{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:08:44Z","timestamp":1792066124851,"version":"4.4.0"},"reference-count":51,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2020\/02190-5"],"award-info":[{"award-number":["2020\/02190-5"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2019\/25119-7"],"award-info":[{"award-number":["2019\/25119-7"]}]},{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o M\u00e9dica, Unidade 56","award":["2020\/02190-5"],"award-info":[{"award-number":["2020\/02190-5"]}]},{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o M\u00e9dica, Unidade 56","award":["2019\/25119-7"],"award-info":[{"award-number":["2019\/25119-7"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>S\u00e9zary syndrome (SS) is a rare and aggressive type of cutaneous T-cell lymphoma, with an abnormal inflammatory response in affected skin. The cytokines IL-1B and IL-18, as key signaling molecules in the immune system, are produced in an inactive form and cleave to the active form by inflammasomes. In this study, we assessed the skin, serum, peripheral mononuclear blood cell (PBMC) and lymph-node samples of SS patients and control groups (healthy donors (HDs) and idiopathic erythroderma (IE) nodes) to investigate the inflammatory markers IL-1B and IL-18 at the protein and transcript expression levels, as potential markers of inflammasome activation. Our findings showed increased IL-1B and decreased IL-18 protein expression in the epidermis of SS patients; however, in the dermis layer, we detected increased IL-18 protein expression. In the lymph nodes of SS patients at advanced stages of the disease (N2\/N3), we also detected an enhancement of IL-18 and a downregulation of IL-1B at the protein level. Moreover, the transcriptomic analysis of the SS and IE nodes confirmed the decreased expression of IL1B and NLRP3, whereas the pathway analysis indicated a further downregulation of IL1B-associated genes. Overall, the present findings showed compartmentalized expressions of IL-1B and IL-18 and provided the first evidence of their imbalance in patients with S\u00e9zary syndrome.<\/jats:p>","DOI":"10.3390\/ijms24054674","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T04:28:41Z","timestamp":1677558521000},"page":"4674","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Imbalanced IL-1B and IL-18 Expression in S\u00e9zary Syndrome"],"prefix":"10.3390","volume":"24","author":[{"given":"Kelly Cristina Gomes","family":"Manfrere","sequence":"first","affiliation":[{"name":"Laboratory of Medical Investigation LIM 56, Tropical Medicine Institute of S\u00e3o Paulo, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8822-353X","authenticated-orcid":false,"given":"Marina Passos","family":"Torrealba","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation LIM 56, Tropical Medicine Institute of S\u00e3o Paulo, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7403-9165","authenticated-orcid":false,"given":"Frederico Moraes","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation LIM 50, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8861-635X","authenticated-orcid":false,"given":"Emanuella Sarmento Alho","family":"de 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S\u00e3o Paulo, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian Nacagami","family":"Sotto","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3008-735X","authenticated-orcid":false,"given":"Anders","family":"Woetmann","sequence":"additional","affiliation":[{"name":"LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, 2177 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3135-5624","authenticated-orcid":false,"given":"Niels","family":"\u00d8dum","sequence":"additional","affiliation":[{"name":"LEO Foundation Skin Immunology Research Center, Department of Immunology 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