{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T10:31:13Z","timestamp":1775817073404,"version":"3.50.1"},"reference-count":229,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","doi-asserted-by":"publisher","award":["451-03-68\/2022-14\/200015"],"award-info":[{"award-number":["451-03-68\/2022-14\/200015"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Myeloproliferative neoplasms (MPNs) are hematologic malignancies characterized by gene mutations that promote myeloproliferation and resistance to apoptosis via constitutively active signaling pathways, with Janus kinase 2-signal transducers and the activators of transcription (JAK-STAT) axis as a core part. Chronic inflammation has been described as a pivot for the development and advancement of MPNs from early stage cancer to pronounced bone marrow fibrosis, but there are still unresolved questions regarding this issue. The MPN neutrophils are characterized by upregulation of JAK target genes, they are in a state of activation and with deregulated apoptotic machinery. Deregulated neutrophil apoptotic cell death supports inflammation and steers them towards secondary necrosis or neutrophil extracellular trap (NET) formation, a trigger of inflammation both ways. NETs in proinflammatory bone marrow microenvironment induce hematopoietic precursor proliferation, which has an impact on hematopoietic disorders. In MPNs, neutrophils are primed for NET formation, and even though it seems obvious for NETs to intervene in the disease progression by supporting inflammation, no reliable data are available. We discuss in this review the potential pathophysiological relevance of NET formation in MPNs, with the intention of contributing to a better understanding of how neutrophils and neutrophil clonality can orchestrate the evolution of a pathological microenvironment in MPNs.<\/jats:p>","DOI":"10.3390\/ijms24054497","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T03:23:36Z","timestamp":1677468216000},"page":"4497","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Putative Role of Neutrophil Extracellular Trap Formation in Chronic Myeloproliferative Neoplasms"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3646-8505","authenticated-orcid":false,"given":"Dragana C.","family":"Markovi\u0107","sequence":"first","affiliation":[{"name":"Group for Immunology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Suboti\u0107a 4, 11129 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0892-5617","authenticated-orcid":false,"given":"Irina S.","family":"Maslovari\u0107","sequence":"additional","affiliation":[{"name":"Group for Immunology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Suboti\u0107a 4, 11129 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijana","family":"Kova\u010di\u0107","sequence":"additional","affiliation":[{"name":"Group for Immunology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Suboti\u0107a 4, 11129 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7379-1630","authenticated-orcid":false,"given":"Sanja","family":"Vignjevi\u0107 Petrinovi\u0107","sequence":"additional","affiliation":[{"name":"Group for Neuroendocrinology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Suboti\u0107a 4, 11129 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1119-1343","authenticated-orcid":false,"given":"Vesna Lj.","family":"Ili\u0107","sequence":"additional","affiliation":[{"name":"Group for Immunology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Suboti\u0107a 4, 11129 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.7326\/0003-4819-152-5-201003020-00008","article-title":"Narrative Review: Thrombocytosis, Polycythemia Vera, and JAK2 Mutations: The Phenotypic Mimicry of Chronic Myeloproliferation","volume":"152","author":"Spivak","year":"2010","journal-title":"Ann. 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