{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:14:51Z","timestamp":1790802891248,"version":"4.1.0"},"reference-count":118,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Slovak Research Grant Agency","award":["VEGA 1\/0563\/21"],"award-info":[{"award-number":["VEGA 1\/0563\/21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Left ventricular hypertrophy (LVH) refers to a complex rebuilding of the left ventricle that can gradually lead to serious complications\u2014heart failure and life-threatening ventricular arrhythmias. LVH is defined as an increase in the size of the left ventricle (i.e., anatomically), therefore the basic diagnosis detecting the increase in the LV size is the domain of imaging methods such as echocardiography and cardiac magnetic resonance. However, to evaluate the functional status indicating the gradual deterioration of the left ventricular myocardium, additional methods are available approaching the complex process of hypertrophic remodeling. The novel molecular and genetic biomarkers provide insights on the underlying processes, representing a potential basis for targeted therapy. This review summarizes the spectrum of the main biomarkers employed in the LVH valuation.<\/jats:p>","DOI":"10.3390\/ijms24043881","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T03:09:21Z","timestamp":1676430561000},"page":"3881","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers"],"prefix":"10.3390","volume":"24","author":[{"given":"Ljuba","family":"Bacharova","sequence":"first","affiliation":[{"name":"International Laser Center CVTI, 841 04 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0023-1541","authenticated-orcid":false,"given":"Marta","family":"Kollarova","sequence":"additional","affiliation":[{"name":"Premedix Academy, 811 02 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1042-9743","authenticated-orcid":false,"given":"Branislav","family":"Bezak","sequence":"additional","affiliation":[{"name":"Premedix Academy, 811 02 Bratislava, Slovakia"},{"name":"National Institute for Cardiovascular Diseases, 833 08 Bratislava, Slovakia"},{"name":"Faculty of Medicine, Comenius University in Bratislava, 831 01 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Bohm","sequence":"additional","affiliation":[{"name":"Premedix Academy, 811 02 Bratislava, Slovakia"},{"name":"National Institute for Cardiovascular Diseases, 833 08 Bratislava, Slovakia"},{"name":"Faculty of Medicine, Comenius University in Bratislava, 831 01 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1177\/2047487317702519","article-title":"Risk factors for sudden cardiac death in childhood hypertrophic cardiomyopathy: A systematic review and meta-analysis","volume":"24","author":"Norrish","year":"2017","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e002188","DOI":"10.1161\/JAHA.115.002188","article-title":"Left ventricular structure and risk of cardiovascular events: A Framingham Heart Study Cardiac Magnetic Resonace Study","volume":"4","author":"Tsao","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ajh.2008.16","article-title":"Left ventricular hypertrophy and clinical outcomes in hypertensive patients","volume":"21","author":"Ruilope","year":"2008","journal-title":"Am. J. Hypertens."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.CIR.92.4.785","article-title":"Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study","volume":"92","author":"Maron","year":"1995","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.carpath.2008.08.003","article-title":"Myocardial fibrosis in patients with symptomatic obstructive hypertrophic cardiomyopathy: Correlation with echocardiographic measurements, sarcomeric genotypes, and pro-left ventricular hypertrophy polymorphisms involving the renin-angiotensin-aldosterone system","volume":"18","author":"Blauwet","year":"2009","journal-title":"Cardiovasc. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.CIR.81.4.1161","article-title":"Ventricular remodeling after myocardial infarction: Experimental observations and clinical implications","volume":"81","author":"Pfeffer","year":"1990","journal-title":"Circulation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s40292-014-0068-x","article-title":"Left ventricular hypertrophy and obesity: Only a matter of fat?","volume":"22","author":"Murdolo","year":"2015","journal-title":"High Blood Press. Cardiovasc. Prev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1080\/00015385.2021.1992990","article-title":"Cardiac amyloidosis: A review of the literature","volume":"77","author":"Dulgheru","year":"2022","journal-title":"Acta Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1586\/14760584.4.6.867","article-title":"Current status and future prospects for a vaccine against American trypanosomiasis","volume":"4","author":"Garg","year":"2005","journal-title":"Expert Rev. Vaccines"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0894-7317(96)90019-X","article-title":"Two-dimensional echocardiographic calculation of left ventricular mass as recommended by the American Society of Echocardiography: Correlation with autopsy and M-mode echocardiography","volume":"9","author":"Park","year":"1996","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.acvd.2011.04.003","article-title":"How to calculate left ventricular mass in routine practice? An echocardiographic versus cardiac magnetic resonance study","volume":"104","author":"Perdrix","year":"2011","journal-title":"Arch. Cardiovasc. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.amjcard.2013.04.028","article-title":"Comparison of three-dimensional echocardiographic findings to those of magnetic resonance imaging for determination of left ventricular mass in patients with ischemic and non-ischemic cardiomyopathy","volume":"112","author":"Kusunose","year":"2013","journal-title":"Am. J. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1023\/A:1026540809758","article-title":"Three-dimensional echocardiographic measurement of left ventricular mass: Comparison with magnetic resonance imaging and two-dimensional echocardiographic determinations in man","volume":"16","author":"Chuang","year":"2000","journal-title":"Int. J. Card. Imaging"},{"key":"ref_15","first-page":"452","article-title":"Ventricular arrhythmias and left ventricular hypertrophy in hypertrophic cardiomyopathy","volume":"100","author":"Torres","year":"2013","journal-title":"Arq. Bras. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.amjcard.2014.07.015","article-title":"Meta-analysis of left ventricular hypertrophy and sustained arrhythmias","volume":"114","author":"Chatterjee","year":"2014","journal-title":"Am. J. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1540-8175.2011.01427.x","article-title":"Longitudinal left.ventricular strain in hypertrophic cardiomyopathy: Correlation with nonsustained ventricular tachycardia","volume":"28","author":"Correia","year":"2011","journal-title":"Echocardiography"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.7861\/clinmedicine.3-3-273","article-title":"Cardiovascular magnetic resonance: Twenty-first century solutions in cardiology","volume":"3","author":"Pennell","year":"2003","journal-title":"Clin. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12968-020-00683-3","article-title":"Reference ranges (\u201cnormal values\u201d) for cardiovascular magnetic resonance (CMR) in adults and children: 2020 update","volume":"22","author":"Hetzel","year":"2020","journal-title":"J. Cardiovasc. Magn. Reason."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s11897-020-00481-z","article-title":"Cardiovascular magnetic resonance for the differentiation of left ventricular hypertrophy","volume":"17","author":"Burrage","year":"2020","journal-title":"Curr. Heart Fail. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/jce.13855","article-title":"The relationship between the quantitative extent of late gadolinium enhancement and burden of nonsustained ventricular tachycardia in hypertrophic cardiomyopathy: A delayed contrast-enhanced magnetic resonance study","volume":"30","author":"Hindieh","year":"2019","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/jce.12948","article-title":"Diffuse ventricular fibrosis on cardiac magnetic resonance imaging associates with ventricular tachycardia in patients with hypertrophic cardiomyopathy","volume":"27","author":"McLellan","year":"2016","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1136\/heartjnl-2015-307682","article-title":"Myocardial fibrosis on cardiac magnetic resonance and cardiac outcomes in hypertrophic cardiomyopathy: A meta-analysis","volume":"101","author":"Briasoulis","year":"2015","journal-title":"Heart"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.jacc.2008.12.015","article-title":"American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; American College of Cardiology Foundation; Heart Rhythm Society. AHA\/ACCF\/HRS recommendations for the standardization and interpretation of the electrocardiogram: Part V: Electrocardiogram changes associated with cardiac chamber hypertrophy: A scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Endorsed by the International Society for Computerized Electrocardiology","volume":"53","author":"Hancock","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0002-8703(49)90562-1","article-title":"The ventricular complex in left ventricular hypertrophy as obtained by unipolar precordial and limb leads","volume":"37","author":"Sokolow","year":"1949","journal-title":"Am. Heart J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1161\/01.CIR.75.3.565","article-title":"Improved sex-specific criteria of left ventricular hypertrophy for clinical and computer interpretation of electrocardiograms: Validation with autopsy findings","volume":"75","author":"Casale","year":"1987","journal-title":"Circulation"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/0735-1097(92)90376-X","article-title":"Electrocardiographic