{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:35:42Z","timestamp":1783661742445,"version":"3.55.0"},"reference-count":147,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T00:00:00Z","timestamp":1678492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Melanoma is the most serious type of skin cancer, causing a large majority of deaths but accounting for only ~1% of all skin cancer cases. The worldwide incidence of malignant melanoma is increasing, causing a serious socio-economic problem. Melanoma is diagnosed mainly in young and middle-aged people, which distinguishes it from other solid tumors detected mainly in mature people. The early detection of cutaneous malignant melanoma (CMM) remains a priority and it is a key factor limiting mortality. Doctors and scientists around the world want to improve the quality of diagnosis and treatment, and are constantly looking for new, promising opportunities, including the use of microRNAs (miRNAs), to fight melanoma cancer. This article reviews miRNA as a potential biomarker and diagnostics tool as a therapeutic drugs in CMM treatment. We also present a review of the current clinical trials being carried out worldwide, in which miRNAs are a target for melanoma treatment.<\/jats:p>","DOI":"10.3390\/ijms24065386","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T05:36:21Z","timestamp":1678685781000},"page":"5386","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["MicroRNA as a Diagnostic Tool, Therapeutic Target and Potential Biomarker in Cutaneous Malignant Melanoma Detection\u2014Narrative Review"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6719-803X","authenticated-orcid":false,"given":"Agata","family":"Poniewierska-Baran","sequence":"first","affiliation":[{"name":"Institute of Biology, University of Szczecin, Felczaka 3c, 71-412 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Zadroga","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University in Szczecin, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-0520","authenticated-orcid":false,"given":"Edo","family":"Danilyan","sequence":"additional","affiliation":[{"name":"Biology Department, Faculty of Science and Data Analytics, Institut Teknologi Sepuluh Nopember, Surabaya 60111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2430-5020","authenticated-orcid":false,"given":"Paulina","family":"Ma\u0142kowska","sequence":"additional","affiliation":[{"name":"Doctoral School of the University of Szczecin, 71-412 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4065-3842","authenticated-orcid":false,"given":"Paulina","family":"Nied\u017awiedzka-Rystwej","sequence":"additional","affiliation":[{"name":"Institute of Biology, University of Szczecin, Felczaka 3c, 71-412 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6557-1208","authenticated-orcid":false,"given":"Andrzej","family":"Pawlik","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University in Szczecin, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1136\/jcp.2003.014852","article-title":"Are growth phases exclusive to cutaneous melanoma?","volume":"57","author":"Urso","year":"2004","journal-title":"J. Clin. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nature11071","article-title":"Melanoma genome sequencing reveals frequent PREX2 mutations","volume":"485","author":"Berger","year":"2012","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nature03890","article-title":"BRAFE600-associated senescence-like cell cycle arrest of hu-man naevi","volume":"436","author":"Michaloglou","year":"2005","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.jid.2016.11.017","article-title":"Genomic Characterization of Dysplastic Nevi Unveils Implica-tions for Diagnosis of Melanoma","volume":"137","author":"Melamed","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1061832","DOI":"10.3389\/fonc.2022.1061832","article-title":"New panel of biomarkers to discriminate between amelanotic and melanotic metastatic melanoma","volume":"12","author":"Militaru","year":"2023","journal-title":"Front. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.csbj.2023.01.040","article-title":"Spatial patterns of the cap-binding complex eIF4F in human melano-ma cells","volume":"21","author":"Tang","year":"2023","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Roy, S.F., Panse, G., and McNiff, J.M. (2023). PRAME immunohistochemistry can distinguish melanocytic pseudonests of lichenoid reactions from melanoma in situ. J. Cutan. Pathol., 15.","DOI":"10.1111\/cup.14407"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tibs.2011.06.002","article-title":"miRNA response to DNA damage","volume":"36","author":"Wan","year":"2011","journal-title":"Trends. Biochem. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev-pathol-012513-104715","article-title":"MicroRNAs in cancer","volume":"9","author":"Garofalo","year":"2014","journal-title":"Annu. Rev. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Poniewierska-Baran, A., S\u0142uczanowska-G\u0142\u0105bowska, S., Ma\u0142kowska, P., Sierawska, O., Zadroga, \u0141., Pawlik, A., and Nied\u017awiedzka-Rystwej, P. (2022). Role of miRNA in Melanoma Development and Progression. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010201"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"581007","DOI":"10.3389\/fonc.2020.581007","article-title":"microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis","volume":"10","author":"Annese","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of microRNA biogenesis","volume":"15","author":"Ha","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.molcel.2004.12.002","article-title":"Transcription and processing of human microRNA precursors","volume":"16","author":"Cullen","year":"2004","journal-title":"Mol. Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1261\/rna.037424.112","article-title":"Multiple sensors ensure guide strand selection in human RNAi pathways","volume":"19","author":"Noland","year":"2013","journal-title":"RNA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.tig.2007.02.011","article-title":"Mechanisms of microRNA-mediated gene regulation in animal cells","volume":"23","author":"Nilsen","year":"2007","journal-title":"Trends Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"375","DOI":"10.14348\/molcells.2016.0013","article-title":"MicroRNA Target Recognition: Insights from Transcriptome-Wide Non-Canonical Interactions","volume":"39","author":"Seok","year":"2016","journal-title":"Mol. Cells"},{"key":"ref_17","first-page":"236","article-title":"microRNAs: A newly described class of encoded molecules that play a role in health and disease","volume":"14","author":"Felekkis","year":"2010","journal-title":"Hippokratia"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Stavast, C.J., and Erkeland, S.J. (2019). The Non-Canonical Aspects of MicroRNAs: Many Roads to Gene Regulation. Cells, 8.","DOI":"10.3390\/cells8111465"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1101\/gad.1424106","article-title":"mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes","volume":"20","author":"Rehwinkel","year":"2006","journal-title":"Genes Dev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.tcb.2006.12.007","article-title":"Repression of protein synthesis by miRNAs: How many mechanisms?","volume":"17","author":"Pillai","year":"2007","journal-title":"Trends Cell Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature03702","article-title":"MicroRNA expression profiles classify human cancers","volume":"435","author":"Lu","year":"2005","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1073\/pnas.0510565103","article-title":"A microRNA expression signature of human solid tumors defines cancer gene targets","volume":"103","author":"Volinia","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1158\/0008-5472.CAN-06-2698","article-title":"Characterization of microRNA expression levels and their biological correlates in human cancer cell lines","volume":"67","author":"Gaur","year":"2007","journal-title":"Cancer Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1038\/jid.2008.452","article-title":"miRNA expression profiling in melanocytes and melanoma cell lines reveals miRNAs associated with formation and progression of malignant melanoma","volume":"129","author":"Mueller","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrc1840","article-title":"Oncomirs-microRNAs with a role in cancer","volume":"6","author":"Slack","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1158\/0008-5472.CAN-07-2912","article-title":"MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines","volume":"68","author":"Bemis","year":"2008","journal-title":"Cancer Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.canlet.2013.08.021","article-title":"MiR-101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2","volume":"341","author":"Luo","year":"2013","journal-title":"Cancer Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00428-012-1309-9","article-title":"Loss of microRNA-200a and c, and microRNA-203 expression at the invasive front of primary cutaneous melanoma is associated with increased thickness and disease progression","volume":"461","author":"Lazar","year":"2012","journal-title":"Virchows Arch."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Mazar, J., DeYoung, K., Khaitan, D., Meister, E., Almodovar, A., Goydos, J., Ray, A., and Perera, R.J. (2010). The regulation of miRNA-211 expression and its role in melanoma cell invasiveness. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013779"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1038\/onc.2012.307","article-title":"MicroRNA miR-125b controls melanoma progression by direct regulation of c-Jun protein expression","volume":"32","author":"Kappelmann","year":"2013","journal-title":"Oncogene"},{"key":"ref_31","first-page":"939","article-title":"Proto-oncogene c-kit expression in malignant melanoma: Protein loss with tumor progression","volume":"10","author":"Montone","year":"1997","journal-title":"Mod. Pathol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1158\/0008-5472.CAN-07-2538","article-title":"The promyelocytic leukemia zinc finger-microRNA-221\/-222 pathway controls melanoma progression through multiple oncogenic mechanisms","volume":"68","author":"Felicetti","year":"2008","journal-title":"Cancer Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/ijc.28097","article-title":"The abrogation of the HOXB7\/PBX2 complex induces apoptosis in melanoma through the miR-221&222-c-FOS pathway","volume":"133","author":"Errico","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_34","first-page":"393","article-title":"Altered expression of selected microRNAs in melanoma: Antiproliferative and proapoptotic activity of miRNA-155","volume":"35","author":"Levati","year":"2009","journal-title":"Int. J. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1038\/emboj.2011.132","article-title":"Searching for the \u2018melano-miRs\u2019: miR-214 drives melanoma metastasis","volume":"30","year":"2011","journal-title":"EMBO J."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Gilad, S., Meiri, E., Yogev, Y., Benjamin, S., Lebanony, D., Yerushalmi, N., Benjamin, H., Kushnir, M., Cholakh, H., and Melamed, N. (2008). Serum microRNAs are promising novel biomarkers. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003148"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1010428317701646","DOI":"10.1177\/1010428317701646","article-title":"Identification of Plasma MicroRNAs as New Potential Biomarkers with High Diagnostic Power in Human Cutaneous Melanoma","volume":"39","author":"Fogli","year":"2017","journal-title":"Tumour. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Sol\u00e9, C., Tramonti, D., Schramm, M., Goicoechea, I., Armesto, M., Hernandez, L.I., Manterola, L., Fernandez-Mercado, M., Mujika, K., and Tuneu, A. (2019). The Circulating Transcriptome as a Source of Biomarkers for Melanoma. Cancers, 11.","DOI":"10.3390\/cancers11010070"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/bjc.2017.477","article-title":"Development and Validation of a Plasma-Based Melanoma Biomarker Suitable for Clinical Use","volume":"118","author":"Lincoln","year":"2018","journal-title":"Br. J. Cancer"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.18240\/ijo.2020.07.05","article-title":"Identification of Differentially Expressed Metastatic Genes and Their Signatures to Predict the Overall Survival of Uveal Melanoma Patients by Bioinformatics Analysis","volume":"13","author":"Zhao","year":"2020","journal-title":"Int. J. Ophthalmol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/CMR.0000000000000709","article-title":"MicroRNAs Expression Associated with Aggressive Clinicopathological Features and Poor Prognosis in Primary Cutaneous Melanomas","volume":"31","year":"2021","journal-title":"Melanoma Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2147\/CMAR.S163335","article-title":"MiR-497-5p, MiR-195-5p and MiR-455-3p Function as Tumor Suppressors by Targeting HTERT in Melanoma A375 Cells","volume":"10","author":"Chai","year":"2018","journal-title":"Cancer Manag. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3892\/or.2021.8189","article-title":"LncRNA TINCR Attenuates the Proliferation and Invasion, and Enhances the Apoptosis of Cutaneous Malignant Melanoma Cells by Regulating the MiR-424-5p\/LATS1 Axis","volume":"46","author":"Han","year":"2021","journal-title":"Oncol. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/labinvest.2017.5","article-title":"Identification of MicroRNAs Associated with Invasive and Aggressive Phenotype in Cutaneous Melanoma by Next-Generation Sequencing","volume":"97","author":"Babapoor","year":"2017","journal-title":"Lab. Investig."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.2217\/bmm-2021-0289","article-title":"Translation of a Circulating MiRNA Signature of Melanoma into a Solid Tissue Assay to Improve Diagnostic Accuracy and Precision","volume":"15","author":"King","year":"2021","journal-title":"Biomark. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0005-2736(81)90512-5","article-title":"Exfoliation of Membrane Ecto-Enzymes in the Form of Micro-Vesicles","volume":"645","author":"Trams","year":"1981","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1515\/med-2020-0111","article-title":"Identification of Key MicroRNAs of Plasma Extracellular Vesicles and Their Diagnostic and Prognostic Significance in Melanoma","volume":"15","author":"Xiong","year":"2020","journal-title":"Open Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1186\/s12935-021-02164-8","article-title":"The Plasma Exosomal MiR-1180-3p Serves as a Novel Potential Diagnostic Marker for Cutaneous Melanoma","volume":"21","author":"Guo","year":"2021","journal-title":"Cancer Cell Int."