{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:37:37Z","timestamp":1782412657997,"version":"3.54.5"},"reference-count":50,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Neurotensin (NTS) is a peptide discovered in 1973, which has been studied in many fields and mainly in oncology for its action in tumor growth and proliferation. In this review of the literature, we wanted to focus on its involvement in reproductive functions. NTS participates in an autocrine manner in the mechanisms of ovulation via NTS receptor 3 (NTSR3), present in granulosa cells. Spermatozoa express only its receptors, whereas in the female reproductive system (endometrial and tube epithelia and granulosa cells), we find both NTS secretion and the expression of its receptors. It consistently enhances the acrosome reaction of spermatozoa in mammals in a paracrine manner via its interaction with NTSR1 and NTSR2. Furthermore, previous results on embryonic quality and development are discordant. NTS appears to be involved in the key stages of fertilization and could improve the results of in vitro fertilization, especially through its effect on the acrosomal reaction.<\/jats:p>","DOI":"10.3390\/ijms24054594","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T03:29:48Z","timestamp":1677468588000},"page":"4594","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Neurotensin and Its Involvement in Reproductive Functions: An Exhaustive Review of the Literature"],"prefix":"10.3390","volume":"24","author":[{"given":"Pauline","family":"Arbogast","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine, CHRU de Nancy, Universit\u00e9 de Lorraine, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5585-9195","authenticated-orcid":false,"given":"Guillaume","family":"Gauchotte","sequence":"additional","affiliation":[{"name":"Department of Pathology, CHRU de Nancy, Universit\u00e9 de Lorraine, F-54500 Vand\u0153uvre-l\u00e8s-Nancy, France"},{"name":"INSERM UMRS 1256, Nutrition-Genetics and Exposure to Environmental Risks (NGERE), Universit\u00e9 de Lorraine, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7654-8150","authenticated-orcid":false,"given":"Romane","family":"Mougel","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, CHRU de Nancy, Universit\u00e9 de Lorraine, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Morel","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, CHRU de Nancy, Universit\u00e9 de Lorraine, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9724-3831","authenticated-orcid":false,"given":"Ahmed","family":"Ziyyat","sequence":"additional","affiliation":[{"name":"INSERM U1016, CNRS UMR8104, Institut Cochin, Universit\u00e9 de Paris, F-75014 Paris, France"},{"name":"Department of Histology, Embryology and Reproductive Biology, AP-HP, H\u00f4pital Cochin, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika\u00ebl","family":"Agopiantz","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, CHRU de Nancy, Universit\u00e9 de Lorraine, F-54000 Nancy, France"},{"name":"INSERM UMRS 1256, Nutrition-Genetics and Exposure to Environmental Risks (NGERE), Universit\u00e9 de Lorraine, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6854","DOI":"10.1016\/S0021-9258(19)43429-7","article-title":"The Isolation of a New Hypotensive Peptide, Neurotensin, from Bovine Hypothalami","volume":"248","author":"Carraway","year":"1973","journal-title":"J. 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