{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:39:13Z","timestamp":1787243953039,"version":"build-2736575974"},"reference-count":50,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Dentistry, Universidad de Chile","award":["Fiouch 13-11"],"award-info":[{"award-number":["Fiouch 13-11"]}]},{"name":"Faculty of Dentistry, Universidad de Chile","award":["Fondecyt 1220999"],"award-info":[{"award-number":["Fondecyt 1220999"]}]},{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)","award":["Fiouch 13-11"],"award-info":[{"award-number":["Fiouch 13-11"]}]},{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)","award":["Fondecyt 1220999"],"award-info":[{"award-number":["Fondecyt 1220999"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>During orthodontic treatment, diverse cytokines, enzymes, and osteolytic mediators produced within the teeth surrounding periodontal tissues determine the rate of alveolar bone remodeling and consequent teeth movement. In patients with teeth presenting reduced periodontal support, periodontal stability should be ensured during orthodontic treatment. Thus, therapies based on the application of low-intensity intermittent orthodontic forces are recommended. To determine if this kind of treatment is periodontally well tolerated, this study aimed to analyze the production of receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), interleukin (IL)-6, IL-17A, and matrix metalloproteinase (MMP)-8 in periodontal tissues of protruded anterior teeth with reduced periodontal support and undergoing orthodontic treatment. Patients with periodontitis-associated anterior teeth migration received non-surgical periodontal therapy and a specific orthodontic treatment involving controlled low-intensity intermittent orthodontic forces. Samples were collected before periodontitis treatment, after periodontitis treatment, and at 1 week to 24 months of the orthodontic treatment. During the 2 years of orthodontic treatment, no significant differences were detected in the probing depth, clinical attachment level, supragingival bacterial plaque, and bleeding on probing. In line with this, the gingival crevicular levels of RANKL, OPG, IL-6, IL-17A, and MMP-8 did not vary between the different evaluation time-points of the orthodontic treatment. When compared with the levels detected during the periodontitis, the RANKL\/OPG ratio was significantly lower at all the analyzed time-points of the orthodontic treatment. In conclusion, the patient-specific orthodontic treatment based on intermittent orthodontic forces of low intensities was well tolerated by periodontally compromised teeth with pathological migration.<\/jats:p>","DOI":"10.3390\/ijms24054807","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T03:29:00Z","timestamp":1677727740000},"page":"4807","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Levels of Pro-Inflammatory and Bone-Resorptive Mediators in Periodontally Compromised Patients under Orthodontic Treatment Involving Intermittent Forces of Low Intensities"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8372-0764","authenticated-orcid":false,"given":"Cristian","family":"Navarrete","sequence":"first","affiliation":[{"name":"Orthodontics-Periodontics Center, Faculty of Dentistry, Universidad de Chile, Santiago 8380492, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Riquelme","sequence":"additional","affiliation":[{"name":"Orthodontics-Periodontics Center, Faculty of Dentistry, Universidad de Chile, Santiago 8380492, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Baksai","sequence":"additional","affiliation":[{"name":"Orthodontics-Periodontics Center, Faculty of Dentistry, Universidad de Chile, Santiago 8380492, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Orthodontics-Periodontics Center, Faculty of Dentistry, Universidad de Chile, Santiago 8380492, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Orthodontics-Periodontics Center, Faculty of Dentistry, Universidad de Chile, Santiago 8380492, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5104-4781","authenticated-orcid":false,"given":"Mar\u00eda","family":"Michea","sequence":"additional","affiliation":[{"name":"Orthodontics-Periodontics Center, Faculty of Dentistry, Universidad de Chile, Santiago 8380492, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"von M\u00fchlenbrock","sequence":"additional","affiliation":[{"name":"Orthodontics-Periodontics Center, Faculty of Dentistry, Universidad de Chile, Santiago 8380492, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9243-1382","authenticated-orcid":false,"given":"Emilio A.","family":"Cafferata","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry, Universidad Cient\u00edfica del Sur, Lima 15067, Peru"},{"name":"Periodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago 8380492, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1391-320X","authenticated-orcid":false,"given":"Rolando","family":"Vernal","sequence":"additional","affiliation":[{"name":"Periodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago 8380492, Chile"},{"name":"Department of Conservative Dentistry, Faculty of Dentistry, Universidad de Chile, Santiago 8380492, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1902\/jop.2005.76.6.859","article-title":"Pathologic tooth migration","volume":"76","author":"Brunsvold","year":"2005","journal-title":"J. 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