{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:09:46Z","timestamp":1792850986588,"version":"4.5.0"},"reference-count":162,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Diabetic neuropathy (DN) is one of the main microvascular complications of both type 1 and type 2 diabetes mellitus. Sometimes, this could already be present at the time of diagnosis for type 2 diabetes mellitus (T2DM), while it appears in subjects with type 1 diabetes mellitus (T1DM) almost 10 years after the onset of the disease. The impairment can involve both somatic fibers of the peripheral nervous system, with sensory-motor manifestations, as well as the autonomic system, with neurovegetative multiorgan manifestations through an impairment of sympathetic\/parasympathetic conduction. It seems that, both indirectly and directly, the hyperglycemic state and oxygen delivery reduction through the vasa nervorum can determine inflammatory damage, which in turn is responsible for the alteration of the activity of the nerves. The symptoms and signs are therefore various, although symmetrical painful somatic neuropathy at the level of the lower limbs seems the most frequent manifestation. The pathophysiological aspects underlying the onset and progression of DN are not entirely clear. The purpose of this review is to shed light on the most recent discoveries in the pathophysiological and diagnostic fields concerning this complex and frequent complication of diabetes mellitus.<\/jats:p>","DOI":"10.3390\/ijms24043554","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T03:52:49Z","timestamp":1676001169000},"page":"3554","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":221,"title":["Peripheral Neuropathy in Diabetes Mellitus: Pathogenetic Mechanisms and Diagnostic Options"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7766-3430","authenticated-orcid":false,"given":"Raffaele","family":"Galiero","sequence":"first","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7761-7533","authenticated-orcid":false,"given":"Alfredo","family":"Caturano","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Vetrano","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Beccia","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6585-1277","authenticated-orcid":false,"given":"Chiara","family":"Brin","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Alfano","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Di Salvo","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Epifani","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Piacevole","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Tagliaferri","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Rocco","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Iadicicco","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Docimo","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6541-3821","authenticated-orcid":false,"given":"Luca","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestino","family":"Sardu","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Salvatore","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3960-9270","authenticated-orcid":false,"given":"Raffaele","family":"Marfella","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9142-7848","authenticated-orcid":false,"given":"Ferdinando Carlo","family":"Sasso","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, I-80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/db2022-01","article-title":"Diagnosis and Treatment of Painful Diabetic Peripheral Neuropathy","volume":"2022","author":"Ang","year":"2022","journal-title":"ADA Clin. Compend."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S2213-8587(19)30081-6","article-title":"Diabetic peripheral neuropathy: Advances in diagnosis and strategies for screening and early intervention","volume":"7","author":"Selvarajah","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.2337\/diacare.25.11.1909","article-title":"Irbesartan reduces the albumin excretion rate in microalbuminuric type 2 diabetic patients independently of hypertension: A randomized double-blind placebo-controlled crossover study","volume":"25","author":"Sasso","year":"2002","journal-title":"Diabetes Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.numecd.2019.05.065","article-title":"Relationship between albuminuric CKD and diabetic retinopathy in a real-world setting of type 2 diabetes: Findings from No blind study","volume":"29","author":"Sasso","year":"2019","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.2337\/db19-1046","article-title":"Risk Factors for Diabetic Peripheral Neuropathy and Cardiovascular Autonomic Neuropathy in the Diabetes Control and Complications Trial\/Epidemiology of Diabetes Interventions and Complications (DCCT\/EDIC) Study","volume":"69","author":"Braffett","year":"2020","journal-title":"Diabetes"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s001250050586","article-title":"Prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors: The EURODIAB IDDM Complications Study","volume":"39","author":"Tesfaye","year":"1996","journal-title":"Diabetologia"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.2337\/dc17-2062","article-title":"Risk factors for incident diabetic polyneuropathy in a cohort with screen-detected type 2 diabetes followed for 13 years: ADDITION-Denmark","volume":"41","author":"Andersen","year":"2018","journal-title":"Diabetes Care"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/S0026-0495(99)90141-5","article-title":"Cochlear dysfunction in type 2 diabetes: A complication independent of neuropathy and acute hyperglycemia","volume":"48","author":"Sasso","year":"1999","journal-title":"Metabolism"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s11892-012-0278-3","article-title":"Prediabetic neuropathy: Does it exist?","volume":"12","author":"Papanas","year":"2012","journal-title":"Curr. Diabetes Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"107843","DOI":"10.1016\/j.diabres.2019.107843","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"956","DOI":"10.2337\/diacare.28.4.956","article-title":"Diabetic neuropathies: A statement by the American Diabetes Association","volume":"28","author":"Boulton","year":"2005","journal-title":"Diabetes Care"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"(2017). Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Diabetes Care, 40, 136\u2013154.","DOI":"10.2337\/dc16-2042"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/BF00402283","article-title":"Endoneurial localisation of microvascular damage in human diabetic neuropathy","volume":"36","author":"Malik","year":"1993","journal-title":"Diabetologia"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s11892-014-0528-7","article-title":"Glucose control and diabetic neuropathy: Lessons from recent large clinical trials","volume":"14","author":"Ang","year":"2014","journal-title":"Curr. Diabetes Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/jdi.13401","article-title":"Current concepts in the management of diabetic polyneuropathy","volume":"12","author":"Ziegler","year":"2021","journal-title":"J. Diabetes Investig."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/dme.13973","article-title":"The cost of diabetic foot ulcers and amputations to the National Health Service in England","volume":"36","author":"Kerr","year":"2019","journal-title":"Diabet. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1007\/s00125-018-4723-y","article-title":"Amputation-free survival in 17,353 people at high risk for foot ulceration in diabetes: A national observational study","volume":"61","author":"Vadiveloo","year":"2018","journal-title":"Diabetologia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/1753-0407.12612","article-title":"Cost-effectiveness of prevention and management of diabetic foot ulcer and amputation in a health resource-limited setting","volume":"10","author":"Wu","year":"2018","journal-title":"J. Diabetes"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/brain\/106.4.791","article-title":"Progressive centripetal degeneration of axons in small fiber type diabetic polyneuropathy. A clinical and pathological study","volume":"106","author":"Said","year":"1983","journal-title":"Brain"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1002\/ejp.1235","article-title":"Behavioural, morphological and electrophysiological assessment of the effects of type 2 diabetes mellitus on large and small nerve fibres in Zucker diabetic fatty, Zucker lean and Wistar rats","volume":"22","author":"Sumalla","year":"2018","journal-title":"Eur. J. Pain."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1007\/s00125-004-1663-5","article-title":"Sural nerve pathology in diabetic patients with minimal but progressive neuropathy","volume":"48","author":"Malik","year":"2005","journal-title":"Diabetologia"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Smith, S., Normahani, P., Lane, T., Hohenschurz-Schmidt, D., Oliver, N., and Davies, A.H. (2022). Pathogenesis of Distal Symmetrical Polyneuropathy in Diabetes. Life, 12.","DOI":"10.3390\/life12071074"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Takeshita, Y., Sato, R., and Kanda, T. (2020). Blood-Nerve Barrier (BNB) Pathology in Diabetic Peripheral Neuropathy and In Vitro Human BNB Model. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010062"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/jnnp-2012-302312","article-title":"Biology of the blood-nerve barrier and its alteration in immune mediated neuropathies","volume":"84","author":"Kanda","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000353293","article-title":"The molecular and biophysical characterization of the human blood-nerve barrier: Current concepts","volume":"50","author":"Ubogu","year":"2013","journal-title":"J. Vasc. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/00005072-198705000-00006","article-title":"Altered blood-nerve barrier permeability to small molecules in experimental diabetes mellitus","volume":"46","author":"Rechthand","year":"1987","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1073\/pnas.85.13.4879","article-title":"Increase in albumin, IgG, and IgM blood-nerve barrier indices in human diabetic neuropathy","volume":"85","author":"Poduslo","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00401-010-0783-x","article-title":"Homeostatic regulation of the endoneurial microenvironment during development, aging and in response to trauma, disease and toxic insult","volume":"121","author":"Mizisin","year":"2011","journal-title":"Acta Neuropathol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1523\/JNEUROSCI.4040-14.2015","article-title":"Peripheral nerve injury induces persistent vascular dysfunction and endoneurial hypoxia, contributing to the genesis of neuropathic pain","volume":"35","author":"Lim","year":"2015","journal-title":"J Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0002-9440(10)65601-5","article-title":"Production of vascular endothelial growth factor by murine macrophages: Regulation by hypoxia, lactate, and the inducible nitric oxide synthase pathway","volume":"153","author":"Xiong","year":"1998","journal-title":"Am. J. Pathol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.2337\/db07-0740","article-title":"Protective effects of cyclooxygenase-2 gene inactivation against peripheral nerve dysfunction and intraepidermal nerve fiber loss in experimental diabetes","volume":"56","author":"Kellogg","year":"2007","journal-title":"Diabetes"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jns.2006.03.011","article-title":"Enhanced inflammatory response via activation of NF-kappaB in acute experimental diabetic neuropathy subjected to ischemia-reperfusion