{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:54:34Z","timestamp":1773096874623,"version":"3.50.1"},"reference-count":54,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key R&amp;D Projects of Zhejiang Province","award":["2021C02007"],"award-info":[{"award-number":["2021C02007"]}]},{"name":"Key R&amp;D Projects of Zhejiang Province","award":["2021C02068"],"award-info":[{"award-number":["2021C02068"]}]},{"name":"Key R&amp;D Projects of Zhejiang Province","award":["C170105\/31501966"],"award-info":[{"award-number":["C170105\/31501966"]}]},{"name":"Key R&amp;D Projects of Zhejiang Province","award":["CARS-35"],"award-info":[{"award-number":["CARS-35"]}]},{"name":"Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding","award":["2021C02007"],"award-info":[{"award-number":["2021C02007"]}]},{"name":"Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding","award":["2021C02068"],"award-info":[{"award-number":["2021C02068"]}]},{"name":"Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding","award":["C170105\/31501966"],"award-info":[{"award-number":["C170105\/31501966"]}]},{"name":"Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding","award":["CARS-35"],"award-info":[{"award-number":["CARS-35"]}]},{"name":"National Natural Science Foundation of China","award":["2021C02007"],"award-info":[{"award-number":["2021C02007"]}]},{"name":"National Natural Science Foundation of China","award":["2021C02068"],"award-info":[{"award-number":["2021C02068"]}]},{"name":"National Natural Science Foundation of China","award":["C170105\/31501966"],"award-info":[{"award-number":["C170105\/31501966"]}]},{"name":"National Natural Science Foundation of China","award":["CARS-35"],"award-info":[{"award-number":["CARS-35"]}]},{"name":"Modern Agro-industry Technology Research System, China","award":["2021C02007"],"award-info":[{"award-number":["2021C02007"]}]},{"name":"Modern Agro-industry Technology Research System, China","award":["2021C02068"],"award-info":[{"award-number":["2021C02068"]}]},{"name":"Modern Agro-industry Technology Research System, China","award":["C170105\/31501966"],"award-info":[{"award-number":["C170105\/31501966"]}]},{"name":"Modern Agro-industry Technology Research System, China","award":["CARS-35"],"award-info":[{"award-number":["CARS-35"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Long noncoding RNAs (lncRNAs) play crucial roles in various biological processes, and they are considered to be closely associated with the pathogenesis of intestinal diseases. However, the role and expression of lncRNAs in intestinal damage during weaning stress remain unknown. Herein, we investigated the expression profiles of jejunal tissue from weaning piglets at 4 and 7 d after weaning (groups W4 and W7, respectively) and from suckling piglets on the same days (groups S4 and S7, respectively). Genome-wide analysis of lncRNAs was also performed using RNA sequencing technology. A total of 1809 annotated lncRNAs and 1612 novel lncRNAs were obtained from the jejunum of piglets. In W4 vs. S4, a total of 331 lncRNAs showed significant differential expression, and a total of 163 significantly differentially expressed lncRNAs (DElncRNAs) was identified in W7 vs. S7. Biological analysis indicated that DElncRNAs were involved in intestinal diseases, inflammation, and immune functions, and were mainly enriched in the Jak-STAT signaling pathway, inflammatory bowel disease, T cell receptor signaling pathway, B cell receptor signaling pathway and intestinal immune network for IgA production. Moreover, we found that lnc_000884 and target gene KLF5 were significantly upregulated in the intestine of weaning piglets. The overexpression of lnc_000884 also significantly promoted the proliferation and depressed apoptosis of IPEC-J2 cells. This result suggested that lnc_000884 may contribute to repairing intestinal damage. Our study identified the characterization and expression profile of lncRNAs in the small intestine of weaning piglets and provided new insights into the molecular regulation of intestinal damage during weaning stress.<\/jats:p>","DOI":"10.3390\/ijms24065343","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T05:36:21Z","timestamp":1678685781000},"page":"5343","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genome-Wide Analysis of Long Noncoding RNAs in Porcine Intestine during Weaning Stress"],"prefix":"10.3390","volume":"24","author":[{"given":"Shujie","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, 298 Desheng Middle Road, Hangzhou 310021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Tao","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, 298 Desheng Middle Road, Hangzhou 310021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Deng","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, 298 Desheng Middle Road, Hangzhou 310021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongming","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, 298 Desheng Middle Road, Hangzhou 310021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziwei","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, 298 Desheng Middle Road, Hangzhou 310021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/jas\/skx062","article-title":"Weaning disrupts intestinal antioxidant status, impairs intestinal barrier and mitochondrial function, and triggers mitophagy in piglets","volume":"96","author":"Cao","year":"2018","journal-title":"J. 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