{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:11:22Z","timestamp":1788372682689,"version":"build-2803163510"},"reference-count":377,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011011","name":"Junta de Andalucia","doi-asserted-by":"publisher","award":["RH-0141-2020"],"award-info":[{"award-number":["RH-0141-2020"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andalucia","doi-asserted-by":"publisher","award":["CD20\/00022"],"award-info":[{"award-number":["CD20\/00022"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RH-0141-2020"],"award-info":[{"award-number":["RH-0141-2020"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CD20\/00022"],"award-info":[{"award-number":["CD20\/00022"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The life expectancy of the global population has increased. Aging is a natural physiological process that poses major challenges in an increasingly long-lived and frail population. Several molecular mechanisms are involved in aging. Likewise, the gut microbiota, which is influenced by environmental factors such as diet, plays a crucial role in the modulation of these mechanisms. The Mediterranean diet, as well as the components present in it, offer some proof of this. Achieving healthy aging should be focused on the promotion of healthy lifestyle habits that reduce the development of pathologies that are associated with aging, in order to increase the quality of life of the aging population. In this review we analyze the influence of the Mediterranean diet on the molecular pathways and the microbiota associated with more favorable aging patterns, as well as its possible role as an anti-aging treatment.<\/jats:p>","DOI":"10.3390\/ijms24054491","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T03:23:36Z","timestamp":1677468216000},"page":"4491","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Influence of the Mediterranean Diet on Healthy Aging"],"prefix":"10.3390","volume":"24","author":[{"given":"Maria Carmen","family":"Andreo-L\u00f3pez","sequence":"first","affiliation":[{"name":"Endocrinology and Nutrition Unit, University Hospital Cl\u00ednico San Cecilio, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Contreras-Bol\u00edvar","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, University Hospital Cl\u00ednico San Cecilio, 18016 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (Ibs. Granada), 18014 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9645-3260","authenticated-orcid":false,"given":"Manuel","family":"Mu\u00f1oz-Torres","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, University Hospital Cl\u00ednico San Cecilio, 18016 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (Ibs. Granada), 18014 Granada, Spain"},{"name":"CIBER on Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, 18012 Granada, Spain"},{"name":"Department of Medicine, University of Granada, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-5561","authenticated-orcid":false,"given":"Beatriz","family":"Garc\u00eda-Fontana","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (Ibs. Granada), 18014 Granada, Spain"},{"name":"CIBER on Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, 18012 Granada, Spain"},{"name":"Department of Cell Biology, University of Granada, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9328-6022","authenticated-orcid":false,"given":"Cristina","family":"Garc\u00eda-Fontana","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, University Hospital Cl\u00ednico San Cecilio, 18016 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (Ibs. Granada), 18014 Granada, Spain"},{"name":"CIBER on Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0140-6736(15)00516-4","article-title":"The World Report on Ageing and Health: A Policy Framework for Healthy Ageing","volume":"387","author":"Beard","year":"2016","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"R741","DOI":"10.1016\/j.cub.2012.07.024","article-title":"Ageing as a Risk Factor for Disease","volume":"22","author":"Niccoli","year":"2012","journal-title":"Curr. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.maturitas.2020.05.018","article-title":"The World Health Organization (WHO) Approach to Healthy Ageing","volume":"139","author":"Rudnicka","year":"2020","journal-title":"Maturitas"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The Hallmarks of Aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.arr.2017.01.001","article-title":"Gut Microbiota: A Player in Aging and a Target for Anti-Aging Intervention","volume":"35","author":"Vaiserman","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Sanchez-Morate, E., Gimeno-Mallench, L., Stromsnes, K., Sanz-Ros, J., Rom\u00e1n-Dom\u00ednguez, A., Parejo-Pedrajas, S., Ingl\u00e9s, M., Olaso, G., Gambini, J., and Mas-Bargues, C. (2020). Relationship between Diet, Microbiota, and Healthy Aging. Biomedicines, 8.","DOI":"10.3390\/biomedicines8080287"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3389\/fphys.2012.00263","article-title":"The Endoplasmic Reticulum Stress Response in Aging and Age-Related Diseases","volume":"3","author":"Brown","year":"2012","journal-title":"Front. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.mcna.2006.05.019","article-title":"Frailty","volume":"90","author":"Morley","year":"2006","journal-title":"Med. Clin. N. Am."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1126\/scitranslmed.3004925","article-title":"Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans","volume":"5","author":"Titus","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fgene.2012.00134","article-title":"What Is Aging?","volume":"3","author":"Rose","year":"2012","journal-title":"Front. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1474-9726.2012.00807.x","article-title":"Is Cellular Senescence an Example of Antagonistic Pleiotropy?","volume":"11","author":"Giaimo","year":"2012","journal-title":"Aging Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/nm.4000","article-title":"Cellular Senescence in Aging and Age-Related Disease: From Mechanisms to Therapy","volume":"21","author":"Childs","year":"2015","journal-title":"Nat. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cmet.2011.12.006","article-title":"P53-Induced Adipose Tissue Inflammation Is Critically Involved in the Development of Insulin Resistance in Heart Failure","volume":"15","author":"Shimizu","year":"2012","journal-title":"Cell Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2165\/00007256-200030050-00002","article-title":"Insulin Resistance with Aging","volume":"30","author":"Ryan","year":"2012","journal-title":"Sport. Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Capurso, C., Bellanti, F., Buglio, A.L., and Vendemiale, G. (2020). The Mediterranean Diet Slows down the Progression of Aging and Helps to Prevent the Onset of Frailty: A Narrative Review. Nutrients, 12.","DOI":"10.3390\/nu12010035"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/jnu.12258","article-title":"Frailty Is a Major Related Factor for at Risk of Malnutrition in Community-Dwelling Older Adults","volume":"49","author":"Chang","year":"2017","journal-title":"J. Nurs. Scholarsh."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s12603-018-1138-x","article-title":"Association of Obesity and Frailty in Older Adults: NHANES 1999\u20132004","volume":"23","author":"Crow","year":"2019","journal-title":"J. Nutr. Health Aging"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.2147\/CIA.S84632","article-title":"Body Composition as a Frailty Marker for the Elderly Community","volume":"10","author":"Falsarella","year":"2015","journal-title":"Clin. Interv. Aging"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.archger.2017.03.008","article-title":"Body Composition and Frailty Profiles in Brazilian Older People: Frailty in Brazilian Older People Study-FIBRA-BR","volume":"71","author":"Ferriolli","year":"2017","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2147\/CIA.S243211","article-title":"Association between Body Composition and Frailty in Elder Inpatients","volume":"15","author":"Xu","year":"2020","journal-title":"Clin. Interv. Aging"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(12)62167-9","article-title":"Frailty in Elderly People","volume":"381","author":"Clegg","year":"2013","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0091-7435(84)90047-1","article-title":"The Seven Countries Study: 2,289 Deaths in 15 Years","volume":"13","author":"Keys","year":"1984","journal-title":"Prev. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1321S","DOI":"10.1093\/ajcn\/61.6.1321S","article-title":"Mediterranean Diet and Public Health: Personal Reflections","volume":"61","author":"Keys","year":"1995","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Dominguez, L.J., Di Bella, G., Veronese, N., and Barbagallo, M. (2021). Impact of Mediterranean Diet on Chronic Non-Communicable Diseases and Longevity. Nutrients, 13.","DOI":"10.3390\/nu13062028"},{"key":"ref_26","unstructured":"Hern\u00e1ndez, J.M., and Rentero, M.P.Z. (2018). Current Topics on Superfoods, InTech."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1093\/gerona\/gly087","article-title":"Nitric Oxide Boosting Effects of the Mediterranean Diet: A Potential Mechanism of Action","volume":"73","author":"Shannon","year":"2018","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/gerona\/glx227","article-title":"Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms","volume":"73","author":"Tosti","year":"2018","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.neurol.2019.08.005","article-title":"Mediterranean Diet: The Role of Long-Chain \u03c9-3 Fatty Acids in Fish; Polyphenols in Fruits, Vegetables, Cereals, Coffee, Tea, Cacao and Wine; Probiotics and Vitamins in Prevention of Stroke, Age-Related Cognitive Decline, and Alzheimer Disease","volume":"175","author":"Jackson","year":"2019","journal-title":"Rev. Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/s41430-020-00841-x","article-title":"Mediterranean Diet and the Hallmarks of Ageing","volume":"75","author":"Shannon","year":"2021","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/nbu.12429","article-title":"NuBrain: UK Consortium for Optimal Nutrition for Healthy Brain Ageing","volume":"45","author":"Stevenson","year":"2020","journal-title":"Nutr. Bull."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1017\/S0007114514003237","article-title":"Impact of Nutrition on the Ageing Process","volume":"113","author":"Mathers","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nrg2268","article-title":"Genome Instability: A Mechanistic View of Its Causes and Consequences","volume":"9","author":"Aguilera","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Mahat, R.K., Singh, N., Gupta, A., and Rathore, V. (2018). Oxidative DNA Damage and Carotid Intima Media Thickness as Predictors of Cardiovascular Disease in Prediabetic Subjects. J. Cardiovasc. Dev. Dis., 5.","DOI":"10.3390\/jcdd5010015"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Basu, A.K. (2018). DNA Damage, Mutagenesis and Cancer. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19040970"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Freitas-Simoes, T.M., Cof\u00e1n, M., Blasco, M.A., Sober\u00f3n, N., Foronda, M., Serra-Mir, M., Roth, I., Valls-Pedret, C., Dom\u00e9nech, M., and Ponferrada-Ariza, E. (2018). Walnut Consumption for Two Years and Leukocyte Telomere Attrition in Mediterranean Elders: Results of a Randomized Controlled Trial. Nutrients, 10.","DOI":"10.3390\/nu10121907"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Kiokias, S., Proestos, C., and Oreopoulou, V. (2018). Effect of Natural Food Antioxidants against LDL and DNA Oxidative Changes. Antioxidants, 7.","DOI":"10.20944\/preprints201809.0422.v1"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s13105-017-0552-6","article-title":"Adherence to Mediterranean Diet Is Associated with Methylation Changes in Inflammation-Related Genes in Peripheral Blood Cells","volume":"73","author":"Milagro","year":"2016","journal-title":"J. Physiol. Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"LB242","DOI":"10.1096\/fasebj.29.1_supplement.lb242","article-title":"Effect of the Mediterranean Diet on DNA Methylation of Selected Genes in the PREDIMED-Valencia Intervention Trial","volume":"29","author":"Corella","year":"2015","journal-title":"FASEB J."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Herrera-Marcos, L.V., Lou-Bonafonte, J.M., Arnal, C., Navarro, M.A., and Osada, J. (2017). Transcriptomics and the Mediterranean Diet: A Systematic Review. Nutrients, 9.","DOI":"10.3390\/nu9050472"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1152\/ajpheart.00260.2010","article-title":"Resveratrol Confers Endothelial Protection via Activation of the Antioxidant Transcription Factor Nrf2","volume":"299","author":"Ungvari","year":"2010","journal-title":"Am.J. Physiol Heart Circ. Physiol"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.rbmo.2016.09.006","article-title":"Oxidative Stress and Alterations in DNA Methylation: Two Sides of the Same Coin in Reproduction","volume":"33","author":"Menezo","year":"2016","journal-title":"Reprod. BioMedicine Online"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Valko, M., Izakovic, M., Mazur, M., Rhodes, C.J., and Telser, J. (2004). Role of Oxygen Radicals in DNA Damage and Cancer Incidence, Kluwer Academic Publishers.","DOI":"10.1023\/B:MCBI.0000049134.69131.89"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1093\/nar\/28.21.4138","article-title":"Error-Free and Error-Prone Lesion Bypass by Human DNA Polymerase \u03ba in Vitro","volume":"28","author":"Zhang","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.canlet.2007.12.007","article-title":"Mutagenicity of 8-Nitroguanosine, a Product of Nitrative Nucleoside Modification by Reactive Nitrogen Oxides, in Mammalian Cells","volume":"262","author":"Kaneko","year":"2008","journal-title":"Cancer Lett."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.atherosclerosis.2010.04.020","article-title":"Mediterranean Diet and Red Wine Protect against Oxidative Damage in Young Volunteers","volume":"211","author":"Urquiaga","year":"2010","journal-title":"Atherosclerosis"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/mutage\/gew012","article-title":"Dietary and Lifestyle Determinants of Malondialdehyde DNA Adducts in a Representative Sample of the Florence City Population","volume":"31","author":"Saieva","year":"2016","journal-title":"Mutagenesis"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s11130-017-0609-2","article-title":"Protective Effect of Juglans Regia L. Walnut Extract Against Oxidative DNA Damage","volume":"72","author":"Calcabrini","year":"2017","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1016\/j.fct.2012.07.048","article-title":"Phenols of Virgin Olive Oil Protects Nuclear DNA against Oxidative Damage in HeLa Cells","volume":"50","author":"Erol","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.trsl.2014.11.004","article-title":"Intake of Cooked Tomato Sauce Preserves Coronary Endothelial Function and Improves Apolipoprotein A-I and Apolipoprotein J Protein Profile in High-Density Lipoproteins","volume":"166","author":"Vilahur","year":"2015","journal-title":"Transl. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1093\/jnci\/93.24.1872","article-title":"Oxidative DNA Damage in Prostate Cancer Patients Consuming Tomato Sauce-Based Entrees as a Whole-Food Intervention","volume":"93","author":"Chen","year":"2001","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/ajcn\/69.4.712","article-title":"Does Tomato Consumption Effectively Increase the Resistance of Lymphocyte DNA to Oxidative Damage?","volume":"69","author":"Riso","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1080\/01635580802425688","article-title":"Effect of Broccoli Intake on Markers Related to Oxidative Stress and Cancer Risk in Healthy Smokers and Nonsmokers","volume":"61","author":"Riso","year":"2009","journal-title":"Nutr. Cancer"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/mutage\/geq045","article-title":"DNA Damage and Repair Activity after Broccoli Intake in Young Healthy Smokers","volume":"25","author":"Riso","year":"2010","journal-title":"Mutagenesis"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00394-011-0167-6","article-title":"Impact of Spinach Consumption on DNA Stability in Peripheral Lymphocytes and on Biochemical Blood Parameters: Results of a Human Intervention Trial","volume":"50","author":"Moser","year":"2011","journal-title":"Eur. J. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s003940200014","article-title":"Spinach and Tomato Consumption Increases Lymphocyte DNA Resistance to Oxidative Stress but This Is Not Related to Cell Carotenoid Concentrations","volume":"41","author":"Porrini","year":"2014","journal-title":"Eur. J. Nutr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.nutres.2012.12.009","article-title":"A Single Portion of Blueberry (Vaccinium corymbosum L.) Improves Protection against DNA Damage but Not Vascular Function in Healthy Male Volunteers","volume":"33","author":"Riso","year":"2013","journal-title":"Nutr. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00394-012-0402-9","article-title":"Effect of a Wild Blueberry (Vaccinium Angustifolium) Drink Intervention on Markers of Oxidative Stress, Inflammation and Endothelial Function in Humans with Cardiovascular Risk Factors","volume":"52","author":"Riso","year":"2013","journal-title":"Eur. J. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.exger.2004.05.002","article-title":"Dietary Fat Type (Virgin Olive vs. Sunflower Oils) Affects Age-Related Changes in DNA Double-Strand-Breaks, Antioxidant Capacity and Blood Lipids in Rats","volume":"39","author":"Quiles","year":"2004","journal-title":"Exp. Gerontol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.mrrev.2014.11.002","article-title":"Oxidatively Induced DNA Damage and Its Repair in Cancer","volume":"763","author":"Dizdaroglu","year":"2015","journal-title":"Mutat. Res.\/Rev. Mutat. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6073","DOI":"10.1021\/jf030141v","article-title":"Protective Effect of Supplementation of Fish Oil with High N\u22123 Polyunsaturated Fatty Acids against Oxidative Stress-Induced DNA Damage of Rat Liver in Vivo","volume":"51","author":"Kikugawa","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/mnfr.201200343","article-title":"Vegetables and PUFA-Rich Plant Oil Reduce DNA Strand Breaks in Individuals with Type 2 Diabetes","volume":"57","author":"Brath","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.clnu.2012.08.002","article-title":"The Mediterranean Diet Improves the Systemic Lipid and DNA Oxidative Damage in Metabolic Syndrome Individuals. A Randomized, Controlled, Trial","volume":"32","author":"Mitjavila","year":"2013","journal-title":"Clin. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1096\/fj.09-148452","article-title":"In Vivo Nutrigenomic Effects of Virgin Olive Oil Polyphenols within the Frame of the Mediterranean Diet: A Randomized Controlled Trial","volume":"24","author":"Konstantinidou","year":"2010","journal-title":"FASEB J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.3390\/nu7064124","article-title":"Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study","volume":"7","author":"Ramallal","year":"2015","journal-title":"Nutrients"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.numecd.2017.05.004","article-title":"The PREDIMED Trial, Mediterranean Diet and Health Outcomes: How Strong Is the Evidence?","volume":"27","author":"Ros","year":"2017","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pcad.2015.04.003","article-title":"Benefits of the Mediterranean Diet: Insights From the PREDIMED Study","volume":"58","author":"Estruch","year":"2015","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/dmrr.2672","article-title":"Adherence to Mediterranean Diet and 10-Year Incidence (2002\u20132012) of Diabetes: Correlations with Inflammatory and Oxidative Stress Biomarkers in the ATTICA Cohort Study","volume":"32","author":"Koloverou","year":"2016","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1017\/S0007114516002099","article-title":"Association between Dietary Fibre Intake and Fruit, Vegetable or Whole-Grain Consumption and the Risk of CVD: Results from the PREvenci\u00f3n Con DIeta MEDiterr\u00e1nea (PREDIMED) Trial","volume":"116","author":"Toledo","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Del Bo\u2019, C., Marino, M., Martini, D., Tucci, M., Ciappellano, S., Riso, P., and Porrini, M. (2019). Overview of Human Intervention Studies Evaluating the Impact of the Mediterranean Diet on Markers of DNA Damage. Nutrients, 11.","DOI":"10.3390\/nu11020391"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/CEJ.0b013e328354d2d7","article-title":"Cancer Prevention in Europe: The Mediterranean Diet as a Protective Choice","volume":"22","author":"Giacosa","year":"2013","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Grosso, G., Buscemi, S., Galvano, F., Mistretta, A., Marventano, S., Vela, V.L., Drago, F., Gangi, S., Basile, F., and Biondi, A. (2013). Mediterranean Diet and Cancer: Epidemiological Evidence and Mechanism of Selected Aspects. BMC Surg., 13.","DOI":"10.1186\/1471-2482-13-S2-S14"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1002\/ijc.28824","article-title":"Adherence to Mediterranean Diet and Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies","volume":"135","author":"Schwingshackl","year":"2014","journal-title":"Int. J. Cancer"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Acevedo-Le\u00f3n, D., G\u00f3mez-Abril, S.\u00c1., Monz\u00f3-Beltr\u00e1n, L., Esta\u00f1-Capell, N., Arroyo-Monta\u00f1\u00e9s, R., Ba\u00f1uls, C., Salas-Salvad\u00f3, J., and S\u00e1ez, G. (2022). Adherence to the Mediterranean Diet Has a Protective Role against Metabolic and DNA Damage Markers in Colorectal Cancer Patients. Antioxidants, 11.","DOI":"10.3390\/antiox11030499"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1001\/jama.2009.1149","article-title":"Mediterranean Diet and Late-Life Cognitive Impairment: A Taste of Benefit","volume":"302","author":"Knopman","year":"2009","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"ref_76","first-page":"3","article-title":"Alternative Anti-Infective\/Anti-Inflammatory Therapeutic Options for Fighting Alzheimer\u2019s Disease","volume":"6","author":"Tsolaki","year":"2017","journal-title":"Front. Anti-Infect. Drug Discov."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1002\/elps.201300036","article-title":"Detection and Quantification of 8-Hydroxy-2\u2032-Deoxyguanosine in Alzheimer\u2019s Transgenic Mouse Urine Using Capillary Electrophoresis","volume":"34","author":"Zhang","year":"2013","journal-title":"Electrophoresis"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/j.1471-4159.2005.03615.x","article-title":"Increased Oxidative Damage in Nuclear and Mitochondrial DNA in Mild Cognitive Impairment","volume":"96","author":"Wang","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"111621","DOI":"10.1016\/j.exger.2021.111621","article-title":"Extra Virgin Olive Oil Consumption from Mild Cognitive Impairment Patients Attenuates Oxidative and Nitrative Stress Reflecting on the Reduction of the PARP Levels and DNA Damage","volume":"156","author":"Tzekaki","year":"2021","journal-title":"Exp. Gerontol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Coluzzi, E., Colamartino, M., Cozzi, R., Leone, S., Meneghini, C., O\u2019Callaghan, N., and Sgura, A. (2014). Oxidative Stress Induces Persistent Telomeric DNA Damage Responsible for Nuclear Morphology Change in Mammalian Cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0110963"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.3945\/ajcn.2009.27807","article-title":"Leukocyte Telomere Length: The Telomere Tale Continues","volume":"89","author":"Aviv","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/acel.12050","article-title":"Telomere Length Behaves as Biomarker of Somatic Redundancy Rather than Biological Age","volume":"12","author":"Boonekamp","year":"2013","journal-title":"Aging Cell"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1056\/NEJMra0903373","article-title":"Telomere Diseases","volume":"361","author":"Calado","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Boccardi, V., Esposito, A., Rizzo, M.R., Marfella, R., Barbieri, M., and Paolisso, G. (2013). Mediterranean Diet, Telomere Maintenance and Health Status among Elderly. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062781"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"g6674","DOI":"10.1136\/bmj.g6674","article-title":"Mediterranean Diet and Telomere Length in Nurses\u2019 Health Study: Population Based Cohort Study","volume":"349","author":"Fung","year":"2014","journal-title":"BMJ"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3945\/ajcn.115.116863","article-title":"Dietary Inflammatory Index and Telomere Length in Subjects with a High Cardiovascular Disease Risk from the PREDIMED-NAVARRA Study: Cross-Sectional and Longitudinal Analyses over 5 y","volume":"102","author":"Zalba","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1093\/advances\/nmaa079","article-title":"Mediterranean Diet and Telomere Length: A Systematic Review and Meta-Analysis","volume":"11","author":"Canudas","year":"2020","journal-title":"Adv. Nutr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.clnu.2016.03.013","article-title":"Mediterranean Diet and Telomere Length in High Cardiovascular Risk Subjects from the PREDIMED-NAVARRA Study","volume":"35","author":"Razquin","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1038\/s41430-018-0387-4","article-title":"Healthy Diets and Telomere Length and Attrition during a 10-Year Follow-Up","volume":"73","author":"Kautiainen","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s11357-015-9758-0","article-title":"Mediterranean Diet and Leukocyte Telomere Length in a Multi-Ethnic Elderly Population","volume":"37","author":"Gu","year":"2015","journal-title":"Age"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCGENETICS.114.000635","article-title":"Pro12Ala Polymorphism of the PPAR\u03b32 Gene Interacts with a Mediterranean Diet to Prevent Telomere Shortening in the PREDIMED-NAVARRA Randomized Trial","volume":"8","author":"Razquin","year":"2015","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.nut.2013.09.013","article-title":"Telomere Shortening in Elderly Individuals with Mild Cognitive Impairment May Be Attenuated with \u03c9-3 Fatty Acid Supplementation: A Randomized Controlled Pilot Study","volume":"30","author":"Parletta","year":"2014","journal-title":"Nutrition"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12877-019-1383-9","article-title":"Leukocyte Telomere Length and Serum Polyunsaturated Fatty Acids, Dietary Habits, Cardiovascular Risk Factors and Features of Myocardial Infarction in Elderly Patients","volume":"19","author":"Kalstad","year":"2019","journal-title":"BMC Geriatr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mad.2018.03.013","article-title":"The Impact of Oxidative DNA Damage and Stress on Telomere Homeostasis","volume":"177","author":"Barnes","year":"2019","journal-title":"Mech. Ageing Dev."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/mutage\/geaa005","article-title":"Telomere Maintenance in Interplay with DNA Repair in Pathogenesis and Treatment of Colorectal Cancer","volume":"35","author":"Tomasova","year":"2020","journal-title":"Mutagenesis"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12017-012-8207-9","article-title":"Telomere Shortening and Alzheimer\u2019s Disease","volume":"15","author":"Cai","year":"2013","journal-title":"Neuromolecular Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3233\/JAD-190134","article-title":"Leukocyte Telomere Length Shortening and Alzheimer\u2019s Disease Etiology","volume":"69","author":"Guo","year":"2019","journal-title":"J. Alzheimer\u2019s Dis. JAD"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.neuint.2011.02.010","article-title":"Oleuropein and Derivatives from Olives as Tau Aggregation Inhibitors","volume":"58","author":"Daccache","year":"2011","journal-title":"Neurochem. Int."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"S296","DOI":"10.1093\/advances\/nmz026","article-title":"Plant-Rich Dietary Patterns, Plant Foods and Nutrients, and Telomere Length","volume":"10","author":"Molinuevo","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1007\/s11357-012-9489-4","article-title":"Dietary Resveratrol Prevents Alzheimer\u2019s Markers and Increases Life Span in SAMP8","volume":"35","author":"Porquet","year":"2013","journal-title":"Age"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e1600584","DOI":"10.1126\/sciadv.1600584","article-title":"Epigenetics and Aging","volume":"2","author":"Pal","year":"2016","journal-title":"Sci. Adv."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA Methylation Age of Human Tissues and Cell Types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial Sequencing and Analysis of the Human Genome","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1093\/nar\/gnh032","article-title":"A Simple Method for Estimating Global DNA Methylation Using Bisulfite PCR of Repetitive DNA Elements","volume":"32","author":"Yang","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ijcard.2016.03.062","article-title":"The Role of Epigenetic Modifications in Cardiovascular Disease: A Systematic Review","volume":"212","author":"Muka","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Caradonna, F., Consiglio, O., Luparello, C., and Gentile, C. (2020). Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet. Nutrients, 12.","DOI":"10.3390\/nu12061748"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3389\/fgene.2018.00514","article-title":"Mediterranean Diet and Particulate Matter Exposure Are Associated With LINE-1 Methylation: Results From a Cross-Sectional Study in Women","volume":"9","author":"Barchitta","year":"2018","journal-title":"Front. Genet."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"14360","DOI":"10.1038\/s41598-020-71352-9","article-title":"Adherence to the Mediterranean Diet Partially Mediates Socioeconomic Differences in Leukocyte LINE-1 Methylation: Evidence from a Cross-Sectional Study in Italian Women","volume":"10","author":"Maugeri","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s12263-015-0480-4","article-title":"Low Fruit Consumption and Folate Deficiency Are Associated with LINE-1 Hypomethylation in Women of a Cancer-Free Population","volume":"10","author":"Agodi","year":"2015","journal-title":"Genes Nutr."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Arp\u00f3n, A., Milagro, F.I., Razquin, C., Corella, D., Estruch, R., Fit\u00f3, M., Marti, A., Mart\u00ednez-Gonz\u00e1lez, M.A., Ros, E., and Salas-Salvad\u00f3, J. (2018). Impact of Consuming Extra-Virgin Olive Oil or Nuts within a Mediterranean Diet on DNA Methylation in Peripheral White Blood Cells within the PREDIMED-Navarra Randomized Controlled Trial: A Role for Dietary Lipids. Nutrients, 10.","DOI":"10.3390\/nu10010015"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Barchitta, M., Quattrocchi, A., Maugeri, A., Vinciguerra, M., and Agodi, A. (2014). LINE-1 Hypomethylation in Blood and Tissue Samples as an Epigenetic Marker for Cancer Risk: A Systematic Review and Meta-Analysis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0109478"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Park, S.Y., Seo, A.N., Jung, H.Y., Gwak, J.M., Jung, N., Cho, N.Y., and Kang, G.H. (2014). Alu and LINE-1 Hypomethylation Is Associated with HER2 Enriched Subtype of Breast Cancer. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0100429"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.4161\/15592294.2014.969617","article-title":"Type 2 Diabetes Mellitus in Relation to Global LINE-1 DNA Methylation in Peripheral Blood: A Cohort Study","volume":"9","author":"Olveira","year":"2014","journal-title":"Epigenetics"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1868-7083-4-10","article-title":"LINE-1 Methylation in Visceral Adipose Tissue of Severely Obese Individuals Is Associated with Metabolic Syndrome Status and Related Phenotypes","volume":"4","author":"Turcot","year":"2012","journal-title":"Clin. Epigenetics"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13046-016-0371-6","article-title":"MicroRNA-155-3p Promotes Hepatocellular Carcinoma Formation by Suppressing FBXW7 Expression","volume":"35","author":"Tang","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/s41417-020-00223-2","article-title":"BATF3 Promotes Malignant Phenotype of Colorectal Cancer through the S1PR1\/p-STAT3\/MiR-155-3p\/WDR82 Axis","volume":"28","author":"Li","year":"2020","journal-title":"Cancer Gene Ther."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1038\/onc.2017.187","article-title":"Let-7b and Let-7c MicroRNAs Promote Histone H2B Ubiquitylation and Inhibit Cell Migration by Targeting Multiple Components of the H2B Deubiquitylation Machinery","volume":"36","author":"Spolverini","year":"2017","journal-title":"Oncogene"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.21037\/tlcr-21-299","article-title":"Let-7b-3p Inhibits Tumor Growth and Metastasis by Targeting the BRF2-Mediated MAPK\/ERK Pathway in Human Lung Adenocarcinoma","volume":"10","author":"Li","year":"2021","journal-title":"Transl. Lung Cancer Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.nut.2015.06.008","article-title":"Expression of Inflammation-Related MiRNAs in White Blood Cells from Subjects with Metabolic Syndrome after 8 Wk of Following a Mediterranean Diet-Based Weight Loss Program","volume":"32","author":"Milagro","year":"2016","journal-title":"Nutrition"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3389\/fnagi.2022.911635","article-title":"Epigenetics in Alzheimer\u2019s Disease","volume":"14","author":"Gao","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.celrep.2017.01.074","article-title":"Sirt1 Regulates DNA Methylation and Differentiation Potential of Embryonic Stem Cells by Antagonizing Dnmt3l","volume":"18","author":"Heo","year":"2017","journal-title":"Cell Rep."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.biopha.2019.01.035","article-title":"Quercetin Based Derivatives as Sirtuin Inhibitors","volume":"111","author":"Heger","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.neurobiolaging.2014.08.029","article-title":"Oleuropein Aglycone Protects against Pyroglutamylated-3 Amyloid-\u00df Toxicity: Biochemical, Epigenetic and Functional Correlates","volume":"36","author":"Luccarini","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/nm.4001","article-title":"Proteostasis and Aging","volume":"21","author":"Kaushik","year":"2015","journal-title":"Nat. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s11357-013-9597-9","article-title":"Superior Proteome Stability in the Longest Lived Animal","volume":"36","author":"Treaster","year":"2014","journal-title":"Age"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/cphy.c140041","article-title":"Metabolic Shifts during Aging and Pathology","volume":"5","author":"Ma","year":"2015","journal-title":"Compr. Physiol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1093\/gerona\/glu049","article-title":"Proteostasis and the Aging Proteome in Health and Disease","volume":"69","author":"Morimoto","year":"2014","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cell.2011.07.030","article-title":"Autophagy and Aging","volume":"146","author":"Rubinsztein","year":"2011","journal-title":"Cell"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1172\/JCI73946","article-title":"Essential Role for Autophagy in Life Span Extension","volume":"125","author":"Madeo","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"35344","DOI":"10.18632\/oncotarget.6119","article-title":"Oleuropein Aglycone Induces Autophagy via the AMPK\/MTOR Signalling Pathway: A Mechanistic Insight","volume":"6","author":"Rigacci","year":"2015","journal-title":"Oncotarget"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0092-8674(02)00734-1","article-title":"A Senescence Program Controlled by P53 and P16INK4a Contributes to the Outcome of Cancer Therapy","volume":"109","author":"Schmitt","year":"2002","journal-title":"Cell"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/jnc.13575","article-title":"Walking the Tightrope: Proteostasis and Neurodegenerative Disease","volume":"137","author":"Yerbury","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1097\/00001756-199611250-00050","article-title":"Expression of the Cyclin-Dependent Kinase Inhibitor P16 in Alzheimer\u2019s Disease","volume":"7","author":"Arendt","year":"1996","journal-title":"Neuroreport"},{"key":"ref_134","first-page":"1933","article-title":"Abnormal Expression of the Cell Cycle Regulators P16 and CDK4 in Alzheimer\u2019s Disease","volume":"150","author":"Mcshea","year":"1997","journal-title":"Am. J. Pathol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-009-0532-1","article-title":"Classification and Basic Pathology of Alzheimer Disease","volume":"118","author":"Duyckaerts","year":"2009","journal-title":"Acta Neuropathol."