{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:45:11Z","timestamp":1784349911406,"version":"3.55.0"},"reference-count":68,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Neurotrauma Research Program WA (NRP)","award":["APP1087114"],"award-info":[{"award-number":["APP1087114"]}]},{"name":"State Government of Western Australia","award":["APP1087114"],"award-info":[{"award-number":["APP1087114"]}]},{"name":"National Health &amp; Medical Research Fund","award":["APP1087114"],"award-info":[{"award-number":["APP1087114"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Adolescence is a critical period of postnatal development characterized by social, emotional, and cognitive changes. These changes are increasingly understood to depend on white matter development. White matter is highly vulnerable to the effects of injury, including secondary degeneration in regions adjacent to the primary injury site which alters the myelin ultrastructure. However, the impact of such alterations on adolescent white matter maturation is yet to be investigated. To address this, female piebald-virol-glaxo rats underwent partial transection of the optic nerve during early adolescence (postnatal day (PND) 56) with tissue collection two weeks (PND 70) or three months later (PND 140). Axons and myelin in the transmission electron micrographs of tissue adjacent to the injury were classified and measured based on the appearance of the myelin laminae. Injury in adolescence impaired the myelin structure in adulthood, resulting in a lower percentage of axons with compact myelin and a higher percentage of axons with severe myelin decompaction. Myelin thickness did not increase as expected into adulthood after injury and the relationship between the axon diameter and myelin thickness in adulthood was altered. Notably, dysmyelination was not observed 2 weeks postinjury. In conclusion, injury in adolescence altered the developmental trajectory, resulting in impaired myelin maturation when assessed at the ultrastructural level in adulthood.<\/jats:p>","DOI":"10.3390\/ijms24043343","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T03:01:45Z","timestamp":1675825305000},"page":"3343","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Secondary Degeneration Impairs Myelin Ultrastructural Development in Adulthood following Adolescent Neurotrauma in the Rat Optic Nerve"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7960-7782","authenticated-orcid":false,"given":"Brittney R.","family":"Lins","sequence":"first","affiliation":[{"name":"Curtin Health Innovation Research Institute, Curtin University, Bentley, WA 6845, Australia"},{"name":"Perron Institute for Neurological and Translational Sciences, Nedlands, WA 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0618-3173","authenticated-orcid":false,"given":"Chidozie C.","family":"Anyaegbu","sequence":"additional","affiliation":[{"name":"Curtin Health Innovation Research Institute, Curtin University, Bentley, WA 6845, Australia"},{"name":"Perron Institute for Neurological and Translational Sciences, Nedlands, WA 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence","family":"McGonigle","sequence":"additional","affiliation":[{"name":"Curtin Health Innovation Research Institute, Curtin University, Bentley, WA 6845, Australia"},{"name":"Perron Institute for Neurological and Translational Sciences, Nedlands, WA 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2179-2209","authenticated-orcid":false,"given":"Sarah C.","family":"Hellewell","sequence":"additional","affiliation":[{"name":"Curtin 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