{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:06:16Z","timestamp":1791237976939,"version":"4.1.0"},"reference-count":145,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T00:00:00Z","timestamp":1677974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1R01AR073004-01A1"],"award-info":[{"award-number":["1R01AR073004-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01AR071189-01A1"],"award-info":[{"award-number":["R01AR071189-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R21 AI149267-01A1"],"award-info":[{"award-number":["R21 AI149267-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1I01BX004293-01A1"],"award-info":[{"award-number":["1I01BX004293-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["W81XWH2210689"],"award-info":[{"award-number":["W81XWH2210689"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"VA merit","award":["1R01AR073004-01A1"],"award-info":[{"award-number":["1R01AR073004-01A1"]}]},{"name":"VA merit","award":["R01AR071189-01A1"],"award-info":[{"award-number":["R01AR071189-01A1"]}]},{"name":"VA merit","award":["R21 AI149267-01A1"],"award-info":[{"award-number":["R21 AI149267-01A1"]}]},{"name":"VA merit","award":["1I01BX004293-01A1"],"award-info":[{"award-number":["1I01BX004293-01A1"]}]},{"name":"VA merit","award":["W81XWH2210689"],"award-info":[{"award-number":["W81XWH2210689"]}]},{"name":"DOD","award":["1R01AR073004-01A1"],"award-info":[{"award-number":["1R01AR073004-01A1"]}]},{"name":"DOD","award":["R01AR071189-01A1"],"award-info":[{"award-number":["R01AR071189-01A1"]}]},{"name":"DOD","award":["R21 AI149267-01A1"],"award-info":[{"award-number":["R21 AI149267-01A1"]}]},{"name":"DOD","award":["1I01BX004293-01A1"],"award-info":[{"award-number":["1I01BX004293-01A1"]}]},{"name":"DOD","award":["W81XWH2210689"],"award-info":[{"award-number":["W81XWH2210689"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The skin, including the hypodermis, is the largest body organ and is in constant contact with the environment. Neurogenic inflammation is the result of the activity of nerve endings and mediators (neuropeptides secreted by nerve endings in the development of the inflammatory reaction in the skin), as well as interactions with other cells such as keratinocytes, Langerhans cells, endothelial cells and mast cells. The activation of TRPV\u2013ion channels results in an increase in calcitonin gene-related peptide (CGRP) and substance P, induces the release of other pro-inflammatory mediators and contributes to the maintenance of cutaneous neurogenic inflammation (CNI) in diseases such as psoriasis, atopic dermatitis, prurigo and rosacea. Immune cells present in the skin (mononuclear cells, dendritic cells and mast cells) also express TRPV1, and their activation directly affects their function. The activation of TRPV1 channels mediates communication between sensory nerve endings and skin immune cells, increasing the release of inflammatory mediators (cytokines and neuropeptides). Understanding the molecular mechanisms underlying the generation, activation and modulation of neuropeptide and neurotransmitter receptors in cutaneous cells can aid in the development of effective treatments for inflammatory skin disorders.<\/jats:p>","DOI":"10.3390\/ijms24055001","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T03:49:08Z","timestamp":1678074548000},"page":"5001","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":153,"title":["Molecular Mechanisms of Neurogenic Inflammation of the Skin"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-1222","authenticated-orcid":false,"given":"Luiza","family":"Marek-Jozefowicz","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venerology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6286-0693","authenticated-orcid":false,"given":"Bogus\u0142aw","family":"Nedoszytko","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, 80-210 Gdansk, Poland"},{"name":"Molecular Laboratory, Invicta Fertility and Reproductive Centre, 81-740 Sopot, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5121-8777","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Grochocka","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2206-3531","authenticated-orcid":false,"given":"Micha\u0142 A.","family":"\u017bmijewski","sequence":"additional","affiliation":[{"name":"Department of Histology, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Czajkowski","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6343-8454","authenticated-orcid":false,"given":"Wies\u0142aw J.","family":"Cuba\u0142a","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Medical University of Gdansk, Debinki St. 7 Build. 