},{"key":"ref_136","first-page":"217","article-title":"Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with Other Neurodegenerative Diseases","volume":"5","author":"Melki","year":"2015","journal-title":"J. Park. Dis."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a Risk Factor for Neurodegenerative Disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1039\/c1fo10064e","article-title":"New Insights on the Interaction Mechanism between Tau Protein and Oleocanthal, an Extra-Virgin Olive-Oil Bioactive Component","volume":"2","author":"Monti","year":"2011","journal-title":"Food Funct."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1021\/np300384h","article-title":"Modulation of Tau Protein Fibrillization by Oleocanthal","volume":"75","author":"Monti","year":"2012","journal-title":"J. Nat. Prod."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1021\/cn400024q","article-title":"Olive-Oil-Derived Oleocanthal Enhances \u03b2-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer\u2019s Disease: In Vitro and in Vivo Studies","volume":"4","author":"Abuznait","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Del R\u00edo, L.F., Guti\u00e9rrez-Casado, E., Varela-L\u00f3pez, A., and Villalba, J.M. (2016). Olive Oil and the Hallmarks of Aging. Molecules, 21.","DOI":"10.3390\/molecules21020163"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/biof.118","article-title":"Neuroprotective Properties of Resveratrol in Different Neurodegenerative Disorders","volume":"36","author":"Albani","year":"2010","journal-title":"BioFactors"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/acel.12203","article-title":"Altered Proteome Turnover and Remodeling by Short-Term Caloric Restriction or Rapamycin Rejuvenate the Aging Heart","volume":"13","author":"Dai","year":"2014","journal-title":"Aging Cell"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2017.07.005","article-title":"Protein Aggregation, Cardiovascular Diseases, and Exercise Training: Where Do We Stand?","volume":"40","author":"Gouveia","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1172\/JCI118674","article-title":"Activation of Heat Shock Protein (Hsp)70 and Proto-Oncogene Expression by Alpha1 Adrenergic Agonist in Rat Aorta with Age","volume":"97","author":"Chin","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/gerona\/63.2.200","article-title":"Effects of Ubiquitin-Proteasome System Deregulation on the Vascular Senescence and Atherosclerosis Process in Elderly Patients","volume":"63","author":"Marfella","year":"2008","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1089\/rej.2006.0513","article-title":"The Olive Constituent Oleuropein Exhibits Proteasome Stimulatory Properties in Vitro and Confers Life Span Extension of Human Embryonic Fibroblasts","volume":"10","author":"Katsiki","year":"2007","journal-title":"Rejuvenation Res."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Bullon, P., Battino, M., Varela-Lopez, A., Perez-Lopez, P., Granados-Principal, S., Ramirez-Tortosa, M.C., Ochoa, J.J., Cordero, M.D., Gonzalez-Alonso, A., and Ramirez-Tortosa, C.L. (2013). Diets Based on Virgin Olive Oil or Fish Oil but Not on Sunflower Oil Prevent Age-Related Alveolar Bone Resorption by Mitochondrial-Related Mechanisms. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0074234"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.trecan.2016.03.007","article-title":"Endoplasmic Reticulum Stress and the Hallmarks of Cancer","volume":"2","author":"Urra","year":"2016","journal-title":"Trends Cancer"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.molcel.2013.01.009","article-title":"P58IPK-Mediated Attenuation of the Proapoptotic PERK-CHOP Pathway Allows Malignant Progression upon Low Glucose","volume":"49","author":"Huber","year":"2013","journal-title":"Mol. Cell"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature13119","article-title":"XBP1 Promotes Triple-Negative Breast Cancer by Controlling the HIF1\u03b1 Pathway","volume":"508","author":"Chen","year":"2014","journal-title":"Nature"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"e7929","DOI":"10.15252\/emmm.201707929","article-title":"Dual IRE1 RNase Functions Dictate Glioblastoma Development","volume":"10","author":"Lhomond","year":"2018","journal-title":"EMBO Mol. Med."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"9946","DOI":"10.1073\/pnas.1334037100","article-title":"Proteasome Inhibitors Disrupt the Unfolded Protein Response in Myeloma Cells","volume":"100","author":"Lee","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1172\/JCI73448","article-title":"Inhibition of ER Stress-Associated IRE-1\/XBP-1 Pathway Reduces Leukemic Cell Survival","volume":"124","author":"Tang","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1172\/JCI34587","article-title":"Chop Deletion Reduces Oxidative Stress, Improves Beta Cell Function, and Promotes Cell Survival in Multiple Mouse Models of Diabetes","volume":"118","author":"Song","year":"2008","journal-title":"J. Clin. Investig."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41467-018-08152-3","article-title":"IRE1\u03b1-XBP1s Pathway Promotes Prostate Cancer by Activating c-MYC Signaling","volume":"10","author":"Sheng","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/hep.29871","article-title":"Dual Role for Inositol-Requiring Enzyme 1a in Promoting the Development of Hepatocellular Carcinoma During Diet-Induced Obesity in Mice A HE STUDY OF LIVER D I S E ASES T MERICAN ASSOCIATION FOR","volume":"68","author":"Wu","year":"2018","journal-title":"Hepatology"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/gerona\/glr167","article-title":"Mediterranean Diet Supplemented with Coenzyme Q 10 Modifies the Expression of Proinflammatory and Endoplasmic Reticulum Stress-Related Genes in Elderly Men and Women","volume":"67A","author":"Tinahones","year":"2012","journal-title":"J. Gerontol.-Ser. A Biol. Sci. Med. Sci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1017\/S0007114599000094","article-title":"Physical Exercise Affects the Lipid Profile of Mitochondrial Membranes in Rats Fed with Virgin Olive Oil or Sunflower Oil","volume":"81","author":"Quiles","year":"1999","journal-title":"Br. J. Nutr."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"9942","DOI":"10.1021\/jf101502q","article-title":"Prediction of Extra Virgin Olive Oil Varieties through Their Phenolic Profile. Potential Cytotoxic Activity against Human Breast Cancer Cells.","volume":"58","author":"Menendez","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_161","first-page":"1533","article-title":"Crude Phenolic Extracts from Extra Virgin Olive Oil Circumvent de Novo Breast Cancer Resistance to HER1\/HER2-Targeting Drugs by Inducing GADD45-Sensed Cellular Stress, G2\/M Arrest and Hyperacetylation of Histone H3","volume":"38","author":"Joven","year":"2011","journal-title":"Int. J. Oncol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1083\/jcb.201707168","article-title":"Regulation of Reproduction and Longevity by Nutrient-Sensing Pathways","volume":"217","author":"Templeman","year":"2018","journal-title":"J. Cell Biol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s42003-020-0844-1","article-title":"Lifestyle Mediates the Role of Nutrient-Sensing Pathways in Cognitive Aging: Cellular and Epidemiological Evidence","volume":"3","author":"Murphy","year":"2020","journal-title":"Commun. Biol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.1172539","article-title":"Extending Healthy Life Span--from Yeast to Humans","volume":"328","author":"Fontana","year":"2010","journal-title":"Science"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Schumacher, B., Van Der Pluijm, I., Moorhouse, M.J., Kosteas, T., Robinson, A.R., Suh, Y., Breit, T.M., Van Steeg, H., Niedernhofer, L.J., and Van Ijcken, W. (2008). Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms. PLoS Genet., 4.","DOI":"10.1371\/journal.pgen.1000161"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/ncb1108-1241","article-title":"DNA Damage and Ageing: New-Age Ideas for an Age-Old Problem","volume":"10","author":"Garinis","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.2337\/db11-1300","article-title":"The Critical Role of Metabolic Pathways in Aging","volume":"61","author":"Barzilai","year":"2012","journal-title":"Diabetes"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.exger.2005.06.014","article-title":"The Insulin\/IGF-1 Signaling in Mammals and Its Relevance to Human Longevity","volume":"40","author":"Rincon","year":"2005","journal-title":"Exp. Gerontol."},{"key":"ref_169","first-page":"147","article-title":"Insulin, IGF-1 and Longevity","volume":"1","year":"2010","journal-title":"Aging Dis."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1038\/onc.2008.21","article-title":"The FoxO Code","volume":"27","author":"Calnan","year":"2008","journal-title":"Oncogene"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nature11861","article-title":"MTOR Is a Key Modulator of Ageing and Age-Related Disease","volume":"493","author":"Johnson","year":"2013","journal-title":"Nature"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1126\/science.1215135","article-title":"Rapamycin-Induced Insulin Resistance Is Mediated by MTORC2 Loss and Uncoupled from Longevity","volume":"335","author":"Lamming","year":"2012","journal-title":"Science"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1126\/science.1177221","article-title":"Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span","volume":"326","author":"Selman","year":"2009","journal-title":"Science"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1200\/JCO.2008.20.0766","article-title":"Targeting the MTOR Signaling Network for Cancer Therapy","volume":"27","year":"2009","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"ref_175","first-page":"550","article-title":"Targeting PI3K Signalling in Cancer: Opportunities, Challenges and Limitations. Nature reviews","volume":"9","author":"Engelman","year":"2009","journal-title":"Cancer"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"13107","DOI":"10.1074\/jbc.M110.100420","article-title":"Molecular Interplay between Mammalian Target of Rapamycin (MTOR), Amyloid-Beta, and Tau: Effects on Cognitive Impairments","volume":"285","author":"Caccamo","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_177","first-page":"21","article-title":"MTOR: From Growth Signal Integration to Cancer, Diabetes and Ageing. Nature reviews","volume":"12","author":"Zoncu","year":"2011","journal-title":"Mol. Cell Biol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1474-9726.2012.00832.x","article-title":"Rapamycin Slows Aging in Mice","volume":"11","author":"Wilkinson","year":"2012","journal-title":"Aging Cell"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature03314","article-title":"Defective DNA Single-Strand Break Repair in Spinocerebellar Ataxia with Axonal Neuropathy-1","volume":"434","author":"Saifi","year":"2005","journal-title":"Nature"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1128\/MCB.06159-11","article-title":"Role of AMPK-MTOR-Ulk1\/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks","volume":"32","author":"Alers","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature03354","article-title":"Nutrient Control of Glucose Homeostasis through a Complex of PGC-1alpha and SIRT1","volume":"434","author":"Rodgers","year":"2005","journal-title":"Nature"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Clark, J., Reddy, S., Zheng, K., Betensky, R.A., and Simon, D.K. (2011). Association of PGC-1alpha Polymorphisms with Age of Onset and Risk of Parkinson\u2019s Disease. BMC Med. Genet., 12.","DOI":"10.1186\/1471-2350-12-69"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1126\/science.1173635","article-title":"Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys","volume":"325","author":"Colman","year":"2009","journal-title":"Science"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1159\/000363060","article-title":"Mediterranean Diet and Healthy Ageing: A Sicilian Perspective","volume":"60","author":"Vasto","year":"2014","journal-title":"Gerontology"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1073\/pnas.0712145105","article-title":"A Role for the NAD-Dependent Deacetylase Sirt1 in the Regulation of Autophagy","volume":"105","author":"Lee","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.febslet.2010.01.017","article-title":"MTOR Regulation of Autophagy","volume":"584","author":"Jung","year":"2010","journal-title":"FEBS Lett."