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Bustos, M.A., Tran, K.D., Rahimzadeh, N., Gross, R., Lin, S.Y., Shoji, Y., Murakami, T., Boley, C.L., Tran, L.T., and Cole, H. (2020). Integrated Assessment of Circulating Cell-Free MicroRNA Signatures in Plasma of Patients with Melanoma Brain Metastasis. Cancers, 12.","DOI":"10.3390\/cancers12061692"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2340\/00015555-2156","article-title":"Identification of a Circulating MicroRNA Profile as a Biomarker of Metastatic Cutaneous Melanoma","volume":"96","author":"Meyer","year":"2016","journal-title":"Acta Derm. Venereol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/modpathol.2016.44","article-title":"MicroRNA in Situ Hybridization for MiR-211 Detection as an Ancillary Test in Melanoma Diagnosis","volume":"29","author":"Babapoor","year":"2016","journal-title":"Mod. Pathol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"20193","DOI":"10.1002\/jcp.28619","article-title":"MicroRNA-203 Reinforces Stemness Properties in Melanoma and Augments Tumorigenesis in Vivo","volume":"234","author":"Sahranavardfard","year":"2019","journal-title":"J. Cell Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/cbin.11027","article-title":"MicroRNA-378 Regulates Epithelial-Mesenchymal Transition and Metastasis of Melanoma by Inhibiting FOXN3 Expression through the Wnt\/\u03b2-Catenin Pathway","volume":"43","author":"Sun","year":"2019","journal-title":"Cell Biol. Int."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"van Laar, R., Lincoln, M., and Fereday, S. (2019). Characterisation and Validation of Mel38; A Multi-Tissue MicroRNA Signature of Cutaneous Melanoma. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0211504"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"608987","DOI":"10.3389\/fonc.2021.608987","article-title":"MicroRNA Signature in Melanoma: Biomarkers and Therapeutic Targets","volume":"11","author":"Gholipour","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"12921","DOI":"10.1038\/srep12921","article-title":"Serum miRNA expression profile as a prognostic biomarker of stage II\/III colorectal adenocarcinoma","volume":"5","author":"Li","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0009-9120(72)80033-X","article-title":"Ribonuclease activity in human plasma","volume":"5","author":"Kamm","year":"1972","journal-title":"Clin. Biochem."},{"key":"ref_59","first-page":"32","article-title":"Secretory miRNAs as novel cancer biomarkers","volume":"1826","author":"Zhang","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/nar\/gkaa467","article-title":"miRNet 2.0: Network-based visual analytics for miRNA functional analysis and systems biology","volume":"48","author":"Chang","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Barbato, A., Iuliano, A., Volpe, M., D\u2019Alterio, R., Brillante, S., Massa, F., De Cegli, R., Carrella, S., Salati, M., and Russo, A. (2021). Integrated Genomics Identifies miR-181\/TFAM Pathway as a Critical Driver of Drug Resistance in Melanoma. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041801"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3892\/ol.2020.12349","article-title":"MicroRNA-633 enhances melanoma cell proliferation and migration by suppressing KAI1","volume":"21","author":"Wang","year":"2021","journal-title":"Oncol. Lett."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"538894","DOI":"10.3389\/fonc.2020.538894","article-title":"MiRNA-128-3p Restrains Malignant Melanoma Cell Malignancy by Targeting NTRK3","volume":"10","author":"Zhou","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_64","first-page":"173","article-title":"MicroRNA-137 targets EZH2 to exert suppressive functions in uveal melanoma via regulation of Wnt\/\u03b2-catenin signaling and epithelial-to-mesenchymal transition","volume":"26","author":"Zhang","year":"2021","journal-title":"JBUON"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3892\/mmr.2020.11717","article-title":"miR-18a-5p promotes melanoma cell proliferation and inhibits apoptosis and autophagy by targeting EPHA7 signaling","volume":"23","author":"Guo","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.neo.2020.10.009","article-title":"miR-524-5p reduces the progression of the BRAF inhibitor-resistant melanoma","volume":"22","author":"Nguyen","year":"2020","journal-title":"Neoplasia"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00403-020-02051-8","article-title":"MiR-4458\/human antigen R (HuR) modulates PBX3 mRNA stability in melanoma tumorigenesis","volume":"312","author":"Zhou","year":"2020","journal-title":"Arch. Dermatol. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"140","DOI":"10.12659\/MSM.895207","article-title":"Low Expression of Mir-137 Predicts Poor Prognosis in Cutaneous Melanoma Patients","volume":"22","author":"Li","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Xu, S.J., Xu, W.J., Zeng, Z., Zhang, M., and Zhang, D.Y. (2020). MiR-424 Functions as Potential Diagnostic and Prognostic Biomarker in Melanoma. Clin. Lab., 66.","DOI":"10.7754\/Clin.Lab.2019.190917"},{"key":"ref_70","first-page":"13249","article-title":"Expression of miR-203 is decreased and associated with the prognosis of melanoma patients","volume":"8","author":"Wang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"16379","DOI":"10.4238\/2015.December.9.6","article-title":"Expression of microRNA-106b and its clinical significance in cutaneous melanoma","volume":"14","author":"Lin","year":"2015","journal-title":"Genet. Mol. Res."