{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:04:02Z","timestamp":1791813842009,"version":"4.3.4"},"reference-count":37,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T00:00:00Z","timestamp":1676764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973580"],"award-info":[{"award-number":["81973580"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803866"],"award-info":[{"award-number":["81803866"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021YFS0408"],"award-info":[{"award-number":["2021YFS0408"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022YFS0425"],"award-info":[{"award-number":["2022YFS0425"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022YFS0426"],"award-info":[{"award-number":["2022YFS0426"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["HXYS19001"],"award-info":[{"award-number":["HXYS19001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["HXYS19002"],"award-info":[{"award-number":["HXYS19002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ZYXY21002"],"award-info":[{"award-number":["ZYXY21002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["161200012"],"award-info":[{"award-number":["161200012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"COVID-19 Science and Technology Emergency Project of Sichuan Province of China","award":["81973580"],"award-info":[{"award-number":["81973580"]}]},{"name":"COVID-19 Science and Technology Emergency Project of Sichuan Province of China","award":["81803866"],"award-info":[{"award-number":["81803866"]}]},{"name":"COVID-19 Science and Technology Emergency Project of Sichuan Province of China","award":["2021YFS0408"],"award-info":[{"award-number":["2021YFS0408"]}]},{"name":"COVID-19 Science and Technology Emergency Project of Sichuan Province of China","award":["2022YFS0425"],"award-info":[{"award-number":["2022YFS0425"]}]},{"name":"COVID-19 Science and Technology Emergency Project of Sichuan Province of China","award":["2022YFS0426"],"award-info":[{"award-number":["2022YFS0426"]}]},{"name":"COVID-19 Science and Technology Emergency Project of Sichuan Province of China","award":["HXYS19001"],"award-info":[{"award-number":["HXYS19001"]}]},{"name":"COVID-19 Science and Technology Emergency Project of Sichuan Province of China","award":["HXYS19002"],"award-info":[{"award-number":["HXYS19002"]}]},{"name":"COVID-19 Science and Technology Emergency Project of Sichuan Province of China","award":["ZYXY21002"],"award-info":[{"award-number":["ZYXY21002"]}]},{"name":"COVID-19 Science and Technology Emergency Project of Sichuan Province of China","award":["161200012"],"award-info":[{"award-number":["161200012"]}]},{"name":"Key Technology Research and Development Program of Sichuan Province of China","award":["81973580"],"award-info":[{"award-number":["81973580"]}]},{"name":"Key Technology Research and Development Program of Sichuan Province of China","award":["81803866"],"award-info":[{"award-number":["81803866"]}]},{"name":"Key Technology Research and Development Program of Sichuan Province of China","award":["2021YFS0408"],"award-info":[{"award-number":["2021YFS0408"]}]},{"name":"Key Technology Research and Development Program of Sichuan Province of China","award":["2022YFS0425"],"award-info":[{"award-number":["2022YFS0425"]}]},{"name":"Key Technology Research and Development Program of Sichuan Province of China","award":["2022YFS0426"],"award-info":[{"award-number":["2022YFS0426"]}]},{"name":"Key Technology Research and Development Program of Sichuan Province of China","award":["HXYS19001"],"award-info":[{"award-number":["HXYS19001"]}]},{"name":"Key Technology Research and Development Program of Sichuan Province of China","award":["HXYS19002"],"award-info":[{"award-number":["HXYS19002"]}]},{"name":"Key Technology Research and Development Program of Sichuan Province of China","award":["ZYXY21002"],"award-info":[{"award-number":["ZYXY21002"]}]},{"name":"Key Technology Research and Development Program of Sichuan Province of China","award":["161200012"],"award-info":[{"award-number":["161200012"]}]},{"name":"Innovative Chinese Medicine and Health Products Research Academician Workstation of Academician Boli Zhang and Academician Beiwei Zhu, West China Hospital, Sichuan University","award":["81973580"],"award-info":[{"award-number":["81973580"]}]},{"name":"Innovative Chinese Medicine and Health Products Research Academician