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1002\/ptr.5434","article-title":"Olive Oil-Derived Oleocanthal as Potent Inhibitor of Mammalian Target of Rapamycin: Biological Evaluation and Molecular Modeling Studies","volume":"29","author":"Khanfar","year":"2015","journal-title":"Phytother. Res. PTR"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"8798","DOI":"10.1021\/jf901280r","article-title":"Antidiabetic and Antioxidant Effects of Hydroxytyrosol and Oleuropein from Olive Leaves in Alloxan-Diabetic Rats","volume":"57","author":"Jemai","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.lfs.2005.07.029","article-title":"Hypoglycemic and Antioxidant Effect of Oleuropein in Alloxan-Diabetic Rabbits","volume":"78","author":"Alhamdani","year":"2006","journal-title":"Life Sci."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.15252\/embj.201695810","article-title":"Brain Metabolism in Health, Aging, and Neurodegeneration","volume":"36","author":"Camandola","year":"2017","journal-title":"EMBO J."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2174\/156720512799015064","article-title":"Metabolic Dysfunction in Alzheimer\u2019s Disease and Related Neurodegenerative Disorders","volume":"9","author":"Cai","year":"2012","journal-title":"Curr. Alzheimer Res."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/ejcn.2012.107","article-title":"Glycemic Load Effect on Fasting and Post-Prandial Serum Glucose, Insulin, IGF-1 and IGFBP-3 in a Randomized, Controlled Feeding Study","volume":"66","author":"Runchey","year":"2012","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cmet.2014.02.006","article-title":"Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population","volume":"19","author":"Levine","year":"2014","journal-title":"Cell Metab."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.18632\/oncotarget.1586","article-title":"Dietary Protein Restriction Inhibits Tumor Growth in Human Xenograft Models of Prostate and Breast Cancer","volume":"4","author":"Fontana","year":"2013","journal-title":"Oncotarget"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"555","DOI":"10.4161\/cc.23756","article-title":"Xenohormetic and Anti-Aging Activity of Secoiridoid Polyphenols Present in Extra Virgin Olive Oil: A New Family of Gerosuppressant Agents","volume":"12","author":"Menendez","year":"2013","journal-title":"Cell Cycle"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.arr.2016.08.007","article-title":"Cutting Back on the Essentials: Can Manipulating Intake of Specific Amino Acids Modulate Health and Lifespan?","volume":"39","author":"Buffenstein","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"ref_197","first-page":"723","article-title":"Branched-Chain Amino Acids in Metabolic Signalling and Insulin Resistance. Nature reviews","volume":"10","author":"Lynch","year":"2014","journal-title":"Endocrinology"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.celrep.2016.05.092","article-title":"Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health","volume":"16","author":"Fontana","year":"2016","journal-title":"Cell Rep."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0531-5565(01)00093-6","article-title":"Oxidative Damage to Mitochondria and Aging","volume":"36","author":"Remmen","year":"2001","journal-title":"Exp. Gerontol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.scr.2018.01.019","article-title":"Oxidative Stress and Altered Mitochondrial Protein Expression in the Absence of Amyloid-\u03b2 and Tau Pathology in IPSC-Derived Neurons from Sporadic Alzheimer\u2019s Disease Patients","volume":"27","author":"Birnbaum","year":"2018","journal-title":"Stem Cell Res."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11910-018-0829-3","article-title":"Mitochondrial Dysfunction in Parkinson\u2019s Disease: New Mechanistic Insights and Therapeutic Perspectives","volume":"18","author":"Park","year":"2018","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"44879","DOI":"10.18632\/oncotarget.9821","article-title":"Mitochondrial Dysfunction and Oxidative Stress in Aging and Cancer","volume":"7","author":"Kudryavtseva","year":"2016","journal-title":"Oncotarget"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbadis.2016.11.010","article-title":"Mitochondrial Dysfunction and Oxidative Stress in Metabolic Disorders\u2014A Step towards Mitochondria Based Therapeutic Strategies","volume":"1863","author":"Bhatti","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.freeradbiomed.2009.05.004","article-title":"Mitochondria and Reactive Oxygen Species","volume":"47","author":"Kowaltowski","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bbadis.2003.11.007","article-title":"Oxidatively Damaged Proteins of Heart Mitochondrial Electron Transport Complexes","volume":"1688","author":"Choksi","year":"2004","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"H1597-602","DOI":"10.1152\/ajpheart.00026.2004","article-title":"Insulin Resistance and Hypertension","volume":"286","author":"Sowers","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.amjmed.2007.01.002","article-title":"Multiple Risk Factors for Cardiovascular Disease and Diabetes Mellitus","volume":"120","author":"Smith","year":"2007","journal-title":"Am. J. Med."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1172\/JCI25151","article-title":"Reduced Mitochondrial Density and Increased IRS-1 Serine Phosphorylation in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Parents","volume":"115","author":"Morino","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.2337\/diabetes.53.2007.S103","article-title":"Mitochondrial Diabetes: Molecular Mechanisms and Clinical Presentation","volume":"53","author":"Maassen","year":"2004","journal-title":"Diabetes"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"H2009","DOI":"10.1152\/ajpheart.00522.2007","article-title":"Renin-Angiotensin-Aldosterone System and Oxidative Stress in Cardiovascular Insulin Resistance","volume":"293","author":"Cooper","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Khalil, M., Shanmugam, H., Abdallah, H., John Britto, J.S., Galerati, I., G\u00f3mez-Ambrosi, J., Fr\u00fchbeck, G., and Portincasa, P. (2022). The Potential of the Mediterranean Diet to Improve Mitochondrial Function in Experimental Models of Obesity and Metabolic Syndrome. Nutrients, 14.","DOI":"10.3390\/nu14153112"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1056\/NEJMoa1800389","article-title":"Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts","volume":"378","author":"Estruch","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jnutbio.2017.09.007","article-title":"Gene Pathways Associated with Mitochondrial Function, Oxidative Stress and Telomere Length Are Differentially Expressed in the Liver of Rats Fed Lifelong on Virgin Olive, Sunflower or Fish Oils","volume":"52","author":"Battino","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1024\/0300-9831.69.4.243","article-title":"Oxidative Stress Induced by Exercise and Dietary Fat Modulates the Coenzyme Q and Vitamin A Balance between Plasma and Mitochondria","volume":"69","author":"Quiles","year":"1999","journal-title":"Int. J. Vitam. Nutr. Research. Int. Z. Fur Vitam.-Und Ernahrungsforschung. J. Int. Vitaminol. Nutr."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1023\/A:1024615816839","article-title":"Aging-Related Oxidative Stress Depends on Dietary Lipid Source in Rat Postmitotic Tissues","volume":"35","author":"Ochoa","year":"2003","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1024\/0300-9831.76.4.178","article-title":"Olive Oil and Mitochondrial Oxidative Stress. International journal for vitamin and nutrition research","volume":"76","author":"Mataix","year":"2006","journal-title":"Int. Z. Fur Vitam.-Und Ernahrungsforschung. J. Int. Vitaminol. Nutr."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0891-5849(02)00910-3","article-title":"Rate of Generation of Oxidative Stress-Related Damage and Animal Longevity","volume":"33","author":"Barja","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0531-5565(00)00079-6","article-title":"Catalase Expression in Delayed and Premature Aging Mouse Models","volume":"35","author":"Rakoczy","year":"2000","journal-title":"Exp. Gerontol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1152\/physrev.1998.78.2.547","article-title":"The Free Radical Theory of Aging Matures","volume":"78","author":"Beckman","year":"1998","journal-title":"Physiol. Rev."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.neuropharm.2016.11.010","article-title":"Oleuropein Improves Mitochondrial Function to Attenuate Oxidative Stress by Activating the Nrf2 Pathway in the Hypothalamic Paraventricular Nucleus of Spontaneously Hypertensive Rats","volume":"113","author":"Sun","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1021\/jf0703710","article-title":"Hydroxytyrosol-Rich Olive Mill Wastewater Extract Protects Brain Cells in Vitro and Ex Vivo","volume":"55","author":"Schaffer","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1002\/mnfr.201600332","article-title":"Hydroxytyrosol Mildly Improve Cognitive Function Independent of APP Processing in APP\/PS1 Mice","volume":"60","author":"Peng","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/cns.12264","article-title":"The Centrality of Mitochondria in the Pathogenesis and Treatment of Parkinson\u2019s Disease","volume":"20","author":"Camilleri","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.foodchem.2011.02.074","article-title":"Neuroprotective Properties of Spanish Red Wine and Its Isolated Polyphenols on Astrocytes","volume":"128","author":"Carretero","year":"2011","journal-title":"Food Chem."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"H112","DOI":"10.1111\/1750-3841.12000","article-title":"Protective Effects of Merlot Red Wine Extract and Its Major Polyphenols in PC12 Cells under Oxidative Stress Conditions","volume":"78","author":"Carretero","year":"2013","journal-title":"J. Food Sci."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.biopha.2018.05.003","article-title":"Quercetin Attenuates Mitochondrial Dysfunction and Biogenesis via Upregulated AMPK\/SIRT1 Signaling Pathway in OA Rats","volume":"103","author":"Qiu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.brainres.2010.02.031","article-title":"Resveratrol Attenuates 6-Hydroxydopamine-Induced Oxidative Damage and Dopamine Depletion in Rat Model of Parkinson\u2019s Disease","volume":"1328","author":"Khan","year":"2010","journal-title":"Brain Res."