{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:48:24Z","timestamp":1787028504620,"version":"build-2736575974"},"reference-count":35,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T00:00:00Z","timestamp":1677888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Meningiomas are the most frequently diagnosed primary intracranial tumors in adults. Surgical resection is preferred if the meningioma is accessible; for those that are not suitable for surgical resection, radiotherapy should be considered to improve local tumor control. However, recurrent meningiomas are challenging to treat, as the recurrent tumor might be located in the previously irradiated area. Boron Neutron Capture Therapy (BNCT) is a highly selective radiotherapy modality in which the cytotoxic effect focuses mainly on cells with increased uptake of boron-containing drugs. In this article, we describe four patients with recurrent meningiomas treated with BNCT in Taiwan. The mean boron-containing drug tumor-to-normal tissue uptake ratio was 4.125, and the tumor mean dose was 29.414 GyE, received via BNCT. The treatment response showed two stable diseases, one partial response, and one complete response. We also introduce and support the effectiveness and safety of BNCT as an alternative salvage treatment for recurrent meningiomas.<\/jats:p>","DOI":"10.3390\/ijms24054978","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T03:49:08Z","timestamp":1678074548000},"page":"4978","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0972-713X","authenticated-orcid":false,"given":"Tien-Li","family":"Lan","sequence":"first","affiliation":[{"name":"Department of Heavy Particles and Radiation Oncology, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Fu","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of General Neurosurgery, Taipei Veterans General Hospital Neurosurgical Department, No.201, Sec. 2, Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3709-885X","authenticated-orcid":false,"given":"Yi-Yen","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of General Neurosurgery, Taipei Veterans General Hospital Neurosurgical Department, No.201, Sec. 2, Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko-Han","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicinel, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Chi","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Department of Radiology, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Chieh","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Cheng","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Heavy Particles and Radiation Oncology, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fong-In","family":"Chou","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Engineering and Science, National Tsing Hua University, No.101, Sec 2, Kuang-Fu Rd., Hsinchu 300044, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9196-4897","authenticated-orcid":false,"given":"Jinn-Jer","family":"Peir","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Engineering and Science, National Tsing Hua University, No.101, Sec 2, Kuang-Fu Rd., Hsinchu 300044, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Engineering and Science, National Tsing Hua University, No.101, Sec 2, Kuang-Fu Rd., Hsinchu 300044, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Fan","family":"Mu","sequence":"additional","affiliation":[{"name":"Institute of Clinical Nursing, National Yang Ming Chiao Tung University, No.155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Heavy Particles and Radiation Oncology, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11060-010-0386-3","article-title":"Epidemiology and etiology of meningioma","volume":"99","author":"Wiemels","year":"2010","journal-title":"J. Neurooncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: A summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.2217\/fon-2018-0006","article-title":"An overview of meningiomas","volume":"14","author":"Buerki","year":"2018","journal-title":"Future Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jocn.2016.03.014","article-title":"Review of controversies in management of non-benign meningioma","volume":"31","author":"Paldor","year":"2016","journal-title":"J. Clin. Neurosci."},{"key":"ref_5","first-page":"819","article-title":"Simpson grading as predictor of meningioma recurrence","volume":"68","author":"Quddusi","year":"2018","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10143-018-0959-8","article-title":"Impact of radiotherapy in atypical meningioma recurrence: Literature review","volume":"42","author":"Pereira","year":"2019","journal-title":"Neurosurg. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10147-019-01480-4","article-title":"Boron neutron capture therapy (BNCT): A unique role in radiotherapy with a view to entering the accelerator based BNCT era","volume":"25","author":"Suzuki","year":"2020","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Chen, Y.W., Lee, Y.Y., Lin, C.F., Pan, P.S., Chen, J.K., Wang, C.W., Hsu, S.M., Kuo, Y.C., Lan, T.L., and Hsu, S.P.C. (2021). Salvage boron neutron capture therapy for malignant brain tumor patients in compliance with emergency and compassionate use: Evaluation of 34 cases in Taiwan. Biology, 10.","DOI":"10.3390\/biology10040334"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"109105","DOI":"10.1016\/j.apradiso.2020.109105","article-title":"Using salvage boron neutron capture therapy (BNCT) for recurrent malignant brain tumors in Taiwan","volume":"160","author":"Lan","year":"2020","journal-title":"Appl. Radiat. Isot."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40880-018-0299-7","article-title":"Boron delivery agents for neutron capture therapy of cancer","volume":"38","author":"Barth","year":"2018","journal-title":"Cancer Commun."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13014-017-0949-y","article-title":"Dynamic changes in 18F-borono-L-phenylalanine uptake in unresectable, advanced, or recurrent squamous cell carcinoma of the head and neck and malignant melanoma during boron neutron capture therapy patient selection","volume":"13","author":"Morita","year":"2018","journal-title":"Radiat. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s11060-008-9699-x","article-title":"Survival benefit of boron neutron capture therapy for recurrent malignant gliomas","volume":"91","author":"Miyatake","year":"2009","journal-title":"J. Neurooncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11060-020-03586-6","article-title":"Boron neutron capture therapy for malignant brain tumors","volume":"149","author":"Miyatake","year":"2020","journal-title":"J. Neurooncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"35743","DOI":"10.1038\/srep35743","article-title":"Long term surgical outcome and prognostic factors of atypical and malignant meningiomas","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_15","first-page":"3835","article-title":"Bone and lung metastases from intracranial meningioma","volume":"26","author":"Fabi","year":"2006","journal-title":"Anticancer Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"831","DOI":"10.3171\/jns.1998.88.5.0831","article-title":"Factors associated with survival in patients with meningioma","volume":"88","author":"McCarthy","year":"1998","journal-title":"J. Neurosurg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"E4","DOI":"10.3171\/2018.1.FOCUS17752","article-title":"Relationship between tumor location, size, and WHO grade in meningioma","volume":"44","author":"Magill","year":"2018","journal-title":"Neurosurg. Focus"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11060-018-03058-y","article-title":"Repeated craniotomies for intracranial tumors: Is the risk increased? Pooled analysis of two prospective, institutional registries of complications and outcomes","volume":"142","author":"Zattra","year":"2019","journal-title":"J. Neurooncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.wneu.2017.08.166","article-title":"Stereotactic radiosurgery of central skull base meningioma\u2019s\u2014Volumetric evaluation and longterm outcomes","volume":"108","author":"Patibandla","year":"2017","journal-title":"World Neurosurg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s12149-019-01347-8","article-title":"4-Borono-2-18F-fluoro-L-phenylalanine PET for boron neutron capture therapy-oriented diagnosis: Overview of a quarter century of research","volume":"33","author":"Ishiwata","year":"2019","journal-title":"Ann. Nucl. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s12149-016-1121-8","article-title":"Assessment of 10B concentration in boron neutron capture therapy: Potential of image-guided therapy using 18FBPA PET","volume":"30","author":"Shimosegawa","year":"2016","journal-title":"Ann. Nucl. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"107964","DOI":"10.1016\/j.pharmthera.2021.107964","article-title":"Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics","volume":"230","author":"Kanai","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Nakahara, Y., Ito, H., Masuoka, J., and Abe, T. (2020). Boron neutron capture therapy and photodynamic therapy for high-grade meningiomas. Cancers, 12.","DOI":"10.3390\/cancers12051334"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1227\/01.neu.0000279727.90650.24","article-title":"Boron neutron capture therapy for malignant tumors related to meningiomas","volume":"61","author":"Miyatake","year":"2007","journal-title":"Neurosurgery"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13550-019-0518-5","article-title":"Correlation between 18F-1-amino-3-fluorocyclobutane-1-carboxylic acid (18F-fluciclovine) uptake and expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter 1 (LAT1) in primary prostate cancer","volume":"9","author":"Saarinen","year":"2019","journal-title":"EJNMMI Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"S322","DOI":"10.1055\/s-0038-1666837","article-title":"Boron Neutron Capture Therapy for High-Grade Skull-Base Meningioma","volume":"79","author":"Takeuchi","year":"2018","journal-title":"J. Neurol. Surg. B Skull. Base"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1357-4310(98)01226-X","article-title":"New horizons for therapy based on the boron neutron capture reaction","volume":"4","author":"Hawthorne","year":"1998","journal-title":"Mol. Med. Today"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.21037\/tro-20-10","article-title":"Boron neutron capture therapy as salvage treatment for recurrent papillary thyroid carcinoma\u2014A case report","volume":"4","author":"Pan","year":"2020","journal-title":"Ther. Radiol. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"109308","DOI":"10.1016\/j.apradiso.2020.109308","article-title":"Pharmacokinetics of 10B-p-boronophenylalanine (BPA) in the blood and tumors in human patients: A critical review with special reference to tumor-to-blood (T\/B) ratios using resected tumor samples","volume":"166","author":"Fukuda","year":"2020","journal-title":"Appl. Radiat. Isot."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s12194-017-0430-5","article-title":"Physics of epi-thermal boron neutron capture therapy (epi-thermal BNCT)","volume":"10","author":"Seki","year":"2017","journal-title":"Radiol. Phys. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.rpor.2018.07.002","article-title":"Physical, dosimetric and clinical aspects and delivery systems in neutron capture therapy","volume":"23","author":"Farhood","year":"2018","journal-title":"Rep. Pract. Oncol. Radiother."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Lee, J.C., Chuang, K.S., Chen, Y.W., Hsu, F.Y., Chou, F.I., Yen, S.H., and Wu, Y.H. (2017). Preliminary dosimetric study on feasibility of multi-beam boron neutron capture therapy in patients with diffuse intrinsic pontine glioma without craniotomy. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0180461"},{"key":"ref_33","unstructured":"Ono, K., Masunaga, S.I., Kinashi, Y., Nagata, K., Suzuki, M., Sakurai, Y., Maruhashi, A., Kato, I., Nakazawa, M., and Ariyoshi, Y. (2006, January 9\u201313). Neutron Irradiation under Continuous BPA Injection for Solving the Problem of Heterogeneous Distribution of BPA. Proceedings of the 12th International Congress on Neutron Capture Therapy\u2014From the Past to the Future, Takamatsu, Japan."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.apradiso.2009.03.015","article-title":"Survival benefit from boron neutron capture therapy for the newly diagnosed glioblastoma patients","volume":"67","author":"Kawabata","year":"2009","journal-title":"Appl. Radiat. Isot."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur. J. Cancer"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/5\/4978\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:48:06Z","timestamp":1760122086000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/5\/4978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,4]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["ijms24054978"],"URL":"https:\/\/doi.org\/10.3390\/ijms24054978","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,4]]}}}