},{"key":"ref_72","first-page":"3097","article-title":"Decreased serum microRNA-206 level predicts unfavorable prognosis in patients with melanoma","volume":"8","author":"Tian","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Lionetti, M.C., Cola, F., Chepizhko, O., Fumagalli, M.R., Font-Clos, F., Ravasio, R., Minucci, S., Canzano, P., Camera, M., and Tiana, G. (2020). MicroRNA-222 Regulates Melanoma Plasticity. J. Clin. Med., 9.","DOI":"10.3390\/jcm9082573"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/pcmr.12578","article-title":"MicroRNA-125a promotes resistance to BRAF inhibitors through suppression of the intrinsic apoptotic pathway","volume":"30","author":"Hanniford","year":"2017","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.jid.2016.02.803","article-title":"Regulation of Melanoma Progression through the TCF4\/miR-125b\/NEDD9 Cascade","volume":"136","author":"Rambow","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Nyholm, A.M., Lerche, C.M., Manf\u00e9, V., Biskup, E., Johansen, P., Morling, N., Thomsen, B.M., Glud, M., and Gniadecki, R. (2014). miR-125b induces cellular senescence in malignant melanoma. BMC Dermatol., 14.","DOI":"10.1186\/1471-5945-14-8"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/ced.12286","article-title":"MLK3 promotes melanoma proliferation and invasion and is a target of microRNA-125b","volume":"39","author":"Zhang","year":"2014","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"4428","DOI":"10.18632\/oncotarget.6599","article-title":"Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b","volume":"7","author":"Vergani","year":"2016","journal-title":"Oncotarget"},{"key":"ref_79","first-page":"1856","article-title":"Association between microRNA-125b expression in formalin-fixed paraffin-embedded tumor tissues and prognosis in patients with melanoma","volume":"18","author":"Yan","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1016\/j.jid.2021.03.036","article-title":"Slow Transcription of the 99a\/let-7c\/125b-2 Cluster Results in Differential MiRNA Expression and Promotes Melanoma Phenotypic Plasticity","volume":"141","author":"Sheinboim","year":"2021","journal-title":"J. Investig. Dermatol."},{"key":"ref_81","first-page":"331","article-title":"miR-106b-5p promotes cell cycle progression of malignant melanoma by targeting PTEN","volume":"39","author":"Chen","year":"2018","journal-title":"Oncol. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13046-021-01906-w","article-title":"Exosomal miR-106b-5p derived from melanoma cell promotes primary melanocytes epithelial-mesenchymal transition through targeting EphA4","volume":"40","author":"Luan","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"10636","DOI":"10.18632\/oncotarget.2527","article-title":"Down-regulation of miRNA-106b inhibits growth of melanoma cells by promoting G1-phase cell cycle arrest and reactivation of p21\/WAF1\/Cip1 protein","volume":"5","author":"Prasad","year":"2014","journal-title":"Oncotarget"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1172\/JCI98060","article-title":"Tumor-derived microRNAs induce myeloid suppressor cells and predict immunotherapy resistance in melanoma","volume":"128","author":"Huber","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/ijc.29151","article-title":"MicroRNA-155 deficiency enhances the recruitment and functions of myeloid-derived suppressor cells in tumor microenvironment and promotes solid tumor growth","volume":"136","author":"Wang","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00262-013-1468-9","article-title":"Chronic inflammation and cancer: Suppressing the suppressors","volume":"63","author":"Baniyash","year":"2014","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1158\/2326-6066.CIR-18-0504","article-title":"MicroRNA-155 Expression Is Enhanced by T-cell Receptor Stimulation Strength and Correlates with Improved Tumor Control in Melanoma","volume":"7","author":"Sempere","year":"2019","journal-title":"Cancer Immunol. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"18530","DOI":"10.1074\/jbc.M117.808121","article-title":"Antitumor immunity is defective in T cell-specific microRNA-155-deficient mice and is rescued by immune checkpoint blockade","volume":"292","author":"Huffaker","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s13046-018-0911-3","article-title":"Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1\/JAK2\/STAT3 signaling pathway","volume":"37","author":"Zhou","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/bjc.2011.288","article-title":"Carson WE 3rd. miR-21 and miR-155 are associated with mitotic activity and lesion depth of borderline melanocytic lesions","volume":"105","author":"Grignol","year":"2011","journal-title":"Br. J. Cancer"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/j.1755-148X.2011.00857.x","article-title":"MicroRNA-155 targets the SKI gene in human