{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:06:11Z","timestamp":1791237971467,"version":"4.1.0"},"reference-count":77,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T00:00:00Z","timestamp":1677283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EU\u2019s Horizon 2020 research and innovation program","award":["739593"],"award-info":[{"award-number":["739593"]}]},{"name":"EU\u2019s Horizon 2020 research and innovation program","award":["K135084"],"award-info":[{"award-number":["K135084"]}]},{"name":"EU\u2019s Horizon 2020 research and innovation program","award":["K143576"],"award-info":[{"award-number":["K143576"]}]},{"name":"Hungarian scientific research funds","award":["739593"],"award-info":[{"award-number":["739593"]}]},{"name":"Hungarian scientific research funds","award":["K135084"],"award-info":[{"award-number":["K135084"]}]},{"name":"Hungarian scientific research funds","award":["K143576"],"award-info":[{"award-number":["K143576"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The disease-residual transcriptomic profile (DRTP) within psoriatic healed\/resolved skin and epidermal tissue-resident memory T (TRM) cells have been proposed to be crucial for the recurrence of old lesions. However, it is unclear whether epidermal keratinocytes are involved in disease recurrence. There is increasing evidence regarding the importance of epigenetic mechanisms in the pathogenesis of psoriasis. Nonetheless, the epigenetic changes that contribute to the recurrence of psoriasis remain unknown. The aim of this study was to elucidate the role of keratinocytes in psoriasis relapse. The epigenetic marks 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) were visualized using immunofluorescence staining, and RNA sequencing was performed on paired never-lesional and resolved epidermal and dermal compartments of skin from psoriasis patients. We observed diminished 5-mC and 5-hmC amounts and decreased mRNA expression of the ten-eleven translocation (TET) 3 enzyme in the resolved epidermis. SAMHD1, C10orf99, and AKR1B10: the highly dysregulated genes in resolved epidermis are known to be associated with pathogenesis of psoriasis, and the DRTP was enriched in WNT, TNF, and mTOR signaling pathways. Our results suggest that epigenetic changes detected in epidermal keratinocytes of resolved skin may be responsible for the DRTP in the same regions. Thus, the DRTP of keratinocytes may contribute to site-specific local relapse.<\/jats:p>","DOI":"10.3390\/ijms24054556","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T03:29:48Z","timestamp":1677468588000},"page":"4556","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Psoriatic Resolved Skin Epidermal Keratinocytes Retain Disease-Residual Transcriptomic and Epigenomic Profiles"],"prefix":"10.3390","volume":"24","author":[{"given":"Ameneh","family":"Ghaffarinia","sequence":"first","affiliation":[{"name":"HCEMM-USZ Skin Research Group, H-6720 Szeged, Hungary"},{"name":"Department of Dermatology and Allergology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferhan","family":"Ayaydin","sequence":"additional","affiliation":[{"name":"HCEMM-USZ, Functional Cell Biology and Immunology, Advanced Core Facility, H-6728 Szeged, Hungary"},{"name":"Laboratory of Cellular Imaging, Biological Research Centre, E\u00f6tv\u00f6s Lor\u00e1nd Research Network, H-6726 Szeged, Hungary"},{"name":"Institute of Plant Biology, Biological Research Centre, H-6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9722-251X","authenticated-orcid":false,"given":"Szil\u00e1rd","family":"P\u00f3liska","sequence":"additional","affiliation":[{"name":"Genomic Medicine and Bioinformatics Core Facility, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1t\u00e9","family":"Manczinger","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, H-6720 Szeged, Hungary"},{"name":"Systems 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Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanni","family":"Balogh","sequence":"additional","affiliation":[{"name":"HCEMM-USZ Skin Research Group, H-6720 Szeged, Hungary"},{"name":"Department of Dermatology and Allergology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, H-6720 Szeged, Hungary"},{"name":"ELKH-SZTE Dermatological Research Group, Department of Dermatology and Allergology, University of Szeged, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Ver\u00e9b","sequence":"additional","affiliation":[{"name":"Regenerative Medicine and Cellular Pharmacology Laboratory (HECRIN), Department of Dermatology and Allergology, University of Szeged, H-6720 Szeged, Hungary"},{"name":"Research Institute of Translational Biomedicine, Department of Dermatology and Allergology, University of Szeged, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4242-2474","authenticated-orcid":false,"given":"Ren\u00e1ta","family":"Boz\u00f3","sequence":"additional","affiliation":[{"name":"HCEMM-USZ Skin Research Group, H-6720 Szeged, Hungary"},{"name":"Department of Dermatology and Allergology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, H-6720 Szeged, Hungary"},{"name":"ELKH-SZTE Dermatological Research Group, Department of Dermatology and Allergology, University of Szeged, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korn\u00e9lia","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"HCEMM-USZ Skin Research Group, H-6720 Szeged, Hungary"},{"name":"Department of Dermatology and Allergology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, H-6720 Szeged, Hungary"},{"name":"ELKH-SZTE Dermatological Research Group, Department of Dermatology and 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