25, 80-952 Gdansk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej T.","family":"Slominski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Alabama at Birmingham, 500 22nd Street South, Birmingham, AL 35294, USA"},{"name":"Comprehensive Cancer Center, University of Alabama at Birmingham, 1824 6th Avenue, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-19683-6_1","article-title":"Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin\u2019s Neuroendocrine System","volume":"212","author":"Slominski","year":"2012","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"C1757","DOI":"10.1152\/ajpcell.00147.2022","article-title":"Neuroendocrine Signaling in the Skin with a Special Focus on the Epidermal Neuropeptides","volume":"323","author":"Slominski","year":"2022","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_3","first-page":"457","article-title":"Neuroendocrinology of the Skin","volume":"21","author":"Slominski","year":"2000","journal-title":"Endocr. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00281-018-0675-z","article-title":"Skin Neurogenic Inflammation","volume":"40","author":"Choi","year":"2018","journal-title":"Semin. Immunopathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1038\/sj.jid.5700270","article-title":"Neurotrophins in Skin Biology and Pathology","volume":"126","author":"Botchkarev","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1152\/physrev.00026.2005","article-title":"Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ","volume":"86","author":"Roosterman","year":"2006","journal-title":"Physiol. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/ACI.0b013e3282a644d2","article-title":"Neuroimmune Interactions in Allergic Skin Diseases","volume":"7","author":"Cevikbas","year":"2007","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4161\/derm.3.1.14618","article-title":"Stress, Atopy and Allergy: A Re-Evaluation from a Psychoneuroimmunologic Persepective","volume":"3","author":"Liezmann","year":"2011","journal-title":"Derm.-Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0923-1811(99)00038-9","article-title":"The Effects of Substance P and Vasoactive Intestinal Peptide on Interleukin-6 Synthesis in Cultured Human Keratinocytes","volume":"22","author":"Park","year":"1999","journal-title":"J. Dermatol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1046\/j.0022-202x.2001.01498.x","article-title":"The Neurosensory Tachykinins Substance P and Neurokinin a Directly Induce Keratinocyte Nerve Growth Factor","volume":"117","author":"Burbach","year":"2001","journal-title":"J. Investig. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.neuroscience.2011.06.085","article-title":"Proteinase-Activated Receptor 2 Sensitizes Transient Receptor Potential Vanilloid 1, Transient Receptor Potential Vanilloid 4, and Transient Receptor Potential Ankyrin 1 in Paclitaxel-Induced Neuropathic Pain","volume":"193","author":"Chen","year":"2011","journal-title":"Neuroscience"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1523\/JNEUROSCI.23-15-06176.2003","article-title":"Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin","volume":"23","author":"Steinhoff","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2174\/1871528113666140616112708","article-title":"Neuromodulatory and Anti-Inflammatory Ingredient for Sensitive Skin: In Vitro Assessment","volume":"13","author":"Costa","year":"2014","journal-title":"Inflamm. Allergy Drug Targets"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/exd.13143","article-title":"Integrative Concepts of Rosacea Pathophysiology, Clinical Presentation and New Therapeutics","volume":"26","author":"Holmes","year":"2017","journal-title":"Exp. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"820817","DOI":"10.3389\/fmed.2022.820817","article-title":"Dramatic Effect of Botulinum Toxin Type A on Hypertrophic Scar: A Promising Therapeutic Drug and Its Mechanism Through the SP-NK1R Pathway in Cutaneous Neurogenic Inflammation","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e12677","DOI":"10.1111\/cpr.12677","article-title":"The Importance of the Neuro-immuno-cutaneous System on Human Skin Equivalent Design","volume":"52","author":"Tamamoto","year":"2019","journal-title":"Cell Prolif."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"106755","DOI":"10.1016\/j.intimp.2020.106755","article-title":"A Promising Therapeutic Target for Psoriasis: Neuropeptides in Human Skin","volume":"87","author":"Zhang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000496538","article-title":"Immunoregulatory Effects of Neuropeptides on Endothelial Cells: Relevance to Dermatological Disorders","volume":"235","author":"Mehta","year":"2019","journal-title":"Dermatology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"102004","DOI":"10.1016\/j.npep.2019.102004","article-title":"Neurotransmitters, Neuropeptides and Their Receptors Interact with Immune Response in Healthy and Psoriatic Skin","volume":"79","year":"2020","journal-title":"Neuropeptides"},{"key":"ref_20","unstructured":"Graefe, S.B., and Mohiuddin, S.S. (2022). Biochemistry, Substance P, StatPearls Publishing."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jcp.20061","article-title":"The Role of Substance P in Inflammatory Disease","volume":"201","author":"Goode","year":"2004","journal-title":"J. Cell. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1152\/physrev.00031.2013","article-title":"Tachykinins and Their Receptors: Contributions to Physiological Control and the Mechanisms of Disease","volume":"94","author":"Steinhoff","year":"2014","journal-title":"Physiol. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1042\/CS20050161","article-title":"Clinical Relevance of the Neurotrophins and Their Receptors","volume":"110","author":"Allen","year":"2006","journal-title":"Clin. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.it.2005.10.002","article-title":"Neuroimmunoendocrine Circuitry of the \u2018Brain-Skin Connection\u2019","volume":"27","author":"Paus","year":"2006","journal-title":"Trends Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.3389\/fphys.2018.01249","article-title":"The Role of Calcitonin Gene Related Peptide (CGRP) in Neurogenic Vasodilation and Its Cardioprotective Effects","volume":"9","author":"Kee","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/j.1476-5381.1991.tb12497.x","article-title":"A Calcitonin Gene-Related Peptide (CGRP) Antagonist (CGRP8-37) Inhibits Microvascular Responses Induced by CGRP and Capsaicin in Skin","volume":"104","author":"Hughes","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.jaci.2022.03.010","article-title":"Neuroimmune Communication Regulating Pruritus in Atopic Dermatitis","volume":"149","author":"Steinhoff","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.0306164","article-title":"DAMPs, PAMPs and Alarmins: All We Need to Know about Danger","volume":"81","author":"Bianchi","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev-pathmechdis-012419-032847","article-title":"DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation","volume":"15","author":"Zindel","year":"2020","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","article-title":"DAMP-Sensing Receptors in Sterile Inflammation and Inflammatory Diseases","volume":"20","author":"Gong","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u039aB Pathway for the Therapy of Diseases: Mechanism and Clinical Study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct. Target Ther."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Minnone, G., de Benedetti, F., and Bracci-Laudiero, L. (2017). NGF and Its Receptors in the Regulation of Inflammatory Response. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18051028"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/all.13239","article-title":"Emerging Role of Interleukin-31 and Interleukin-31 Receptor in Pruritus in Atopic Dermatitis","volume":"73","author":"Furue","year":"2018","journal-title":"Allergy"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Jin, R., Luo, L., and Zheng, J. (2022). The Trinity of Skin: Skin Homeostasis as a Neuro\u2013Endocrine\u2013Immune Organ. Life, 12.","DOI":"10.3390\/life12050725"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.lfs.2003.09.039","article-title":"Tachykinins and Tachykinin Receptors: A Growing Family","volume":"74","author":"Pennefather","year":"2004","journal-title":"Life Sci."},{"key":"ref_36","first-page":"1","article-title":"Biological and Pharmacological Aspects of the NK1-Receptor","volume":"2015","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"D1091","DOI":"10.1093\/nar\/gkx1121","article-title":"The IUPHAR\/BPS Guide to Pharmacology in 2018: Updates and Expansion to Encompass the New Guide to Immunopharmacology","volume":"46","author":"Harding","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1097\/ALN.0b013e31824bb303","article-title":"Substance P Signaling Controls Mast Cell Activation, Degranulation, and Nociceptive Sensitization in a Rat Fracture Model of Complex Regional Pain Syndrome","volume":"116","author":"Li","year":"2012","journal-title":"Anesthesiology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e00990","DOI":"10.1002\/prp2.990","article-title":"The Effect of Substance P and Its Common in Vivo-formed Metabolites on MRGPRX2 and Human Mast Cell Activation","volume":"10","author":"Hsin","year":"2022","journal-title":"Pharmacol. Res. Perspec."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.immuni.2020.10.001","article-title":"Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens","volume":"53","author":"Perner","year":"2020","journal-title":"Immunity"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.anai.2020.07.007","article-title":"The Impact of Psychological Stress on Mast Cells","volume":"125","author":"Theoharides","year":"2020","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0923-1811(03)00070-7","article-title":"The Effect of Substance P on Peripheral Blood Mononuclear Cells in Patients with Atopic Dermatitis","volume":"32","author":"Kim","year":"2003","journal-title":"J. Dermatol. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3389\/fncel.2019.00422","article-title":"Mast Cells and Sensory Nerves Contribute to Neurogenic Inflammation and Pruritus in Chronic Skin Inflammation","volume":"13","author":"Siiskonen","year":"2019","journal-title":"Front. Cell Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"100361","DOI":"10.1016\/j.bbih.2021.100361","article-title":"Roles of Calcitonin Gene-Related Peptide in the Skin, and Other Physiological and Pathophysiological Functions","volume":"18","author":"Kim","year":"2021","journal-title":"Brain Behav. Immun.-Health"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0923-1811(02)00103-2","article-title":"Neuromediators\u2014A Crucial Component of the Skin Immune System","volume":"30","author":"Luger","year":"2002","journal-title":"J. Dermatol. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.immuni.2019.03.013","article-title":"Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-Histaminergic Itch","volume":"50","author":"Meixiong","year":"2019","journal-title":"Immunity"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"ra45","DOI":"10.1126\/scisignal.2001925","article-title":"The Distinct Roles of Two GPCRs, MrgprC11 and PAR2, in Itch and Hyperalgesia","volume":"4","author":"Liu","year":"2011","journal-title":"Sci. Signal."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1529-8019.2008.00166.x","article-title":"Psychoneuroimmunology","volume":"21","author":"Tausk","year":"2008","journal-title":"Dermatol. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Lee, E.Y., Nam, Y.J., Kang, S., Choi, E.J., Han, I., Kim, J., Kim, D.H., An, J.H., Lee, S., and Lee, M.H. (2020). The Local Hypothalamic\u2013Pituitary\u2013Adrenal Axis in Cultured Human Dermal Papilla Cells. BMC Mol. Cell Biol., 21.","DOI":"10.1186\/s12860-020-00287-w"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/s41593-018-0119-z","article-title":"Circuit Dissection of the Role of Somatostatin in Itch and Pain","volume":"21","author":"Huang","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.clindermatol.2014.04.011","article-title":"The Role of Neuropeptides in the Control of Regional Immunity","volume":"32","author":"Lotti","year":"2014","journal-title":"Clin. Dermatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"627985","DOI":"10.3389\/fmed.2021.627985","article-title":"Involvement of Neuro-Immune Interactions in Pruritus with Special Focus on Receptor Expressions","volume":"8","author":"Ruppenstein","year":"2021","journal-title":"Front. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-3-662-44605-8_14","article-title":"NK-1 Antagonists and itch","volume":"Volume 226","author":"Cowan","year":"2015","journal-title":"Pharmacology of Itch"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s13555-019-0305-2","article-title":"NK-1 Receptor Antagonists and Pruritus: Review of Current Literature","volume":"9","author":"Jaworecka","year":"2019","journal-title":"Dermatol. Ther."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.jaci.2018.09.005","article-title":"Itch: From Mechanism to (Novel) Therapeutic Approaches","volume":"142","author":"Yosipovitch","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10565-016-9330-4","article-title":"Upregulated Expression of Substance P in Basophils of the Patients with Chronic Spontaneous Urticaria: Induction of Histamine Release and Basophil Accumulation by Substance P","volume":"32","author":"Zheng","year":"2016","journal-title":"Cell Biol. Toxicol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12967-017-1196-6","article-title":"Up-Regulated Expression of Substance P in CD8+ T Cells and NK1R on Monocytes of Atopic Dermatitis","volume":"15","author":"Zhang","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e01981","DOI":"10.1016\/j.heliyon.2019.e01981","article-title":"Expression of Precipitating Factors of Pruritus Found in Humans in an Imiquimod-Induced Psoriasis Mouse Model","volume":"5","author":"Oishi","year":"2019","journal-title":"Heliyon"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3892\/etm.2021.10031","article-title":"Role of NGF and Its Receptors in Wound Healing (Review)","volume":"21","author":"Liu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Datta-Mitra, A., Kundu-Raychaudhuri, S., Mitra, A., and Raychaudhuri, S.P. (2015). Cross Talk between Neuroregulatory Molecule and Monocyte: Nerve Growth Factor Activates the Inflammasome. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0121626"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3389\/fimmu.2018.00939","article-title":"Nerve Growth Factor and Pathogenesis of Leprosy: Review and Update","volume":"9","author":"Quaresma","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"101568","DOI":"10.1016\/j.jbc.2022.101568","article-title":"High-Affinity TrkA and P75 Neurotrophin Receptor Complexes: A Twisted Affair","volume":"298","author":"Conroy","year":"2022","journal-title":"J. Biol. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"C360","DOI":"10.1152\/ajpcell.00180.2019","article-title":"The Pleiotropic Molecule NGF Regulates the in Vitro Properties of Fibroblasts, Keratinocytes, and Endothelial Cells: Implications for Wound Healing","volume":"318","author":"Gostynska","year":"2020","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Calz\u00e0, L., Aloe, L., and Giardino, L. (2021). Recent Advances in NGF and Related Molecules: The Continuum of the NGF \u201cSaga\u201d, Springer International Publishing.","DOI":"10.1007\/978-3-030-74046-7"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3389\/fendo.2014.00067","article-title":"Biased Signaling of Protease-Activated Receptors","volume":"5","author":"Zhao","year":"2014","journal-title":"Front. Endocrinol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1007\/s10753-014-9999-6","article-title":"Protease-Activated Receptor 4: A Critical Participator in Inflammatory Response","volume":"38","author":"Fu","year":"2015","journal-title":"Inflammation"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1124\/pr.113.008425","article-title":"Pharmacology and Signaling of MAS-Related G Protein\u2013Coupled Receptors","volume":"66","author":"Solinski","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1124\/pr.113.008136","article-title":"Mas and Its Related G Protein\u2013Coupled Receptors, Mrgprs","volume":"66","author":"Bader","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41586-021-04126-6","article-title":"Structure, Function and Pharmacology of Human Itch GPCRs","volume":"600","author":"Cao","year":"2021","journal-title":"Nature"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.cell.2009.11.034","article-title":"Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus","volume":"139","author":"Liu","year":"2009","journal-title":"Cell"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nn.2789","article-title":"TRPA1 Is Required for Histamine-Independent, Mas-Related G Protein\u2013Coupled Receptor\u2013Mediated Itch","volume":"14","author":"Wilson","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"118906","DOI":"10.1016\/j.lfs.2020.118906","article-title":"TRPA1 Deficiency Alleviates Inflammation of Atopic Dermatitis by Reducing Macrophage Infiltration","volume":"266","author":"Zeng","year":"2021","journal-title":"Life Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1096\/fj.13-229948","article-title":"TRPA1 Controls Inflammation and Pruritogen Responses in Allergic Contact Dermatitis","volume":"27","author":"Liu","year":"2013","journal-title":"FASEB J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-018-0001-z","article-title":"Atopic Dermatitis","volume":"4","author":"Weidinger","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"16082","DOI":"10.1038\/nrdp.2016.82","article-title":"Psoriasis","volume":"2","author":"Greb","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Komiya, E., Tominaga, M., Kamata, Y., Suga, Y., and Takamori, K. (2020). Molecular and Cellular Mechanisms of Itch in Psoriasis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218406"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"590261","DOI":"10.3389\/fimmu.2020.590261","article-title":"Involvement of Neural Transient Receptor Potential Channels in Peripheral Inflammation","volume":"11","author":"Silverman","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"782","DOI":"10.3389\/fnins.2020.00782","article-title":"TRP Channels Role in Pain Associated with Neurodegenerative Diseases","volume":"14","author":"Duitama","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mcn.2014.04.007","article-title":"Calcium Entry via TRPV1 but Not ASICs Induces Neuropeptide Release from Sensory Neurons","volume":"61","author":"Boillat","year":"2014","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s13238-017-0395-5","article-title":"TRPV1 and TRPA1 in Cutaneous Neurogenic and Chronic Inflammation: Pro-Inflammatory Response Induced by Their Activation and Their Sensitization","volume":"8","author":"Gouin","year":"2017","journal-title":"Protein Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"696784","DOI":"10.3389\/fimmu.2021.696784","article-title":"Th2 Modulation of Transient Receptor Potential Channels: An Unmet Therapeutic Intervention for Atopic Dermatitis","volume":"12","author":"Meng","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1016\/j.pain.2011.08.025","article-title":"TRP-Channel-Specific Cutaneous Eicosanoid Release Patterns","volume":"152","author":"Jain","year":"2011","journal-title":"Pain"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Landini, L., Souza Monteiro de Araujo, D., Titiz, M., Geppetti, P., Nassini, R., and de Logu, F. (2022). TRPA1 Role in Inflammatory Disorders: What Is Known So Far?. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094529"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2013.08.057","article-title":"The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch","volume":"155","author":"Wilson","year":"2013","journal-title":"Cell"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Lamas, J.A., Rueda-Ruzafa, L., and Herrera-P\u00e9rez, S. (2019). Ion Channels and Thermosensitivity: TRP, TREK, or Both?. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20102371"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Giniatullin, R. (2020). Ion Channels of Nociception. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103553"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"136379","DOI":"10.1016\/j.neulet.2021.136379","article-title":"Role of TRP Ion Channels in Pruritus","volume":"768","author":"Shirolkar","year":"2022","journal-title":"Neurosci. Lett."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1002\/ski2.66","article-title":"A Re-innervated in Vitro Skin Model of Non-histaminergic Itch and Skin Neurogenic Inflammation: PAR2-, TRPV1- and TRPA1-agonist Induced Functionality","volume":"1","author":"Lebonvallet","year":"2021","journal-title":"Ski. Health Dis."},{"key":"ref_89","first-page":"13","article-title":"TRP channels in nociception and pathological pain","volume":"Volume 1099","author":"Shyu","year":"2018","journal-title":"Advances in Pain Research: Mechanisms and Modulation of Chronic Pain"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s12016-015-8488-5","article-title":"Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?","volume":"51","author":"Mollanazar","year":"2016","journal-title":"Clinic Rev. Allerg. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.jid.2020.01.012","article-title":"PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes","volume":"140","author":"Zhao","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.3389\/fimmu.2020.01740","article-title":"Protease-Activated Receptor-2 Regulates Neuro-Epidermal Communication in Atopic Dermatitis","volume":"11","author":"Buhl","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1074\/jbc.M112.438184","article-title":"Protease-Activated Receptor 2 (PAR2) Protein and Transient Receptor Potential Vanilloid 4 (TRPV4) Protein Coupling Is Required for Sustained Inflammatory Signaling*","volume":"288","author":"Poole","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.0022-202X.2004.23539.x","article-title":"Agonists of Proteinase-Activated Receptor-2 Stimulate Upregulation of Intercellular Cell Adhesion Molecule-1 in Primary Human Keratinocytes via Activation of NF-Kappa B","volume":"124","author":"Buddenkotte","year":"2005","journal-title":"J. Investig. Dermatol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e1390","DOI":"10.1002\/cti2.1390","article-title":"Molecular and Cellular Mechanisms of Itch and Pain in Atopic Dermatitis and Implications for Novel Therapeutics","volume":"11","author":"Kwatra","year":"2022","journal-title":"Clin. Trans. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Maglie, R., Souza Monteiro de Araujo, D., Antiga, E., Geppetti, P., Nassini, R., and de Logu, F. (2021). The Role of TRPA1 in Skin Physiology and Pathology. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22063065"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/mi.2009.136","article-title":"Advances in Mast Cell Biology: New Understanding of Heterogeneity and Function","volume":"3","author":"Moon","year":"2010","journal-title":"Mucosal. Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neubiorev.2017.05.001","article-title":"Mast Cells in Neuroinflammation and Brain Disorders","volume":"79","author":"Hendriksen","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.tins.2013.06.001","article-title":"Mast Cells on the Mind: New Insights and Opportunities","volume":"36","author":"Silver","year":"2013","journal-title":"Trends Neurosci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/imr.12622","article-title":"Mast Cell-Neural Interactions Contribute to Pain and Itch","volume":"282","author":"Gupta","year":"2018","journal-title":"Immunol. Rev."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3389\/fncel.2019.00110","article-title":"Mast Cell Neural Interactions in Health and Disease","volume":"13","author":"Mittal","year":"2019","journal-title":"Front. Cell Neurosci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/ejp.1086","article-title":"Evidence for the Modulation of Nociception in Mice by Central Mast Cells","volume":"21","author":"Kissel","year":"2017","journal-title":"Eur. J. Pain"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0006-8993(00)03026-2","article-title":"Acute Stress Increases Permeability of the Blood\u2013Brain-Barrier through Activation of Brain Mast Cells","volume":"888","author":"Esposito","year":"2001","journal-title":"Brain Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3389\/fnins.2017.00703","article-title":"Mast Cell Activation in Brain Injury, Stress, and Post-Traumatic Stress Disorder and Alzheimer\u2019s Disease Pathogenesis","volume":"11","author":"Kempuraj","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"29069","DOI":"10.3390\/ijms161226151","article-title":"Mast Cell-Mediated Mechanisms of Nociception","volume":"16","author":"Aich","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s12016-017-8619-2","article-title":"Mastocytosis: From a Molecular Point of