{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:11:57Z","timestamp":1789164717050,"version":"build-2803163510"},"reference-count":101,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"George Emil Palade\u201d University of Medicine, Pharmacy, Science, and Technology of Targu Mures","award":["294\/6\/14.01.2020"],"award-info":[{"award-number":["294\/6\/14.01.2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chronic inflammation and endothelium dysfunction are present in diabetic patients. COVID-19 has a high mortality rate in association with diabetes, partially due to the development of thromboembolic events in the context of coronavirus infection. The purpose of this review is to present the most important underlying pathomechanisms in the development of COVID-19-related coagulopathy in diabetic patients. The methodology consisted of data collection and synthesis from the recent scientific literature by accessing different databases (Cochrane, PubMed, Embase). The main results are the comprehensive and detailed presentation of the very complex interrelations between different factors and pathways involved in the development of arteriopathy and thrombosis in COVID-19-infected diabetic patients. Several genetic and metabolic factors influence the course of COVID-19 within the background of diabetes mellitus. Extensive knowledge of the underlying pathomechanisms of SARS-CoV-2-related vasculopathy and coagulopathy in diabetic subjects contributes to a better understanding of the manifestations in this highly vulnerable group of patients; thus, they can benefit from a modern, more efficient approach regarding diagnostic and therapeutic management.<\/jats:p>","DOI":"10.3390\/ijms24054319","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T03:32:17Z","timestamp":1677036737000},"page":"4319","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pathways of Coagulopathy and Inflammatory Response in SARS-CoV-2 Infection among Type 2 Diabetic Patients"],"prefix":"10.3390","volume":"24","author":[{"given":"Orsolya-Zsuzsa","family":"Ak\u00e1csos-Sz\u00e1sz","sequence":"first","affiliation":[{"name":"Doctoral School, Faculty of Medicine, George Emil Palade University of Medicine Pharmacy, Science, and Technology of T\u00e2rgu Mure\u015f, 540142 T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3993-7947","authenticated-orcid":false,"given":"S\u00e1ndor","family":"P\u00e1l","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga-Ilona","family":"Nyulas","sequence":"additional","affiliation":[{"name":"Doctoral School, Faculty of Medicine, George Emil Palade University of Medicine Pharmacy, Science, and Technology of T\u00e2rgu Mure\u015f, 540142 T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enik\u0151","family":"Nemes-Nagy","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Medical Biochemistry, Faculty of Medicine in English, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u015f, 540142 T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Maria","family":"F\u00e1rr","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u015f, 540142 T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00f3r\u00e1nd","family":"D\u00e9nes","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u015f, 540142 T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nika","family":"Szilveszter","sequence":"additional","affiliation":[{"name":"Clinic of Plastic Surgery, Mure\u0219 County Emergency Hospital, 540136 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika-Gy\u00f6ngyi","family":"B\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine in English, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u015f, 540142 T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Cornelia","family":"Tilinca","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Faculty of Medicine in English, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u015f, 540142 T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6655-5987","authenticated-orcid":false,"given":"Zsuzs\u00e1nna","family":"Simon-Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u015f, 540142 T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"key":"ref_1","unstructured":"(2022, December 30). WHO\u2013Diabetes Mellitus Classification. Available online: https:\/\/www.who.int\/publications\/i\/item\/classification-of-diabetes-mellitus."},{"key":"ref_2","unstructured":"(2022, December 30). WHO\u2013COVID-19. Available online: https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019."},{"key":"ref_3","first-page":"1123","article-title":"Impact of COVID-19 Pandemic on Vascular Surgery Unit Activity in Central Romania","volume":"9","author":"Kaller","year":"2022","journal-title":"Front. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"772865","DOI":"10.3389\/fendo.2021.772865","article-title":"COVID-19 and Diabetes: A Comprehensive Review of Angiotensin Converting Enzyme 2, Mutual Effects and Pharmacotherapy","volume":"19","author":"Xie","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Arb\u0103na\u0219i, E.M., Halmaciu, I., Kaller, R., Mure\u0219an, A.V., Arb\u0103na\u0219i, E.M., Suciu, B.A., Co\u0219arc\u0103, C.M., Cojocaru, I.I., Melinte, R.M., and Russu, E. (2022). Systemic Inflammatory Biomarkers and Chest CT Findings as Predictors of Acute Limb Ischemia Risk, Intensive Care Unit Admission, and Mortality in COVID-19 Patients. Diagnostics, 12.","DOI":"10.3390\/diagnostics12102379"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Simon, P., Le Borgne, P., Lefevbre, F., Cipolat, L., Remillon, A., Dib, C., Hoffmann, M., Gardeur, I., Sabah, J., and Kepka, S. (2022). Platelet-to-Lymphocyte Ratio (PLR) Is Not a Predicting Marker of Severity but of Mortality in COVID-19 Patients Admitted to the Emergency Department: A Retrospective Multicenter Study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11164903"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Rose, J., Suter, F., Furrer, E., Sendoel, A., St\u00fcssi-Helbling, M., and Huber, L.C. (2022). Neutrophile-to-Lymphocyte Ratio (NLR) Identifies Patients with Coronavirus Infectious Disease 2019 (COVID-19) at High Risk for Deterioration and Mortality\u2014A Retrospective, Monocentric Cohort Study. Diagnostics, 12.","DOI":"10.3390\/diagnostics12051109"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/jmv.27297","article-title":"Role of Platelet-to-Lymphocyte Count Ratio (PLR), as a Prognostic Indicator in COVID-19: A Systematic Review and Meta-Analysis","volume":"94","author":"Sarkar","year":"2022","journal-title":"J. Med. Virol."},{"key":"ref_9","first-page":"10","article-title":"Diabetes Mellitus and Peripheral Vascular Disease","volume":"7","author":"Radha","year":"2020","journal-title":"Int. J. Contemp. Med. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.thromres.2020.04.013","article-title":"Incidence of thrombotic complications in critically ill ICU patients with COVID-19","volume":"191","author":"Klok","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1007\/s11239-021-02475-7","article-title":"Incidence of thrombotic complications in COVID-19","volume":"52","author":"Jenner","year":"2021","journal-title":"J. Thromb."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/anae.15300","article-title":"The impact of protocol-based high-intensity pharmacological thromboprophylaxis on thrombotic events in critically ill COVID-19 patients","volume":"76","author":"Atallah","year":"2021","journal-title":"Anaesthesia"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e575","DOI":"10.1016\/S2352-3026(20)30216-7","article-title":"Endotheliopathy in COVID-19-associated coagulopathy: Evidence from a single-centre, cross-sectional study","volume":"7","author":"Goshua","year":"2020","journal-title":"Lancet Haematol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Moisa, E., Corneci, D., Negoita, S., Filimon, C.R., Serbu, A., Negutu, M.I., and Grintescu, I.M. (2021). Dynamic Changes of the Neutrophil-to-Lymphocyte Ratio, Systemic Inflammation Index, and Derived Neutrophil-to-Lymphocyte Ratio Independently Predict Invasive Mechanical Ventilation Need and Death in Critically Ill COVID-19 Patients. Biomedicines, 9.","DOI":"10.3390\/biomedicines9111656"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Halmaciu, I., Arb\u0103na\u0219i, E.M., Kaller, R., Mure\u0219an, A.V., Arb\u0103na\u0219i, E.M., Bacalbasa, N., Suciu, B.A., Cojocaru, I.I., Runcan, A.I., and Grosu, F. (2022). Chest CT Severity Score and Systemic Inflammatory Biomarkers as Predictors of the Need for Invasive Mechanical Ventilation and of COVID-19 Patients\u2019 Mortality. Diagnostics, 12.","DOI":"10.3390\/diagnostics12092089"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"E629","DOI":"10.1152\/ajpendo.00247.2020","article-title":"Endothelial dysfunction due to selective insulin resistance in vascular endothelium: Insights from mechanistic modeling","volume":"319","author":"Muniyappa","year":"2020","journal-title":"Am. J. Physio. Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.3390\/cimb44080233","article-title":"Topical Reappraisal of Molecular Pharmacological Approaches to Endothelial Dysfunction in Diabetes Mellitus Angiopathy","volume":"44","author":"Munteanu","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1093\/jmcb\/mjab024","article-title":"Diabetes pathogenesis and management: The endothelium comes of age, J","volume":"13","author":"Love","year":"2021","journal-title":"Mol. Cell Biol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Maruhashi, T., and Higashi, Y. (2021). Pathophysiological Association between Diabetes Mellitus and Endothelial Dysfunction. Antioxidants, 10.","DOI":"10.3390\/antiox10081306"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3803\/EnM.2020.35.2.260","article-title":"Recent updates on vascular complications in patients with type 2 diabetes mellitus","volume":"35","author":"Jung","year":"2020","journal-title":"Endocrinol. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K.B., Ostolaza, H., and Mart\u00edn, C. (2020). Pathophysiology of Type 2 Diabetes Mellitus. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176275"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.2147\/DMSO.S302621","article-title":"Dpp-4 inhibitors have different effects on endothelial low-grade inflammation and on the m1-m2 macrophage polarization under hyperglycemic conditions","volume":"14","author":"Prattichizzo","year":"2021","journal-title":"Diabetes Metab. Syndr. Obes. Targets Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3389\/fimmu.2020.01582","article-title":"The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System","volume":"11","author":"Daryabor","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"62235","DOI":"10.1007\/s11356-021-16356-2","article-title":"Mechanical dependency of the SARS-CoV-2 virus and the renin-angiotensin-aldosterone (RAAS) axis: A possible new threat","volume":"29","author":"Sen","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Iacobini, C., Vitale, M., Pesce, C., Pugliese, G., and Menini, S. (2021). Diabetic Complications and Oxidative Stress: A 20-Year Voyage Back in Time and Back to the Future. Antioxidants, 10.","DOI":"10.3390\/antiox10050727"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Gusev, E., Sarapultsev, A., Hu, D., and Chereshnev, V. (2021). Problems of Pathogenesis and Pathogenetic Therapy of COVID-19 from the Perspective of the General Theory of Pathological Systems (General Pathological Processes). Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147582"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41368-020-0074-x","article-title":"High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa","volume":"12","author":"Xu","year":"2020","journal-title":"Int. J. Oral Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"109813","DOI":"10.1016\/j.diabres.2022.109813","article-title":"Diabetes and COVID-19: The potential role of mTOR","volume":"186","author":"Pinchera","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"154845","DOI":"10.1016\/j.metabol.2021.154845","article-title":"Thromboembolism risk among patients with diabetes\/stress hyperglycemia and COVID-19","volume":"123","author":"Calvisi","year":"2021","journal-title":"Metabolism"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fmed.2020.00248","article-title":"The Lung, the Heart, the Novel Coronavirus, and the Renin-Angiotensin System; The Need for Clinical Trials","volume":"22","author":"Lumbers","year":"2020","journal-title":"Front. Med. (Lausanne)"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00408-020-00408-4","article-title":"ACE2: The Major Cell Entry Receptor for SARS-CoV-2","volume":"198","author":"Scialo","year":"2020","journal-title":"Lung"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.tcm.2020.12.004","article-title":"COVID-19 and thrombosis: From bench to bedside","volume":"31","author":"Ali","year":"2021","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Gudowska-Sawczuk, M., and Mroczko, B. (2022). The Role of Nuclear Factor Kappa B (NF-\u03baB) in Development and Treatment of COVID-19: Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23095283"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1097\/CCM.0000000000004458","article-title":"Coagulopathy of Coronavirus Disease 2019","volume":"48","author":"Iba","year":"2020","journal-title":"Crit. Care Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Lab\u00f2, N., Ohnuki, H., and Tosato, G. (2020). Vasculopathy and Coagulopathy Associated with SARS-CoV-2 Infection. Cells, 9.","DOI":"10.3390\/cells9071583"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Iba, T., Warkentin, T.E., Thachil, J., Levi, M., and Levy, J.H. (2021). Proposal of the Definition for COVID-19-Associated Coagulopathy. J. Clin. Med., 10.","DOI":"10.3390\/jcm10020191"},{"key":"ref_39","first-page":"e9438","article-title":"A review of postmortem findings in patients with COVID-19","volume":"12","author":"Eketunde","year":"2020","journal-title":"Cureus"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s10456-020-09730-0","article-title":"Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients","volume":"23","author":"Smadja","year":"2020","journal-title":"Angiogenesis"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Gemmati, D., Bramanti, B., Serino, M.L., Secchiero, P., Zauli, G., and Tisato, V. (2020). COVID-19 and Individual Genetic Susceptibility\/Receptivity: Role of ACE1\/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103474"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"100745","DOI":"10.1016\/j.blre.2020.100745","article-title":"Coagulation dysfunction in COVID-19: The interplay between inflammation, viral infection and the coagulation system","volume":"46","author":"Lazzaroni","year":"2021","journal-title":"Blood Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1080\/14787210.2021.1915129","article-title":"Cytokine storm associated coagulation complications in COVID-19 patients: Pathogenesis and