{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:35:01Z","timestamp":1790642101711,"version":"4.1.0"},"reference-count":61,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PRIN (Progetti di Rilevante Interesse Nazionale)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Duchenne Muscular Dystrophy (DMD) is a very severe X-linked dystrophinopathy. It is due to a mutation in the DMD gene and causes muscular degeneration in conjunction with several secondary co-morbidities, such cardiomyopathy and respiratory failure. DMD is characterized by a chronic inflammatory state, and corticosteroids represent the main therapy for these patients. To contradict drug-related side effects, there is need for novel and more safe therapeutic strategies. Macrophages are immune cells stringently involved in both physiological and pathological inflammatory processes. They express the CB2 receptor, one of the main elements of the endocannabinoid system, and have been proposed as an anti-inflammatory target in several inflammatory and immune diseases. We observed a lower expression of the CB2 receptor in DMD-associated macrophages, hypothesizing its involvement in the pathogenesis of this pathology. Therefore, we analyzed the effect of JWH-133, a CB2 receptor selective agonist, on DMD-associated primary macrophages. Our study describes the beneficial effect of JWH-133 in counteracting inflammation by inhibiting pro-inflammatory cytokines release and by directing macrophages\u2019 phenotype toward the M2 anti-inflammatory one.<\/jats:p>","DOI":"10.3390\/ijms24043345","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T03:01:45Z","timestamp":1675825305000},"page":"3345","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["CB2 Receptor as Emerging Anti-Inflammatory Target in Duchenne Muscular Dystrophy"],"prefix":"10.3390","volume":"24","author":[{"given":"Maura","family":"Argenziano","sequence":"first","affiliation":[{"name":"Department of Woman, Child and General and Specialistic Surgery, University of Campania \u201cLuigi Vanvitelli\u201d, Via Luigi De Crecchio, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9999-3388","authenticated-orcid":false,"given":"Vincenzo","family":"Pota","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialistic Surgery, University of Campania \u201cLuigi Vanvitelli\u201d, Via Luigi De Crecchio, 80138 Naples, Italy"},{"name":"Centro Clinico NeMO, Via Leonardo Bianchi, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Di Paola","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialistic Surgery, University of Campania \u201cLuigi Vanvitelli\u201d, Via Luigi De Crecchio, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Tortora","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialistic Surgery, University of Campania \u201cLuigi Vanvitelli\u201d, Via Luigi De Crecchio, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Maddalena","family":"Marrapodi","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialistic Surgery, University of Campania \u201cLuigi Vanvitelli\u201d, Via Luigi De Crecchio, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Giliberti","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, Via Luigi De Crecchio, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0948-3910","authenticated-orcid":false,"given":"Domenico","family":"Roberti","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialistic Surgery, University of Campania \u201cLuigi Vanvitelli\u201d, Via Luigi De Crecchio, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Caterina","family":"Pace","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialistic Surgery, University of Campania \u201cLuigi Vanvitelli\u201d, Via Luigi De Crecchio, 80138 Naples, Italy"},{"name":"Centro Clinico NeMO, Via Leonardo Bianchi, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialistic Surgery, University of Campania \u201cLuigi Vanvitelli\u201d, Via Luigi De Crecchio, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/s41580-021-00389-z","article-title":"Molecular and cellular basis of genetically inherited skeletal muscle disorders","volume":"22","author":"Dowling","year":"2021","journal-title":"Nat. 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