injury","volume":"247","author":"Wang","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.expneurol.2008.02.011","article-title":"Transforming growth factor-beta induces cellular injury in experimental diabetic neuropathy","volume":"211","author":"Anjaneyulu","year":"2008","journal-title":"Exp. Neurol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/01.CIR.0000084536.87322.BB","article-title":"Role of cyclooxygenase-2 in the generation of vasoactive prostanoids in the rat pulmonary and systemic vascular beds","volume":"108","author":"Baber","year":"2003","journal-title":"Circulation"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1161\/01.CIR.0000104565.78013.AD","article-title":"Cyclooxygenase isoforms and platelet vessel wall interactions in the apolipoprotein E knockout mouse model of atherosclerosis","volume":"108","author":"Belton","year":"2003","journal-title":"Circulation"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/01.HYP.0000085650.29823.F2","article-title":"Role of COX-2 in the enhanced vasoconstrictor effect of arachidonic acid in the diabetic rat kidney","volume":"42","author":"Quilley","year":"2003","journal-title":"Hypertension"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1073\/pnas.93.6.2317","article-title":"COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex","volume":"93","author":"Kaufmann","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0006-8993(97)00381-8","article-title":"Effects of pro-inflammatory cytokines in experimental spinal cord injury","volume":"762","author":"Klusman","year":"1997","journal-title":"Brain Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2337\/dc14-1403","article-title":"Differential association between biomarkers of subclinical inflammation and painful polyneuropathy: Results from the KORA F4 study","volume":"38","author":"Herder","year":"2015","journal-title":"Diabetes Care"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e394","DOI":"10.1038\/emm.2017.173","article-title":"Lower serum extracellular superoxide dismutase levels are associated with polyneuropathy in recent-onset diabetes","volume":"49","author":"Strom","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/rp.56.1.1","article-title":"Protein glycation, diabetes, and aging","volume":"56","author":"Ulrich","year":"2001","journal-title":"Recent Prog. Horm. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0074-7742(02)50072-6","article-title":"Glycation in diabetic neuropathy: Characteristics, consequences, causes, and therapeutic options","volume":"50","author":"Thornalley","year":"2002","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"108025","DOI":"10.1016\/j.diabres.2020.108025","article-title":"Metformin: An old drug against old age and associated morbidities","volume":"160","author":"Salvatore","year":"2020","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1210\/en.2006-0073","article-title":"Receptor for advanced glycation end products activation injures primary sensory neurons via oxidative stress","volume":"148","author":"Vincent","year":"2007","journal-title":"Endocrinology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/S0002-9440(10)63909-0","article-title":"RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy","volume":"162","author":"Wendt","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"101799","DOI":"10.1016\/j.redox.2020.101799","article-title":"Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications","volume":"37","author":"Kang","year":"2020","journal-title":"Redox Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/mus.27086","article-title":"Metabolic syndrome and peripheral neuropathy","volume":"63","author":"Kazamel","year":"2021","journal-title":"Muscle Nerve"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1210\/er.2003-0019","article-title":"Oxidative stress in the pathogenesis of diabetic neuropathy","volume":"25","author":"Vincent","year":"2004","journal-title":"Endocr. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1002\/acn3.51367","article-title":"Plasma lipid metabolites associate with diabetic polyneuropathy in a cohort with type 2 diabetes","volume":"8","author":"Rumora","year":"2021","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s11306-022-01879-7","article-title":"Sphingolipid metabolism plays a key role in diabetic peripheral neuropathy","volume":"18","author":"Song","year":"2022","journal-title":"Metabolomics"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3389\/fnmol.2017.00317","article-title":"Sphingosine-1-Phosphate and the S1P3 Receptor Initiate Neuronal Retraction via RhoA\/ROCK Associated with CRMP2 Phosphorylation","volume":"10","author":"Quarta","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"ref_53","first-page":"3297","article-title":"Antibodies to glutamic acid decarboxylase and peripheral nerve function in type 1 diabetes","volume":"85","author":"Hoeldtke","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.imlet.2015.09.009","article-title":"Diabetic peripheral neuropathy, is it an autoimmune disease?","volume":"168","author":"Janahi","year":"2015","journal-title":"Immunol. Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.2337\/diacare.28.8.2067","article-title":"Antibodies to neuronal structures: Innocent bystanders or neurotoxins?","volume":"28","author":"Vinik","year":"2005","journal-title":"Diabetes Care"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1055\/s-2007-979091","article-title":"Persistent GAD 65 antibodies in longstanding IDDM are not associated with residual beta-cell function, neuropathy or HLA-DR status","volume":"29","author":"Jaeger","year":"1997","journal-title":"Horm. Metab. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5593608","DOI":"10.1155\/2021\/5593608","article-title":"What Is in the Field for Genetics and Epigenetics of Diabetic Neuropathy: The Role of MicroRNAs","volume":"2021","author":"Spallone","year":"2021","journal-title":"J. Diabetes Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"6890501","DOI":"10.1155\/2018\/6890501","article-title":"MicroRNA and Microvascular Complications of Diabetes","volume":"2018","author":"Barutta","year":"2018","journal-title":"Int. J. Endocrinol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.3892\/mmr.2017.6874","article-title":"miR-199a-3p is involved in the pathogenesis and progression of diabetic neuropathy through downregulation of SerpinE2","volume":"16","author":"Li","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2217\/epi-2019-0242","article-title":"Expression study of candidate miRNAs and evaluation of their potential use as biomarkers of diabetic neuropathy","volume":"12","author":"Ciccacci","year":"2020","journal-title":"Epigenomics"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee (2022). 12. Retinopathy, Neuropathy, and Foot Care: Standards of Medical Care in Diabetes-2022. Diabetes Care., 45, S185\u2013S194.","DOI":"10.2337\/dc22-S012"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.2337\/dc10-1303","article-title":"Toronto Diabetic Neuropathy Expert Group. Diabetic neuropathies: Update on definitions, diagnostic criteria, estimation of severity, and treatments","volume":"33","author":"Tesfaye","year":"2010","journal-title":"Diabetes Care"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S1474-4422(17)30329-0","article-title":"The diagnostic challenge of small fibre neuropathy: Clinical presentations, evaluations, and causes","volume":"16","author":"Terkelsen","year":"2017","journal-title":"Lancet Neurol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/ejp.1498","article-title":"Douleur Neuropathique 4 (DN4) stratifies possible and definite neuropathic pain after surgical peripheral nerve lesion","volume":"24","author":"Aho","year":"2020","journal-title":"Eur. J. Pain"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1097\/j.pain.0000000000000492","article-title":"Neuropathic pain: An updated grading system for research and clinical practice","volume":"157","author":"Finnerup","year":"2016","journal-title":"Pain"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1464-5491.2011.03500.x","article-title":"Validation of DN4 as a screening tool for neuropathic pain in painful diabetic polyneuropathy","volume":"29","author":"Spallone","year":"2012","journal-title":"Diabet. Med."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Timmerman, H., Steegers, M.A.H., Huygen, F.J.P.M., Goeman, J.J., van Dasselaar, N.T., Schenkels, M.J., Wilder-Smith, O.H.G., Wolff, A.P., and Vissers, K.C.P. (2017). Investigating the validity of the DN4 in a consecutive population of patients with chronic pain. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187961"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/j.1464-5491.2012.03644.x","article-title":"Use of the Michigan Neuropathy Screening Instrument as a measure of distal symmetrical peripheral neuropathy in Type 1 diabetes: Results from the Diabetes Control and Complications Trial\/Epidemiology of Diabetes Interventions and Complications","volume":"29","author":"Herman","year":"2012","journal-title":"Diabet Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.bjpt.2017.10.004","article-title":"Cross-cultural adaptation and measurement properties of the Brazilian Version of the Michigan Neuropathy Screening Instrument","volume":"22","author":"Sartor","year":"2018","journal-title":"Braz. J. Phys. Ther."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/ene.13533","article-title":"Toronto Clinical Neuropathy Score is valid for a wide spectrum of polyneuropathies","volume":"25","author":"Abraham","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e27104","DOI":"10.1097\/MD.0000000000027104","article-title":"Value of shear wave elastography combined with the Toronto clinical scoring system in diagnosis of diabetic peripheral neuropathy","volume":"100","author":"Wang","year":"2021","journal-title":"Medicine"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1464-5491.2009.02667.x","article-title":"Reliability and validity of the modified Toronto Clinical Neuropathy Score in diabetic sensorimotor polyneuropathy","volume":"26","author":"Bril","year":"2009","journal-title":"Diabet. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"11","DOI":"10.23736\/S0391-1977.16.02505-0","article-title":"Differential efficacy of methylcobalamin and alpha-lipoic acid treatment on symptoms of diabetic peripheral neuropathy","volume":"43","author":"Han","year":"2018","journal-title":"Minerva Endocrinol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/BF00400697","article-title":"A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population","volume":"36","author":"Young","year":"1993","journal-title":"Diabetologia"},{"key":"ref_75","first-page":"164","article-title":"The Correlation Between HbA1c and Neuropathy Disability Score in Type 2 Diabetes","volume":"53","author":"Hunaifi","year":"2021","journal-title":"Acta Med. Indones."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s41983-018-0024-0","article-title":"Sleep disturbances in diabetic peripheral neuropathy patients: A clinical and polysomnographic study","volume":"54","author":"Bahnasy","year":"2018","journal-title":"Egypt. J. Neurol. Psychiatr. Neurosurg."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jdiacomp.2015.01.011","article-title":"Clinical neuropathy scales in neuropathy associated with impaired glucose tolerance","volume":"29","author":"Zilliox","year":"2015","journal-title":"J. Diabetes Complicat."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3233\/JND-200490","article-title":"Current View of Diagnosing Small Fiber Neuropathy","volume":"8","author":"Raasing","year":"2021","journal-title":"J. Neuromuscul. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4093\/dmj.2020.0216","article-title":"Lost in Translation? Measuring Diabetic Neuropathy in Humans and Animals","volume":"45","author":"Jin","year":"2021","journal-title":"Diabetes Metab. J."