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1007\/s12035-017-0448-z","article-title":"Resveratrol and Brain Mitochondria: A Review","volume":"55","author":"Jardim","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"14336","DOI":"10.3390\/molecules171214336","article-title":"In Vitro Antioxidant Activities of Three Red Wine Polyphenols and Their Mixtures: An Interaction Study","volume":"17","author":"Kurin","year":"2012","journal-title":"Molecules"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"6578","DOI":"10.1021\/jf901863w","article-title":"Changes in Antioxidant Endogenous Enzymes (Activity and Gene Expression Levels) after Repeated Red Wine Intake","volume":"57","author":"Otaolaurruchi","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.plefa.2014.05.008","article-title":"Omega-3 Polyunsaturated Fatty Acids Improve Mitochondrial Dysfunction in Brain Aging - Impact of Bcl-2 and NPD-1 like Metabolites","volume":"92","author":"Afshordel","year":"2015","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.plefa.2012.05.006","article-title":"Omega-3 Fatty Acids in Neurodegenerative Diseases: Focus on Mitochondria","volume":"88","author":"Eckert","year":"2013","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2174\/156720211795495349","article-title":"Brain-Targeting Form of Docosahexaenoic Acid for Experimental Stroke Treatment: MRI Evaluation and Anti-Oxidant Impact","volume":"8","author":"Chauveau","year":"2011","journal-title":"Curr. Neurovascular Res."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jtemb.2014.12.003","article-title":"Correlation of Serum Toll like Receptor 9 and Trace Elements with Lipid Peroxidation in the Patients of Breast Diseases","volume":"30","author":"Karki","year":"2015","journal-title":"J. Trace Elem. Med. Biol. Organ Soc. Miner. Trace Elem. (GMS)"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s00432-008-0535-7","article-title":"Plasma Malondialdehyde Levels and CXCR4 Expression in Peripheral Blood Cells of Breast Cancer Patients","volume":"135","author":"Nixdorf","year":"2009","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1590\/S1679-45082014RC3110","article-title":"lias Oxidative Stress and Plasma Lipoproteins in Cancer Patients","volume":"12","author":"Maia","year":"2014","journal-title":"Einstein"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.medici.2014.09.001","article-title":"Significance of Blood Serum Catalase Activity and Malondialdehyde Level for Survival Prognosis of Ovarian Cancer Patients","volume":"50","author":"Smailyte","year":"2014","journal-title":"Medicina"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4103\/0973-1482.77106","article-title":"Estimation of Serum Malondialdehyde in Oral Cancer and Precancer and Its Association with Healthy Individuals, Gender, Alcohol, and Tobacco Abuse","volume":"6","author":"Chole","year":"2010","journal-title":"J. Cancer Res. Ther."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"10151","DOI":"10.7314\/APJCP.2014.15.23.10151","article-title":"4-Hydroxynonenal Promotes Growth and Angiogenesis of Breast Cancer Cells through HIF-1\u03b1 Stabilization","volume":"15","author":"Li","year":"2014","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"ref_241","doi-asserted-by":"crossref","unstructured":"Moral, R., and Escrich, E. (2022). Influence of Olive Oil and Its Components on Breast Cancer: Molecular Mechanisms. Molecules, 27.","DOI":"10.3390\/molecules27020477"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.201009094","article-title":"Four Faces of Cellular Senescence","volume":"192","author":"Rodier","year":"2011","journal-title":"J. Cell Biol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1101\/gad.1971610","article-title":"The Essence of Senescence","volume":"24","author":"Kuilman","year":"2010","journal-title":"Genes Dev."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1089\/ars.2020.8048","article-title":"Senescence in Post-Mitotic Cells: A Driver of Aging?","volume":"34","author":"Wan","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1172\/JCI64098","article-title":"Cellular Senescence and the Senescent Secretory Phenotype: Therapeutic Opportunities","volume":"123","author":"Tchkonia","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0092-8674(00)81902-9","article-title":"Oncogenic Ras Provokes Premature Cell Senescence Associated with Accumulation of P53 and P16INK4a","volume":"88","author":"Serrano","year":"1997","journal-title":"Cell"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1172\/JCI22475","article-title":"Ink4a\/Arf Expression Is a Biomarker of Aging","volume":"114","author":"Krishnamurthy","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1474-9726.2006.00231.x","article-title":"P16INK4A Is a Robust in Vivo Biomarker of Cellular Aging in Human Skin","volume":"5","author":"Ressler","year":"2006","journal-title":"Aging Cell"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1474-9726.2012.00871.x","article-title":"Review: A Meta-Analysis of GWAS and Age-Associated Diseases","volume":"11","author":"Jeck","year":"2012","journal-title":"Aging Cell"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature16932","article-title":"Naturally Occurring P16 Ink4a-Positive Cells Shorten Healthy Lifespan","volume":"530","author":"Baker","year":"2016","journal-title":"Nature"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/s41591-018-0092-9","article-title":"Senolytics Improve Physical Function and Increase Lifespan in Old Age","volume":"24","author":"Xu","year":"2018","journal-title":"Nat. Med."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.clnu.2009.12.008","article-title":"Effect of Nut Consumption on Oxidative Stress and the Endothelial Function in Metabolic Syndrome","volume":"29","author":"Saez","year":"2010","journal-title":"Clin. Nutr."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/437045a","article-title":"Ibuprofen-like Activity in Extra-Virgin Olive Oil","volume":"437","author":"Beauchamp","year":"2005","journal-title":"Nature"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.3390\/molecules20034655","article-title":"Potential Role of Olive Oil Phenolic Compounds in the Prevention of Neurodegenerative Diseases","volume":"20","author":"Xicota","year":"2015","journal-title":"Molecules"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"793","DOI":"10.5650\/jos.ess15042","article-title":"Radical-Scavenging Activity and Antioxidative Effects of Olive Leaf Components Oleuropein and Hydroxytyrosol in Comparison with Homovanillic Alcohol","volume":"64","author":"Umeno","year":"2015","journal-title":"J. Oleo Sci."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-018-0543-y","article-title":"Clearance of Senescent Glial Cells Prevents Tau-Dependent Pathology and Cognitive Decline","volume":"562","author":"Bussian","year":"2018","journal-title":"Nature"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"109419","DOI":"10.1016\/j.celrep.2021.109419","article-title":"Tau Oligomer Induced HMGB1 Release Contributes to Cellular Senescence and Neuropathology Linked to Alzheimer\u2019s Disease and Frontotemporal Dementia","volume":"36","author":"Gaikwad","year":"2021","journal-title":"Cell Rep."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"e2011226118","DOI":"10.1073\/pnas.2011226118","article-title":"NAD+ Supplementation Reduces Neuroinflammation and Cell Senescence in a Transgenic Mouse Model of Alzheimer\u2019s Disease via CGAS-STING","volume":"118","author":"Hou","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_259","first-page":"7698560","article-title":"A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer\u2019s Amyloid- \u03b2-Induced Oxidative Stress, Mitochondrial Dysfunction, and Cell Senescence through Upregulating SIRT3","volume":"2020","author":"Li","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3389\/fneur.2020.00929","article-title":"Interleukin-1\u03b2 Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid \u03b2 Peptide and Oxidative Stress","volume":"11","author":"Shang","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"733945","DOI":"10.3389\/fcell.2021.733945","article-title":"Clemastine Ameliorates Myelin Deficits via Preventing Senescence of Oligodendrocytes Precursor Cells in Alzheimer\u2019s Disease Model Mouse","volume":"9","author":"Xie","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"109228","DOI":"10.1016\/j.celrep.2021.109228","article-title":"Replicative Senescence Dictates the Emergence of Disease-Associated Microglia and Contributes to A\u03b2 Pathology","volume":"35","author":"Hu","year":"2021","journal-title":"Cell Rep."},{"key":"ref_263","first-page":"1169","article-title":"Resveratrol Derivative, 3,3\u2032,4,4\u2032-Tetrahydroxy-Trans-Stilbene, Retards Senescence of Mesothelial Cells via Hormetic-Like Prooxidative Mechanism","volume":"70","author":"Murias","year":"2014","journal-title":"J. Gerontol.-Ser. A Biol. Sci. Med. Sci."},{"key":"ref_264","doi-asserted-by":"crossref","unstructured":"Peltz, L., Gomez, J., Marquez, M., Alencastro, F., Atashpanjeh, N., Quang, T., Bach, T., and Zhao, Y. (2012). Resveratrol Exerts Dosage and Duration Dependent Effect on Human Mesenchymal Stem Cell Development. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0037162"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","article-title":"Senolytics Decrease Senescent Cells in Humans: Preliminary Report from a Clinical Trial of Dasatinib plus Quercetin in Individuals with Diabetic Kidney Disease","volume":"47","author":"Hickson","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41569-021-00624-2","article-title":"The Role of Cellular Senescence in Cardiac Disease: Basic Biology and Clinical Relevance","volume":"19","author":"Mehdizadeh","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1093\/eurheartj\/ehz961","article-title":"Inflamm-Ageing: The Role of Inflammation in Age-Dependent Cardiovascular Disease","volume":"41","author":"Liberale","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","article-title":"Cellular Senescence in Ageing: From Mechanisms to Therapeutic Opportunities","volume":"22","author":"Krizhanovsky","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"e10234","DOI":"10.15252\/emmm.201810234","article-title":"Targeting Senescent Cells in Translational Medicine","volume":"11","author":"Doherty","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nrc2772","article-title":"Senescence in Tumours: Evidence from Mice and Humans","volume":"10","author":"Collado","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1093\/jnci\/djq364","article-title":"Therapy-Induced Senescence in Cancer","volume":"102","author":"Ewald","year":"2010","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ebiom.2018.09.015","article-title":"Fisetin Is a Senotherapeutic That Extends Health and Lifespan","volume":"36","author":"Yousefzadeh","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cmet.2020.05.002","article-title":"Defined P16High Senescent Cell Types Are Indispensable for Mouse Healthspan","volume":"32","author":"Grosse","year":"2020","journal-title":"Cell Metab."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.cmet.2020.09.006","article-title":"Generation of a P16 Reporter Mouse and Its Use to Characterize and Target P16high Cells In Vivo","volume":"32","author":"Omori","year":"2020","journal-title":"Cell Metab."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.stem.2014.02.008","article-title":"Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer","volume":"14","author":"Mihaylova","year":"2014","journal-title":"Cell Stem Cell"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/path.2104","article-title":"Immunosenescence of Ageing","volume":"211","author":"Gruver","year":"2007","journal-title":"J. Pathol."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature05862","article-title":"Deficiencies in DNA Damage Repair Limit the Function of Haematopoietic Stem Cells with Age","volume":"447","author":"Rossi","year":"2007","journal-title":"Nature"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature05159","article-title":"Stem-Cell Ageing Modified by the Cyclin-Dependent Kinase Inhibitor P16INK4a","volume":"443","author":"Janzen","year":"2006","journal-title":"Nature"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1016\/j.febslet.2010.07.042","article-title":"The Role of Telomeres and Telomerase in Stem Cell Aging","volume":"584","author":"Flores","year":"2010","journal-title":"FEBS Lett."