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Biomedicine","award":["JCYJ20220530154402005"],"award-info":[{"award-number":["JCYJ20220530154402005"]}]},{"name":"Shenzhen Science and Technology Program","award":["2021ZD0201003"],"award-info":[{"award-number":["2021ZD0201003"]}]},{"name":"Shenzhen Science and Technology Program","award":["XDB32030200"],"award-info":[{"award-number":["XDB32030200"]}]},{"name":"Shenzhen Science and Technology Program","award":["31830035"],"award-info":[{"award-number":["31830035"]}]},{"name":"Shenzhen Science and Technology Program","award":["21921004"],"award-info":[{"award-number":["21921004"]}]},{"name":"Shenzhen Science and Technology Program","award":["ZDSYS20200811142401005"],"award-info":[{"award-number":["ZDSYS20200811142401005"]}]},{"name":"Shenzhen Science and Technology Program","award":["JCYJ20220530154402005"],"award-info":[{"award-number":["JCYJ20220530154402005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Centrifugal projections in the olfactory system are critical to both olfactory processing and behavior. The olfactory bulb (OB), the first relay station in odor processing, receives a substantial number of centrifugal inputs from the central brain regions. However, the anatomical organization of these centrifugal connections has not been fully elucidated, especially for the excitatory projection neurons of the OB, the mitral\/tufted cells (M\/TCs). Using rabies virus-mediated retrograde monosynaptic tracing in Thy1-Cre mice, we identified that the three most prominent inputs of the M\/TCs came from the anterior olfactory nucleus (AON), the piriform cortex (PC), and the basal forebrain (BF), similar to the granule cells (GCs), the most abundant population of inhibitory interneurons in the OB. However, M\/TCs received proportionally less input from the primary olfactory cortical areas, including the AON and PC, but more input from the BF and contralateral brain regions than GCs. Unlike organizationally distinct inputs from the primary olfactory cortical areas to these two types of OB neurons, inputs from the BF were organized similarly. Furthermore, individual BF cholinergic neurons innervated multiple layers of the OB, forming synapses on both M\/TCs and GCs. Taken together, our results indicate that the centrifugal projections to different types of OB neurons may provide complementary and coordinated strategies in olfactory processing and behavior.<\/jats:p>","DOI":"10.3390\/ijms24054579","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T03:29:48Z","timestamp":1677468588000},"page":"4579","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Organizational Principles of the Centrifugal Projections to the Olfactory Bulb"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1427-3803","authenticated-orcid":false,"given":"Li","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China"},{"name":"Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangning","family":"Li","sequence":"additional","affiliation":[{"name":"Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China"},{"name":"Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengming","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Wuhan University, Wuhan 430072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5774-7397","authenticated-orcid":false,"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Viral Vectors for Biomedicine, Shenzhen Key Laboratory of Quality Control Technology for Virus-Based Therapeutics, Guangdong Provincial Medical Products Administration, NMPA Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal Products, The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqiang","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China"},{"name":"Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China"},{"name":"Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China"},{"name":"Shenzhen Key Laboratory of Viral Vectors for Biomedicine, Shenzhen Key Laboratory of Quality Control Technology for Virus-Based Therapeutics, Guangdong Provincial Medical Products Administration, NMPA Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal Products, The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7269","DOI":"10.1523\/JNEUROSCI.2667-19.2020","article-title":"Dynamic impairment of olfactory behavior and signaling mediated by an olfactory corticofugal system","volume":"40","author":"Quintela","year":"2020","journal-title":"J. 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