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/jns.12298","article-title":"Small-fiber neuropathy: Expanding the clinical pain universe","volume":"24","author":"Sopacua","year":"2019","journal-title":"J. Peripher. Nerv. Syst."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e001566","DOI":"10.1136\/bmjdrc-2020-001566","article-title":"Altered pain processing in patients with type 1 and 2 diabetes: Systematic review and meta-analysis of pain detection thresholds and pain modulation mechanisms","volume":"8","author":"Somerville","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.pain.2013.05.047","article-title":"Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus","volume":"154","author":"Backonja","year":"2013","journal-title":"Pain"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e002528","DOI":"10.1136\/bmjdrc-2021-002528","article-title":"Reliability of recommended non-invasive chairside screening tests for diabetes-related peripheral neuropathy: A systematic review with meta-analyses","volume":"9","author":"McIllhatton","year":"2021","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"904","DOI":"10.2337\/diacare.19.8.904","article-title":"Reproducibility of Michigan Neuropathy Screening Instrument (MNSI). A comparison with tests using the vibratory and thermal perception thresholds","volume":"19","author":"Bax","year":"1996","journal-title":"Diabetes Care"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Dom\u00ednguez-Mu\u00f1oz, F.J., Adsuar, J.C., Villafaina, S., Garc\u00eda-Gordillo, M.A., Hern\u00e1ndez-Mochol\u00ed, M.\u00c1., Collado-Mateo, D., and Gusi, N. (2020). Test-Retest Reliability of Vibration Perception Threshold Test in People with Type 2 Diabetes Mellitus. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17051773"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13047-020-0371-9","article-title":"Non-invasive assessment of vibration perception and protective sensation in people with diabetes mellitus: Inter- and intra-rater reliability","volume":"13","author":"Lanting","year":"2020","journal-title":"J. Foot Ankle Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"576","DOI":"10.4158\/EP.14.5.576","article-title":"Comprehensive foot examination and risk assessment","volume":"14","author":"Boulton","year":"2008","journal-title":"Endocr. Pract."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1046\/j.1464-5491.2001.00503.x","article-title":"Vibration perception threshold testing in patients with diabetic neuropathy: Ceiling effects and reliability","volume":"18","author":"Sanchez","year":"2001","journal-title":"Diabet. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1136\/bmj.296.6617.233","article-title":"Variability in vibration perception threshold among sites: A potential source of error in biothesiometry","volume":"296","author":"Williams","year":"1988","journal-title":"Br. Med. J. Clin. Res. Ed."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1556\/650.2020.31799","article-title":"A diabeteses neuropathia \u00e9s egy\u00e9b sz\u00f6v\u0151dm\u00e9nyek el\u0151fordul\u00e1sa a Debreceni Egyetem Diabeteses Neuropathia Centrum\u00e1ban [Diabetic neuropathy and other diabetic complications at the Diabetic Neuropathy Center of the University of Debrecen]","volume":"161","author":"Sztanek","year":"2020","journal-title":"Orv Hetil."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s13300-019-00738-4","article-title":"The Diagnostic Utility of VibraTip for Distal Symmetrical Polyneuropathy in Type 2 Diabetes Mellitus","volume":"11","author":"Papanas","year":"2020","journal-title":"Diabetes Ther."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1111\/j.1464-5491.2012.03730.x","article-title":"A pocket-sized disposable device for testing the integrity of sensation in the outpatient setting","volume":"29","author":"Bowling","year":"2012","journal-title":"Diabet. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.dsx.2021.03.023","article-title":"The utility of Vibratip in accurate identification of loss of protective sensation in the contralateral foot of patients admitted with a diabetic foot ulcer","volume":"15","author":"Pasangha","year":"2021","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.eprac.2021.03.009","article-title":"Comparison of Clinical Tests for Peripheral Diabetic Neuropathy in a Type 1 Diabetes Cohort","volume":"27","author":"Tania","year":"2021","journal-title":"Endocr. Pract."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e3269","DOI":"10.1002\/dmrr.3269","article-title":"Guidelines on the prevention of foot ulcers in persons with diabetes (IWGDF 2019 update)","volume":"36","author":"Bus","year":"2020","journal-title":"Diabetes Metab Res Rev."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.2337\/dc11-0156","article-title":"The Ipswich Touch Test: A simple and novel method to identify inpatients with diabetes at risk of foot ulceration","volume":"34","author":"Rayman","year":"2011","journal-title":"Diabetes Care"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s13340-020-00451-9","article-title":"A review of the current evidence on the sensitivity and specificity of the Ipswich touch test for the screening of loss of protective sensation in patients with diabetes mellitus","volume":"12","author":"Hu","year":"2020","journal-title":"Diabetol. Int."