detection of left ventricular hypertrophy by the simple QRS voltage duration product","volume":"20","author":"Molloy","year":"1992","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/0002-8703(68)90035-5","article-title":"A point-score system for the ECG diagnosis of left ventricular hypertrophy","volume":"75","author":"Romhilt","year":"1968","journal-title":"Am. Heart J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1136\/bmj.39276.636354.AE","article-title":"Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in arterial hypertension: Systematic review","volume":"335","author":"Pewsner","year":"2007","journal-title":"BMJ"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.jelectrocard.2014.05.006","article-title":"Left ventricular hypertrophy: Disagreements between increased left ventricular mass and ECG-LVH criteria: The effect of impaired electrical properties of myocardium","volume":"47","author":"Bacharova","year":"2014","journal-title":"J. Electrocardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jelectrocard.2022.06.002","article-title":"ECG in left ventricular hypertrophy: A change in paradigm from assessing left ventricular mass to its electrophysiological properties","volume":"73","author":"Bacharova","year":"2022","journal-title":"J. Electrocardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"54D","DOI":"10.1016\/S0002-9149(99)80493-7","article-title":"Cardiac arrhythmias and left ventricular hypertrophy in systemic hypertension and their influences on prognosis","volume":"76","author":"Guindo","year":"1995","journal-title":"Am. J. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1093\/eurheartj\/ehp321","article-title":"QRS duration predicts sudden cardiac death in hypertensive patients undergoing intensive medical therapy: The LIFE study","volume":"30","author":"Morin","year":"2009","journal-title":"Eur. Heart J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/jce.12629","article-title":"QRS fragmentation and QTc duration relate to malignant ventricular tachyarrhythmias and sudden cardiac death in patients with hypertrophic cardiomyopathy","volume":"26","author":"Debonnaire","year":"2015","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.hrthm.2020.03.030","article-title":"Usefulness of positive T wave in lead aVR in predicting arrhythmic events and mortality in patients with hypertrophic cardiomyopathy","volume":"17","author":"Ekizler","year":"2020","journal-title":"Heart Rhythm."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1467-789X.2005.00199.x","article-title":"Obesity and the electrocardiogram","volume":"6","author":"Fraley","year":"2005","journal-title":"Obes. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.hrthm.2014.03.023","article-title":"Electrocardiographic versus echocardiographic left ventricular hypertrophy and sudden cardiac arrest in the community","volume":"11","author":"Narayanan","year":"2014","journal-title":"Heart Rhythm."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.hrtlng.2017.10.008","article-title":"Prognostic significance of late gadolinium enhancement on cardiac magnetic resonance in patients with hypertrophic cardiomyopathy","volume":"47","author":"He","year":"2018","journal-title":"Heart Lung"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jjcc.2015.07.020","article-title":"The value of cardiac magnetic resonance and distribution of late gadolinium enhancement for risk stratification of sudden cardiac death in patients with hypertrophic cardiomyopathy","volume":"68","author":"Klopotowski","year":"2016","journal-title":"J. Cardiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.jcmg.2016.02.031","article-title":"Prognostic Value of LGE-CMR in HCM: A Meta-Analysis","volume":"9","author":"Weng","year":"2016","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12968-019-0561-4","article-title":"The amount of late gadolinium enhancement outperforms current guideline-recommended criteria in the identification of patients with hypertrophic cardiomyopathy at risk of sudden cardiac death","volume":"21","author":"Freitas","year":"2019","journal-title":"J. Cardiovasc. Magn. Reason."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijcard.2018.09.104","article-title":"ECG left ventricular hypertrophy as a risk predictor of sudden cardiac death","volume":"276","author":"Porthan","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e12424","DOI":"10.1111\/anec.12424","article-title":"The Romhilt-Estes electrocardiographic score predicts sudden cardiac arrest independent of left ventricular mass and ejection fraction","volume":"22","author":"Darouian","year":"2017","journal-title":"Ann. Noninvasive Electrocardiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"578059","DOI":"10.3389\/fphys.2020.578059","article-title":"Electrocardiographic risk markers of cardiac death: Gender differences in the general