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In people with obesity, exacerbation of gastric lesion severity and delayed healing may aggravate gastric mucosal lesions. Accordingly, we aimed to evaluate the citral effects on gastric lesion healing in eutrophic and obese animals. C57Bl\/6 male mice were divided into two groups: animals fed a standard diet (SD) or high-fat diet (HFD) for 12 weeks. Gastric ulcers were induced using acetic acid (80%) in both groups. Citral (25, 100, or 300 mg\/kg) was administered orally for 3 or 10 days. A vehicle-treated negative control (1% Tween 80, 10 mL\/kg) and lansoprazole-treated (30 mg\/kg) were also established. Lesions were macroscopically examined by quantifying regenerated tissue and ulcer areas. Matrix metalloproteinases (MMP-2 and -9) were analyzed by zymography. The ulcer base area between the two examined periods was significantly reduced in HFD 100 and 300 mg\/kg citral-treated animals. In the 100 mg\/kg citral-treated group, healing progression was accompanied by reduced MMP-9 activity. Accordingly, HFD could alter MMP-9 activity, delaying the initial healing phase. Although macroscopic changes were undetectable, 10-day treatment with 100 mg\/kg citral exhibited improved scar tissue progression in obese animals, with reduced MMP-9 activity and modulation of MMP-2 activation.<\/jats:p>","DOI":"10.3390\/ijms24054888","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T02:27:25Z","timestamp":1677810445000},"page":"4888","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Citral Modulates MMP-2 and MMP-9 Activities on Healing of Gastric Ulcers Associated with High-Fat Diet-Induced Obesity"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4430-0016","authenticated-orcid":false,"given":"Rie","family":"Ohara","sequence":"first","affiliation":[{"name":"Department of Structural and Functional Biology (Physiology), Institute of Biosciences of Botucatu, S\u00e3o Paulo State University, Botucatu 18618-970, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1957-6152","authenticated-orcid":false,"given":"Felipe Lima","family":"Dario","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology (Physiology), Institute of Biosciences of Botucatu, S\u00e3o Paulo State University, Botucatu 18618-970, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5466-3414","authenticated-orcid":false,"given":"Maycon Tavares","family":"Em\u00edlio-Silva","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology (Physiology), Institute of Biosciences of Botucatu, S\u00e3o Paulo State University, Botucatu 18618-970, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Assun\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology (Physiology), Institute of Biosciences of Botucatu, S\u00e3o Paulo State University, Botucatu 18618-970, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9312-2431","authenticated-orcid":false,"given":"Vin\u00edcius Peixoto","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology (Physiology), Institute of Biosciences of Botucatu, S\u00e3o Paulo State University, Botucatu 18618-970, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Bueno","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology (Physiology), Institute of Biosciences of Botucatu, S\u00e3o Paulo State University, Botucatu 18618-970, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Romano","family":"Raimundo","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology (Physiology), Institute of Biosciences of Botucatu, S\u00e3o Paulo State University, Botucatu 18618-970, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facia Regina Machado","family":"da Rocha","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology (Physiology), Institute of Biosciences of Botucatu, S\u00e3o Paulo State University, Botucatu 18618-970, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clelia Akiko","family":"Hiruma-Lima","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology (Physiology), Institute of Biosciences of Botucatu, S\u00e3o Paulo State University, Botucatu 18618-970, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"ref_1","unstructured":"WHO (2022, January 20). 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