{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:27:13Z","timestamp":1789241233878,"version":"build-2803163510"},"reference-count":73,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T00:00:00Z","timestamp":1675555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["31871511"],"award-info":[{"award-number":["31871511"]}]},{"name":"National Natural Science Foundation of China","award":["32171114"],"award-info":[{"award-number":["32171114"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Decidualization is necessary for the successful establishment of early pregnancy in rodents and humans. Disturbed decidualization results in recurrent implantation failure, recurrent spontaneous abortion, and preeclampsia. Tryptophan (Trp), one of the essential amino acids in humans, has a positive effect on mammalian pregnancy. Interleukin 4-induced gene 1 (IL4I1) is a recently identified enzyme that can metabolize L-Trp to activate aryl hydrocarbon receptor (AHR). Although IDO1-catalyzed kynurenine (Kyn) from Trp has been shown to enhance human in vitro decidualization via activating AHR, whether IL4I1-catalyzed metabolites of Trp are involved in human decidualization is still unknown. In our study, human chorionic gonadotropin stimulates IL4I1 expression and secretion from human endometrial epithelial cells through ornithine decarboxylase-induced putrescine production. Either IL4I1-catalyzed indole-3-pyruvic acid (I3P) or its metabolite indole-3-aldehyde (I3A) from Trp is able to induce human in vitro decidualization by activating AHR. As a target gene of AHR, Epiregulin induced by I3P and I3A promotes human in vitro decidualization. Our study indicates that IL4I1-catalyzed metabolites from Trp can enhance human in vitro decidualization through AHR-Epiregulin pathway.<\/jats:p>","DOI":"10.3390\/ijms24043163","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T03:34:30Z","timestamp":1675654470000},"page":"3163","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Human Chorionic Gonadotropin-Stimulated Interleukin-4-Induced-1 (IL4I1) Promotes Human Decidualization via Aryl Hydrocarbon Receptor"],"prefix":"10.3390","volume":"24","author":[{"given":"Jia-Mei","family":"Luo","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-Tong","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ying","family":"He","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Na","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qi","family":"Hong","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6016-5710","authenticated-orcid":false,"given":"Zeng-Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"},{"name":"Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountain Region, College of Animal Science, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.mce.2013.08.011","article-title":"Heparin-binding epidermal growth factor-like growth factor (HB-EGF) induction on Snail expression during mouse decidualization","volume":"381","author":"Zhang","year":"2013","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1210\/er.2003-0020","article-title":"Molecular cues to implantation","volume":"25","author":"Dey","year":"2004","journal-title":"Endocr. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-0029-1242989","article-title":"Endometrial decidualization: Of mice and men","volume":"28","author":"Ramathal","year":"2010","journal-title":"Semin. Reprod. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic Decidualization of the human endometrium in reproductive health and failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocr. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.5468\/ogs.2014.57.4.249","article-title":"The tryptophan utilization concept in pregnancy","volume":"57","author":"Badawy","year":"2014","journal-title":"Obstet. Gynecol. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Xu, K., Liu, H., Bai, M., Gao, J., Wu, X., and Yin, Y. (2017). Redox properties of tryptophan metabolism and the concept of tryptophan use in pregnancy. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18071595"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.biochi.2017.07.008","article-title":"Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase","volume":"140","author":"Laurent","year":"2017","journal-title":"Biochimie"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0301-2115(00)00367-5","article-title":"Pathophysiology of preeclampsia and the role of serotonin","volume":"95","author":"Bolte","year":"2001","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s42003-021-01900-0","article-title":"Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice","volume":"4","author":"Fields","year":"2021","journal-title":"Commun. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"152458","DOI":"10.1016\/j.tox.2020.152458","article-title":"Kynurenine produced by indoleamine 2,3-dioxygenase 2 exacerbates acute liver injury by carbon tetrachloride in mice","volume":"438","author":"Hoshi","year":"2020","journal-title":"Toxicology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1006\/bbrc.2000.3115","article-title":"Induction of tryptophan 2,3-dioxygenase in the mouse endometrium during implantation","volume":"274","author":"Tatsumi","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e12786","DOI":"10.1111\/aji.12786","article-title":"The role of indoleamine-2,3-dioxygenase in normal and pathological pregnancies","volume":"79","author":"Chang","year":"2018","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e00261","DOI":"10.1042\/BSR20150197","article-title":"Tryptophan metabolism, disposition and utilization in pregnancy","volume":"35","author":"Badawy","year":"2015","journal-title":"Biosci. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jri.2017.01.003","article-title":"Downregulation of indoleamine 2, 3-dioxygenase expression in the villous stromal endothelial cells of placentas with preeclampsia","volume":"119","author":"Iwahashi","year":"2017","journal-title":"J. Reprod. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1067\/mob.2003.156","article-title":"Decreased tryptophan catabolism by placental indoleamine 2,3-dioxygenase in preeclampsia","volume":"188","author":"Kudo","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.4049\/jimmunol.0903670","article-title":"An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells","volume":"185","author":"Mezrich","year":"2010","journal-title":"J. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1021\/acs.chemrestox.9b00476","article-title":"The Ah receptor: Adaptive metabolism, ligand diversity, and the Xenokine Model","volume":"33","author":"Avilla","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cotox.2017.01.001","article-title":"Canonical and non-canonical aryl hydrocarbon receptor signaling pathways","volume":"2","author":"Wright","year":"2017","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmb.2008.04.056","article-title":"Recruitment of CREB1 and histone deacetylase 2 (HDAC2) to the mouse Ltbp-1 promoter regulates its constitutive expression in a dioxin receptor-dependent manner","volume":"380","author":"Ballestar","year":"2008","journal-title":"J. Mol. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.it.2018.10.010","article-title":"The aryl hydrocarbon receptor: Connecting immunity to the microenvironment","volume":"39","author":"Shinde","year":"2018","journal-title":"Trends Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bcp.2008.08.031","article-title":"The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways","volume":"77","author":"Puga","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.bcp.2008.09.037","article-title":"The role of the aryl hydrocarbon receptor in the female reproductive system","volume":"77","author":"Karman","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/toxsci\/kfl090","article-title":"In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces amphiregulin gene expression in the developing mouse ureter","volume":"94","author":"Choi","year":"2006","journal-title":"Toxicol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/mc.22032","article-title":"The Ah receptor regulates growth factor expression in head and neck squamous cell carcinoma cell lines","volume":"53","author":"John","year":"2014","journal-title":"Mol. Carcinog."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1477-7827-10-50","article-title":"Preimplantation factor (PIF) promoting role in embryo implantation: Increases endometrial integrin-\u03b12\u03b23, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in decidua","volume":"10","author":"Barnea","year":"2012","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/s13046-019-1318-5","article-title":"A positive feedback between IDO1 metabolite and COL12A1 via MAPK pathway to promote gastric cancer metastasis","volume":"38","author":"Xiang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1186\/s13058-014-0410-1","article-title":"Cancer\/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression","volume":"16","author":"Chen","year":"2014","journal-title":"Breast Cancer Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature10491","article-title":"An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor","volume":"478","author":"Opitz","year":"2011","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1124\/mol.116.105361","article-title":"An aryl hydrocarbon receptor-mediated amplification loop that enforces cell migration in ER-\/PR-\/Her2- human breast cancer cells","volume":"90","author":"Novikov","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1158\/0008-5472.CAN-15-2011","article-title":"A TDO2-AhR signaling axis facilitates anoikis resistance and metastasis in triple-negative breast cancer","volume":"75","author":"Rogers","year":"2015","journal-title":"Cancer Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41573-019-0016-5","article-title":"Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond","volume":"18","author":"Platten","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41568-019-0106-z","article-title":"Immune control by amino acid catabolism during tumorigenesis and therapy","volume":"19","author":"Lemos","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41392-021-00529-z","article-title":"IL4I1-driven AHR signature: A new avenue for cancer therapy","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.coi.2020.12.003","article-title":"Detrimental activation of AhR pathway in cancer: An overview of therapeutic strategies","volume":"70","author":"Leclerc","year":"2021","journal-title":"Curr. Opin. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1182\/blood-2006-07-036210","article-title":"Human IL4I1 is a secreted l-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation","volume":"110","author":"Boulland","year":"2007","journal-title":"Blood"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.cell.2020.07.038","article-title":"IL4I1 Is a metabolic immune checkpoint that activates the AHR and promotes tumor progression","volume":"182","author":"Sadik","year":"2020","journal-title":"Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.reprotox.2020.07.011","article-title":"Tryptophan and kynurenine stimulate human decidualization via activating Aryl hydrocarbon receptor: Short title: Kynurenine action on human decidualization","volume":"96","author":"Wang","year":"2020","journal-title":"Reprod. Toxicol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1095\/biolreprod47.3.441","article-title":"Effect of progestin, antiprogestin, and relaxin on the accumulation of prolactin and insulin-like growth factor-binding protein-1 messenger ribonucleic acid in human endometrial stromal cells","volume":"47","author":"Tseng","year":"1992","journal-title":"Biol. Reprod."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1210\/me.2007-0058","article-title":"Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cells","volume":"21","author":"Takano","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/s41467-021-20896-z","article-title":"Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas","volume":"12","author":"Khan","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s10735-008-9188-8","article-title":"Embryonic and postnatal development in experimental tryptophan deprived rats. A preliminary study","volume":"39","author":"Imbesi","year":"2008","journal-title":"J. Mol. Histol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"eaaf9794","DOI":"10.1126\/science.aaf9794","article-title":"Kynurenines: Tryptophan\u2019s metabolites in exercise, inflammation, and mental health","volume":"357","author":"Cervenka","year":"2017","journal-title":"Science"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e12257","DOI":"10.14814\/phy2.12257","article-title":"Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes","volume":"3","author":"Santillan","year":"2015","journal-title":"Physiol. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1530\/JOE-13-0429","article-title":"Differential expression and regulation of Tdo2 during mouse decidualization","volume":"220","author":"Li","year":"2014","journal-title":"J. Endocrinol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e158346","DOI":"10.1172\/JCI158346","article-title":"Impaired renal reserve contributes to preeclampsia via the kynurenine and soluble fms\u2013like tyrosine kinase 1 pathway","volume":"132","author":"Dupont","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"624293","DOI":"10.3389\/fimmu.2021.624293","article-title":"The Aryl Hydrocarbon Receptor as a modulator of anti-viral immunity","volume":"12","author":"Torti","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Cho, T.E., Bott, D., Ahmed, S., Hutin, D., Gomez, A., Tamblyn, L., Zhou, A.C., Watts, T.H., Grant, D.M., and Matthews, J. (2019). 3-Methylcholanthrene induces Chylous ascites in TCDD-inducible poly-ADP-ribose polymerase (tiparp) knockout mice. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092312"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"188335","DOI":"10.1016\/j.bbcan.2019.188335","article-title":"The role of AhR in transcriptional regulation of immune cell development and function","volume":"1873","author":"Trikha","year":"2020","journal-title":"Biochim. Biophys. Acta (BBA) Rev. Cancer"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1007\/s00204-012-0870-y","article-title":"Regulation of uterine AHR battery gene expression by 17\u03b2-Estradiol is predominantly mediated by estrogen receptor \u03b1","volume":"86","author":"Rataj","year":"2012","journal-title":"Arch. Toxicol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00204-014-1261-3","article-title":"Progesterone, as well as 17\u03b2-estradiol, is important for regulating AHR battery homoeostasis in the rat uterus","volume":"89","author":"Rataj","year":"2015","journal-title":"Arch. Toxicol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1006\/taap.1998.8601","article-title":"Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse","volume":"155","author":"Abbott","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"10040","DOI":"10.1128\/MCB.25.22.10040-10051.2005","article-title":"Intrinsic function of the aryl hydrocarbon (dioxin) receptor as a key factor in female reproduction","volume":"25","author":"Baba","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00441-017-2679-8","article-title":"Development of an in vitro model to study uterine functions and early implantation using rat uterine explants","volume":"370","author":"Islam","year":"2017","journal-title":"Cell Tissue Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1006\/dbio.1997.8694","article-title":"Expression of betacellulin and epiregulin genes in the mouse uterus temporally by the blastocyst solely at the site of its apposition is coincident with the \u201cwindow\u201d of implantation","volume":"190","author":"Das","year":"1997","journal-title":"Dev. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12522-016-0236-x","article-title":"Roles of epidermal growth factor (EGF)-like factor in the ovulation process","volume":"15","author":"Shimada","year":"2016","journal-title":"Reprod. Med. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1002\/eji.201040428","article-title":"Dichotomy between factors inducing the immunosuppressive enzyme IL-4-induced gene 1 (IL4I1) in B lym-phocytes and mononuclear phagocytes","volume":"40","author":"Marquet","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/ni.3818","article-title":"Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation","volume":"18","author":"Park","year":"2017","journal-title":"Nat. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Mazzoni, A., Capone, M., Ramazzotti, M., Vanni, A., Locatello, L.G., Gallo, O., De Palma, R., Cosmi, L., Liotta, F., and Annunziato, F. (2021). IL4I1 is expressed by head-neck cancer-derived mesenchymal stromal cells and contributes to suppress T cell proliferation. J. Clin. Med., 10.","DOI":"10.3390\/jcm10102111"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"16621","DOI":"10.1073\/pnas.1900401116","article-title":"Blastocyst activation engenders transcriptome reprogram affecting X-chromosome reactivation and inflammatory trigger of implantation","volume":"116","author":"He","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1093\/humrep\/det264","article-title":"Tumor necrosis factor-308 polymorphism increases the embryo implantation rate in women undergoing in vitro fertilization","volume":"28","author":"Vialard","year":"2013","journal-title":"Hum. Reprod."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1210\/jcem-67-6-1322","article-title":"Chorionic gonadotropin secretion by human embryos in vitro","volume":"67","author":"Hay","year":"1988","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Makrigiannakis, A., Vrekoussis, T., Zoumakis, E., Kalantaridou, S.N., and Jeschke, U. (2017). The role of HCG in implantation: A mini-review of molecular and clinical evidence. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18061305"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13567-020-00792-y","article-title":"Interleukin 4 inducible 1 gene (IL4I1) is induced in chicken phagocytes by salmonella enteritidis infection","volume":"51","author":"Polansky","year":"2020","journal-title":"Vet. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ajog.2016.09.075","article-title":"Evidence that the endometrial microbiota has an effect on implantation success or failure","volume":"215","author":"Moreno","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/rda.12835","article-title":"Regulation of diapause in carnivores","volume":"52","author":"Fenelon","year":"2017","journal-title":"Reprod. Domest. Anim."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1017\/S0967199417000120","article-title":"Physiological importance of polyamines","volume":"25","author":"Lenis","year":"2017","journal-title":"Zygote"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1210\/en.2007-1420","article-title":"Polyamines are essential in embryo implantation: Expression and function of polyamine-related genes in mouse uterus during peri-implantation period","volume":"149","author":"Zhao","year":"2008","journal-title":"Endocrinology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/biolre\/iox060","article-title":"Inhibition of polyamine synthesis causes entry of the mouse blastocyst into embryonic diapause","volume":"97","author":"Fenelon","year":"2017","journal-title":"Biol. Reprod."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e12737","DOI":"10.1111\/cpr.12737","article-title":"ATP mediates the interaction between human blastocyst and endometrium","volume":"53","author":"Gu","year":"2020","journal-title":"Cell Prolif."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Yang, Z.-S., Pan, H.-Y., Shi, W.-W., Chen, S.-T., Wang, Y., Li, M.-Y., Zhang, H.-Y., Yang, C., Liu, A.-X., and Yang, Z.-M. (2021). Regulation and function of laminin A5 during mouse and human decidualization. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010199"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"21280","DOI":"10.1074\/jbc.M115.656629","article-title":"Warburg-like glycolysis and lactate shuttle in mouse decidua during early pregnancy","volume":"290","author":"Zuo","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1002\/1873-3468.12645","article-title":"Molecular characterization of lysyl oxidase-mediated extracellular matrix remodeling during mouse decidualization","volume":"591","author":"Li","year":"2017","journal-title":"FEBS Lett."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41419-020-02844-9","article-title":"Aldosterone from endometrial glands is benefit for human decidualization","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/4\/3163\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:25:03Z","timestamp":1760120703000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/4\/3163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,5]]},"references-count":73,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["ijms24043163"],"URL":"https:\/\/doi.org\/10.3390\/ijms24043163","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,5]]}}}