{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:30:39Z","timestamp":1785537039256,"version":"3.56.0"},"reference-count":94,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Patients with chronic kidney disease (CKD) inevitably develop mineral and bone disorders (CKD\u2013MBD), which negatively impact their survival and quality of life. For a better understanding of underlying pathophysiology and identification of novel therapeutic approaches, mouse models are essential. CKD can be induced by surgical reduction of a functional kidney mass, by nephrotoxic compounds and by genetic engineering specifically interfering with kidney development. These models develop a large range of bone diseases, recapitulating different types of human CKD\u2013MBD and associated sequelae, including vascular calcifications. Bones are usually studied by quantitative histomorphometry, immunohistochemistry and micro-CT, but alternative strategies have emerged, such as longitudinal in vivo osteoblast activity quantification by tracer scintigraphy. The results gained from the CKD\u2013MBD mouse models are consistent with clinical observations and have provided significant knowledge on specific pathomechanisms, bone properties and potential novel therapeutic strategies. This review discusses available mouse models to study bone disease in CKD.<\/jats:p>","DOI":"10.3390\/ijms24065325","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T05:36:21Z","timestamp":1678685781000},"page":"5325","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease"],"prefix":"10.3390","volume":"24","author":[{"given":"Ariane","family":"Zaloszyc","sequence":"first","affiliation":[{"name":"Service de P\u00e9diatrie 1, H\u00f4pital de Hautepierre, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"},{"name":"Institut de Chimie et Proc\u00e9d\u00e9s pour l\u2019Energie, l\u2019Environnement et la Sant\u00e9 (ICPEES), UMR-7515 CNRS-Universit\u00e9 de Strasbourg, 67087 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Bernardor","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie P\u00e9diatrique, CHU de Nice, H\u00f4pital Archet, 06202 Nice, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 C\u00f4te d\u2019Azur, 06107 Nice, France"},{"name":"INSERM UMR S1033 Research Unit, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Bacchetta","sequence":"additional","affiliation":[{"name":"INSERM UMR S1033 Research Unit, 69008 Lyon, France"},{"name":"Reference Center for Rare Renal Diseases, Pediatric Nephrology Rheumatology and Dermatology Unit, Hopital Femme M\u00e8re Enfant, 69500 Bron, France"},{"name":"Reference Center for Rare Diseases of Calcium and Phosphate Metabolism, Pediatric Nephrology Rheumatology and Dermatology Unit, Hopital Femme M\u00e8re Enfant, 69500 Bron, France"},{"name":"Lyon Est Medical School, Universit\u00e9 Claude Bernard Lyon 1, 69003 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2666-6877","authenticated-orcid":false,"given":"Gilles","family":"Laverny","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, 67400 Illkirch, France"},{"name":"Centre National de la Recherche Scientifique, UMR7104, 67400 Illkirch, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1258, 67400 Illkirch, France"},{"name":"IGBMC, Universit\u00e9 de Strasbourg, 67400 Illkirch, France"},{"name":"OSCAR, French Network for Rare Bone Diseases, 94270 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4487-3332","authenticated-orcid":false,"given":"Claus Peter","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/j.1651-2227.2000.tb00361.x","article-title":"Bone biopsy results and serum bone turnover parameters in uremic children","volume":"89","author":"Ziolkowska","year":"2000","journal-title":"Acta Paediatr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.kint.2015.12.004","article-title":"Changing bone patterns with progression of chronic kidney disease","volume":"89","author":"Drueke","year":"2016","journal-title":"Kidney Int."},{"key":"ref_3","unstructured":"De Groot, L.J., Chrousos, G., Dungan, K., Feingold, K.R., Grossman, A., Hershman, J.M., Koch, C., Korbonits, M., McLachlan, R., and New, M. 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