},{"key":"ref_280","first-page":"703","article-title":"How Stem Cells Age and Why This Makes Us Grow Old. Nature reviews","volume":"8","author":"Sharpless","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.3389\/fimmu.2017.01960","article-title":"Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?","volume":"8","author":"Fulop","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.numecd.2017.09.003","article-title":"Aging Process, Adherence to Mediterranean Diet and Nutritional Status in a Large Cohort of Nonagenarians: Effects on Endothelial Progenitor Cells","volume":"28","author":"Cesari","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1161\/01.CIR.0000089084.48655.49","article-title":"Autologous Culture-Modified Mononuclear Cells Confer Vascular Protection after Arterial Injury","volume":"108","author":"Gulati","year":"2003","journal-title":"Circulation"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4137\/NMI.S32909","article-title":"Molecular Properties of Red Wine Compounds and Cardiometabolic Benefits","volume":"9","author":"Markoski","year":"2016","journal-title":"Nutr. Metab. Insights"},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.phymed.2013.05.002","article-title":"Oleuropein and Oleacein May Restore Biological Functions of Endothelial Progenitor Cells Impaired by Angiotensin II via Activation of Nrf2\/Heme Oxygenase-1 Pathway","volume":"20","author":"Parzonko","year":"2013","journal-title":"Phytomedicine"},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1210\/jc.2012-2221","article-title":"A Mediterranean Diet Enriched with Olive Oil Is Associated with Higher Serum Total Osteocalcin Levels in Elderly Men at High Cardiovascular Risk","volume":"97","author":"Ricart","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.2147\/CIA.S72006","article-title":"Olive Oil in the Prevention and Treatment of Osteoporosis after Artificial Menopause","volume":"9","author":"Liu","year":"2014","journal-title":"Clin. Interv. Aging"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.coi.2010.05.003","article-title":"Aging of the Innate Immune System","volume":"22","author":"Shaw","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15272\/ajbps.v4i39.612","article-title":"Effect of Olive Leaf Components on the Proliferation and Viability of Hematopoietic Stem Cells","volume":"4","author":"Samet","year":"2014","journal-title":"Asian J. Biomed. Pharm."},{"key":"ref_290","first-page":"645","article-title":"P53-Related Apoptosis Resistance and Tumor Suppression Activity in UVB-Induced Premature Senescent Human Skin Fibroblasts","volume":"21","author":"Chen","year":"2008","journal-title":"Int. J. Mol. Med."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1158\/0008-5472.CAN-08-0174","article-title":"Alpha Vbeta 6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma through Stromal Modulation","volume":"68","author":"Marsh","year":"2008","journal-title":"Cancer Res."},{"key":"ref_292","first-page":"777","article-title":"Extracellular Matrix Secreted by Senescent Fibroblasts Induced by UVB Promotes Cell Proliferation in HaCaT Cells through PI3K\/AKT and ERK Signaling Pathways","volume":"21","author":"Kang","year":"2008","journal-title":"Int. J. Mol. Med."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1473-2165.2008.00354.x","article-title":"Anti-Aging Properties of Resveratrol: Review and Report of a Potent New Antioxidant Skin Care Formulation","volume":"7","author":"Baxter","year":"2008","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3389\/fnagi.2020.00148","article-title":"Astrocyte Senescence and Alzheimer\u2019s Disease: A Review","volume":"12","author":"Han","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"190","DOI":"10.2174\/156720510791050911","article-title":"Cognitive and Cardiovascular Benefits of Docosahexaenoic Acid in Aging and Cognitive Decline","volume":"7","year":"2010","journal-title":"Curr. Alzheimer Res."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"252","DOI":"10.2174\/1574884713666180807145648","article-title":"A Recent Update on the Effects of Omega-3 Fatty Acids in Alzheimer\u2019s Disease","volume":"13","author":"Ajith","year":"2018","journal-title":"Curr. Clin. Pharmacol."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.trci.2018.09.002","article-title":"The Protective Effects of Polyphenols on Alzheimer\u2019s Disease: A Systematic Review","volume":"5","author":"Colizzi","year":"2019","journal-title":"Alzheimer\u2019s Dement. Transl. Res. Clin. Interv."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2174\/1567205016666190315093520","article-title":"Mitigating Alzheimer\u2019s Disease with Natural Polyphenols: A Review","volume":"16","author":"Gaudreault","year":"2019","journal-title":"Curr. Alzheimer Res."},{"key":"ref_299","doi-asserted-by":"crossref","unstructured":"Zheng, Q., Kebede, M.T., Kemeh, M.M., Islam, S., Lee, B., Bleck, S.D., Wurfl, L.A., and Lazo, N.D. (2019). Inhibition of the Self-Assembly of A\u03b2 and of Tau by Polyphenols: Mechanistic Studies. Molecules, 24.","DOI":"10.3390\/molecules24122316"},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3389\/fnagi.2019.00155","article-title":"Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders","volume":"11","author":"Ayaz","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nrm3335","article-title":"Intercellular Communication: Diverse Structures for Exchange of Genetic Information","volume":"13","author":"Mittelbrunn","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.3389\/fimmu.2017.01385","article-title":"Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice","volume":"8","author":"Fransen","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13148-015-0068-2","article-title":"From Inflammaging to Healthy Aging by Dietary Lifestyle Choices: Is Epigenetics the Key to Personalized Nutrition?","volume":"7","author":"Declerck","year":"2015","journal-title":"Clin. Epigenetics"},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"8426874","DOI":"10.1155\/2016\/8426874","article-title":"An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment","volume":"2016","author":"Xia","year":"2016","journal-title":"J. Immunol. Res."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"584","DOI":"10.7326\/0003-4819-159-9-201311050-00004","article-title":"The Association between Dietary Patterns at Midlife and Health in Aging an Observational Study","volume":"159","author":"Samieri","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10522-015-9578-8","article-title":"Inflammaging Decreases Adaptive and Innate Immune Responses in Mice and Humans","volume":"17","author":"Frasca","year":"2016","journal-title":"Biogerontology"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jamda.2013.05.009","article-title":"Proinflammatory Cytokines, Aging, and Age-Related Diseases","volume":"14","author":"Michaud","year":"2013","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-145-1-200607040-00004","article-title":"Effects of a Mediterranean-Style Diet on Cardiovascular Risk Factors A Randomized Trial","volume":"145","author":"Estruch","year":"2006","journal-title":"Ann. Intern. Med."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/sj.ejcn.1602762","article-title":"Components of the Mediterranean-Type Food Pattern and Serum Inflammatory Markers among Patients at High Risk for Cardiovascular Disease","volume":"62","author":"Estruch","year":"2008","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00210-009-0399-7","article-title":"Hydroxytyrosol Inhibits Pro-Inflammatory Cytokines, INOS, and COX-2 Expression in Human Monocytic Cells","volume":"379","author":"Zhang","year":"2009","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.jnutbio.2012.12.011","article-title":"Effect of Olive Oil Phenols on the Production of Inflammatory Mediators in Freshly Isolated Human Monocytes","volume":"24","author":"Rosignoli","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1021\/jf9042503","article-title":"Olive Oil Phenols Modulate the Expression of Metalloproteinase 9 in THP-1 Cells by Acting on Nuclear Factor-KappaB Signaling","volume":"58","author":"Fagnani","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/mnfr.201400705","article-title":"Dietary Apigenin Reduces LPS-Induced Expression of MiR-155 Restoring Immune Balance during Inflammation","volume":"59","author":"Arango","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1021\/jf0529161","article-title":"Minor Components of Olive Oil Modulate Proatherogenic Adhesion Molecules Involved in Endothelial Activation","volume":"54","author":"Fagnani","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"839298","DOI":"10.1155\/2012\/839298","article-title":"Dietary Phenolic Acids Act as Effective Antioxidants in Membrane Models and in Cultured Cells, Exhibiting Proapoptotic Effects in Leukaemia Cells","volume":"2012","author":"Zambonin","year":"2012","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00394-015-0868-3","article-title":"Virgin Olive Oil Rich in Phenolic Compounds Modulates the Expression of Atherosclerosis-Related Genes in Vascular Endothelium","volume":"55","author":"Haro","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"ref_317","doi-asserted-by":"crossref","unstructured":"Camargo, A., Ruano, J., Fernandez, J.M., Parnell, L.D., Jimenez, A., Santos-Gonzalez, M., Marin, C., Perez-Martinez, P., Uceda, M., and Lopez-Miranda, J. (2010). Gene Expression Changes in Mononuclear Cells in Patients with Metabolic Syndrome after Acute Intake of Phenol-Rich Virgin Olive Oil. BMC Genom., 11.","DOI":"10.1186\/1471-2164-11-253"},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1017\/S0007114513000482","article-title":"Extra-Virgin Olive Oil Consumption Reduces the Age-Related Decrease in HDL and Paraoxonase 1 Anti-Inflammatory Activities","volume":"110","author":"Loued","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"101594","DOI":"10.1016\/j.smim.2022.101594","article-title":"APOE Mediated Neuroinflammation and Neurodegeneration in Alzheimer\u2019s Disease","volume":"59","author":"Parhizkar","year":"2022","journal-title":"Semin. Immunol."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"120166","DOI":"10.1016\/j.jns.2022.120166","article-title":"Mediterranean Diet Adherence, Gut Microbiota, and Alzheimer\u2019s or Parkinson\u2019s Disease Risk: A Systematic Review","volume":"434","author":"Solch","year":"2022","journal-title":"J. Neurol. Sci."},{"key":"ref_321","doi-asserted-by":"crossref","unstructured":"Ciulla, M., Marinelli, L., Cacciatore, I., and Di Stefano, A. (2019). Role of Dietary Supplements in the Management of Parkinson\u2019s Disease. Biomolecules, 9.","DOI":"10.3390\/biom9070271"},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.joim.2021.03.007","article-title":"Natural Antioxidants in the Management of Parkinson\u2019s Disease: Review of Evidence from Cell Line and Animal Models","volume":"19","author":"Stupans","year":"2021","journal-title":"J. Integr. Med."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41392-022-01251-0","article-title":"Aging and Aging-Related Diseases: From Molecular Mechanisms to Interventions and Treatments","volume":"7","author":"Guo","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41419-019-1366-y","article-title":"Fisetin Induces Autophagy in Pancreatic Cancer Cells via Endoplasmic Reticulum Stress- and Mitochondrial Stress-Dependent Pathways","volume":"10","author":"Jia","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"109604","DOI":"10.1016\/j.biopha.2019.109604","article-title":"Pharmacological Basis and New Insights of Quercetin Action in Respect to Its Anti-Cancer Effects","volume":"121","author":"Tang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_326","doi-asserted-by":"crossref","unstructured":"Borz\u00ec, A.M., Biondi, A., Basile, F., Luca, S., Vicari, E.S.D., and Vacante, M. (2019). Olive Oil Effects on Colorectal Cancer. Nutrients, 11.","DOI":"10.3390\/nu11010032"},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"12882","DOI":"10.1021\/jf203715m","article-title":"Oleuropein Ameliorates Acute Colitis in Mice","volume":"59","author":"Giner","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/mnfr.201500605","article-title":"Chemopreventive Effect of Oleuropein in Colitis-Associated Colorectal Cancer in C57bl\/6 Mice","volume":"60","author":"Giner","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1021\/jf026042j","article-title":"Sensory Properties of Virgin Olive Oil Polyphenols: Identification of Deacetoxy-Ligstroside Aglycon as a Key Contributor to Pungency","volume":"51","author":"Andrewes","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/00001648-200101000-00015","article-title":"Reduced Risk of Colorectal Cancer among Long-Term Users of Aspirin and Nonaspirin Nonsteroidal Antiinflammatory Drugs","volume":"12","year":"2001","journal-title":"Epidemiology"},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.3748\/wjg.v23.i10.1909","article-title":"Markers of Systemic Inflammation and Colorectal Adenoma Risk: Meta-Analysis of Observational Studies","volume":"23","author":"Godos","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_332","first-page":"394","article-title":"Polyphenols, Intracellular Signalling and Inflammation","volume":"43","author":"Santangelo","year":"2007","journal-title":"Ann.