{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:48:22Z","timestamp":1787028502528,"version":"build-2736575974"},"reference-count":50,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The analysis was supported by the Ministry of Science and Higher Education of the Russian Fed-eration within the \u201cPriority \u2013 2030\u201d Development Program of the Ural Federal University","award":["Priority 2030"],"award-info":[{"award-number":["Priority 2030"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Particulate matter, including iron nanoparticles, is one of the constituents of ambient air pollution. We assessed the effect of iron oxide (Fe2O3) nanoparticles on the structure and function of the brain of rats. Electron microscopy showed Fe2O3 nanoparticles in the tissues of olfactory bulbs but not in the basal ganglia of the brain after their subchronic intranasal administration. We observed an increase in the number of axons with damaged myelin sheaths and in the proportion of pathologically altered mitochondria in the brains of the exposed animals against the background of almost stable blood parameters. We conclude that the central nervous system can be a target for toxicity of low-dose exposure to Fe2O3 nanoparticles.<\/jats:p>","DOI":"10.3390\/ijms24043572","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T05:18:35Z","timestamp":1676006315000},"page":"3572","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of Experimental Data on Changes in Various Structures and Functions of the Rat Brain following Intranasal Administration of Fe2O3 Nanoparticles"],"prefix":"10.3390","volume":"24","author":[{"given":"Ilzira A.","family":"Minigalieva","sequence":"first","affiliation":[{"name":"Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, 620014 Yekaterinburg, Russia"},{"name":"Laboratory of Stochastic Transport of Nanoparticles in Living Systems, Laboratory of Multi-Scale Mathematical Modeling, Ural Federal University, 51 Lenin Avenue, 620002 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2677-0479","authenticated-orcid":false,"given":"Yuliya V.","family":"Ryabova","sequence":"additional","affiliation":[{"name":"Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, 620014 Yekaterinburg, Russia"},{"name":"Laboratory of Stochastic Transport of Nanoparticles in Living Systems, Laboratory of Multi-Scale Mathematical Modeling, Ural Federal University, 51 Lenin Avenue, 620002 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan G.","family":"Shelomencev","sequence":"additional","affiliation":[{"name":"Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, 620014 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lev A.","family":"Amromin","sequence":"additional","affiliation":[{"name":"Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, 620014 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina F.","family":"Minigalieva","sequence":"additional","affiliation":[{"name":"Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, 620014 Yekaterinburg, Russia"},{"name":"Laboratory of Stochastic Transport of Nanoparticles in Living Systems, Laboratory of Multi-Scale Mathematical Modeling, Ural Federal University, 51 Lenin Avenue, 620002 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliya M.","family":"Sutunkova","sequence":"additional","affiliation":[{"name":"Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, 620014 Yekaterinburg, Russia"},{"name":"Laboratory of Stochastic Transport of Nanoparticles in Living Systems, Laboratory of Multi-Scale Mathematical Modeling, Ural Federal University, 51 Lenin Avenue, 620002 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa I.","family":"Privalova","sequence":"additional","affiliation":[{"name":"Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, 620014 Yekaterinburg, Russia"},{"name":"Laboratory of Stochastic Transport of Nanoparticles in Living Systems, Laboratory of Multi-Scale Mathematical Modeling, Ural Federal University, 51 Lenin Avenue, 620002 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina P.","family":"Sutunkova","sequence":"additional","affiliation":[{"name":"Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, 620014 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s10661-019-7824-2","article-title":"Concentration trends of metals in ambient air in the UK: A review","volume":"191","author":"Goddard","year":"2019","journal-title":"Environ. 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