melanoma cell lines","volume":"24","author":"Levati","year":"2011","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Arts, N., Can\u00e9, S., Hennequart, M., Lamy, J., Bommer, G., Van den Eynde, B., and De Plaen, E. (2015). microRNA-155, induced by interleukin-1\u00df, represses the expression of microphthalmia-associated transcription factor (MITF-M) in melanoma cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0122517"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"15894","DOI":"10.18632\/oncotarget.15213","article-title":"PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p","volume":"8","author":"Audrito","year":"2017","journal-title":"Oncotarget"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Taraz\u00f3n, E., de Unamuno Bustos, B., Murria Estal, R., P\u00e9rez Sim\u00f3, G., Sahuquillo Torralba, A., Simarro, J., Palanca Suela, S., and Botella Estrada, R. (2021). MiR-138-5p Suppresses Cell Growth and Migration in Melanoma by Targeting Telomerase Reverse Transcriptase. Genes, 12.","DOI":"10.3390\/genes12121931"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Zhu, H., Kang, M., and Bai, X. (2021). TCF21 regulates miR-10a-5p\/LIN28B signaling to block the proliferation and invasion of melanoma cells. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0255971"},{"key":"ref_96","first-page":"1","article-title":"miR-302a-3p suppresses melanoma cell progression via targeting METTL3","volume":"21","author":"Chang","year":"2021","journal-title":"J. Chemother."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/cbin.11575","article-title":"Tumor suppressive microRNA-485-5p targets PRRX1 in human skin melanoma cells, regulating epithelial-mesenchymal transition and apoptosis","volume":"45","author":"Wu","year":"2021","journal-title":"Cell Biol. Int."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"15538","DOI":"10.18632\/aging.203114","article-title":"miR-34a inhibits melanoma growth by targeting ZEB1","volume":"13","author":"Xu","year":"2021","journal-title":"Aging"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Gebhardt, K., Edemir, B., Gro\u00df, E., Nemetschke, L., Kewitz-Hempel, S., Moritz, R., Sunderk\u00f6tter, C., and Gerloff, D. (2021). BRAF\/EZH2 Signaling Represses miR-129-5p Inhibition of SOX4 Thereby Modulating BRAFi Resistance in Melanoma. Cancers, 13.","DOI":"10.3390\/cancers13102393"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"104804","DOI":"10.1016\/j.micpath.2021.104804","article-title":"MicroRNA-365 promotes apoptosis in human melanoma cell A375 treated with hydatid cyst fluid of Echinococcus granulosus sensu stricto","volume":"153","author":"Mohammadi","year":"2021","journal-title":"Microb. Pathog."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1080\/10799893.2020.1804280","article-title":"miR-942-5p promotes the proliferation and invasion of human melanoma cells by targeting DKK3","volume":"41","author":"Zhang","year":"2021","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41419-021-03575-1","article-title":"hnRNPK-regulated LINC00263 promotes malignant phenotypes through miR-147a\/CAPN2","volume":"12","author":"Lee","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_103","first-page":"189","article-title":"miR-548b Suppresses Melanoma Cell Growth, Migration, and Invasion by Negatively Regulating Its Target Gene HMGB1","volume":"36","author":"Feng","year":"2021","journal-title":"Cancer Biother. Radiopharm."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1007\/s13577-020-00473-0","article-title":"Comprehensive upstream and downstream regulatory analyses identify miR-675-3p as a potential prognostic biomarker in melanoma","volume":"34","author":"Zhao","year":"2021","journal-title":"Hum. Cell"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.7150\/ijms.52177","article-title":"Hydroxyurea regulates the development and survival of B16 Melanoma Cells by upregulating MiR-7013-3p","volume":"18","author":"Huang","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1774323","DOI":"10.1080\/2162402X.2020.1774323","article-title":"Identification of miR-200a-5p targeting the peptide transporter TAP1 and its association with the clinical outcome of melanoma patients","volume":"9","author":"Lazaridou","year":"2020","journal-title":"Oncoimmunology"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Amaro, A., Croce, M., Ferrini, S., Barisione, G., Gualco, M., Perri, P., Pfeffer, U., Jager, M.J., Coupland, S.E., and Mosci, C. (2020). Potential Onco-Suppressive Role of miR122 and miR144 in Uveal Melanoma through ADAM10 and C-Met Inhibition. Cancers, 12.","DOI":"10.3390\/cancers12061468"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"718","DOI":"10.18240\/ijo.2020.05.04","article-title":"miRNA-145\/miRNA-205 inhibits proliferation and invasion of uveal melanoma cells by targeting NPR1\/CDC42","volume":"13","author":"Li","year":"2020","journal-title":"Int. J. Ophthalmol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10495-019-01586-0","article-title":"BRAFi induced demethylation of miR-152-5p