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In fact, more than 9 million deaths worldwide were associated with respiratory diseases in 2016, equivalent to 15% of global deaths, and the prevalence is increasing every year as the population ages. Due to inadequate treatment options, the treatments for many respiratory diseases are limited to relieving symptoms rather than curing the disease. Therefore, new therapeutic strategies for respiratory diseases are urgently needed. Poly (lactic-co-glycolic acid) micro\/nanoparticles (PLGA M\/NPs) have good biocompatibility, biodegradability and unique physical and chemical properties, making them one of the most popular and effective drug delivery polymers. In this review, we summarized the synthesis and modification methods of PLGA M\/NPs and their applications in the treatment of respiratory diseases (asthma, COPD, cystic fibrosis (CF), etc.) and also discussed the research progress and current research status of PLGA M\/NPs in respiratory diseases. It was concluded that PLGA M\/NPs are the promising drug delivery vehicles for the treatment of respiratory diseases due to their advantages of low toxicity, high bioavailability, high drug loading capacity, plasticity and modifiability. And at the end, we presented an outlook on future research directions, aiming to provide some new ideas for future research directions and hopefully to promote their widespread application in clinical treatment.<\/jats:p>","DOI":"10.3390\/ijms24054333","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T03:32:17Z","timestamp":1677036737000},"page":"4333","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["PLGA-Based Micro\/Nanoparticles: An Overview of Their Applications in Respiratory Diseases"],"prefix":"10.3390","volume":"24","author":[{"given":"Xiaoping","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinuo","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caina","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Basic Medical Sciences, Jilin University, Changchun 130021, China"},{"name":"Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0871-3454","authenticated-orcid":false,"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China"},{"name":"Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"103541","DOI":"10.1016\/j.jddst.2022.103541","article-title":"Advances and applications of monoolein as a novel nanomaterial in mitigating chronic lung diseases","volume":"74","author":"Chan","year":"2022","journal-title":"J. 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