View","volume":"54","author":"Komi","year":"2018","journal-title":"Clin. Rev. Allerg. Immunol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/j.jaip.2022.03.001","article-title":"Standards of Genetic Testing in the Diagnosis and Prognostication of Systemic Mastocytosis in 2022: Recommendations of the EU-US Cooperative Group","volume":"10","author":"Hoermann","year":"2022","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1016\/j.jaip.2022.05.037","article-title":"Refined Treatment Response Criteria for Indolent Systemic Mastocytosis Proposed by the ECNM-AIM Consortium","volume":"10","author":"Pyatilova","year":"2022","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/j.jaip.2022.05.007","article-title":"Global Classification of Mast Cell Activation Disorders: An ICD-10-CM\u2013Adjusted Proposal of the ECNM-AIM Consortium","volume":"10","author":"Valent","year":"2022","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Romantowski, J., G\u00f3rska, A., Niedoszytko, M., Gulen, T., Grucha\u0142a-Niedoszytko, M., Nedoszytko, B., Lange, M., Brockow, K., Arock, M., and Akin, C. (2021). A Challenge for Allergologist: Application of Allergy Diagnostic Methods in Mast Cell Disorders. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031454"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Nedoszytko, B., Arock, M., Lyons, J., Bachelot, G., Schwartz, L., Reiter, A., Jawhar, M., Schwaab, J., Lange, M., and Greiner, G. (2021). Clinical Impact of Inherited and Acquired Genetic Variants in Mastocytosis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010411"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.coi.2021.04.001","article-title":"Mast Cell Tryptases in Allergic Inflammation and Immediate Hypersensitivity","volume":"72","author":"Lyons","year":"2021","journal-title":"Curr. Opin. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.jaci.2017.10.010","article-title":"Mechanisms of Allergen Immunotherapy for Inhaled Allergens and Predictive Biomarkers","volume":"140","author":"Shamji","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.trsl.2016.02.011","article-title":"Emerging Concepts: Mast Cell Involvement in Allergic Diseases","volume":"174","author":"Modena","year":"2016","journal-title":"Transl. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1016\/j.jaci.2022.01.029","article-title":"Mast Cells Instruct Keratinocytes to Produce Thymic Stromal Lymphopoietin: Relevance of the Tryptase\/Protease-Activated Receptor 2 Axis","volume":"149","author":"Redhu","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s12016-019-08769-2","article-title":"Mast Cell Biology at Molecular Level: A Comprehensive Review","volume":"58","author":"Bielory","year":"2020","journal-title":"Clin. Rev. Allerg. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1615\/CritRevImmunol.v31.i6.30","article-title":"Regulation of Mast Cell Responses in Health and Disease","volume":"31","author":"Gilfillan","year":"2011","journal-title":"Crit. Rev. Immunol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature14022","article-title":"Identification of a Mast-Cell-Specific Receptor Crucial for Pseudo-Allergic Drug Reactions","volume":"519","author":"McNeil","year":"2015","journal-title":"Nature"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"833","DOI":"10.2165\/00128071-200304120-00003","article-title":"Psychiatric and Psychological Co-Morbidity in Patients with Dermatologic Disorders: Epidemiology and Management","volume":"4","author":"Gupta","year":"2003","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1210\/er.2012-1092","article-title":"Key Role of CRF in the Skin Stress Response System","volume":"34","author":"Slominski","year":"2013","journal-title":"Endocr. Rev."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1152\/physrev.2000.80.3.979","article-title":"Corticotropin Releasing Hormone and Proopiomelanocortin Involvement in the Cutaneous Response to Stress","volume":"80","author":"Slominski","year":"2000","journal-title":"Physiol. Rev."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1210\/en.2017-03230","article-title":"How UV Light Touches the Brain and Endocrine System Through Skin, and Why","volume":"159","author":"Slominski","year":"2018","journal-title":"Endocrinology"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/ejn.14720","article-title":"Neuroinflammation and Depression: A Review","volume":"53","author":"Troubat","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Grigore, O., Mihailescu, A., Solomon, I., Boda, D., and Caruntu, C. (2018). Role of Stress in Modulation of Skin Neurogenic Inflammation. Exp. Ther. Med., 997\u20131003.","DOI":"10.3892\/etm.2018.7058"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000515594","article-title":"Neuroinflammation in Mood Disorders: Role of Regulatory Immune Cells","volume":"28","author":"Bauer","year":"2021","journal-title":"Neuroimmunomodulation"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/nrendo.2009.106","article-title":"Stress and Disorders of the Stress System","volume":"5","author":"Chrousos","year":"2009","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.mce.2006.12.012","article-title":"Differential Expression of HPA Axis Homolog in the Skin","volume":"265\u2013266","author":"Slominski","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1172\/JCI33508","article-title":"A Nervous Breakdown in the Skin: Stress and the Epidermal Barrier","volume":"117","author":"Slominski","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.physbeh.2016.11.014","article-title":"A Users Guide to HPA Axis Research","volume":"178","author":"Spencer","year":"2017","journal-title":"Physiol. Behav."