population","volume":"11","author":"Haukilahti","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1001\/jama.2010.1708","article-title":"Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults","volume":"304","author":"deFilippi","year":"2010","journal-title":"JAMA"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1001\/jama.2010.1768","article-title":"Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population","volume":"304","author":"Drazner","year":"2010","journal-title":"JAMA"},{"key":"ref_47","first-page":"773","article-title":"Cardiac troponin-I and risk of heart failure: A community-based cohort study","volume":"30","author":"Ingelsson","year":"2009","journal-title":"Eur. Heart J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jacc.2012.10.012","article-title":"Biomarkers of chronic cardiac injury and hemodynamic stress identify a malignant phenotype of left ventricular hypertrophy in the general population","volume":"61","author":"Neeland","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e010107","DOI":"10.1161\/JAHA.118.010107","article-title":"Cardiac biomarkers and left ventricular hypertrophy in relation to outcomes in patients with atrial fibrillation: Experiences from the RE\u2014LY Trial","volume":"8","author":"Hijazi","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4103\/2230-8210.107869","article-title":"Physiology and clinical significance of natriuretic hormones","volume":"17","author":"Chopra","year":"2013","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_51","first-page":"3259","article-title":"An association between N-terminal pro-brain natriuretic protein level and risk of left ventricular hypertrophy in patients without heart failure","volume":"19","author":"Huang","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"306-a","DOI":"10.1016\/j.eupc.2005.02.072","article-title":"CRT37: The development of malignant ventricular arrhythmia in patients with ischemic cardiomyopathy and the prognostic significance of NT-PROBNP","volume":"7","author":"Mavrakis","year":"2005","journal-title":"Europace"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fcvm.2018.00044","article-title":"Initial phase NT-proBNP, but not copeptin and high-sensitivity cardiac troponin-T yielded diagnostic and prognostic information in addition to clinical assessment of out-of-hospital cardiac arrest patients with documented ventricular fibrillation","volume":"5","author":"Hagve","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.hlc.2007.02.083","article-title":"N-terminal pro brain natriuretic peptide to predict prognosis in dilated cardiomyopathy with sinus rhythm","volume":"16","author":"Tigen","year":"2007","journal-title":"Heart Lung Circ."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.amjcard.2012.11.041","article-title":"Relation of B-type natriuretic peptide level in heart failure to sudden cardiac death in patients with and without QT interval prolongation","volume":"111","author":"Vrtovec","year":"2013","journal-title":"Am. J. Cardiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.recesp.2013.04.021","article-title":"High-sensitivity cardiac troponin: From theory to clinical practice","volume":"66","author":"Jaffe","year":"2013","journal-title":"Rev. Esp. Cardiol. (Engl. Ed.)"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jjcc.2011.07.009","article-title":"High-sensitivity cardiac troponin T in essential hypertension","volume":"58","author":"Sato","year":"2011","journal-title":"J. Cardiol."},{"key":"ref_58","first-page":"305","article-title":"Clinical importance of high- sensitivity troponin T in patients without coronary artery disease","volume":"7","author":"Askin","year":"2020","journal-title":"North. Clin. \u0130stanbul"},{"key":"ref_59","first-page":"437","article-title":"Association between serum cardiac troponin I and myocardial remodeling in patients with chronic heart failure","volume":"34","author":"Liu","year":"2006","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1161\/01.CIR.101.12.1372","article-title":"Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques: Potential implications for inflammation and plaque instability","volume":"101","author":"Schieffer","year":"2000","journal-title":"Circulation"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1161\/CIRCRESAHA.116.308688","article-title":"Deletion of Interleukin-6 attenuates pressure overload-induced left ventricular hypertrophy and dysfunction","volume":"118","author":"Zhao","year":"2016","journal-title":"Circ. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"56","DOI":"10.5604\/17322693.1194612","article-title":"Inflammation markers are associated with metabolic syndrome and ventricular arrhythmia in patients with coronary artery disease","volume":"70","author":"Safranow","year":"2016","journal-title":"Postep. Hig. Med. Dosw."