{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:49:34Z","timestamp":1791254974265,"version":"4.1.0"},"reference-count":64,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Ministry of Science and Higher Education of Poland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Osteoarthritis (OA) is one of the most prevalent diseases of the osteoarticular system. Progressive destruction of joints is accompanied by development of pathological changes in the muscle tissue, i.e., weakening, atrophy, and remodelling (sarcopenia). The aim of the present study is to assess the impact of physical activity on the musculoskeletal system in an animal model of early degenerative lesions in the knee joint. The study involved 30 male Wistar rats. The animals were allocated to three subgroups of 10 animals each. Each animal from the three subgroups received sodium iodoacetate by injection into the patellar ligament of the right knee joint, whereas saline was administered through the patellar ligament in the left knee joint. The rats in the first group were stimulated to exercise on a treadmill. The animals in the second group were allowed to lead a natural lifestyle (no treadmill stimulation). In the third group, all parts of the right hind limb muscle were injected with Clostridium botulinum toxin type A. The study demonstrated that, compared to the active rats, bone density in the immobilised rats decreased, as indicated by the densitometric assessment of the whole body and the examination of rats\u2019 hind limbs and knee joints alone. This clearly evidenced the impact of physical activity on bone mineralisation. The weight of both fat and muscle tissues in the physically inactive rats was reduced. Additionally, the adipose tissue had higher weight in the entire right hind limbs, where monoiodoacetic acid was administered to the knee joint. The animal model clearly showed the importance of physical activity in the early stages of OA, as it slows down the process of joint destruction, bone atrophy, and muscle wasting, whereas physical inactivity contributes to progression of generalised changes in the musculoskeletal system.<\/jats:p>","DOI":"10.3390\/ijms24043540","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T02:56:13Z","timestamp":1675997773000},"page":"3540","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Assessment of the Impact of Physical Activity on the Musculoskeletal System in Early Degenerative Knee Joint Lesions in an Animal Model"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6866-3850","authenticated-orcid":false,"given":"Jaromir","family":"Jarecki","sequence":"first","affiliation":[{"name":"Department of Rehabilitation and Orthopaedics, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Polkowska","sequence":"additional","affiliation":[{"name":"Department and Clinic of Animal Surgery, University of Life Sciences, 20-033 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8576-4701","authenticated-orcid":false,"given":"Waldemar","family":"Kazimierczak","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Environmental Research, Faculty of Medicine John Paul II, Catholic University of Lublin, 20-708 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0466-1343","authenticated-orcid":false,"given":"Magdalena","family":"W\u00f3jciak","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Lublin, Aleje Raclawickie 1, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9346-6325","authenticated-orcid":false,"given":"Ireneusz","family":"Sowa","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Lublin, Aleje Raclawickie 1, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4413-3748","authenticated-orcid":false,"given":"S\u0142awomir","family":"Dresler","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Lublin, Aleje Raclawickie 1, 20-059 Lublin, Poland"},{"name":"Department of Plant Physiology and Biophysics, Institute of Biological Sciences, Maria Curie-Sk\u0142odowska University, 20-033 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9747-8817","authenticated-orcid":false,"given":"Tomasz","family":"Blicharski","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Orthopaedics, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Jarecki, J., Ma\u0142ecka-Massalska, T., Polkowska, I., Potoczniak, B., Kosior-Jarecka, E., Szerb, I., Tomaszewska, E., Gutbier, M., Dobrzy\u0144ski, M., and Blicharski, T. (2021). Level of Adiponectin, Leptin and Selected Matrix Metalloproteinases in Female Overweight Patients with Primary Gonarthrosis. J. Clin. Med., 10.","DOI":"10.3390\/jcm10061263"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.35784\/acs-2022-14","article-title":"Knee joint osteoarthritis diagnosis based on selected acoustic signal discriminants using machine learning","volume":"18","year":"2022","journal-title":"Appl. Comput. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Krakowski, P., Karpi\u0144ski, R., Maciejewski, R., Jonak, J., and Jurkiewicz, A. (2020). Short-Term Effects of Arthroscopic Microfracturation of Knee Chondral Defects in Osteoarthritis. Appl. Sci., 10.","DOI":"10.3390\/app10238312"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.rcl.2009.03.003","article-title":"The Role of the Meniscus in Knee Osteoarthritis: A Cause or Consequence?","volume":"47","author":"Englund","year":"2009","journal-title":"Radiol. Clin. N. Am."