{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:58:16Z","timestamp":1791313096557,"version":"4.3.1"},"reference-count":182,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T00:00:00Z","timestamp":1678492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003827","name":"National Research Development and Innovation Office (NKFIH)","doi-asserted-by":"publisher","award":["GINOP-2.3.2-15-2016-00060"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00060"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003827","name":"National Research Development and Innovation Office (NKFIH)","doi-asserted-by":"publisher","award":["GINOP-2.3.2-15-2016-00034"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00034"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is an incurable, progressive neurodegenerative disorder. AD is a complex and multifactorial disease that is responsible for 60\u201380% of dementia cases. Aging, genetic factors, and epigenetic changes are the main risk factors for AD. Two aggregation-prone proteins play a decisive role in AD pathogenesis: \u03b2-amyloid (A\u03b2) and hyperphosphorylated tau (pTau). Both of them form deposits and diffusible toxic aggregates in the brain. These proteins are the biomarkers of AD. Different hypotheses have tried to explain AD pathogenesis and served as platforms for AD drug research. Experiments demonstrated that both A\u03b2 and pTau might start neurodegenerative processes and are necessary for cognitive decline. The two pathologies act in synergy. Inhibition of the formation of toxic A\u03b2 and pTau aggregates has been an old drug target. Recently, successful A\u03b2 clearance by monoclonal antibodies has raised new hopes for AD treatments if the disease is detected at early stages. More recently, novel targets, e.g., improvements in amyloid clearance from the brain, application of small heat shock proteins (Hsps), modulation of chronic neuroinflammation by different receptor ligands, modulation of microglial phagocytosis, and increase in myelination have been revealed in AD research.<\/jats:p>","DOI":"10.3390\/ijms24065383","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T05:36:21Z","timestamp":1678685781000},"page":"5383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["New Pathways Identify Novel Drug Targets for the Prevention and Treatment of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"24","author":[{"given":"Botond","family":"Penke","sequence":"first","affiliation":[{"name":"Department of Medical Chemistry, University of Szeged, D\u00f3m Square 8, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ria","family":"Sz\u0171cs","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, University of Szeged, D\u00f3m Square 8, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0611-1452","authenticated-orcid":false,"given":"Ferenc","family":"Bog\u00e1r","sequence":"additional","affiliation":[{"name":"ELKH-SZTE Biomimetic Systems Research Group, E\u00f6tv\u00f6s Lor\u00e1nd Research Network (ELKH), D\u00f3m Square 8, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1146\/annurev-biochem-061516-045049","article-title":"Propagation of Protein Aggregation in Neurodegenerative Diseases","volume":"88","author":"Diamond","year":"2019","journal-title":"Annu. 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