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1161\/01.CIR.0000096055.62724.C5","article-title":"Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells","volume":"108","author":"Calabro","year":"2003","journal-title":"Circulation"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1161\/01.CIR.0000017493.03108.1C","article-title":"Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death","volume":"105","author":"Albert","year":"2002","journal-title":"Circulation"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1136\/heartjnl-2016-311079","article-title":"Systemic inflammation as a novel QT-prolonging risk factor in patients with torsades de pointes","volume":"103","author":"Lazzerini","year":"2017","journal-title":"Heart"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.cyto.2009.06.003","article-title":"Role of proinflammatory markers and NT-proBNP in patients with an implantable cardioverter-defibrillator and an electrical storm","volume":"47","author":"Streitner","year":"2009","journal-title":"Cytokine"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e003188","DOI":"10.1161\/JAHA.115.003188","article-title":"Soluble ST2 for prediction of heart failure and cardiovascular death in an elderly, community-dwelling population","volume":"5","author":"Parikh","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"ref_68","first-page":"344","article-title":"Galectin-3 levels in patients with hypertrophic cardiomyopathy and its relationship with left ventricular mass index and function","volume":"16","author":"Emren","year":"2016","journal-title":"Anatol. J. Cardiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.ajpath.2015.12.017","article-title":"Myocardial galectin-3 expression is associated with remodeling of the pressure-overloaded heart and may delay the hypertrophic response without affecting survival, dysfunction, and cardiac fibrosis","volume":"186","author":"Frunza","year":"2016","journal-title":"Am. J. Pathol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.repc.2020.12.013","article-title":"A new biomarker that predicts ventricular arrhythmia in patients with ischemic dilated cardiomyopathy: Galectin-3","volume":"40","author":"Erdogan","year":"2021","journal-title":"Rev. Port. Cardiol. (Engl. Ed.)"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1161\/CIRCULATIONAHA.105.594929","article-title":"Receiver-operating characteristic analysis for evaluating diagnostic tests and predictive models","volume":"115","author":"Zou","year":"2007","journal-title":"Circulation"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e016765","DOI":"10.1161\/JAHA.120.016765","article-title":"Impact of reactive oxidative metabolites among new categories of nonischemic heart failure","volume":"10","author":"Nishihara","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0300-9084(02)00005-6","article-title":"Peroxynitrite-induced inhibition and nitration of cardiac myofibrillar creatine kinase","volume":"84","author":"Mihm","year":"2002","journal-title":"Biochimie"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.yjmcc.2015.12.018","article-title":"Matrix metalloproteinases as input and output signals for post-myocardial infarction remodeling","volume":"91","author":"Lindsey","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/bs.pmbts.2017.02.001","article-title":"Matrix metalloproteinases in myocardial infarction and heart failure","volume":"147","author":"Meschiari","year":"2017","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.ahj.2012.07.006","article-title":"Serum markers of deranged myocardial collagen turnover: Their relation to malignant ventricular arrhythmias in cardioverter-defibrillator recipients with heart failure","volume":"164","author":"Flevari","year":"2012","journal-title":"Am. Heart J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1161\/CIRCHEARTFAILURE.110.958199","article-title":"Plasma biomarkers that reflect determinants of matrix composition identify the presence of left ventricular hypertrophy and diastolic heart failure","volume":"4","author":"Zile","year":"2011","journal-title":"Circ. Heart Fail."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Lu, Y., Ussher, N., Zhou, Y., Jelinek, H., Hambly, B., Li, A., and McLachlan, C.S. (2021). Matrix metalloproteinase-3 (MMP-3) polymorphisms are associated with prolonged ECG-derived QTc interval: A Cross-Sectional Study of the Australian Rural Population. J. Pers. Med., 11.","DOI":"10.3390\/jpm11080705"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cca.2014.03.030","article-title":"Plasma apelin: A novel biomarker for predicting diabetes","volume":"435","author":"Ma","year":"2014","journal-title":"Clin. Chim. Acta"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3389\/fcvm.2021.742601","article-title":"Association between apelin and atrial fibrillation in patients with high risk of ischemic stroke","volume":"8","author":"Bohm","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_81","first-page":"484","article-title":"Association of apelin and AF in patients with implanted loop recorders undergoing catheter ablation","volume":"121","author":"Uher","year":"2020","journal-title":"Bratisl. Lek. Listy"},{"key":"ref_82","first-page":"165","article-title":"Concentration of apelin inversely correlates with atrial fibrillation burden","volume":"122","author":"Bohm","year":"2021","journal-title":"Bratisl. Lek. Listy"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3233\/CBM-160654","article-title":"High apelin levels could be used as a diagnostic marker in multiple myeloma: A comparative study","volume":"17","author":"Maden","year":"2016","journal-title":"Cancer Biomark."