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1302\/2058-5241.4.180102","article-title":"Subchondral Bone Remodelling in Osteoarthritis","volume":"4","author":"Donell","year":"2019","journal-title":"EFORT Open Rev."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Belluzzi, E., Macchi, V., Fontanella, C., Carniel, E., Olivotto, E., Filardo, G., Sarasin, G., Porzionato, A., Granzotto, M., and Pozzuoli, A. (2020). Infrapatellar Fat Pad Gene Expression and Protein Production in Patients with and without Osteoarthritis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176016"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.joca.2021.12.003","article-title":"Association between Knee Inflammation and Knee Pain in Patients with Knee Osteoarthritis: A Systematic Review","volume":"30","author":"Dainese","year":"2022","journal-title":"Osteoarthr. Cartil."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1007\/s11357-020-00272-3","article-title":"Sarcopenia during COVID-19 Lockdown Restrictions: Long-Term Health Effects of Short-Term Muscle Loss","volume":"42","author":"Kirwan","year":"2020","journal-title":"GeroScience"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/0897190010397716","article-title":"Osteoporosis in Men: A Review of Endogenous Sex Hormones and Testosterone Replacement Therapy","volume":"24","author":"Martin","year":"2011","journal-title":"J. Pharm. Pr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1002\/jbmr.5650100805","article-title":"Skeletal Unloading Induces Selective Resistance to the Anabolic Actions of Growth Hormone on Bone","volume":"10","author":"Halloran","year":"1995","journal-title":"J. Bone Miner. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s11914-009-0023-2","article-title":"Proinflammatory Cytokines and Osteoporosis","volume":"7","author":"McLean","year":"2009","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_13","first-page":"111","article-title":"Sarcopenia and Fragility Fractures","volume":"49","author":"Cederholm","year":"2013","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/00914037.2013.830255","article-title":"Synergistic Effect of Polyaniline Modified Silica Gel for Highly Efficient Separation of Non Resolvable Amino Acids","volume":"63","author":"Siddiq","year":"2014","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Jarecki, J., Sobiech, M., Tur\u017ca\u0144ska, K., Tomczyk-Warunek, A., and Jab\u0142o\u0144ski, M. (2021). A Kinesio Taping Method Applied in the Treatment of Postsurgical Knee Swelling after Primary Total Knee Arthroplasty. J. Clin. Med., 10.","DOI":"10.3390\/jcm10132992"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Krakowski, P., Karpi\u0144ski, R., Jojczuk, M., Nogalska, A., and Jonak, J. (2021). Knee MRI Underestimates the Grade of Cartilage Lesions. Appl. Sci., 11.","DOI":"10.3390\/app11041552"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1055\/s-2005-872824","article-title":"Articular Cartilage, Degenerative Process, and Repair: Current Progress","volume":"27","author":"Polle","year":"2006","journal-title":"Int. J. Sports Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.cger.2020.06.009","article-title":"Physical Activity and Healthy Aging","volume":"36","author":"Eckstrom","year":"2020","journal-title":"Clin. Geriatr. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s40520-019-01191-w","article-title":"Nutrition, Osteoarthritis and Cartilage Metabolism","volume":"31","author":"Messina","year":"2019","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"105207","DOI":"10.1016\/j.jbspin.2021.105207","article-title":"Physical Activity for Osteoarthritis: Efficiency and Review of Recommandations","volume":"88","author":"Daste","year":"2021","journal-title":"Jt. Bone Spine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/s41584-018-0073-x","article-title":"Modern-Day Environmental Factors in the Pathogenesis of Osteoarthritis","volume":"14","author":"Berenbaum","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/ajcn\/50.5.1231","article-title":"Summary Comments","volume":"50","author":"Rosenberg","year":"1989","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_23","first-page":"177","article-title":"Clinical Definition of Sarcopenia","volume":"11","author":"Santilli","year":"2014","journal-title":"Clin. Cases Miner Bone. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","author":"Sayer","year":"2019","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.eurger.2016.01.003","article-title":"Sarcopenia, the Last Organ Insufficiency","volume":"7","year":"2016","journal-title":"Eur. Geriatr. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12306-014-0311-6","article-title":"Sarcopenia and Its Relationship with Osteoarthritis: Risk Factor or Direct Consequence?","volume":"98","author":"Papalia","year":"2014","journal-title":"Musculoskelet. