{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T07:04:02Z","timestamp":1785308642319,"version":"3.55.0"},"reference-count":50,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Biotechnology (DBT)","award":["SR\/PURSE\/2018\/81c"],"award-info":[{"award-number":["SR\/PURSE\/2018\/81c"]}]},{"name":"Indian Council of Medical Research (ICMR)","award":["SR\/PURSE\/2018\/81c"],"award-info":[{"award-number":["SR\/PURSE\/2018\/81c"]}]},{"name":"ICMR-SRF","award":["SR\/PURSE\/2018\/81c"],"award-info":[{"award-number":["SR\/PURSE\/2018\/81c"]}]},{"name":"Department of Science and Technology\u2019s Promotion of University Research and Scientific Excellence","award":["SR\/PURSE\/2018\/81c"],"award-info":[{"award-number":["SR\/PURSE\/2018\/81c"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The pathophysiology of nonalcoholic steatohepatitis (NASH) is complex, owing to its diverse pathological drivers and, until recently, there were no approved drugs for this disease. Tecomella is a popular herbal medicine used to treat hepatosplenomegaly, hepatitis, and obesity. However, the potential role of Tecomella undulata in NASH has not yet been scientifically investigated. The administration of Tecomella undulata via oral gavage lowered body weight, insulin resistance, alanine transaminase (ALT), aspartate transaminase (AST), triglycerides, and total cholesterol in western diet sugar water (WDSW) fed mice but had no effect on chow diet normal water (CDNW) fed mice. Tecomella undulata improved steatosis, lobular inflammation, and hepatocyte ballooning and resolved NASH in WDSW mice. Furthermore, Tecomella undulata also alleviated the WDSW-induced Endoplasmic Reticulum stress and oxidative stress, enhanced antioxidant status, and thus reduced inflammation in the treated mice. Of note, these effects were comparable to saroglitazar, the approved drug used to treat human NASH and the positive control used in the study. Thus, our findings indicate the potential of Tecomella undulata to ameliorate WDSW-induced steatohepatitis, and these preclinical data provide a strong rationale for assessing Tecomella undulata for the treatment of NASH.<\/jats:p>","DOI":"10.3390\/ijms24043244","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T01:56:48Z","timestamp":1675735008000},"page":"3244","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Unraveling the Potential Role of Tecomella undulata in Experimental NASH"],"prefix":"10.3390","volume":"24","author":[{"given":"Akshatha N.","family":"Srinivas","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR), JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diwakar","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR), JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Suvarna","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru 570004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Pathak","sequence":"additional","affiliation":[{"name":"JSS Ayurveda Medical College and Hospital, Mysuru 570028, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Giri","sequence":"additional","affiliation":[{"name":"Zydus Research Centre, Cadila Healthcare Limited, Ahmedabad 382213, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Suman","sequence":"additional","affiliation":[{"name":"Government Ayurveda Medical College, Mysuru 570001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchitha","family":"Satish","sequence":"additional","affiliation":[{"name":"Department of Pathology, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru 570004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saravana Babu","family":"Chidambaram","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru 570004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5935-379X","authenticated-orcid":false,"given":"Divya P.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR), JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: Trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2017","journal-title":"Nat. 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