Management","volume":"19","author":"Savla","year":"2021","journal-title":"Expert Rev. Anti-Infect Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"100742","DOI":"10.1016\/j.cpcardiol.2020.100742","article-title":"Thrombosis and Coagulopathy in COVID-19","volume":"46","author":"Montes","year":"2021","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3389\/fimmu.2020.01446","article-title":"The COVID-19 Cytokine Storm; What We Know So Far","volume":"11","author":"Ragab","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3389\/fcvm.2020.00143","article-title":"Renin-Angiotensin System and Coronavirus Disease 2019: A Narrative Review","volume":"7","author":"Mascolo","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00134-020-05985-9","article-title":"Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: Molecular mechanisms and potential therapeutic target","volume":"46","author":"Zhang","year":"2020","journal-title":"Intensive Care Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e13097","DOI":"10.1111\/sji.13097","article-title":"Systemic inflammation in COVID-19 patients may induce various types of venous and arterial thrombosis: A systematic review","volume":"94","author":"Tomerak","year":"2021","journal-title":"Scand J. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kaiafa, G., Savopoulos, C., Karlafti, E., Pantazi, K., Paramythiotis, D., Thomaidou, E., Daios, S., Ztriva, E., Gionis, M., and Fyntanidou, V. (2022). Coagulation Profile of COVID-19 Patients. Life, 12.","DOI":"10.3390\/life12101658"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/17474086.2021.1875813","article-title":"Complement activation and coagulopathy\u2014An ominous duo in COVID19","volume":"14","author":"Tomo","year":"2021","journal-title":"Expert Rev. Hematol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1111\/jth.15050","article-title":"Is the COVID-19 thrombotic catastrophe complement-connected?","volume":"18","author":"Conway","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Galarza, J., Pr\u00f3cel, C., Ca\u00f1adas, C., Aguirre, D., Pibaque, R., Bed\u00f3n, R., Semp\u00e9rtegui, F., Drexhage, H., and Balde\u00f3n, L. (2021). Immune Response to SARS-CoV-2 Infection in Obesity and T2D: Literature Review. Vaccines, 9.","DOI":"10.3390\/vaccines9020102"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.kisu.2021.12.001","article-title":"The innate immune response, microenvironment proteinases, and the COVID-19 pandemic: Pathophysiologic mechanisms and emerging therapeutic targets","volume":"12","author":"Hollenberg","year":"2022","journal-title":"Kidney Int. Suppl."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"112087","DOI":"10.1016\/j.fct.2021.112087","article-title":"Inflammation, immunity and potential target therapy of SARS-COV-2: A total scale analysis review","volume":"150","author":"Smail","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"109749","DOI":"10.1016\/j.mehy.2020.109749","article-title":"May IL-17 have a role in COVID-19 infection?","volume":"140","author":"Megna","year":"2020","journal-title":"Med. Hypotheses"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41586-020-2600-6","article-title":"Association of COVID-19 inflammation with activation of the C5a\u2013C5aR1 axis","volume":"588","author":"Carvelli","year":"2020","journal-title":"Nature"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"eabh2259","DOI":"10.1126\/sciimmunol.abh2259","article-title":"Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection","volume":"6","author":"Ma","year":"2021","journal-title":"Sci. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s11239-020-02324-z","article-title":"Neutrophil extracellular traps and thrombosis in COVID-19","volume":"51","author":"Zuo","year":"2021","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/1074248420958973","article-title":"COVID-19 Infection: Viral Macro- and Micro-Vascular Coagulopathy and Thromboembolism\/Prophylactic and Therapeutic Management","volume":"26","author":"Manolis","year":"2021","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"6151","DOI":"10.1172\/JCI141374","article-title":"Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis","volume":"130","author":"Skendros","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13045-021-01082-6","article-title":"SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism","volume":"14","author":"Shen","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Thierry, A.R., and Roch, B. (2020). Neutrophil Extracellular Traps and By-Products Play a Key Role in COVID-19: Pathogenesis, Risk Factors, and Therapy. J. Clin. Med., 9.","DOI":"10.3390\/jcm9092942"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1161\/CIRCULATIONAHA.120.048488","article-title":"Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy","volume":"142","author":"Nicolai","year":"2020","journal-title":"Circulation"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"953129","DOI":"10.3389\/fimmu.2022.953129","article-title":"Platelets in the NETworks interweaving