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/jcsm.12417","article-title":"Circulating Factors Associated with Sarcopenia during Ageing and after Intensive Lifestyle Intervention","volume":"10","author":"Li","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/acr.20545","article-title":"Prospective Study of Self-Reported Pain, Radiographic Osteoarthritis, Sarcopenia Progression, and Falls Risk in Community-Dwelling Older Adults","volume":"64","author":"Scott","year":"2012","journal-title":"Arthritis Care Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1007\/s11999-011-1819-9","article-title":"Physical Stimulation of Chondrogenic Cells In Vitro: A Review","volume":"469","author":"Grad","year":"2011","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0002-9440(10)63179-3","article-title":"Intervertebral Disc Degeneration","volume":"164","author":"Rannou","year":"2004","journal-title":"Am. J. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1002\/art.37696","article-title":"Sarcopenic Obesity Is More Closely Associated with Knee Osteoarthritis than Is Nonsarcopenic Obesity: A Cross-Sectional Study","volume":"64","author":"Lee","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Lee, S.Y., Ro, H.J., Chung, S.G., Kang, S.H., Seo, K.M., and Kim, D.-K. (2016). Low Skeletal Muscle Mass in the Lower Limbs Is Independently Associated to Knee Osteoarthritis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0166385"},{"key":"ref_33","first-page":"2449","article-title":"A Decline in Lower Extremity Lean Body Mass per Body Weight Is Characteristic of Women with Early Phase Osteoarthritis of the Knee","volume":"27","author":"Toda","year":"2000","journal-title":"J. Rheumatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"804560","DOI":"10.3389\/fendo.2021.804560","article-title":"Lower Limb Muscle Strength and Muscle Mass Are Associated with Incident Symptomatic Knee Osteoarthritis: A Longitudinal Cohort Study","volume":"12","author":"Veronese","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_35","first-page":"1549","article-title":"Research progress on the correlation between sarcopenia and osteoarthritis","volume":"36","author":"Peng","year":"2022","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological Assessment of Osteo-Arthrosis","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann. Rheum. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Karpi\u0144ski, R., Krakowski, P., Jonak, J., Machrowska, A., Maciejewski, M., and Nogalski, A. (2022). Diagnostics of Articular Cartilage Damage Based on Generated Acoustic Signals Using ANN\u2014Part I: Femoral-Tibial Joint. Sensors, 22.","DOI":"10.3390\/s22062176"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S1063-4584(03)00163-8","article-title":"Weight Bearing as a Measure of Disease Progression and Efficacy of Anti-Inflammatory Compounds in a Model of Monosodium Iodoacetate-Induced Osteoarthritis","volume":"11","author":"Bove","year":"2003","journal-title":"Osteoarthr. Cartil."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/art.1780400917","article-title":"Mono-Iodoacetate-Induced Experimental Osteoarthritis. A Dose-Response Study of Loss of Mobility, Morphology, and Biochemistry","volume":"40","author":"Guingamp","year":"1997","journal-title":"Arthritis Rheum."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Orita, S., Ishikawa, T., Miyagi, M., Ochiai, N., Inoue, G., Eguchi, Y., Kamoda, H., Arai, G., Toyone, T., and Aoki, Y. (2011). Pain-Related Sensory Innervation in Monoiodoacetate-Induced Osteoarthritis in Rat Knees That Gradually Develops Neuronal Injury in Addition to Inflammatory Pain. BMC Musculoskelet. Disord., 12.","DOI":"10.1186\/1471-2474-12-134"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1292\/jvms.65.1195","article-title":"Sodium Iodoacetate-Induced Experimental Osteoarthritis and Associated Pain Model in Rats","volume":"65","author":"Kobayashi","year":"2003","journal-title":"J. Vet. Med. Sci."},{"key":"ref_42","first-page":"1744","article-title":"Dose-Dependent Expression of Neuronal Injury Markers during Experimental Osteoarthritis Induced by Monoiodoacetate in the Rat","volume":"8","author":"Sousa","year":"2012","journal-title":"Mol. Pain"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1590\/2359-3997000000011","article-title":"Relationship between Pre-Sarcopenia, Sarcopenia and Bone Mineral Density in Elderly Men","volume":"59","author":"Pereira","year":"2015","journal-title":"Arch. Endocrinol. Metab."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00198-012-2057-z","article-title":"Sarcopenia and Its Relationship with Bone Mineral Density in Middle-Aged and Elderly European Men","volume":"24","author":"Verschueren","year":"2013","journal-title":"Osteoporos. Int."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"990S","DOI":"10.1093\/jn\/127.5.990S","article-title":"Sarcopenia: Origins and Clinical Relevance","volume":"127","author":"Rosenberg","year":"1997","journal-title":"J. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European Consensus on Definition and Diagnosis","volume":"48","author":"Bahat","year":"2019","journal-title":"Age Ageing"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3109\/09638289709166827","article-title":"Muscle Function and Gait in Patients with Knee Osteoarthritis before and after Muscle Rehabilitation","volume":"19","author":"Fisher","year":"1997","journal-title":"Disabil. Rehabil."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/jor.22236","article-title":"Dystrophin and Utrophin \u201cDouble Knockout\u201d Dystrophic Mice Exhibit a Spectrum of Degenerative Musculoskeletal Abnormalities","volume":"31","author":"Isaac","year":"2013","journal-title":"J. Orthop. Res."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"de Silva, J.M.S., Alabarse, P.V.G., Teixeira, V.d.O.N., Freitas, E.C., de Oliveira, F.H., Chakr, R.M.d.S., and Xavier, R.M. (2018). Muscle Wasting in Osteoarthritis Model Induced by Anterior Cruciate Ligament Transection. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0196682"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/physrev.00061.2017","article-title":"Sarcopenia: Aging-Related Loss of Muscle Mass and Function","volume":"99","author":"Larsson","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/j.1749-6632.2000.tb06524.x","article-title":"The Usefulness of Walking for Preventing Sarcopenia in Dieting Postmenopausal Women Complaining of Knee Pain","volume":"904","author":"Toda","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0022-510X(80)90123-9","article-title":"Selective Type II Fibre Muscular Atrophy in Patients with Osteoarthritis of the Hip","volume":"44","year":"1980","journal-title":"J. Neurol. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1046\/j.1532-5415.2002.50216.x","article-title":"Low Relative Skeletal Muscle Mass (Sarcopenia) in Older Persons Is Associated with Functional Impairment and Physical Disability","volume":"50","author":"Janssen","year":"2002","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0889-857X(05)70068-5","article-title":"The Role of Muscle Weakness in the Pathogenesis of Osteoarthritis","volume":"25","author":"Hurley","year":"1999","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.semarthrit.2009.10.001","article-title":"Quadriceps Arthrogenic Muscle Inhibition: Neural Mechanisms and Treatment Perspectives","volume":"40","author":"Rice","year":"2010","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1152\/jappl.1997.82.2.552","article-title":"Nociceptive Atrophy of the Rat Soleus Muscle Induced by Bone Fracture: A Morphometric Study","volume":"82","author":"Soukup","year":"1997","journal-title":"J. Appl. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/ard.56.11.641","article-title":"Sensorimotor Changes and Functional Performance in Patients with Knee Osteoarthritis","volume":"56","author":"Hurley","year":"1997","journal-title":"Ann. Rheum. Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0736-0266(03)00128-1","article-title":"Strength and Voluntary Activation of the Quadriceps Femoris Muscle at Different Severities of Osteoarthritic Knee Joint Damage","volume":"22","author":"Pap","year":"2004","journal-title":"J. Orthop. Res."},{"key":"ref_59","first-page":"467","article-title":"Muscular Changes in Osteoarthritis of the Hip and Knee","volume":"66","author":"Nakamura","year":"1992","journal-title":"Nihon Seikeigeka Gakkai Zasshi"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1007\/s00264-012-1594-6","article-title":"Muscular Atrophy of the Lower Leg in Unilateral Post Traumatic Osteoarthritis of the Ankle Joint","volume":"36","author":"Wiewiorski","year":"2012","journal-title":"Int. Orthop. (SICOT)"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Braun, S., Zaucke, F., Brenneis, M., Rapp, A.E., Pollinger, P., Sohn, R., Jenei-Lanzl, Z., and Meurer, A. (2022). The Corpus Adiposum Infrapatellare (Hoffa\u2019s Fat Pad)\u2014The Role of the Infrapatellar Fat Pad in Osteoarthritis Pathogenesis. Biomedicines, 10.","DOI":"10.3390\/biomedicines10051071"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Jarecki, J., Ma\u0142ecka-Masalska, T., Kosior-Jarecka, E., Widuchowski, W., Krasowski, P., Gutbier, M., Dobrzy\u0144ski, M., and Blicharski, T. (2022). Concentration of Selected Metalloproteinases and Osteocalcin in the Serum and Synovial Fluid of Obese Women with Advanced Knee Osteoarthritis. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19063530"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/jor.24987","article-title":"Infrapatellar Fat Pad Volume and Hoffa-synovitis after ACL Reconstruction: Association with Early Osteoarthritis Features and Pain over 5 Years","volume":"40","author":"Hart","year":"2022","journal-title":"J. Orthop. Res."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Fontanella, C.G., Belluzzi, E., Pozzuoli, A., Scioni, M., Olivotto, E., Reale, D., Ruggieri, P., De Caro, R., Ramonda, R., and Carniel, E.L. (2022). Exploring Anatomo-Morphometric Characteristics of Infrapatellar, Suprapatellar Fat Pad, and Knee Ligaments in Osteoarthritis Compared to Post-Traumatic Lesions. 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