Workstation of Academician Boli Zhang and Academician Beiwei Zhu, West China Hospital, Sichuan University","award":["81803866"],"award-info":[{"award-number":["81803866"]}]},{"name":"Innovative Chinese Medicine and Health Products Research Academician Workstation of Academician Boli Zhang and Academician Beiwei Zhu, West China Hospital, Sichuan University","award":["2021YFS0408"],"award-info":[{"award-number":["2021YFS0408"]}]},{"name":"Innovative Chinese Medicine and Health Products Research Academician Workstation of Academician Boli Zhang and Academician Beiwei Zhu, West China Hospital, Sichuan University","award":["2022YFS0425"],"award-info":[{"award-number":["2022YFS0425"]}]},{"name":"Innovative Chinese Medicine and Health Products Research Academician Workstation of Academician Boli Zhang and Academician Beiwei Zhu, West China Hospital, Sichuan University","award":["2022YFS0426"],"award-info":[{"award-number":["2022YFS0426"]}]},{"name":"Innovative Chinese Medicine and Health Products Research Academician Workstation of Academician Boli Zhang and Academician Beiwei Zhu, West China Hospital, Sichuan University","award":["HXYS19001"],"award-info":[{"award-number":["HXYS19001"]}]},{"name":"Innovative Chinese Medicine and Health Products Research Academician Workstation of Academician Boli Zhang and Academician Beiwei Zhu, West China Hospital, Sichuan University","award":["HXYS19002"],"award-info":[{"award-number":["HXYS19002"]}]},{"name":"Innovative Chinese Medicine and Health Products Research Academician Workstation of Academician Boli Zhang and Academician Beiwei Zhu, West China Hospital, Sichuan University","award":["ZYXY21002"],"award-info":[{"award-number":["ZYXY21002"]}]},{"name":"Innovative Chinese Medicine and Health Products Research Academician Workstation of Academician Boli Zhang and Academician Beiwei Zhu, West China Hospital, Sichuan University","award":["161200012"],"award-info":[{"award-number":["161200012"]}]},{"name":"1\u00b73\u00b75 Project for Disciplines of Excellence, West China Hospital, Sichuan University","award":["81973580"],"award-info":[{"award-number":["81973580"]}]},{"name":"1\u00b73\u00b75 Project for Disciplines of Excellence, West China Hospital, Sichuan University","award":["81803866"],"award-info":[{"award-number":["81803866"]}]},{"name":"1\u00b73\u00b75 Project for Disciplines of Excellence, West China Hospital, Sichuan University","award":["2021YFS0408"],"award-info":[{"award-number":["2021YFS0408"]}]},{"name":"1\u00b73\u00b75 Project for Disciplines of Excellence, West China Hospital, Sichuan University","award":["2022YFS0425"],"award-info":[{"award-number":["2022YFS0425"]}]},{"name":"1\u00b73\u00b75 Project for Disciplines of Excellence, West China Hospital, Sichuan University","award":["2022YFS0426"],"award-info":[{"award-number":["2022YFS0426"]}]},{"name":"1\u00b73\u00b75 Project for Disciplines of Excellence, West China Hospital, Sichuan University","award":["HXYS19001"],"award-info":[{"award-number":["HXYS19001"]}]},{"name":"1\u00b73\u00b75 Project for Disciplines of Excellence, West China Hospital, Sichuan University","award":["HXYS19002"],"award-info":[{"award-number":["HXYS19002"]}]},{"name":"1\u00b73\u00b75 Project for Disciplines of Excellence, West China Hospital, Sichuan University","award":["ZYXY21002"],"award-info":[{"award-number":["ZYXY21002"]}]},{"name":"1\u00b73\u00b75 Project for Disciplines of Excellence, West China Hospital, Sichuan University","award":["161200012"],"award-info":[{"award-number":["161200012"]}]},{"name":"Innovative Chinese Medicine Preclinical Research Fund of \u201cLiqing No. 2\u201d, West China Hospital, Sichuan University","award":["81973580"],"award-info":[{"award-number":["81973580"]}]},{"name":"Innovative Chinese Medicine Preclinical Research Fund of \u201cLiqing No. 2\u201d, West China Hospital, Sichuan University","award":["81803866"],"award-info":[{"award-number":["81803866"]}]},{"name":"Innovative Chinese Medicine Preclinical Research Fund of \u201cLiqing No. 2\u201d, West China Hospital, Sichuan University","award":["2021YFS0408"],"award-info":[{"award-number":["2021YFS0408"]}]},{"name":"Innovative Chinese Medicine Preclinical Research Fund of \u201cLiqing No. 2\u201d, West China Hospital, Sichuan University","award":["2022YFS0425"],"award-info":[{"award-number":["2022YFS0425"]}]},{"name":"Innovative Chinese Medicine Preclinical Research