{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:32:40Z","timestamp":1792096360997,"version":"4.4.0"},"reference-count":122,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004794","name":"French National Centre for Scientific Research","doi-asserted-by":"publisher","award":["EXPOGEN-CANCER IRP"],"award-info":[{"award-number":["EXPOGEN-CANCER IRP"]}],"id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR20-CE14-0007"],"award-info":[{"award-number":["ANR20-CE14-0007"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Steroidogenic factor-1 (SF-1, also termed Ad4BP; NR5A1 in the official nomenclature) is a nuclear receptor transcription factor that plays a crucial role in the regulation of adrenal and gonadal development, function and maintenance. In addition to its classical role in regulating the expression of P450 steroid hydroxylases and other steroidogenic genes, involvement in other key processes such as cell survival\/proliferation and cytoskeleton dynamics have also been highlighted for SF-1. SF-1 has a restricted pattern of expression, being expressed along the hypothalamic-pituitary axis and in steroidogenic organs since the time of their establishment. Reduced SF-1 expression affects proper gonadal and adrenal organogenesis and function. On the other hand, SF-1 overexpression is found in adrenocortical carcinoma and represents a prognostic marker for patients\u2019 survival. This review is focused on the current knowledge about SF-1 and the crucial importance of its dosage for adrenal gland development and function, from its involvement in adrenal cortex formation to tumorigenesis. Overall, data converge towards SF-1 being a key player in the complex network of transcriptional regulation within the adrenal gland in a dosage-dependent manner.<\/jats:p>","DOI":"10.3390\/ijms24043585","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T03:28:46Z","timestamp":1676258926000},"page":"3585","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Steroidogenic Factor 1, a Goldilocks Transcription Factor from Adrenocortical Organogenesis to Malignancy"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2323-1528","authenticated-orcid":false,"given":"Lauriane","family":"Relav","sequence":"first","affiliation":[{"name":"Institut de Pharmacologie Moleculaire et Cellulaire CNRS UMR 7275, 06560 Valbonne, France"},{"name":"Universite Cote d\u2019Azur, 06560 Valbonne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mabrouka","family":"Doghman-Bouguerra","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie Moleculaire et Cellulaire CNRS UMR 7275, 06560 Valbonne, France"},{"name":"Universite Cote d\u2019Azur, 06560 Valbonne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Ruggiero","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie Moleculaire et Cellulaire CNRS UMR 7275, 06560 Valbonne, France"},{"name":"Universite Cote d\u2019Azur, 06560 Valbonne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6994-5577","authenticated-orcid":false,"given":"Jo\u00e3o C. D.","family":"Muzzi","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunoqu\u00edmica (LIMQ), P\u00f3s-Gradua\u00e7\u00e3o em Microbiologia, Parasitologia e Patologia, Departamento de Patologia B\u00e1sica, Universidade Federal do Paran\u00e1 (UFPR), Curitiba 81530-990, PR, Brazil"},{"name":"Laborat\u00f3rio de Bioinform\u00e1tica e Biologia de Sistemas, P\u00f3s-Gradua\u00e7\u00e3o em Bioinform\u00e1tica, Universidade Federal do Paran\u00e1 (UFPR), Curitiba 81520-260, PR, Brazil"},{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Oncology Division, Curitiba 80250-060, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1051-2056","authenticated-orcid":false,"given":"Bonald C.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Oncology Division, Curitiba 80250-060, PR, Brazil"},{"name":"Centro de Gen\u00e9tica Molecular e Pesquisa do C\u00e2ncer em Crian\u00e7as (CEGEMPAC), Molecular Oncology Laboratory, Curitiba 80030-110, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0584-5681","authenticated-orcid":false,"given":"Enzo","family":"Lalli","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie Moleculaire et Cellulaire CNRS UMR 7275, 06560 Valbonne, France"},{"name":"Universite Cote d\u2019Azur, 06560 Valbonne, France"},{"name":"Inserm, 06560 Valbonne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jsbmb.2019.04.006","article-title":"The adrenal gland in stress\u2014Adaptation on a cellular level","volume":"190","author":"Berger","year":"2019","journal-title":"J. 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