{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:17:26Z","timestamp":1793222246377,"version":"4.5.0"},"reference-count":63,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, Italy","award":["PIACERI Found\u2014NATURE-OA-2020\u20132022"],"award-info":[{"award-number":["PIACERI Found\u2014NATURE-OA-2020\u20132022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Osteoarthritis is a chronic degenerative musculoskeletal disease that worsens with age and is defined by pathological alterations in joint components. All clinical treatment recommendations for osteoarthritis promote exercise, although precise molecular pathways are unclear. The purpose of this study was to critically analyze the research on lubricin and irisin and how they relate to healthy and diseased joint tissue. Our research focused specifically on exercise strategies and offered new perspectives for future potential osteoarthritis treatment plans. Although lubricin and irisin have only recently been discovered, there is evidence that they have an impact on cartilage homeostasis. A crucial component of cartilage lubrication and integrity, lubricin is a surface-active mucinous glycoprotein released by the synovial joint. Its expression increases with joint movement. In healthy joints, lubricin molecules cover the cartilage surface to lubricate the boundary of the joint and inhibit protein and cell attachment. Patients with joint trauma, inflammatory arthritis, or genetically mediated lubricin deficiency, who do not produce enough lubricin to protect the articular cartilage, develop arthropathy. Irisin, sometimes known as the \u201csports hormone\u201d, is a myokine secreted primarily by skeletal muscle. It is a physiologically active protein that can enter the circulation as an endocrine factor, and its synthesis and secretion are primarily triggered by exercise-induced muscle contraction. We searched PubMed, Web of Science, Google Scholar, and Scopus using the appropriate keywords to identify the most recent research. The studies considered advance our knowledge of the role that exercise plays in the fight against osteoarthritis, serve as a valuable resource, and support the advancement of osteoarthritis prevention and therapy.<\/jats:p>","DOI":"10.3390\/ijms24065126","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T02:30:23Z","timestamp":1678242623000},"page":"5126","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["The Role of Lubricin, Irisin and Exercise in the Prevention and Treatment of Osteoarthritis"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7655-4489","authenticated-orcid":false,"given":"Federico","family":"Roggio","sequence":"first","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, Section of Anatomy, Histology and Movement Science, School of Medicine, University of Catania, Via S. Sofia 97, 95123 Catania, Italy"},{"name":"Sport and Exercise Sciences Research Unit, Department of Psychology, Educational Science and Human Movement, University of Palermo, Via Giovanni Pascoli 6, 90144 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8106-537X","authenticated-orcid":false,"given":"Luca","family":"Petrigna","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, Section of Anatomy, Histology and Movement Science, School of Medicine, University of Catania, Via S. Sofia 97, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7483-8944","authenticated-orcid":false,"given":"Bruno","family":"Trovato","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, Section of Anatomy, Histology and Movement Science, School of Medicine, University of Catania, Via S. Sofia 97, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1837-9325","authenticated-orcid":false,"given":"Michelino","family":"Di Rosa","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, Section of Anatomy, Histology and Movement Science, School of Medicine, University of Catania, Via S. Sofia 97, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-8890","authenticated-orcid":false,"given":"Giuseppe","family":"Musumeci","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, Section of Anatomy, Histology and Movement Science, School of Medicine, University of Catania, Via S. Sofia 97, 95123 Catania, Italy"},{"name":"Research Center on Motor Activities (CRAM), University of Catania, Via S. Sofia 97, 95123 Catania, Italy"},{"name":"Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3390\/jfmk1020154","article-title":"The Effect of Mechanical Loading on Articular Cartilage","volume":"1","author":"Musumeci","year":"2016","journal-title":"J. Funct. Morphol. Kinesiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e01134","DOI":"10.1016\/j.heliyon.2019.e01134","article-title":"A correlation between intestinal microbiota dysbiosis and osteoarthritis","volume":"5","author":"Szychlinska","year":"2019","journal-title":"Heliyon"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1093\/ptj\/60.12.1556","article-title":"Knee anatomy: A brief review","volume":"60","author":"Blackburn","year":"1980","journal-title":"Phys. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"R156","DOI":"10.1186\/ar1471","article-title":"Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading","volume":"7","author":"Lorenz","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/bdrc.20048","article-title":"Transcriptional control of chondrocyte fate and differentiation","volume":"75","author":"Lefebvre","year":"2005","journal-title":"Birth Defects Res. Part C Embryo Today Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1006\/abbi.1994.1219","article-title":"A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage","volume":"311","author":"Schumacher","year":"1994","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1679\/aohc.63.17","article-title":"Morphology and functional roles of synoviocytes in the joint","volume":"63","author":"Iwanaga","year":"2000","journal-title":"Arch. Histol. Cytol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1679\/aohc.62.219","article-title":"Three-dimensional ultrastructure of synoviocytes in the horse joint as revealed by the scanning electron microscope","volume":"62","author":"Shikichi","year":"1999","journal-title":"Arch. Histol. Cytol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1113\/jphysiol.2007.146753","article-title":"Cyclic movement stimulates hyaluronan secretion into the synovial cavity of rabbit joints","volume":"586","author":"Ingram","year":"2008","journal-title":"J. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Castrogiovanni, P., Di Rosa, M., Ravalli, S., Castorina, A., Guglielmino, C., Imbesi, R., Vecchio, M., Drago, F., Szychlinska, M.A., and Musumeci, G. (2019). Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030511"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.joca.2022.09.003","article-title":"Osteoarthritis year in review 2022: Biology","volume":"30","author":"Han","year":"2022","journal-title":"Osteoarthr. Cartil."},{"key":"ref_12","first-page":"293","article-title":"Chondrocyte-like apoptosis in temporomandibular joint disc internal derangement as a repair-limiting mechanism. An in vivo study","volume":"24","author":"Loreto","year":"2009","journal-title":"Histol. Histopathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/ar2655","article-title":"Developments in the scientific understanding of osteoarthritis","volume":"11","author":"Abramson","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"ref_14","first-page":"865","article-title":"Primary cilia in fibroblast-like type B synoviocytes lie within a cilium pit: A site of endocytosis","volume":"25","author":"Rattner","year":"2010","journal-title":"Histol. Histopathol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Szychlinska, M.A., Trovato, F.M., Di Rosa, M., Malaguarnera, L., Puzzo, L., Leonardi, R., Castrogiovanni, P., and Musumeci, G. (2016). Co-Expression and Co-Localization of Cartilage Glycoproteins CHI3L1 and Lubricin in Osteoarthritic Cartilage: Morphological, Immunohistochemical and Gene Expression Profiles. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17030359"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.22203\/eCM.v013a04","article-title":"Bioregulation of lubricin expression by growth factors and cytokines","volume":"13","author":"Jones","year":"2007","journal-title":"Eur. Cell Mater."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(12)61031-9","article-title":"Effect of physical inactivity on major non-communicable diseases worldwide: An analysis of burden of disease and life expectancy","volume":"380","author":"Lee","year":"2012","journal-title":"Lancet"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"16056","DOI":"10.1038\/boneres.2016.56","article-title":"Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism","volume":"5","author":"Zhang","year":"2017","journal-title":"Bone Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"703670","DOI":"10.3389\/fcell.2021.703670","article-title":"Roles and Mechanisms of Irisin in Attenuating Pathological Features of Osteoarthritis","volume":"9","author":"Li","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0736-0266(00)00040-1","article-title":"Homology of lubricin and superficial zone protein (SZP): Products of megakaryocyte stimulating factor (MSF) gene expression by human synovial fibroblasts and articular chondrocytes localized to chromosome 1q25","volume":"19","author":"Jay","year":"2001","journal-title":"J. Orthop. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/jor.20431","article-title":"PRG4 exchange between the articular cartilage surface and synovial fluid","volume":"25","author":"Chan","year":"2007","journal-title":"J. Orthop. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/jor.20325","article-title":"Binding and localization of recombinant lubricin to articular cartilage surfaces","volume":"25","author":"Jones","year":"2007","journal-title":"J. Orthop. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1172\/JCI200522263","article-title":"The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth","volume":"115","author":"Rhee","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/wsbm.157","article-title":"A systems biology approach to synovial joint lubrication in health, injury, and disease","volume":"4","author":"Hui","year":"2012","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1002\/art.27550","article-title":"Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transection","volume":"62","author":"Jay","year":"2010","journal-title":"Arthritis Rheum."