{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:27:56Z","timestamp":1792254476896,"version":"4.4.0"},"reference-count":73,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Trisno Family Fellowship","award":["1153607"],"award-info":[{"award-number":["1153607"]}]},{"name":"Trisno Family Fellowship","award":["1156072"],"award-info":[{"award-number":["1156072"]}]},{"name":"Trisno Family Fellowship","award":["2017131"],"award-info":[{"award-number":["2017131"]}]},{"name":"Trisno Family Fellowship","award":["2008971"],"award-info":[{"award-number":["2008971"]}]},{"name":"NHMRC Senior Principal Research Fellowship and Leadership 3 Investigator","award":["1153607"],"award-info":[{"award-number":["1153607"]}]},{"name":"NHMRC Senior Principal Research Fellowship and Leadership 3 Investigator","award":["1156072"],"award-info":[{"award-number":["1156072"]}]},{"name":"NHMRC Senior Principal Research Fellowship and Leadership 3 Investigator","award":["2017131"],"award-info":[{"award-number":["2017131"]}]},{"name":"NHMRC Senior Principal Research Fellowship and Leadership 3 Investigator","award":["2008971"],"award-info":[{"award-number":["2008971"]}]},{"name":"NHMRC Investigator","award":["1153607"],"award-info":[{"award-number":["1153607"]}]},{"name":"NHMRC Investigator","award":["1156072"],"award-info":[{"award-number":["1156072"]}]},{"name":"NHMRC Investigator","award":["2017131"],"award-info":[{"award-number":["2017131"]}]},{"name":"NHMRC Investigator","award":["2008971"],"award-info":[{"award-number":["2008971"]}]},{"name":"Multiple Sclerosis Research Australia early-career fellowship","award":["1153607"],"award-info":[{"award-number":["1153607"]}]},{"name":"Multiple Sclerosis Research Australia early-career fellowship","award":["1156072"],"award-info":[{"award-number":["1156072"]}]},{"name":"Multiple Sclerosis Research Australia early-career fellowship","award":["2017131"],"award-info":[{"award-number":["2017131"]}]},{"name":"Multiple Sclerosis Research Australia early-career fellowship","award":["2008971"],"award-info":[{"award-number":["2008971"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Minocycline has anti-inflammatory, antioxidant, and anti-apoptotic properties that explain the renewed interest in its use as an adjunctive treatment for psychiatric and neurological conditions. Following the completion of several new clinical trials using minocycline, we proposed an up-to-date systematic review and meta-analysis of the data available. The PICO (patient\/population, intervention, comparison and outcomes) framework was used to search 5 databases aiming to identify randomized controlled trials that used minocycline as an adjunctive treatment for psychiatric and neurological conditions. Search results, data extraction, and risk of bias were performed by two independent authors for each publication. Quantitative meta-analysis was performed using RevMan software. Literature search and review resulted in 32 studies being included in this review: 10 in schizophrenia, 3 studies in depression, and 7 in stroke, with the benefit of minocycline being used in some of the core symptoms evaluated; 2 in bipolar disorder and 2 in substance use, without demonstrating a benefit for using minocycline; 1 in obsessive-compulsive disorder, 2 in brain and spinal injuries, 2 in amyotrophic lateral sclerosis, 1 in Alzheimer\u2019s disease, 1 in multiple systems atrophy, and 1 in pain, with mixes results. For most of the conditions included in this review the data is still limited and difficult to interpret, warranting more well-designed and powered studies. On the other hand, the studies available for schizophrenia seem to suggest an overall benefit favoring the use of minocycline as an adjunctive treatment.<\/jats:p>","DOI":"10.3390\/ijms24065250","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T02:30:33Z","timestamp":1678415433000},"page":"5250","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Minocycline as Treatment for Psychiatric and Neurological Conditions: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8825-734X","authenticated-orcid":false,"given":"Bruna","family":"Panizzutti","sequence":"first","affiliation":[{"name":"IMPACT, Institute for Innovation in Physical and Mental Health and Clinical Translation, Barwon Health, School of Medicine, Deakin University, Geelong, VIC 3220, 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in Physical and Mental Health and Clinical Translation, Barwon Health, School of Medicine, Deakin University, Geelong, VIC 3220, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Walker","sequence":"additional","affiliation":[{"name":"IMPACT, Institute for Innovation in Physical and Mental Health and Clinical Translation, Barwon Health, School of Medicine, Deakin University, Geelong, VIC 3220, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4400-8499","authenticated-orcid":false,"given":"Kyoko","family":"Hasebe","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, UNSW Sydney, Kensington, NSW 2052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca E.","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"IMPACT, Institute for Innovation in Physical and Mental Health and Clinical Translation, Barwon Health, School 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