Fund of \u201cLiqing No. 2\u201d, West China Hospital, Sichuan University","award":["2022YFS0426"],"award-info":[{"award-number":["2022YFS0426"]}]},{"name":"Innovative Chinese Medicine Preclinical Research Fund of \u201cLiqing No. 2\u201d, West China Hospital, Sichuan University","award":["HXYS19001"],"award-info":[{"award-number":["HXYS19001"]}]},{"name":"Innovative Chinese Medicine Preclinical Research Fund of \u201cLiqing No. 2\u201d, West China Hospital, Sichuan University","award":["HXYS19002"],"award-info":[{"award-number":["HXYS19002"]}]},{"name":"Innovative Chinese Medicine Preclinical Research Fund of \u201cLiqing No. 2\u201d, West China Hospital, Sichuan University","award":["ZYXY21002"],"award-info":[{"award-number":["ZYXY21002"]}]},{"name":"Innovative Chinese Medicine Preclinical Research Fund of \u201cLiqing No. 2\u201d, West China Hospital, Sichuan University","award":["161200012"],"award-info":[{"award-number":["161200012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Disseminated intravascular coagulation (DIC), which is closely related to platelet activation, is a key factor leading to high mortality in sepsis. The release of contents from plasma membrane rupture after platelet death further aggravates thrombosis. Nerve injury-induced protein 1 (NINJ1) is a cell membrane protein that mediates membrane disruption, a typical marker of cell death, through oligomerization. Nevertheless, whether NINJ1 is expressed in platelets and regulates the platelet function remains unclear. The aim of this study was to evaluate the expression of NINJ1 in human and murine platelets and elucidate the role of NINJ1 in platelets and septic DIC. In this study, NINJ1 blocking peptide (NINJ126\u201337) was used to verify the effect of NINJ1 on platelets in vitro and in vivo. Platelet \u03b1IIb\u03b23 and P-selectin were detected by flow cytometry. Platelet aggregation was measured by turbidimetry. Platelet adhesion, spreading and NINJ1 oligomerization were examined by immunofluorescence. Cecal perforation-induced sepsis and FeCl3-induced thrombosis models were used to evaluate the role of NINJ1 in platelet, thrombus and DIC in vivo. We found that inhibition of NINJ1 alleviates platelet activation in vitro. The oligomerization of NINJ1 is verified in membrane-broken platelets, which is regulated by the PANoptosis pathway. In vivo studies demonstrate that inhibition of NINJ1 effectively reduces platelet activation and membrane disruption, thus suppressing platelet-cascade reaction and leading to anti-thrombosis and anti-DIC in sepsis. These data demonstrate that NINJ1 is critical in platelet activation and plasma membrane disruption, and inhibition of NINJ1 effectively reduces platelet-dependent thrombosis and DIC in sepsis. This is the first study to reveal the key role of NINJ1 in platelet and its related disorders.<\/jats:p>","DOI":"10.3390\/ijms24044168","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T04:28:57Z","timestamp":1676867337000},"page":"4168","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["NINJ1 Regulates Platelet Activation and PANoptosis in Septic Disseminated Intravascular Coagulation"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1567-8511","authenticated-orcid":false,"given":"Xiaoli","family":"Zhou","sequence":"first","affiliation":[{"name":"Laboratory of Ethnopharmacology, Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuxian","family":"Yu","sequence":"additional","affiliation":[{"name":"Laboratory of Ethnopharmacology, Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Wan","sequence":"additional","affiliation":[{"name":"Laboratory of Ethnopharmacology, Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Ethnopharmacology, Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilan","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Ethnopharmacology, Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Ethnopharmacology, Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Feng","sequence":"additional","affiliation":[{"name":"Laboratory of Ethnopharmacology, Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Wen","sequence":"additional","affiliation":[{"name":"Laboratory of Ethnopharmacology, Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangrong","family":"Deng","sequence":"additional","affiliation":[{"name":"Laboratory of