-Ist. Super. Sanita"},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"8836","DOI":"10.3748\/wjg.v21.i29.8787","article-title":"Role of the Normal Gut Microbiota","volume":"21","author":"Jandhyala","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"13780","DOI":"10.1073\/pnas.0706625104","article-title":"Molecular-Phylogenetic Characterization of Microbial Community Imbalances in Human Inflammatory Bowel Diseases","volume":"104","author":"Frank","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1017\/S0007114513002560","article-title":"Intestinal Microbiota, Diet and Health","volume":"111","author":"Power","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"100","DOI":"10.14306\/renhyd.16.3.75","article-title":"Efecto de Los Probi\u00f3ticos En El Control de La Obesidad En Humanos: Hip\u00f3tesis No Demostradas","volume":"16","author":"Arias","year":"2012","journal-title":"Rev. Esp. Nutr. Hum. Y Diet."},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.nrl.2019.03.017","article-title":"Papel de La Microbiota Intestinal En El Desarrollo de Diferentes Enfermedades Neurol\u00f3gicas","volume":"37","year":"2022","journal-title":"Neurolog\u00eda"},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ismej.2015.88","article-title":"Composition and Temporal Stability of the Gut Microbiota in Older Persons","volume":"10","author":"Jeffery","year":"2016","journal-title":"ISME J."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"ofv004","DOI":"10.1093\/ofid\/ofv004","article-title":"Weight Gain after Fecal Microbiota Transplantation","volume":"2","author":"Alang","year":"2015","journal-title":"Open Forum Infect. Dis."},{"key":"ref_340","doi-asserted-by":"crossref","unstructured":"Mills, S., Stanton, C., Lane, J.A., Smith, G.J., and Ross, R.P. (2019). Precision Nutrition and the Microbiome, Part I: Current State of the Science. Nutrients, 11.","DOI":"10.3390\/nu11040923"},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"156","DOI":"10.12998\/wjcc.v3.i2.156","article-title":"Review on Microbiota and Effectiveness of Probiotics Use in Older","volume":"3","author":"Rondanelli","year":"2015","journal-title":"World J. Clin. Cases"},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1073\/pnas.1000097107","article-title":"Composition, Variability, and Temporal Stability of the Intestinal Microbiota of the Elderly","volume":"108","author":"Claesson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3233\/NHA-170030","article-title":"Gut Microbiome and Aging: Physiological and Mechanistic Insights","volume":"4","author":"Nagpal","year":"2018","journal-title":"Nutr. Healthy Aging"},{"key":"ref_344","doi-asserted-by":"crossref","unstructured":"Kaliannan, K., Wang, B., Li, X.Y., Kim, K.J., and Kang, J.X. (2015). A Host-Microbiome Interaction Mediates the Opposing Effects of Omega-6 and Omega-3 Fatty Acids on Metabolic Endotoxemia. Sci. Rep., 5.","DOI":"10.1038\/srep11276"},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet Rapidly and Reproducibly Alters the Human Gut Microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.cell.2012.01.035","article-title":"The Impact of the Gut Microbiota on Human Health: An Integrative View","volume":"148","author":"Clemente","year":"2012","journal-title":"Cell"},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1038\/cti.2016.29","article-title":"Dietary Metabolites and the Gut Microbiota: An Alternative Approach to Control Inflammatory and Autoimmune Diseases","volume":"5","author":"Richards","year":"2016","journal-title":"Clin. Transl. Immunol."},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"108218","DOI":"10.1016\/j.jnutbio.2019.108218","article-title":"Resveratrol-Mediated Glycemic Regulation Is Blunted by Curcumin and Is Associated to Modulation of Gut Microbiota","volume":"72","author":"Sreng","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.immuni.2014.05.014","article-title":"Diet, Metabolites, and \u201cWestern-Lifestyle\u201d Inflammatory Diseases","volume":"40","author":"Thorburn","year":"2014","journal-title":"Immunity"},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1056\/NEJMoa1109400","article-title":"Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk","volume":"368","author":"Tang","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cell.2016.02.011","article-title":"Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk","volume":"165","author":"Zhu","year":"2016","journal-title":"Cell"},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41430-018-0306-8","article-title":"Importance of Gut Microbiota in Obesity","volume":"72","author":"Tinahones","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1007\/s11095-008-9661-9","article-title":"Cancer Is a Preventable Disease That Requires Major Lifestyle Changes","volume":"25","author":"Anand","year":"2008","journal-title":"Pharm. Res."},{"key":"ref_354","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans Biological Agents (2012). Volume 100 B. A Review of Human Carcinogens. Iarc Monogr. Eval. Carcinog. Risks Hum., 100, 1."},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.3390\/nu7042589","article-title":"Inflammaging and Cancer: A Challenge for the Mediterranean Diet","volume":"7","author":"Ostan","year":"2015","journal-title":"Nutrients"},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrmicro3344","article-title":"The Gut Microbiota, Bacterial Metabolites and Colorectal Cancer","volume":"12","author":"Louis","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"s73","DOI":"10.1079\/BJN2002632","article-title":"Diet and Cancer: Assessing the Risk","volume":"88","author":"Gill","year":"2002","journal-title":"Br. J. Nutr."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tibtech.2015.06.011","article-title":"Proteobacteria: Microbial Signature of Dysbiosis in Gut Microbiota","volume":"33","author":"Shin","year":"2015","journal-title":"Trends Biotechnol."},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/19490976.2016.1150414","article-title":"Taurocholic Acid Metabolism by Gut Microbes and Colon Cancer","volume":"7","author":"Ridlon","year":"2016","journal-title":"Gut Microbes"},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.immuni.2013.12.007","article-title":"Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis","volume":"40","author":"Singh","year":"2014","journal-title":"Immunity"},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jnutbio.2009.04.012","article-title":"Anti-Inflammatory Properties of a Pomegranate Extract and Its Metabolite Urolithin-A in a Colitis Rat Model and the Effect of Colon Inflammation on Phenolic Metabolism","volume":"21","author":"Larrosa","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3322\/caac.21398","article-title":"The Role of the Microbiome in Cancer Development and Therapy","volume":"67","author":"Bhatt","year":"2017","journal-title":"CA A Cancer J. Clin."},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1136\/jnnp-2012-304792","article-title":"Mediterranean Diet Improves Cognition: The PREDIMED-NAVARRA Randomised Trial","volume":"84","author":"Clavero","year":"2013","journal-title":"J. Neurol Neurosurg. Psychiatry"},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1001\/jamainternmed.2015.1668","article-title":"Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial","volume":"175","author":"Corella","year":"2015","journal-title":"JAMA Intern. Med."},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3389\/fphys.2018.00349","article-title":"Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults: A Randomized Controlled Trial","volume":"9","author":"Marseglia","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3945\/an.117.015495","article-title":"The Impact of the Mediterranean Diet on the Cognitive Functioning of Healthy Older Adults: A Systematic Review and Meta-Analysis","volume":"8","author":"Loughrey","year":"2017","journal-title":"Adv. Nutr."},{"key":"ref_367","doi-asserted-by":"crossref","unstructured":"Servick, K. Do Gut Bacteria Make a Second Home in Our Brains. Science, 2018.","DOI":"10.1126\/science.aaw0147"},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.phrs.2018.03.012","article-title":"Nutritional Patterns Associated with the Maintenance of Neurocognitive Functions and the Risk of Dementia and Alzheimer\u2019s Disease: A Focus on Human Studies","volume":"131","author":"Pistollato","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5056\/jnm18087","article-title":"Brain-Gut-Microbiota Axis in Alzheimer\u2019s Disease","volume":"25","author":"Kowalski","year":"2019","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_370","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1007\/s12035-018-1188-4","article-title":"The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer\u2019s Disease\u2014A Critical Review","volume":"56","author":"Sochocka","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1007\/s00415-018-8943-3","article-title":"Can epilepsy be treated by antibiotics?","volume":"265","author":"Braakman","year":"2018","journal-title":"J. Neurol."},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1111\/jcmm.14195","article-title":"The Role of Intestinal Microbiota in Cardiovascular Disease","volume":"23","author":"Jin","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1017\/S0007114515002093","article-title":"Low-Grade Inflammation, Diet Composition and Health: Current Research Evidence and Its Translation","volume":"114","author":"Minihane","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"890","DOI":"10.3389\/fmicb.2018.00890","article-title":"Shifts on Gut Microbiota Associated to Mediterranean Diet Adherence and Specific Dietary Intakes on General Adult Population","volume":"9","author":"Alcantara","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fshw.2019.02.002","article-title":"Medical Foods in Alzheimer\u2019s Disease","volume":"8","author":"Lange","year":"2019","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_376","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1093\/ajcn\/nqz114","article-title":"Mediterranean Diet Adherence and Cognitive Function in Older UK Adults: The European Prospective Investigation into Cancer and Nutrition-Norfolk (EPIC-Norfolk) Study","volume":"110","author":"Shannon","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cell.2015.08.059","article-title":"Regulators of Gut Motility Revealed by a Gnotobiotic Model of Diet-Microbiome Interactions Related to Travel","volume":"163","author":"Dey","year":"2015","journal-title":"Cell"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/5\/4491\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:41:29Z","timestamp":1760121689000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/5\/4491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,24]]},"references-count":377,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["ijms24054491"],"URL":"https:\/\/doi.org\/10.3390\/ijms24054491","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,24]]}}}