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s00415-008-0872-0","article-title":"Early diabetic neuropathy: Thermal thresholds and intraepidermal nerve fibre density in patients with normal nerve conduction studies","volume":"255","author":"Jorde","year":"2008","journal-title":"J. Neurol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"719953","DOI":"10.3389\/fendo.2021.719953","article-title":"Peripheral and Autonomic Neuropathy Status of Young Patients with Type 1 Diabetes Mellitus at the Time of Transition from Pediatric Care to Adult-Oriented Diabetes Care","volume":"12","author":"Nemes","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jdiacomp.2006.08.003","article-title":"Sensitivity and specificity of a new indicator test (Neuropad) for the diagnosis of peripheral neuropathy in type 2 diabetes patients: A comparison with clinical examination and nerve conduction study","volume":"21","author":"Papanas","year":"2007","journal-title":"J. Diabetes Complicat."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s10198-019-01134-2","article-title":"Cost-effectiveness analysis of the Neuropad device as a screening tool for early diabetic peripheral neuropathy","volume":"21","author":"Sinclair","year":"2020","journal-title":"Eur. J. Health Econ."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1055\/s-2005-837735","article-title":"Evaluation of a new indicator test for sudomotor function (Neuropad) in the diagnosis of peripheral neuropathy in type 2 diabetic patients","volume":"113","author":"Papanas","year":"2005","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4067\/S0034-98872020000100054","article-title":"Prueba diagn\u00f3stica de disfunci\u00f3n sudomotora en la detecci\u00f3n precoz de la neuropat\u00eda diab\u00e9tica [Sudomotor dysfunction diagnostic test for early detection of diabetic neuropathy]","volume":"148","author":"Lorenzini","year":"2020","journal-title":"Rev. Med. Chile"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"517","DOI":"10.2174\/1570161117666190723155324","article-title":"Validation of Neuropad in the Assessment of Peripheral Diabetic Neuropathy in Patients with Diabetes Mellitus Versus the Michigan Neuropathy Screening Instrument, 10g Monofilament Application and Biothesiometer Measurement","volume":"18","author":"Zografou","year":"2020","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1089\/dia.2013.0129","article-title":"Sudoscan, a noninvasive tool for detecting diabetic small fiber neuropathy and autonomic dysfunction","volume":"15","author":"Casellini","year":"2013","journal-title":"Diabetes Technol. Ther."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"103714","DOI":"10.5402\/2012\/103714","article-title":"Quick and simple evaluation of sudomotor function for screening of diabetic neuropathy","volume":"2012","author":"Yajnik","year":"2012","journal-title":"ISRN Endocrinol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/13506129.2018.1545640","article-title":"Sudoscan in the evaluation and follow-up of patients and carriers with TTR mutations: Experience from an Italian Centre","volume":"25","author":"Luigetti","year":"2018","journal-title":"Amyloid"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.2147\/DMSO.S384881","article-title":"Consistency Analysis Between SUDOSCAN Examinations and Electromyography Results in Patients with Diabetes","volume":"15","author":"Zhao","year":"2022","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.diabres.2018.01.036","article-title":"Detection of relationships between SUDOSCAN with estimated glomerular filtration rate (eGFR) in Chinese patients with type 2 diabetes","volume":"138","author":"Mao","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3389\/fneur.2018.00803","article-title":"Sudomotor Testing of Diabetes Polyneuropathy","volume":"9","author":"Krieger","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_111","first-page":"80","article-title":"Assessment of small fiber neuropathy through a quick, simple and non invasive method in a German diabetes outpatient clinic","volume":"121","author":"Calvet","year":"2013","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pcd.2019.05.003","article-title":"The role of Sudoscan feet asymmetry in the diabetic foot","volume":"14","author":"Gatev","year":"2020","journal-title":"Prim. Care Diabetes"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4093\/dmj.2021.0014","article-title":"SUDOSCAN in Combination with the Michigan Neuropathy Screening Instrument Is an Effective Tool for Screening Diabetic Peripheral Neuropathy","volume":"46","author":"Oh","year":"2022","journal-title":"Diabetes Metab. J."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cnp.2020.12.001","article-title":"Assessment of sudomotor function in hypertensive with\/without type-2 diabetes patients using SUDOSCAN: An electrophysiological study","volume":"6","author":"Hussein","year":"2020","journal-title":"Clin. Neurophysiol. Pract."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.diabres.2015.12.023","article-title":"NerveCheck: An inexpensive quantitative sensory testing device for patients with diabetic neuropathy","volume":"113","author":"Ponirakis","year":"2016","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1089\/dia.2016.0279","article-title":"NerveCheck for the Detection of Sensory Loss and Neuropathic Pain in Diabetes","volume":"18","author":"Ponirakis","year":"2016","journal-title":"Diabetes Technol. Ther."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"108631","DOI":"10.1016\/j.diabres.2020.108631","article-title":"Widespread sensory neuropathy in diabetic patients hospitalized with severe COVID-19 infection","volume":"172","author":"Odriozola","year":"2021","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Galiero, R., Salvatore, T., Ferrara, R., Masini, F., Caturano, A., Docimo, G., Borrelli, M., Rinaldi, L., Cuomo, G., and Sasso, F.C. (2022). The Role of Neuropathy Screening Tools in Patients Affected by Fibromyalgia. J. Clin. Med., 11.","DOI":"10.3390\/jcm11061533"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.apmr.2004.09.011","article-title":"Distal symmetrical polyneuropathy: A definition for clinical research. A report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation","volume":"86","author":"England","year":"2005","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1055\/s-0039-1694747","article-title":"A Clinician\u2019s Approach to Peripheral Neuropathy","volume":"39","author":"Siao","year":"2019","journal-title":"Semin. Neurol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/1756-185X.14042","article-title":"Large fiber peripheral neuropathy in systemic sclerosis: A prospective study using clinical and electrophysiological definition","volume":"24","author":"Raja","year":"2021","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00264-021-05272-2","article-title":"The effectiveness of manual therapy on pain, physical function, and nerve conduction studies in carpal tunnel syndrome patients: A systematic review and meta-analysis","volume":"46","year":"2022","journal-title":"Int. Orthop."