inflammation and thrombosis","volume":"13","author":"Wienkamp","year":"2022","journal-title":"Front. Imunol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1007\/s10067-020-05275-1","article-title":"Thrombosis in Coronavirus disease 2019 (COVID-19) through the prism of Virchow\u2019s triad","volume":"39","author":"Ahmed","year":"2020","journal-title":"Clin. Rheumatol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1213\/ANE.0000000000004985","article-title":"Technologies to optimize the care of severe COVID-19 patients for health care providers challenged by limited resources","volume":"131","author":"Rubulotta","year":"2020","journal-title":"Anesth. Analg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"332","DOI":"10.5152\/TJAR.2021.21118","article-title":"Role of Thromboelastography and Thromboelastometry in Predicting Risk of Hypercoagulability and Thrombosis in Critically Ill COVID-19 Patients: A Qualitative Systematic Review","volume":"50","author":"Singh","year":"2022","journal-title":"Turk J. Anaesthesiol. Reanim."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s11239-020-02312-3","article-title":"Rotational thromboelastometry results are associated with care level in COVID-19","volume":"51","author":"Almskog","year":"2021","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e29738","DOI":"10.1097\/MD.0000000000029738","article-title":"\u00df Rotational thromboelastometry in patients with type 2 diabetes and mild COVID-19 pneumonia: A pilot prospective study","volume":"101","author":"Bolek","year":"2022","journal-title":"Medicine"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1080\/09537104.2021.1881949","article-title":"Rotational Thromboelastometry (ROTEM) Profiling of COVID\u201319 Patients","volume":"32","author":"Mitrovic","year":"2021","journal-title":"Platelets"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Schrick, D., T\u0151k\u00e9s-F\u00fczesi, M., R\u00e9ger, B., and Moln\u00e1r, T. (2021). Plasma Fibrinogen Independently Predicts Hypofibrinolysis in Severe COVID-19. Metabolites, 11.","DOI":"10.3390\/metabo11120826"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1093\/bib\/bbaa426","article-title":"Bioinformatics, and system biology approach to identify the influences of COVID-19 on cardiovascular and hypertensive comorbidities","volume":"22","author":"Nashiry","year":"2021","journal-title":"Brief Bioinform."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"104668","DOI":"10.1016\/j.compbiomed.2021.104668","article-title":"Identifying molecular insight of synergistic complexities for SARS-CoV-2 infection with pre-existing type 2 diabetes","volume":"136","author":"Islam","year":"2021","journal-title":"Comput. Biol. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.physrep.2019.12.004","article-title":"Computational network biology: Data, model, and applications","volume":"846","author":"Liu","year":"2020","journal-title":"Phys. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1093\/bib\/bbaa207","article-title":"Comparative host\u2013pathogen protein\u2013protein interaction analysis of recent coronavirus outbreaks and important host targets identification","volume":"22","author":"Khan","year":"2021","journal-title":"Brief Bioinform."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1093\/cid\/ciaa462","article-title":"Down-regulated gene expression spectrum and immune responses changed during the disease progression in COVID-19 patients","volume":"71","author":"Ouyang","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2147\/JIR.S278335","article-title":"Inflammatory cytokine: IL-17A signaling pathway in patients present with COVID-19 and current treatment strategy","volume":"13","author":"Shibabaw","year":"2020","journal-title":"J. Inflamm. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jmii.2020.03.005","article-title":"TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor fedratinib","volume":"53","author":"Wu","year":"2020","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e3377","DOI":"10.1002\/dmrr.3377","article-title":"Obesity and diabetes as high-risk factors for severe coronavirus disease 2019 (Covid-19)","volume":"37","author":"Zhou","year":"2021","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cytogfr.2020.05.003","article-title":"The cytokine storm in COVID-19: An overview of the involvement of the chemokine\/chemokine-receptor system","volume":"53","author":"Coperchini","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1388415","DOI":"10.1155\/2022\/1388415","article-title":"MicroRNA-34a Promotes Ischemia-Induced Cardiomyocytes Apoptosis through Targeting Notch1","volume":"2022","author":"Pan","year":"2022","journal-title":"Evid. Based Complement Altern. Med."