{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:47:40Z","timestamp":1790711260537,"version":"4.1.0"},"reference-count":212,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health-Grant Giovani Ricercatori","award":["GR-019-12370076"],"award-info":[{"award-number":["GR-019-12370076"]}]},{"name":"Italian Ministry of Health-Grant Giovani Ricercatori","award":["FAR2019"],"award-info":[{"award-number":["FAR2019"]}]},{"name":"Italian Ministry of Health-Grant Giovani Ricercatori","award":["FAR2020"],"award-info":[{"award-number":["FAR2020"]}]},{"name":"University of Insubria","award":["GR-019-12370076"],"award-info":[{"award-number":["GR-019-12370076"]}]},{"name":"University of Insubria","award":["FAR2019"],"award-info":[{"award-number":["FAR2019"]}]},{"name":"University of Insubria","award":["FAR2020"],"award-info":[{"award-number":["FAR2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Vitamin D is a secosteroid hormone that is highly involved in bone health. Mounting evidence revealed that, in addition to the regulation of mineral metabolism, vitamin D is implicated in cell proliferation and differentiation, vascular and muscular functions, and metabolic health. Since the discovery of vitamin D receptors in T cells, local production of active vitamin D was demonstrated in most immune cells, addressing the interest in the clinical implications of vitamin D status in immune surveillance against infections and autoimmune\/inflammatory diseases. T cells, together with B cells, are seen as the main immune cells involved in autoimmune diseases; however, growing interest is currently focused on immune cells of the innate compartment, such as monocytes, macrophages, dendritic cells, and natural killer cells in the initiation phases of autoimmunity. Here we reviewed recent advances in the onset and regulation of Graves\u2019 and Hashimoto\u2019s thyroiditis, vitiligo, and multiple sclerosis in relation to the role of innate immune cells and their crosstalk with vitamin D and acquired immune cells.<\/jats:p>","DOI":"10.3390\/ijms24054689","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T06:09:52Z","timestamp":1677564592000},"page":"4689","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["How Does Vitamin D Affect Immune Cells Crosstalk in Autoimmune Diseases?"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1873-3048","authenticated-orcid":false,"given":"Daniela","family":"Gallo","sequence":"first","affiliation":[{"name":"Endocrine Unit, Department of Medicine and Surgery, University of Insubria, ASST dei Sette Laghi, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisa","family":"Baci","sequence":"additional","affiliation":[{"name":"Immunology and General Pathology Laboratory, Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy"},{"name":"Molecular Cardiology Laboratory, IRCCS-Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasa","family":"Kustrimovic","sequence":"additional","affiliation":[{"name":"Center for Translational Research on Autoimmune and Allergic Disease\u2014CAAD, Universit\u00e0 del Piemonte Orientale, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3839-6421","authenticated-orcid":false,"given":"Nicola","family":"Lanzo","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Department of Medicine and Surgery, University of Insubria, ASST dei Sette Laghi, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohdan","family":"Patera","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Department of Medicine and Surgery, University of Insubria, ASST dei Sette Laghi, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7551-1751","authenticated-orcid":false,"given":"Maria Laura","family":"Tanda","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Department of Medicine and Surgery, University of Insubria, ASST dei Sette Laghi, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana","family":"Piantanida","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Department of Medicine and Surgery, University of Insubria, ASST dei Sette Laghi, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4757-7101","authenticated-orcid":false,"given":"Lorenzo","family":"Mortara","sequence":"additional","affiliation":[{"name":"Immunology and General Pathology Laboratory, Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Martens, P.J., Gysemans, C., Verstuyf, A., and Mathieu, A.C. 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