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"369","DOI":"10.4103\/0028-3886.314529","article-title":"Utility of Serial Nerve Conduction Studies in the Electrodiagnosis of Guillain-Barre Syndrome","volume":"69","author":"Mani","year":"2021","journal-title":"Neurol. India"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1093\/brain\/awaa265","article-title":"Diagnostic challenges in chronic inflammatory demyelinating polyradiculoneuropathy","volume":"143","author":"Eftimov","year":"2020","journal-title":"Brain"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"(2020). Establishing Standards for Acceptable Waveforms in Nerve Conduction Studies. Muscle Nerve, 62, 455\u2013461.","DOI":"10.1002\/mus.27004"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/B978-0-444-64032-1.00014-X","article-title":"Nerve conduction studies: Basic concepts","volume":"160","author":"Tavee","year":"2019","journal-title":"Handb. Clin. Neurol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/mus.23454","article-title":"Neurophysiological examination of dorsal sural nerve","volume":"46","author":"Frigeni","year":"2012","journal-title":"Muscle Nerve"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/mus.26739","article-title":"Sural nerve sensory response in diabetic distal symmetrical polyneuropathy","volume":"61","author":"Lai","year":"2020","journal-title":"Muscle Nerve"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"834","DOI":"10.2337\/dc11-1001","article-title":"Assessment of the medial dorsal cutaneous, dorsal sural, and medial plantar nerves in impaired glucose tolerance and diabetic patients with normal sural and superficial peroneal nerve responses","volume":"35","author":"Im","year":"2012","journal-title":"Diabetes Care"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"108856","DOI":"10.1016\/j.diabres.2021.108856","article-title":"Whole plantar nerve conduction study: A new tool for early diagnosis of peripheral diabetic neuropathy","volume":"176","author":"Galiero","year":"2021","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/mus.24715","article-title":"Whole plantar nerve conduction study with disposable strip electrodes","volume":"53","author":"Hemmi","year":"2016","journal-title":"Muscle Nerve"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.clinph.2007.01.008","article-title":"Medial plantar nerve conduction studies in healthy controls and diabetics","volume":"118","author":"Nebuchennykh","year":"2007","journal-title":"Clin. Neurophysiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.clinph.2008.01.001","article-title":"Medial plantar and dorsal sural nerve conduction studies increase the sensitivity in the detection of neuropathy in diabetic patients","volume":"119","author":"Uluc","year":"2008","journal-title":"Clin. Neurophysiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/mus.20183","article-title":"Medial dorsal superficial peroneal nerve studies in patients with polyneuropathy and normal sural responses","volume":"31","author":"Kushnir","year":"2005","journal-title":"Muscle Nerve"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.clinph.2017.06.031","article-title":"Diagnostic utility of distal nerve conduction studies and sural near-nerve needle recording in polyneuropathy","volume":"128","author":"Kural","year":"2017","journal-title":"Clin. Neurophysiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.clinthera.2021.04.003","article-title":"Corneal Confocal Microscopy: A Biomarker for Diabetic Peripheral Neuropathy","volume":"43","author":"Petropoulos","year":"2021","journal-title":"Clin. Ther."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pathophysiology29010001","article-title":"Corneal Confocal Microscopy in the Diagnosis of Small Fiber Neuropathy: Faster, Easier, and More Efficient Than Skin Biopsy?","volume":"29","author":"Lukashenko","year":"2021","journal-title":"Pathophysiology"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1038\/s41598-021-81302-8","article-title":"Corneal confocal microscopy identifies small fibre damage and progression of diabetic neuropathy","volume":"11","author":"Dhage","year":"2021","journal-title":"Sci Rep."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.2337\/db13-1819","article-title":"Early detection of nerve fiber loss by corneal confocal microscopy and skin biopsy in recently diagnosed type 2 diabetes","volume":"63","author":"Ziegler","year":"2014","journal-title":"Diabetes"},{"key":"ref_140","first-page":"2851","article-title":"Early diagnosis of diabetic autonomic neuropathy by corneal confocal microscopy","volume":"95","author":"Wang","year":"2015","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1167\/iovs.15-16711","article-title":"In Vivo Confocal Microscopy of Corneal Nerves: An Ocular Biomarker for Peripheral and Cardiac Autonomic Neuropathy in Type 1 Diabetes Mellitus","volume":"56","author":"Misra","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"255","DOI":"10.4093\/dmj.2018.0056","article-title":"Diagnosing Diabetic Neuropathy: Something Old, Something New","volume":"42","author":"Petropoulos","year":"2018","journal-title":"Diabetes Metab. J."