{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:58:01Z","timestamp":1791295081590,"version":"4.1.0"},"reference-count":227,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T00:00:00Z","timestamp":1676073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Association of Biomedical Research La Mancha Centro","award":["PI18\/01252 III"],"award-info":[{"award-number":["PI18\/01252 III"]}]},{"name":"Association of Biomedical Research La Mancha Centro","award":["JR19\/00005"],"award-info":[{"award-number":["JR19\/00005"]}]},{"name":"Association of Biomedical Research La Mancha Centro","award":["CD19\/00102"],"award-info":[{"award-number":["CD19\/00102"]}]},{"name":"Instituto de Salud Carlos III","award":["PI18\/01252 III"],"award-info":[{"award-number":["PI18\/01252 III"]}]},{"name":"Instituto de Salud Carlos III","award":["JR19\/00005"],"award-info":[{"award-number":["JR19\/00005"]}]},{"name":"Instituto de Salud Carlos III","award":["CD19\/00102"],"award-info":[{"award-number":["CD19\/00102"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Eosinophilic esophagitis (EoE) is a chronic, Th2-inflammatory disease of the esophagus that can severely affect food intake. Currently, diagnosis and assessing response to treatment of EoE is highly invasive and requires endoscopy with esophageal biopsies. Finding non-invasive and accurate biomarkers is important for improving patient well-being. Unfortunately, EoE is usually accompanied by other atopies, which make it difficult to identify specific biomarkers. Providing an update of circulating EoE biomarkers and concomitant atopies is therefore timely. This review summarizes the current knowledge in EoE blood biomarkers and two of its most common comorbidities, bronchial asthma (BA) and atopic dermatitis (AD), focusing on dysregulated proteins, metabolites, and RNAs. It also revises the current knowledge on extracellular vesicles (EVs) as non-invasive biomarkers for BA and AD, and concludes with the potential use of EVs as biomarkers in EoE.<\/jats:p>","DOI":"10.3390\/ijms24043669","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T03:28:46Z","timestamp":1676258926000},"page":"3669","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Blood-Based Biomarkers for Eosinophilic Esophagitis and Concomitant Atopic Diseases: A Look into the Potential of Extracellular Vesicles"],"prefix":"10.3390","volume":"24","author":[{"given":"Elena","family":"Grueso-Navarro","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, 13700 Ciudad Real, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45004 Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, 13700 Ciudad Real, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45004 Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9039-7667","authenticated-orcid":false,"given":"Emilio J.","family":"Laserna-Mendieta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, 13700 Ciudad Real, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45004 Toledo, Spain"},{"name":"Laboratory Medicine Department, Hospital Universitario de La Princesa, 28006 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-IP), 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1183-1072","authenticated-orcid":false,"given":"Alfredo J.","family":"Lucendo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, 13700 Ciudad Real, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45004 Toledo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-IP), 28006 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Arias-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, 13700 Ciudad Real, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45004 Toledo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-IP), 28006 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/2050640616689525","article-title":"Guidelines on eosinophilic esophagitis: Evidence-based statements and recommendations for diagnosis and management in children and adults","volume":"5","author":"Lucendo","year":"2017","journal-title":"United Eur. 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