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/20587392211042443","article-title":"Apelin: A new biomarker in fatty liver disease","volume":"19","author":"Kalyon","year":"2021","journal-title":"Eur. J. Inflamm."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s12967-015-0635-5","article-title":"Serum apelin is associated with left ventricular hypertrophy in untreated hypertension patients","volume":"13","author":"Ye","year":"2015","journal-title":"J. Transl. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1536\/ihj.18-598","article-title":"Predictive values of apelin for myocardial fibrosis in hypertrophic cardiomyopathy","volume":"60","author":"Zhou","year":"2019","journal-title":"Int. Heart J."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Shah, A.K., Bhullar, S.K., Elimban, V., and Dhalla, N.S. (2021). Oxidative stress as a mechanism for functional alterations in cardiac hypertrophy and heart failure. Antioxidants, 10.","DOI":"10.3390\/antiox10060931"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"141","DOI":"10.5603\/AH.a2022.0018","article-title":"Changes of apelin-13 concentration in patients with essential hypertension and extrasystole","volume":"26","author":"Ivankova","year":"2022","journal-title":"Arter. Hypertens."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/eci.12012","article-title":"Apelin regulates the electrophysiological characteristics of atrial myocytes","volume":"43","author":"Cheng","year":"2013","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.bbrc.2007.04.017","article-title":"Terracciano CM. Direct effects of apelin on cardiomyocyte contractility and electrophysiology","volume":"357","author":"Farkasfalvi","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11897-010-0005-9","article-title":"ST2: A novel remodeling biomarker in acute and chronic heart failure","volume":"7","author":"Shah","year":"2010","journal-title":"Curr. Heart Fail. Rep."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1161\/01.CIR.0000038705.69871.D9","article-title":"Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction","volume":"106","author":"Weinberg","year":"2002","journal-title":"Circulation"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1161\/CIRCULATIONAHA.113.006702","article-title":"Epidemiology and pathophysiology of mitral valve prolapse: New insights into disease progression, genetics, and molecular basis","volume":"129","author":"Delling","year":"2014","journal-title":"Circulation"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/1354750X.2016.1278266","article-title":"Soluble ST2 is associated with disease severity in arrhythmogenic right ventricular cardiomyopathy","volume":"22","author":"Broch","year":"2017","journal-title":"Biomarkers"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Stadiotti, I., Lippi, M., Maione, A.S., Compagnucci, P., Andreini, D., Casella, M., Pompilio, G., and Sommariva, E. (2021). Cardiac biomarkers and autoantibodies in endurance athletes: Potential similarities with arrhythmogenic cardiomyopathy pathogenic mechanisms. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126500"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1249\/MSS.0000000000001806","article-title":"Exercise-induced Changes in Soluble ST2 Concentrations in Marathon Runners","volume":"51","author":"Aengevaeren","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1073\/pnas.92.4.1142","article-title":"Expression cloning of cardiotrophin-1, a cytokine that induces cardiac myocyte hypertrophy","volume":"92","author":"Pennica","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1242\/dev.122.2.419","article-title":"Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival","volume":"122","author":"Sheng","year":"1996","journal-title":"Development"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.yjmcc.2008.11.002","article-title":"Novel insights into the role of cardiotrophin-1 in cardiovascular diseases","volume":"46","author":"Calabro","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/eurheartj\/ehq400","article-title":"Cardiotrophin-1 plasma levels are associated with the severity of hypertrophy in hypertrophic cardiomyopathy","volume":"32","author":"Monserrat","year":"2011","journal-title":"Eur. Heart J."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00380-013-0337-y","article-title":"Growth differentiation factor 15 can distinguish between hypertrophic cardiomyopathy and hypertensive hearts","volume":"29","author":"Hanatani","year":"2014","journal-title":"Heart Vessel."