regulates phenotype switching by targeting TXNIP in cutaneous melanoma","volume":"25","author":"Li","year":"2020","journal-title":"Apoptosis Int. J. Program. Cell Death"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"151508","DOI":"10.1016\/j.acthis.2020.151508","article-title":"miRNA-183\u223c96\u223c182 regulates melanogenesis, cell proliferation and migration in B16 cells","volume":"122","author":"Du","year":"2020","journal-title":"Acta Histochem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"8722","DOI":"10.12659\/MSM.917099","article-title":"miR-652 Promotes Proliferation and Migration of Uveal Melanoma Cells by Targeting HOXA9","volume":"25","author":"Xia","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"7831","DOI":"10.7717\/peerj.7831","article-title":"Identification of a five-miRNA signature predicting survival in cutaneous melanoma cancer patients","volume":"7","author":"Lu","year":"2019","journal-title":"PeerJ"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1002\/mc.23089","article-title":"Role of miR-214 in regulation of \u03b2-catenin and the malignant phenotype of melanoma","volume":"58","author":"Prabhakar","year":"2019","journal-title":"Mol. Carcinog."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.3389\/fonc.2019.01005","article-title":"MicroRNA-300: A Transcellular Mediator in Exosome Regulates Melanoma Progression","volume":"9","author":"Chen","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"663110","DOI":"10.3389\/fgene.2021.663110","article-title":"Identification of Metastasis-Associated MicroRNAs in Metastatic Melanoma by miRNA Expression Profile and Experimental Validation","volume":"12","author":"Gao","year":"2021","journal-title":"Front. Genet."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s40139-017-0123-0","article-title":"MicroRNAs in Cancer: Challenges and opportunities in early detection, disease monitoring, and therapeutic agents","volume":"5","author":"Chatterjee","year":"2017","journal-title":"Curr. Pathobiol. Rep."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: Target Recognition and Regulatory Functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2217\/nmt-2018-0033","article-title":"Patisiran, an RNAi Therapeutic for the Treatment of Hereditary Transthyretin-Mediated Amyloidosis","volume":"9","author":"Kristen","year":"2019","journal-title":"Neurodegener. Dis. Manag."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/17512433.2019.1567326","article-title":"Patisiran for the Treatment of Hereditary Transthyretin-Mediated Amyloidosis","volume":"12","author":"Yang","year":"2019","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1080\/17460441.2020.1765770","article-title":"Challenges Identifying Efficacious MiRNA Therapeutics for Cancer","volume":"15","author":"Segal","year":"2020","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/wrna.1114","article-title":"MicroRNA Degradation and Turnover: Regulating the Regulators","volume":"3","author":"Zhang","year":"2012","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Stepanov, G., Zhuravlev, E., Shender, V., Nushtaeva, A., Balakhonova, E., Mozhaeva, E., Kasakin, M., Koval, V., Lomzov, A., and Pavlyukov, M. (2018). Nucleotide Modifications Decrease Innate Immune Response Induced by Synthetic Analogs of SnRNAs and SnoRNAs. Genes, 9.","DOI":"10.3390\/genes9110531"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s41544-019-0039-4","article-title":"Biogenesis and Function of Extracellular MiRNAs","volume":"1","author":"Zhao","year":"2019","journal-title":"ExRNA"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3109\/10717544.2014.882469","article-title":"A Review of Mechanistic Insight and Application of PH-Sensitive Liposomes in Drug Delivery","volume":"22","author":"Paliwal","year":"2015","journal-title":"Drug Deliv."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.molcel.2016.09.027","article-title":"Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression","volume":"64","author":"Denzler","year":"2016","journal-title":"Molecular. Cell"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3389\/fimmu.2017.00331","article-title":"RNA Interference-Induced Innate Immunity, Off-Target Effect, or Immune Adjuvant?","volume":"8","author":"Meng","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.omtn.2019.11.008","article-title":"Hydrophobically Modified Let-7b MiRNA Enhances Biodistribution to NSCLC and Downregulates HMGA2 In Vivo","volume":"19","author":"Segal","year":"2020","journal-title":"Mol. Ther.-Nucleic Acids"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/gt.2011.100","article-title":"Chemical Modification and Design of Anti-MiRNA Oligonucleotides","volume":"18","author":"Lennox","year":"2011","journal-title":"Gene. Ther."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/mt.2013.55","article-title":"Liposome Delivery of MicroRNA-145 to Mesenchymal Stem Cells Leads to Immunological Off-Target Effects Mediated by RIG-I","volume":"21","author":"Karlsen","year":"2013","journal-title":"Mol. Ther."