mitochondrial Dysfunction Syndromes (MMDS) Complicated with Cardiomyopathy","volume":"4","author":"Ling","year":"2021","journal-title":"Anim. Model. Exp. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"120485","DOI":"10.1016\/j.lfs.2022.120485","article-title":"Myocardium-Specific Isca1 Knockout Causes Iron Metabolism Disorder and Myocardial Oncosis in Rat","volume":"297","author":"Ling","year":"2022","journal-title":"Life Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1038\/s41467-018-06533-2","article-title":"Chemogenetic Generation of Hydrogen Peroxide in the Heart Induces Severe Cardiac Dysfunction","volume":"9","author":"Steinhorn","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"H451","DOI":"10.1152\/ajpheart.00628.2021","article-title":"Metabolomic and Transcriptomic Signatures of Chemogenetic Heart Failure","volume":"322","author":"Spyropoulos","year":"2022","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"H617","DOI":"10.1152\/ajpheart.00177.2019","article-title":"Reversal of Heart Failure in a Chemogenetic Model of Persistent Cardiac Redox Stress","volume":"317","author":"Sorrentino","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1073\/pnas.1208863110","article-title":"Regulation of Neonatal and Adult Mammalian Heart Regeneration by the MiR-15 Family","volume":"110","author":"Porrello","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"14","DOI":"10.14797\/mdcj-14-1-14","article-title":"Stenting in Primary Percutaneous Coronary Intervention for Acute ST-Segment Elevation Myocardial Infarction","volume":"14","author":"Kalra","year":"2018","journal-title":"Methodist Debakey Cardiovasc. J."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3390\/jcdd8090100","article-title":"New Interventional Therapies beyond Stenting to Treat ST-Segment Elevation Acute Myocardial Infarction","volume":"8","author":"Brugaletta","year":"2021","journal-title":"J. Cardiovasc. Dev. Dis."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jtcvs.2013.08.046","article-title":"Pulmonary Vein Stenosis and the Pathophysiology of \u201cUpstream\u201d Pulmonary Veins","volume":"148","author":"Kato","year":"2014","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_138","unstructured":"Ryan, J.J., Marsboom, G., and Archer, S.L. (2013). Pharmacotherapy of Pulmonary Hypertension, Springer."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"5.47.1","DOI":"10.1002\/0471141755.ph0547s70","article-title":"Streptozotocin-Induced Diabetic Models in Mice and Rats","volume":"70","author":"Furman","year":"2015","journal-title":"Curr. Protoc. Pharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1038\/ncomms5533","article-title":"Integrin-Linked Kinase Mediates Force Transduction in Cardiomyocytes by Modulating SERCA2a\/PLN Function","volume":"5","author":"Traister","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1530\/ERP-16-0020","article-title":"Right Heart Function Deteriorates in Breast Cancer Patients Undergoing Anthracycline-Based Chemotherapy","volume":"3","author":"Boczar","year":"2016","journal-title":"Echo Res. Pract."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"174406","DOI":"10.1016\/j.ejphar.2021.174406","article-title":"Tetrahydrobiopterin Paradoxically Mediates Cardiac Oxidative Stress and Mitigates Ethanol-Evoked Cardiac Dysfunction in Conscious Female Rats","volume":"909","author":"Yao","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2174\/1871530319666190626143832","article-title":"Future Perspective of Diabetic Animal Models","volume":"20","author":"Pandey","year":"2020","journal-title":"Endocr. Metab. Immune Disord.\u2014Drug Targets"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Lafuse, W.P., Wozniak, D.J., and Rajaram, M.V.S. (2020). Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair. Cells, 10.","DOI":"10.3390\/cells10010051"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Nagasaka, A., Terawaki, T., Noda, M., Takashima, M., Fujino, M., Yamauchi, Y., Arawaka, S., Kato, T., and Nakaya, M. (2023). GRK5 -mediated Inflammation and Fibrosis Exert Cardioprotective Effects during the Acute Phase of Myocardial Infarction. FEBS Open Bio.","DOI":"10.1002\/2211-5463.13551"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Chalise, U., Becirovic-Agic, M., and Lindsey, M.L. (2023). The Cardiac Wound Healing Response to Myocardial Infarction. WIREs Mech. Dis., 15.","DOI":"10.1002\/wsbm.1584"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"100492","DOI":"10.1016\/j.cophys.2022.100492","article-title":"Hippo-Yap Signaling in Cardiac and Fibrotic Remodeling","volume":"26","year":"2022","journal-title":"Curr. Opin. Physiol."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Sarohi, V., Chakraborty, S., and Basak, T. (2022). Exploring the Cardiac ECM during Fibrosis: A New Era with next-Gen Proteomics. Front. Mol. Biosci., 9.","DOI":"10.3389\/fmolb.2022.1030226"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41569-020-00435-x","article-title":"Myocarditis and Inflammatory Cardiomyopathy: Current Evidence and Future Directions","volume":"18","author":"Ammirati","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Farrag, N.A., Thornhill, R.E., Prato, F.S., Skanes, A.C., Sullivan, R., Sebben, D., Butler, J., Sykes, J., Wilk, B., and Ukwatta, E. (2022). Assessment of Left Atrial Fibrosis Progression in Canines Following Rapid Ventricular Pacing Using 3D Late Gadolinium Enhanced CMR Images. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0269592"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Schiabor Barrett, K.M., Cirulli, E.T., Bolze, A., Rowan, C., Elhanan, G., Grzymski, J.J., Lee, W., and Washington, N.L. (2023). Cardiomyopathy Prevalence Exceeds 30% in Individuals with TTN Variants and Early Atrial Fibrillation. Genet. Med., 100012.","DOI":"10.1016\/j.gim.2023.100012"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1111\/jcmm.17533","article-title":"Use of Animal Models to Understand Titin Physiology and Pathology","volume":"26","author":"Marcello","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jacbts.2021.11.004","article-title":"Cardiovascular Disease in Duchenne Muscular Dystrophy","volume":"7","author":"Schultz","year":"2022","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Fujikura, Y., Sugihara, H., Hatakeyama, M., Oishi, K., and Yamanouchi, K. (2021). Ketogenic Diet with Medium-chain Triglycerides Restores Skeletal Muscle Function and Pathology in a Rat Model of Duchenne Muscular Dystrophy. FASEB J., 35.","DOI":"10.1096\/fj.202100629R"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s41434-020-0147-7","article-title":"AAV-Mediated Cardiac Gene Transfer of Wild-Type Desmin in Mouse Models for Recessive Desminopathies","volume":"27","author":"Ruppert","year":"2020","journal-title":"Gene Ther."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Caravia, X.M., Ramirez-Martinez, A., Gan, P., Wang, F., McAnally, J.R., Xu, L., Bassel-Duby, R., Liu, N., and Olson, E.N. (2022). Loss of Function of the Nuclear Envelope Protein LEMD2 Causes DNA Damage\u2013Dependent Cardiomyopathy. J. Clin. Invest., 132.","DOI":"10.1172\/JCI158897"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Brodehl, A., Belke, D.D., Garnett, L., Martens, K., Abdelfatah, N., Rodriguez, M., Diao, C., Chen, Y.-X., Gordon, P.M.K., and Nygren, A. (2017). Transgenic Mice Overexpressing Desmocollin-2 (DSC2) Develop Cardiomyopathy Associated with Myocardial Inflammation and Fibrotic Remodeling. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0174019"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s00059-012-3651-8","article-title":"Genetic Cardiomyopathies","volume":"37","author":"Kloos","year":"2012","journal-title":"Herz"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/4\/3162\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:25:01Z","timestamp":1760120701000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/4\/3162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,5]]},"references-count":158,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["ijms24043162"],"URL":"https:\/\/doi.org\/10.3390\/ijms24043162","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,5]]}}}