{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:03:34Z","timestamp":1792458214253,"version":"4.5.0"},"reference-count":47,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["31470929"],"award-info":[{"award-number":["31470929"]}]},{"name":"National Natural Science Foundation of China","award":["81970971"],"award-info":[{"award-number":["81970971"]}]},{"name":"National Natural Science Foundation of China","award":["2022SF-179"],"award-info":[{"award-number":["2022SF-179"]}]},{"name":"National Natural Science Foundation of China","award":["21ZT12"],"award-info":[{"award-number":["21ZT12"]}]},{"name":"Shaanxi General Project-Social Development Field","award":["31470929"],"award-info":[{"award-number":["31470929"]}]},{"name":"Shaanxi General Project-Social Development Field","award":["81970971"],"award-info":[{"award-number":["81970971"]}]},{"name":"Shaanxi General Project-Social Development Field","award":["2022SF-179"],"award-info":[{"award-number":["2022SF-179"]}]},{"name":"Shaanxi General Project-Social Development Field","award":["21ZT12"],"award-info":[{"award-number":["21ZT12"]}]},{"name":"Air Force Medical Center, The Fourth Military Medical University","award":["31470929"],"award-info":[{"award-number":["31470929"]}]},{"name":"Air Force Medical Center, The Fourth Military Medical University","award":["81970971"],"award-info":[{"award-number":["81970971"]}]},{"name":"Air Force Medical Center, The Fourth Military Medical University","award":["2022SF-179"],"award-info":[{"award-number":["2022SF-179"]}]},{"name":"Air Force Medical Center, The Fourth Military Medical University","award":["21ZT12"],"award-info":[{"award-number":["21ZT12"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In recent years, porous titanium (Ti) scaffolds with BaTiO3 coatings have been designed to promote bone regeneration. However, the phase transitions of BaTiO3 have been understudied, and their coatings have yielded low effective piezoelectric coefficients (EPCs &lt; 1 pm\/V). In addition, piezoelectric nanomaterials bring many advantages in eliciting cell-specific responses. However, no study has attempted to design a nanostructured BaTiO3 coating with high EPCs. Herein, nanoparticulate tetragonal phase BaTiO3 coatings with cube-like nanoparticles but different effective piezoelectric coefficients were fabricated via anodization combining two hydrothermal processes. The effects of nanostructure-mediated piezoelectricity on the spreading, proliferation, and osteogenic differentiation of human jaw bone marrow mesenchymal stem cells (hJBMSCs) were explored. We found that the nanostructured tetragonal BaTiO3 coatings exhibited good biocompatibility and an EPC-dependent inhibitory effect on hJBMSC proliferation. The nanostructured tetragonal BaTiO3 coatings of relatively smaller EPCs (&lt;10 pm\/V) exhibited hJBMSC elongation and reorientation, broad lamellipodia extension, strong intercellular connection and osteogenic differentiation enhancement. Overall, the improved hJBMSC characteristics make the nanostructured tetragonal BaTiO3 coatings promising for application on implant surfaces to promote osseointegration.<\/jats:p>","DOI":"10.3390\/ijms24044051","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T03:27:41Z","timestamp":1676604461000},"page":"4051","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Nanostructure Mediated Piezoelectric Effect of Tetragonal BaTiO3 Coatings on Bone Mesenchymal Stem Cell Shape and Osteogenic Differentiation"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8075-1717","authenticated-orcid":false,"given":"Yafei","family":"Zheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhou","family":"Zhao","sequence":"additional","affiliation":[{"name":"Air Force Medical Center, The Fourth Military Medical University, 30 Fucheng Road, Beijing 100089, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Air Force Medical Center, The Fourth Military Medical University, 30 Fucheng Road, Beijing 100089, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Xi\u2019an University of Technology, Xi\u2019an 710048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipeng","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikang","family":"An","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Jiao","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Xi\u2019an University of Technology, Xi\u2019an 710048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chufan","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"},{"name":"Air Force Medical Center, The Fourth Military Medical University, 30 Fucheng Road, Beijing 100089, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1016\/j.biomaterials.2010.03.014","article-title":"The influence of hierarchical hybrid micro\/nano-textured titanium surface with titania nanotubes on osteoblast functions","volume":"31","author":"Zhao","year":"2010","journal-title":"Biomaterials"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"12828","DOI":"10.1039\/D1CS00572C","article-title":"Regulation of stem cell fate using nanostructure-mediated physical signals","volume":"50","author":"Kong","year":"2021","journal-title":"Chem. 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