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Xue, H., Fu, Z., Chen, Y., Xing, Y., Liu, J., Zhu, H., and Zhou, X. (2012). The association of growth differentiation factor-15 with left ventricular hypertrophy in hypertensive patients. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0046534"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/labinvest.3780016","article-title":"Expression and localization of the annexins II, V, and VI in myocardium from patients with end-stage heart failure","volume":"80","author":"Benevolensky","year":"2000","journal-title":"Lab. Investig."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1006\/bbrc.1993.2382","article-title":"Annexins V and VI in rat tissues during post-natal development: Immunochemical measurements","volume":"196","author":"Giambanco","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e8305","DOI":"10.1097\/MD.0000000000008305","article-title":"The association between annexin A5 (ANXA5) gene polymorphism and left ventricular hypertrophy (LVH) in Chinese endogenous hypertension patients","volume":"96","author":"Zhang","year":"2017","journal-title":"Medicine"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"6753","DOI":"10.1038\/s41598-018-25143-y","article-title":"Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response","volume":"8","author":"Pluijmert","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1093\/eurheartj\/ehm370","article-title":"Upregulation of myocardial Annexin A5 in hypertensive heart disease: Association with systolic dysfunction","volume":"28","author":"Ravassa","year":"2007","journal-title":"Eur. Heart J."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.gde.2005.08.005","article-title":"How microRNAs control cell division, differentiation and death","volume":"15","author":"Miska","year":"2005","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"850","DOI":"10.4161\/rna.20378","article-title":"Small RNAs have a large impact: Circulating microRNAs as biomarkers for human diseases","volume":"9","author":"Weiland","year":"2012","journal-title":"RNA Biol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"B\u00f6hm, A., Vachalcova, M., Snopek, P., Bacharova, L., Komarova, D., and Hatala, R. (2020). Molecular mechanisms, diagnostic aspects and therapeutic opportunities of micro ribonucleic acids in atrial fibrillation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082742"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"798954","DOI":"10.3389\/fcvm.2022.798954","article-title":"Relationship between circulating microRNAs and left ventricular hypertrophy in hypertensive patients","volume":"9","author":"Lopes","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1182\/blood-2011-07-370635","article-title":"miR-27b controls venous specification and tip cell fate","volume":"11","author":"Biyashev","year":"2012","journal-title":"Blood"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"108405","DOI":"10.1016\/j.abb.2020.108405","article-title":"MicroRNA-27 attenuates pressure overload-Induced cardiac hypertrophy and dysfunction by targeting galectin-3","volume":"689","author":"Zhang","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1177\/0300060518786907","article-title":"Midregional pro-atrial natriuretic peptide, an important member of the natriuretic peptide family: Potential role in diagnosis and prognosis of cardiovascular disease","volume":"46","author":"Idzikowska","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"ref_115","first-page":"321","article-title":"Natriuretic peptides","volume":"339","author":"Levin","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1136\/heart.89.6.661","article-title":"Brain natriuretic peptide facilitates severity classification of stable chronic heart failure with left ventricular dysfunction","volume":"89","author":"Sakurai","year":"2003","journal-title":"Heart"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1093\/eurheartj\/ehac262","article-title":"2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death","volume":"43","author":"Zeppenfeld","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Homanova, Z., Ohnewein, B., Schernthaner, C., H\u00f6fer, K., Pogoda, C.A., Frommeyer, G., Wernly, B., Brandt, M.C., Dieplinger, A.M., and Reinecke, H. (2020). Classic and novel biomarkers as potential predictors of ventricular arrhythmias and sudden cardiac death. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020578"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/4\/3881\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:36:02Z","timestamp":1760121362000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/4\/3881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,15]]},"references-count":118,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["ijms24043881"],"URL":"https:\/\/doi.org\/10.3390\/ijms24043881","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,15]]}}}