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.euroneuro.2017.04.001","article-title":"Why Are Depressed Patients Inflamed? A Reflection on 20 Years of Research on Depression, Glucocorticoid Resistance and Inflammation","volume":"27","author":"Pariante","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000362724","article-title":"One Hormone, Two Actions: Anti- and Pro-Inflammatory Effects of Glucocorticoids","volume":"22","author":"Cidlowski","year":"2015","journal-title":"Neuroimmunomodulation"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1152\/physrev.00044.2003","article-title":"Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation","volume":"84","author":"Slominski","year":"2004","journal-title":"Physiol. Rev."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/exd.12376","article-title":"Cutaneous Glucocorticosteroidogenesis: Securing Local Homeostasis and the Skin Integrity","volume":"23","author":"Slominski","year":"2014","journal-title":"Exp. Dermatol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbrc.2010.11.059","article-title":"Steroid Synthesis by Primary Human Keratinocytes; Implications for Skin Disease","volume":"404","author":"Hannen","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"111238","DOI":"10.1016\/j.mce.2021.111238","article-title":"The Significance of CYP11A1 Expression in Skin Physiology and Pathology","volume":"530","author":"Slominski","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1111\/j.1432-1033.2004.04356.x","article-title":"A Novel Pathway for Sequential Transformation of 7-Dehydrocholesterol and Expression of the P450scc System in Mammalian Skin: P450scc in the Skin","volume":"271","author":"Slominski","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"E701","DOI":"10.1152\/ajpendo.00519.2004","article-title":"CRH Stimulation of Corticosteroids Production in Melanocytes Is Mediated by ACTH","volume":"288","author":"Slominski","year":"2005","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jneuroim.2005.01.014","article-title":"CRH Stimulates POMC Activity and Corticosterone Production in Dermal Fibroblasts","volume":"162","author":"Slominski","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41435-020-0096-6","article-title":"Extra-Adrenal Glucocorticoid Biosynthesis: Implications for Autoimmune and Inflammatory Disorders","volume":"21","author":"Slominski","year":"2020","journal-title":"Genes Immun."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/sj.jid.5700204","article-title":"Cultured Human Dermal Fibroblasts Do Produce Cortisol","volume":"126","author":"Slominski","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejphar.2015.03.086","article-title":"Mast Cells, Brain Inflammation and Autism","volume":"778","author":"Theoharides","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fncel.2019.00054","article-title":"Mast Cells in Stress, Pain, Blood-Brain Barrier, Neuroinflammation and Alzheimer\u2019s Disease","volume":"13","author":"Kempuraj","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s12026-018-9004-9","article-title":"Impact of Mast Cells in Depression Disorder: Inhibitory Effect of IL-37 (New Frontiers)","volume":"66","author":"Conti","year":"2018","journal-title":"Immunol. Res."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1046\/j.1471-4159.2001.00008.x","article-title":"Potentiation by Histamine of Synaptically Mediated Excitotoxicity in Cultured Hippocampal Neurones: A Possible Role for Mast Cells: Histamine, Synaptic Activity and Neuronal Death","volume":"76","author":"Skaper","year":"2008","journal-title":"J. Neurochem."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Wo\u017aniak, E., Owczarczyk-Saczonek, A., and Placek, W. (2021). Psychological Stress, Mast Cells, and Psoriasis\u2014Is There Any Relationship?. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222413252"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/5\/5001\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:48:27Z","timestamp":1760122107000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/5\/5001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,5]]},"references-count":145,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["ijms24055001"],"URL":"https:\/\/doi.org\/10.3390\/ijms24055001","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,5]]}}}