Ethnopharmacology, Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Ethnopharmacology, Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Xin","sequence":"additional","affiliation":[{"name":"Laboratory of Ethnopharmacology, Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Huang","sequence":"additional","affiliation":[{"name":"Laboratory of Ethnopharmacology, Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990\u20132020: Analysis for the global burden of disease study","volume":"395","author":"Rudd","year":"2021","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: International guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Vardon-Bounes, F., Ruiz, S., Gratacap, M.P., Garcia, C., Payrastre, B., and Minville, V. (2019). Platelets are critical key players in sepsis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143494"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0035-1564835","article-title":"Platelet physiology","volume":"42","author":"Gremmel","year":"2016","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.3324\/haematol.2018.202309","article-title":"Fatal dysfunction and disintegration of thrombin-stimulated platelets","volume":"104","author":"Kim","year":"2019","journal-title":"Haematologica"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.blre.2015.12.004","article-title":"DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC","volume":"30","author":"Liaw","year":"2016","journal-title":"Blood Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1111\/jth.13493","article-title":"Histones link inflammation and thrombosis through the induction of Weibel-Palade body exocytosis","volume":"14","author":"Michels","year":"2016","journal-title":"J. Thromb. Haemost."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100864","DOI":"10.1016\/j.blre.2021.100864","article-title":"Coagulopathy and sepsis: Pathophysiology, clinical manifestations and treatment","volume":"50","author":"Giustozzi","year":"2021","journal-title":"Blood Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"21373","DOI":"10.1074\/jbc.272.34.21373","article-title":"Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule","volume":"272","author":"Araki","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000512222","article-title":"The role of ninjurin1 and its impact beyond the nervous system","volume":"42","author":"Liu","year":"2020","journal-title":"Dev. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.molcel.2021.03.005","article-title":"NINJ1, rupturing swollen membranes for cataclysmic cell lysis","volume":"81","author":"Wang","year":"2021","journal-title":"Mol. Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/cr.2017.133","article-title":"Plasma membrane changes during programmed cell deaths","volume":"28","author":"Zhang","year":"2018","journal-title":"Cell Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cell.2020.11.025","article-title":"Synergism of TNF-\u03b1 and IFN-\u03b3 triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes","volume":"184","author":"Karki","year":"2021","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1080\/09537104.2017.1378809","article-title":"Auranofin, a thioredoxin reductase inhibitor, causes platelet death through calcium overload","volume":"30","author":"Harper","year":"2019","journal-title":"Platelets"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"9059601","DOI":"10.1155\/2021\/9059601","article-title":"The regulation effect of \u03b17nAChRs and M1AChRs on inflammation and immunity in sepsis","volume":"2021","author":"Hu","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.thromres.2018.04.007","article-title":"Platelet activation and antiplatelet therapy in sepsis: A narrative review","volume":"166","author":"Wang","year":"2018","journal-title":"Thromb Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.blre.2009.04.001","article-title":"Platelet alpha-granules: Basic biology and clinical correlates","volume":"23","author":"Blair","year":"2009","journal-title":"Blood Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1182\/blood-2012-04-420745","article-title":"Mechanism of platelet dense granule biogenesis: Study of cargo transport and function of Rab32 and Rab38 in a model system","volume":"120","author":"Ambrosio","year":"2012","journal-title":"Blood"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1161\/CIRCRESAHA.112.300570","article-title":"Integrin \u03b1IIb\u03b23: From discovery to efficacious therapeutic target","volume":"112","author":"Bledzka","year":"2013","journal-title":"Circ. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1182\/blood-2004-04-1257","article-title":"Integrins: Dynamic scaffolds for adhesion and signaling in platelets","volume":"104","author":"Shattil","year":"2004","journal-title":"Blood"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1182\/blood-2017-03-773614","article-title":"Integrin \u03b1IIb\u03b23 outside-in signaling","volume":"130","author":"Durrant","year":"2017","journal-title":"Blood"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.devcel.2021.12.015","article-title":"Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis","volume":"57","author":"Wang","year":"2022","journal-title":"Dev. Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41586-021-03218-7","article-title":"NINJ1 mediates plasma membrane rupture during lytic cell death","volume":"591","author":"Kayagaki","year":"2021","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1016\/j.csbj.2021.07.038","article-title":"From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways","volume":"19","author":"Wang","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1055\/s-2001-18863","article-title":"Disseminated intravascular coagulation in sepsis","volume":"27","author":"Hardaway","year":"2001","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s40820-022-00894-6","article-title":"Connecting Calcium-based nanomaterials and cancer: From diagnosis to therapy","volume":"14","author":"Bai","year":"2022","journal-title":"Nano-Micro Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-021-03875-8","article-title":"AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence","volume":"597","author":"Lee","year":"2021","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/ijc.33698","article-title":"Caspase-8: A key protein of cross-talk signal way in \u201cPANoptosis\u201d in cancer","volume":"149","author":"Jiang","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"167249","DOI":"10.1016\/j.jmb.2021.167249","article-title":"PANoptosis in viral infection: The missing puzzle piece in the cell death field","volume":"434","author":"Nguyen","year":"2022","journal-title":"J. Mol. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3389\/fcimb.2020.00237","article-title":"Identification of the PANoptosome: A molecular platform triggering pyroptosis, apoptosis, and necroptosis (PANoptosis)","volume":"10","author":"Christgen","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tim.2011.01.001","article-title":"Cecal ligation and puncture: The gold standard model for polymicrobial sepsis?","volume":"19","author":"Dejager","year":"2011","journal-title":"Trends Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1165\/rcmb.2014-0354OC","article-title":"Contribution of Ninjurin1 to Toll-like receptor 4 signaling and systemic inflammation","volume":"53","author":"Jennewein","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1042\/CS20171273","article-title":"Functional blocking of Ninjurin1 as a strategy for protecting endothelial cells in diabetes mellitus","volume":"132","author":"Wang","year":"2018","journal-title":"Clin. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5122","DOI":"10.1111\/jcmm.17538","article-title":"Deficiency of Ninjurin1 attenuates LPS\/D-galactosamine-induced acute liver failure by reducing TNF-\u03b1-induced apoptosis in hepatocytes","volume":"26","author":"Kim","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-0716-1488-4_1","article-title":"Cecal ligation and puncture","volume":"2321","author":"Drechsler","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Shrum, B., Anantha, R.V., Xu, S.X., Donnelly, M., Haeryfar, S.M., McCormick, J.K., and Mele, T. (2014). A robust scoring system to evaluate sepsis severity in an animal model. BMC Res. Notes, 7.","DOI":"10.1186\/1756-0500-7-233"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/4\/4168\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:36:41Z","timestamp":1760121401000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/4\/4168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,19]]},"references-count":37,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["ijms24044168"],"URL":"https:\/\/doi.org\/10.3390\/ijms24044168","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,19]]}}}