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This paper reports synthesis and characterization of well-defined amphiphilic polyethylene-block-poly(L-lysine) (PE-b-PLL) block copolymers by combining nickel-catalyzed living ethylene polymerization with controlled ring-opening polymerization (ROP) of \u03b5-benzyloxycarbonyl-L-lysine-N-carboxyanhydride (Z-Lys-NCA) and sequential post-functionalization. Amphiphilic PE-b-PLL block copolymers self-assembled into spherical micelles with a hydrophobic PE core in aqueous solution. The pH and ionic responsivities of PE-b-PLL polymeric micelles were investigated by means of fluorescence spectroscopy, dynamic light scattering, UV-circular dichroism, and transmission electron microscopy. The variation of pH values led to the conformational alteration of PLL from \u03b1-helix to coil, thereby changing the micelle dimensions.<\/jats:p>","DOI":"10.3390\/ijms24065495","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:29:16Z","timestamp":1678764556000},"page":"5495","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Amphiphilic Polyethylene-b-poly(L-lysine) Block Copolymer: Synthesis, Self-Assembly, and Responsivity"],"prefix":"10.3390","volume":"24","author":[{"given":"Lixia","family":"Pei","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Ma","sequence":"additional","affiliation":[{"name":"Daqing Chemical Engineering Research Center, Petrochemical Research Institute, Daqing 163714, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Daqing Chemical Engineering Research Center, Petrochemical Research Institute, Daqing 163714, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Handou","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, PCFM Lab, GD HPPC Lab, Sun Yat-sen University, Guangzhou 510275, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7865-3787","authenticated-orcid":false,"given":"Haiyang","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, PCFM Lab, GD HPPC Lab, Sun Yat-sen University, Guangzhou 510275, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sauter, D.W., Taoufik, M., and Boisson, C. 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