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Cerf, M.E. (2020). Beta Cell Physiological Dynamics and Dysfunctional Transitions in Response to Islet Inflammation in Obesity and Diabetes. Metabolites, 10.","DOI":"10.3390\/metabo10110452"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"110448","DOI":"10.1016\/j.mehy.2020.110448","article-title":"Downregulation of microRNA-146a in diabetes, obesity and hypertension may contribute to severe COVID-19","volume":"146","year":"2021","journal-title":"Med. Hypotheses"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/bib\/bbaa173","article-title":"Pathogenetic profiling of COVID-19 and SARS-like viruses","volume":"22","author":"Nain","year":"2021","journal-title":"Brief Bioinform."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"107641","DOI":"10.1016\/j.intimp.2021.107641","article-title":"Acute and post-acute phase of COVID-19: Analyzing expression patterns of miRNA-29a-3p, 146a-3p, 155-5p, and let-7b-3p in PBMC","volume":"97","author":"Donyavi","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Saik, O.V., and Klimontov, V.V. (2022). Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity?. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137247"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Fakhouri, E.W., Peterson, S.J., Kothari, J., Alex, R., Shapiro, J.I., and Abraham, N.G. (2020). Genetic polymorphisms complicate COVID-19 therapy pivotal role of HO-1 in cytokine storm. Antioxidants, 9.","DOI":"10.3390\/antiox9070636"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e13571","DOI":"10.1111\/apha.13571","article-title":"Sex differences in antiviral immunity in SARS-CoV-2 infection: Mitochondria and mitomiR come into view","volume":"231","author":"Iessi","year":"2021","journal-title":"Acta Physiol. (Oxf)"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"H296","DOI":"10.1152\/ajpheart.00755.2020","article-title":"Sex differences in COVID-19: Candidate pathways, genetics of ACE2, and sex hormones","volume":"320","author":"Viveiros","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41581-020-0278-5","article-title":"Genetics of diabetes mellitus and diabetes complications","volume":"16","author":"Cole","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_92","first-page":"105520","article-title":"Noncoding RNAs involved in DNA methylation and histone methylation, and acetylation in diabetic vascular complications, Pharmacol","volume":"170","author":"Lu","year":"2021","journal-title":"Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/15384101.2020.1867792","article-title":"MicroRNAs and SARS-CoV-2 life cycle, pathogenesis, and mutations: Biomarkers or therapeutic agents?","volume":"20","author":"Abedi","year":"2021","journal-title":"Cell Cycle"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1111\/dom.14098","article-title":"Why is hyperglycaemia worsening COVID-19 and its prognosis?","volume":"20","author":"Ceriello","year":"2020","journal-title":"Diabetes Obes. Metab."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s40520-020-01631-y","article-title":"COVID-19 and the elderly: Insights into pathogenesis and clinical decision-making","volume":"32","author":"Perrotta","year":"2020","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"833355","DOI":"10.3389\/fimmu.2022.833355","article-title":"Type 2 Diabetes Contributes to Altered Adaptive Immune Responses and Vascular Inflammation in Patients With SARS-CoV-2 Infection","volume":"13","author":"Singh","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2337\/db19-0327","article-title":"A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive \u03b2-Cell Hyperplasia","volume":"69","author":"Kusminski","year":"2020","journal-title":"Diabetes"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e170","DOI":"10.2337\/dc20-1551","article-title":"New-onset type 1 diabetes in children during COVID-19: Multicenter regional findings in the U.K","volume":"43","author":"Unsworth","year":"2020","journal-title":"Diabetes Care"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1177\/1932296820924469","article-title":"Glycemic characteristics and clinical outcomes of COVID-19 patients hospitalized in the United States","volume":"14","author":"Bode","year":"2020","journal-title":"J. Diabetes Sci. Technol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.numecd.2020.05.014","article-title":"Diabetes as a risk factor for greater COVID-19 severity and in-hospital death: A meta-analysis of observational studies","volume":"30","author":"Mantovani","year":"2020","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s40618-020-01236-2","article-title":"Prevalence and impact of diabetes among people infected with SARS-CoV-2","volume":"43","author":"Fadini","year":"2020","journal-title":"J. Endocrinol. Investig."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/5\/4319\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:38:40Z","timestamp":1760121520000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/5\/4319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,21]]},"references-count":101,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["ijms24054319"],"URL":"https:\/\/doi.org\/10.3390\/ijms24054319","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,21]]}}}