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ijpharm.2018.05.045","article-title":"Poly (Amidoamine) (PAMAM) Dendrimer Mediated Delivery of Drug and PDNA\/SiRNA for Cancer Therapy","volume":"546","author":"Li","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1093\/nar\/gky1239","article-title":"Diverse Lipid Conjugates for Functional Extra-Hepatic SiRNA Delivery in Vivo","volume":"47","author":"Biscans","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_132","first-page":"1537","article-title":"Aptamer-Based Targeted Delivery of MiRNA Let-7d to Gastric Cancer Cells as a Novel Anti-Tumor Therapeutic Agent","volume":"17","author":"Daei","year":"2018","journal-title":"Iran J. Pharm. Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"011503","DOI":"10.1063\/1.5087122","article-title":"Challenges and Opportunities in Exosome Research-Perspectives from Biology, Engineering, and Cancer Therapy","volume":"3","author":"Li","year":"2019","journal-title":"APL Bioeng."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1210\/en.2009-1045","article-title":"Delivering the Code: Polyplex Carriers for Deoxyribonucleic Acid and Ribonucleic Acid Interference Therapies","volume":"151","author":"Christie","year":"2010","journal-title":"Endocrinology"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4155\/tde-2016-0060","article-title":"Recent Advances in Light-Responsive on-Demand Drug-Delivery Systems","volume":"8","author":"Linsley","year":"2017","journal-title":"Ther. Deliv."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1517\/17425247.2010.485983","article-title":"Cationic Nanoparticles for Cancer Therapy","volume":"7","author":"Bilensoy","year":"2010","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"10029","DOI":"10.1039\/C7OB02654D","article-title":"Controlling MiRNA-like off-Target Effects of an SiRNA with Nucleobase Modifications","volume":"15","author":"Suter","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"7753","DOI":"10.1093\/nar\/gkz638","article-title":"Systems Biology-Based Investigation of Cooperating MicroRNAs as Monotherapy or Adjuvant Therapy in Cancer","volume":"47","author":"Lai","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1684\/ejd.2011.1210","article-title":"Immunohistochemical expression patterns of the microRNA-processing enzyme Dicer in cutaneous malignant melanomas, benign melanocytic nevi and dysplastic melanocytic nevi","volume":"21","author":"Sand","year":"2011","journal-title":"Eur. J. Dermatol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00441-012-1446-0","article-title":"The miRNA machinery in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases and benign melanocytic nevi","volume":"350","author":"Sand","year":"2012","journal-title":"Cell Tissue Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00441-012-1514-5","article-title":"Comparative microarray analysis of microRNA expression profiles in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases, and benign melanocytic nevi","volume":"351","author":"Sand","year":"2013","journal-title":"Cell Tissue Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.canlet.2018.06.014","article-title":"Roles of MicroRNA in the Immature Immune System of Neonates","volume":"433","author":"Yu","year":"2018","journal-title":"Cancer Lett."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1903827","DOI":"10.1080\/21645515.2021.1903827","article-title":"Immunotherapy and radiotherapy in melanoma: A multidisciplinary comprehensive review","volume":"18","author":"Tagliaferri","year":"2022","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s10456-017-9576-3","article-title":"A genomic screen for angiosuppressor genes in the tumor endothelium identifies a multifaceted angiostatic role for bromodomain containing 7 (BRD7)","volume":"20","author":"Wong","year":"2017","journal-title":"Angiogenesis"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s10456-017-9552-y","article-title":"Anti-angiogenesis for cancer revisited: Is there a role for combinations with immunotherapy?","volume":"20","author":"Ramjiawan","year":"2017","journal-title":"Angiogenesis"},{"key":"ref_146","first-page":"153","article-title":"A review of the literature for whole-body FDG PET in the management of patients with melanoma","volume":"44","author":"Schwimmer","year":"2000","journal-title":"Q. J. Nucl. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3389\/fgene.2019.00933","article-title":"Comprehensive Analysis of Human microRNA-mRNA Interactome","volume":"10","author":"Plotnikova","year":"2019","journal-title":"Front. Genet."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/6\/5386\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:52:49Z","timestamp":1760122369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/6\/5386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,11]]},"references-count":147,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["ijms24065386"],"URL":"https:\/\/doi.org\/10.3390\/ijms24065386","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,11]]}}}