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/0363546510378088","article-title":"Effects of supplemental intra-articular lubricin and hyaluronic acid on the progression of posttraumatic arthritis in the anterior cruciate ligament-deficient rat knee","volume":"39","author":"Teeple","year":"2011","journal-title":"Am. J. Sports Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"100180","DOI":"10.1016\/j.biotri.2021.100180","article-title":"A Moving Contact Of Articulation Enhances The Biosynthetic And Functional Responses Of Articular Cartilage","volume":"26","author":"Shekhawat","year":"2021","journal-title":"Biotribology"},{"key":"ref_28","unstructured":"del Moral, A.M., and Aguilera Garc\u00eda, C.M. (2018). Obesity, Academic Press."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"118954","DOI":"10.1016\/j.lfs.2020.118954","article-title":"The \u201cirisin system\u201d: From biological roles to pharmacological and nutraceutical perspectives","volume":"267","author":"Flori","year":"2021","journal-title":"Life Sci."},{"key":"ref_30","unstructured":"Takei, Y., Ando, H., and Tsutsui, K. (2016). Handbook of Hormones, Academic Press."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-\u03b1-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"Wu","year":"2012","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.13345","article-title":"Irisin and musculoskeletal health","volume":"1402","author":"Colaianni","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"902186","DOI":"10.1155\/2014\/902186","article-title":"Irisin enhances osteoblast differentiation in vitro","volume":"2014","author":"Colaianni","year":"2014","journal-title":"Int. J. Endocrinol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/jcb.25040","article-title":"Interactions between muscle tissues and bone metabolism","volume":"116","author":"Kawao","year":"2015","journal-title":"J. Cell. Biochem."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Jang, S., Lee, K., and Ju, J.H. (2021). Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052619"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s00296-010-1372-y","article-title":"Radiographic hand osteoarthritis and serum levels of osteocalcin: Cross-sectional study","volume":"30","author":"Kalichman","year":"2010","journal-title":"Rheumatol. Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1001\/jama.2020.22171","article-title":"Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review","volume":"325","author":"Katz","year":"2021","journal-title":"JAMA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1089\/gtmb.2015.0170","article-title":"Association of Irisin and CRP Levels with the Radiographic Severity of Knee Osteoarthritis","volume":"20","author":"Mao","year":"2016","journal-title":"Genet. Test. Mol. Biomark."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1210\/jc.2014-2932","article-title":"Serum irisin levels are regulated by acute strenuous exercise","volume":"100","author":"Scheuermann","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Vadal\u00e0, G., Di Giacomo, G., Ambrosio, L., Cannata, F., Cicione, C., Papalia, R., and Denaro, V. (2020). Irisin Recovers Osteoarthritic Chondrocytes In Vitro. Cells, 9.","DOI":"10.3390\/cells9061478"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Wang, F.S., Kuo, C.W., Ko, J.Y., Chen, Y.S., Wang, S.Y., Ke, H.J., Kuo, P.C., Lee, C.H., Wu, J.C., and Lu, W.B. (2020). Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy. Antioxidants, 9.","DOI":"10.3390\/antiox9090810"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"115573","DOI":"10.1016\/j.bone.2020.115573","article-title":"Irisin inhibits osteocyte apoptosis by activating the Erk signaling pathway in vitro and attenuates ALCT-induced osteoarthritis in mice","volume":"141","author":"He","year":"2020","journal-title":"Bone"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s40520-019-01191-w","article-title":"Nutrition, osteoarthritis and cartilage metabolism","volume":"31","author":"Messina","year":"2019","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"413","DOI":"10.4103\/ijmr.IJMR_436_20","article-title":"Cartilage-derived biomarkers in osteoarthritis","volume":"153","author":"Oliviero","year":"2021","journal-title":"Indian J. Med. Res."},{"key":"ref_45","first-page":"2879","article-title":"Recombinant human irisin regulated collagen II, matrix metalloproteinase-13 and the Wnt\/\u03b2-catenin and NF-\u03baB signaling pathways in interleukin-1\u03b2-induced human SW1353 cells","volume":"19","author":"Li","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"797855","DOI":"10.3389\/fcell.2022.797855","article-title":"Mechanical Stimulation Protects Against Chondrocyte Pyroptosis Through Irisin-Induced Suppression of PI3K\/Akt\/NF-\u03baB Signal Pathway in Osteoarthritis","volume":"10","author":"Jia","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s11845-022-02970-7","article-title":"Effects of acute aerobic exercise on cytokines, klotho, irisin, and vascular endothelial growth factor responses in rheumatoid arthritis patients","volume":"192","author":"Ercan","year":"2022","journal-title":"Ir. J. Med. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e222","DOI":"10.1111\/sms.12290","article-title":"Physical activity ameliorates cartilage degeneration in a rat model of aging: A study on lubricin expression","volume":"25","author":"Musumeci","year":"2015","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s00774-012-0414-9","article-title":"The effects of physical activity on apoptosis and lubricin expression in articular cartilage in rats with glucocorticoid-induced osteoporosis","volume":"31","author":"Musumeci","year":"2013","journal-title":"J. Bone Miner. Metab."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.rehab.2016.02.005","article-title":"Educating patients about the benefits of physical activity and exercise for their hip and knee osteoarthritis. Systematic literature review","volume":"59","author":"Gay","year":"2016","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e08991","DOI":"10.1016\/j.heliyon.2022.e08991","article-title":"Exploiting real-world data to monitor physical activity in patients with osteoarthritis: The opportunity of digital epidemiology","volume":"8","author":"Ravalli","year":"2022","journal-title":"Heliyon"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1007\/s00421-016-3404-0","article-title":"The effect of vigorous running and cycling on serum COMP, lubricin, and femoral cartilage thickness: A pilot study","volume":"116","author":"Roberts","year":"2016","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.joca.2016.09.024","article-title":"Osteoarthritis year in review 2016: Biology","volume":"25","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"R256","DOI":"10.1186\/ar4101","article-title":"Intensity-dependent effect of treadmill running on lubricin metabolism of rat articular cartilage","volume":"14","author":"Ni","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.joca.2012.04.021","article-title":"The impact of forced joint exercise on lubricin biosynthesis from articular cartilage following ACL transection and intra-articular lubricin\u2019s effect in exercised joints following ACL transection","volume":"20","author":"Elsaid","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"934406","DOI":"10.3389\/fnagi.2022.934406","article-title":"Exercise-induced modulation of myokine irisin in bone and cartilage tissue-Positive effects on osteoarthritis: A narrative review","volume":"14","author":"Ning","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Pesce, M., La Fratta, I., Paolucci, T., Grilli, A., Patruno, A., Agostini, F., Bernetti, A., Mangone, M., Paoloni, M., and Invernizzi, M. (2021). From Exercise to Cognitive Performance: Role of Irisin. Appl. Sci., 11.","DOI":"10.3390\/app11157120"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1620\/tjem.233.135","article-title":"High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption","volume":"233","author":"Tsuchiya","year":"2014","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Park, J., Bae, J., and Lee, J. (2021). Complex Exercise Improves Anti-Inflammatory and Anabolic Effects in Osteoarthritis-Induced Sarcopenia in Elderly Women. Healthcare, 9.","DOI":"10.3390\/healthcare9060711"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"J\u00fcrim\u00e4e, J., Remmel, L., Tamm, A.L., Purge, P., Maasalu, K., and Tillmann, V. (2022). Associations of Circulating Irisin and Fibroblast Growth Factor-21 Levels with Measures of Energy Homeostasis in Highly Trained Adolescent Rhythmic Gymnasts. J. Clin Med., 11.","DOI":"10.3390\/jcm11247450"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"151936","DOI":"10.1016\/j.acthis.2022.151936","article-title":"Immunohistochemical evaluation of autotaxin and lubricin in mild osteoarthritic rat model performing moderate physical activity","volume":"124","author":"Ravalli","year":"2022","journal-title":"Acta Histochem."},{"key":"ref_62","first-page":"1605","article-title":"AB0962 Irisin levels are associated with exercise, pain and function in patients with knee osteoarthritis","volume":"77","author":"Orellana","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"811","DOI":"10.2147\/CIA.S308893","article-title":"Eight Weeks of High-Intensity Interval Static Strength Training Improves Skeletal Muscle Atrophy and Motor Function in Aged Rats via the PGC-1\u03b1\/FNDC5\/UCP1 Pathway","volume":"16","author":"Liu","year":"2021","journal-title":"Clin. Interv. Aging"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/6\/5126\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:50:05Z","timestamp":1760122205000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/6\/5126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,7]]},"references-count":63,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["ijms24065126"],"URL":"https:\/\/doi.org\/10.3390\/ijms24065126","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,7]]}}}