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Alam, U., Jeziorska, M., Petropoulos, I.N., Asghar, O., Fadavi, H., Ponirakis, G., Marshall, A., Tavakoli, M., Boulton, A.J.M., and Efron, N. (2017). Diagnostic utility of corneal confocal microscopy and intra-epidermal nerve fibre density in diabetic neuropathy. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0180175"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.2337\/dc21-0476","article-title":"Corneal Confocal Microscopy Predicts the Development of Diabetic Neuropathy: A Longitudinal Diagnostic Multinational Consortium Study","volume":"44","author":"Perkins","year":"2021","journal-title":"Diabetes Care"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1093\/brain\/awz333","article-title":"Diagnostic criteria for small fibre neuropathy in clinical practice and research","volume":"142","author":"Devigili","year":"2019","journal-title":"Brain"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1212\/WNL.47.4.1042","article-title":"Quantitation of epidermal nerves in diabetic neuropathy","volume":"47","author":"Kennedy","year":"1996","journal-title":"Neurology"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1529-8027.2010.00271.x","article-title":"Intraepidermal nerve fiber density at the distal leg: A worldwide normative reference study","volume":"15","author":"Lauria","year":"2010","journal-title":"J. Peripher. Nerv. Syst."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1468-1331.2005.01260.x","article-title":"EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy","volume":"12","author":"Lauria","year":"2005","journal-title":"Eur. J. Neurol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1464-5491.2008.02446.x","article-title":"Small-fibre involvement in diabetic patients with neuropathic foot pain","volume":"25","author":"Bednarik","year":"2008","journal-title":"Diabet. Med."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Nolano, M., Tozza, S., Caporaso, G., and Provitera, V. (2020). Contribution of Skin Biopsy in Peripheral Neuropathies. Brain Sci., 10.","DOI":"10.3390\/brainsci10120989"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1093\/brain\/awh180","article-title":"Skin denervation in type 2 diabetes: Correlations with diabetic duration and functional impairments","volume":"127","author":"Shun","year":"2004","journal-title":"Brain"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/j.pain.0000000000002054","article-title":"Increased peptidergic fibers as a potential cutaneous marker of pain in diabetic small fiber neuropathy","volume":"162","author":"Karlsson","year":"2021","journal-title":"Pain"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3389\/fneur.2020.00342","article-title":"Which Method for Diagnosing Small Fiber Neuropathy?","volume":"11","author":"Fabry","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/j.1468-1331.2010.02969.x","article-title":"EFNS guidelines on neuropathic pain assessment: Revised 2009","volume":"17","author":"Cruccu","year":"2010","journal-title":"Eur. J. Neurol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1007\/s00415-011-6031-z","article-title":"Asymptomatic small fiber neuropathy in diabetes mellitus: Investigations with intraepidermal nerve fiber density, quantitative sensory testing and laser-evoked potentials","volume":"258","author":"Knaapen","year":"2011","journal-title":"J. Neurol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1097\/j.pain.0000000000000889","article-title":"Diagnostic accuracy of laser-evoked potentials in diabetic neuropathy","volume":"158","author":"Leone","year":"2017","journal-title":"Pain"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"695792","DOI":"10.3389\/fmed.2021.695792","article-title":"The Diabetic Cardiomyopathy: The Contributing Pathophysiological Mechanisms","volume":"8","author":"Salvatore","year":"2021","journal-title":"Front. Med."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Salvatore, T., Caturano, A., Galiero, R., Di Martino, A., Albanese, G., Vetrano, E., Sardu, C., Marfella, R., Rinaldi, L., and Sasso, F.C. (2021). Cardiovascular Benefits from Gliflozins: Effects on Endothelial Function. Biomedicines, 9.","DOI":"10.3390\/biomedicines9101356"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Palmiero, G., Cesaro, A., Vetrano, E., Pafundi, P.C., Galiero, R., Caturano, A., Moscarella, E., Gragnano, F., Salvatore, T., and Rinaldi, L. (2021). Impact of SGLT2 Inhibitors on Heart Failure: From Pathophysiology to Clinical Effects. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115863"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1016\/j.numecd.2021.04.016","article-title":"Impact of direct acting antivirals (DAAs) on cardiovascular events in HCV cohort with pre-diabetes","volume":"31","author":"Sasso","year":"2021","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Salvatore, T., Pafundi, P.C., Galiero, R., Gjeloshi, K., Masini, F., Acierno, C., Di Martino, A., Albanese, G., Alfano, M., and Rinaldi, L. (2020). Metformin: A Potential Therapeutic Tool for Rheumatologists. Pharmaceuticals, 13.","DOI":"10.3390\/ph13090234"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0735-1097(00)00717-8","article-title":"Effects of insulin-glucose infusion on left ventricular function at rest and during dynamic exercise in healthy subjects and noninsulin dependent diabetic patients: A radionuclide ventriculographic study","volume":"36","author":"Sasso","year":"2000","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/4\/3554\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:29:57Z","timestamp":1760120997000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/4\/3554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,10]]},"references-count":162,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["ijms24043554"],"URL":"https:\/\/doi.org\/10.3390\/ijms24043554","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,10]]}}}