{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:40:47Z","timestamp":1790779247254,"version":"4.1.0"},"reference-count":33,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Association of Persons Affected by PXE"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Pseudoxanthoma elasticum (PXE) is characterized by low levels of inorganic pyrophosphate (PPi) and a high activity of tissue-nonspecific alkaline phosphatase (TNAP). Lansoprazole is a partial inhibitor of TNAP. The aim was to investigate whether lansoprazole increases plasma PPi levels in subjects with PXE. We conducted a 2 \u00d7 2 randomized, double-blind, placebo-controlled crossover trial in patients with PXE. Patients were allocated 30 mg\/day of lansoprazole or a placebo in two sequences of 8 weeks. The primary outcome was the differences in plasma PPi levels between the placebo and lansoprazole phases. 29 patients were included in the study. There were eight drop-outs due to the pandemic lockdown after the first visit and one due to gastric intolerance, so twenty patients completed the trial. A generalized linear mixed model was used to evaluate the effect of lansoprazole. Overall, lansoprazole increased plasma PPi levels from 0.34 \u00b1 0.10 \u00b5M to 0.41 \u00b1 0.16 \u00b5M (p = 0.0302), with no statistically significant changes in TNAP activity. There were no important adverse events. 30 mg\/day of lansoprazole was able to significantly increase plasma PPi in patients with PXE; despite this, the study should be replicated with a large number of participants in a multicenter trial, with a clinical end point as the primary outcome.<\/jats:p>","DOI":"10.3390\/ijms24054899","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T02:56:50Z","timestamp":1677812210000},"page":"4899","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lansoprazole Increases Inorganic Pyrophosphate in Patients with Pseudoxanthoma Elasticum: A Double-Blind, Randomized, Placebo-Controlled Crossover Trial"],"prefix":"10.3390","volume":"24","author":[{"given":"Bel\u00e9n","family":"Murcia Casas","sequence":"first","affiliation":[{"name":"Internal Medicine Unit, Hospital Universitario Virgen de la Victoria, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Luis","family":"Carrillo Linares","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, Hospital Universitario Virgen de la Victoria, 29010 M\u00e1laga, Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Baquero Aranda","sequence":"additional","affiliation":[{"name":"Ophtalmology Unit, Hospital Universitario Virgen de la Victoria, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1196-0352","authenticated-orcid":false,"given":"Jos\u00e9","family":"Rioja Villodres","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), 29010 M\u00e1laga, Spain"},{"name":"Centro de Investigaciones M\u00e9dico-Sanitarias (CIMES), Universidad de M\u00e1laga, 29071 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-3411","authenticated-orcid":false,"given":"Vicente","family":"Merino Boh\u00f3rquez","sequence":"additional","affiliation":[{"name":"Pharmacy Unit, Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7059-1577","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Gonz\u00e1lez Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Rico Corral","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Bosch","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Hospital Universitario Virgen de la Victoria, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"S\u00e1nchez Chaparro","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, Hospital Universitario Virgen de la Victoria, 29010 M\u00e1laga, Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), 29010 M\u00e1laga, Spain"},{"name":"Department of Medicine and Dermatology, University of M\u00e1laga, 29016 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6436-1361","authenticated-orcid":false,"given":"Mar\u00eda","family":"Garc\u00eda Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), 29010 M\u00e1laga, Spain"},{"name":"Department of Phisiology, Universidad de M\u00e1laga, 29016 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4458-9833","authenticated-orcid":false,"given":"Pedro","family":"Valdivielso","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, Hospital Universitario Virgen de la Victoria, 29010 M\u00e1laga, Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), 29010 M\u00e1laga, Spain"},{"name":"Centro de Investigaciones M\u00e9dico-Sanitarias (CIMES), Universidad de M\u00e1laga, 29071 M\u00e1laga, Spain"},{"name":"Department of Medicine and Dermatology, University of M\u00e1laga, 29016 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/76109","article-title":"Mutations in ABCC6 Cause Pseudoxanthoma Elasticum","volume":"25","author":"Bergen","year":"2000","journal-title":"Nat. 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