{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:41:26Z","timestamp":1788968486416,"version":"build-2803163510"},"reference-count":231,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["88887.601586\/2021-00"],"award-info":[{"award-number":["88887.601586\/2021-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["305402\/2019-6"],"award-info":[{"award-number":["305402\/2019-6"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["88887.601586\/2021-00"],"award-info":[{"award-number":["88887.601586\/2021-00"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["305402\/2019-6"],"award-info":[{"award-number":["305402\/2019-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ageing is a complex process characterized mainly by a decline in the function of cells, tissues, and organs, resulting in an increased risk of mortality. This process involves several changes, described as hallmarks of ageing, which include genomic instability, telomere attrition, epigenetic changes, loss of proteostasis, dysregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell depletion, and altered intracellular communication. The determining role that environmental factors such as diet and lifestyle play on health, life expectancy, and susceptibility to diseases, including cancer and neurodegenerative diseases, is wellestablished. In view of the growing interest in the beneficial effects of phytochemicals in the prevention of chronic diseases, several studies have been conducted, and they strongly suggest that the intake of dietary polyphenols may bring numerous benefits due to their antioxidant and anti-inflammatory properties, and their intake has been associated with impaired ageing in humans. Polyphenol intake has been shown to be effective in ameliorating several age-related phenotypes, including oxidative stress, inflammatory processes, impaired proteostasis, and cellular senescence, among other features, which contribute to an increased risk of ageing-associated diseases. This review aims to address, in a general way, the main findings described in the literature about the benefits of polyphenols in each of the hallmarks of ageing, as well as the main regulatory mechanisms responsible for the observed antiageing effects.<\/jats:p>","DOI":"10.3390\/ijms24065508","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:29:16Z","timestamp":1678764556000},"page":"5508","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["The Molecular Mechanism of Polyphenols in the Regulation of Ageing Hallmarks"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3442-7224","authenticated-orcid":false,"given":"Qu\u00e9lita Cristina","family":"Pereira","sequence":"first","affiliation":[{"name":"Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University Medical School, Braganca Paulista 12916-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanila Wood","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University Medical School, Braganca Paulista 12916-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1144-3208","authenticated-orcid":false,"given":"Isabela Monique","family":"Fortunato","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University Medical School, Braganca Paulista 12916-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4529-7832","authenticated-orcid":false,"given":"Marcelo Lima","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University Medical School, Braganca Paulista 12916-900, SP, Brazil"},{"name":"Lymphoma Translational Group, Josep Carreras Leukemia Research Institute, 08916 Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101407","DOI":"10.1016\/j.arr.2021.101407","article-title":"The hoverfly and the wasp: A critique of the hallmarks of aging as a paradigm","volume":"70","author":"Gems","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev-physiol-030212-183712","article-title":"Genetics of longevity in model organisms: Debates and paradigm shifts","volume":"75","author":"Gems","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature08980","article-title":"The genetics of ageing","volume":"464","author":"Kenyon","year":"2010","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Meccariello, R., and D\u2019Angelo, S. (2021). Impact of Polyphenolic-Food on Longevity: An Elixir of Life. An Overview. Antioxidants, 10.","DOI":"10.3390\/antiox10040507"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1474-9726.2006.00192.x","article-title":"Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans","volume":"5","author":"Wilson","year":"2006","journal-title":"Aging Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.exger.2009.09.004","article-title":"Black tea theaflavins extend the lifespan of fruit flies","volume":"44","author":"Peng","year":"2009","journal-title":"Exp. Gerontol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1055\/s-0030-1250204","article-title":"Procyanidins from apples (Malus pumila Mill.) extend the lifespan of Caenorhabditis elegans","volume":"77","author":"Sunagawa","year":"2011","journal-title":"Planta Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.mad.2007.07.007","article-title":"Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans","volume":"128","author":"Bass","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.mad.2011.07.008","article-title":"Curcumin-mediated lifespan extension in Caenorhabditis elegans","volume":"132","author":"Liao","year":"2011","journal-title":"Mech. Ageing Dev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.phymed.2010.03.008","article-title":"Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2\/insulin-like signaling pathway","volume":"17","author":"Abbas","year":"2010","journal-title":"Phytomedicine"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Leri, M., Scuto, M., Ontario, M.L., Calabrese, V., Calabrese, E.J., Bucciantini, M., and Stefani, M. (2020). Healthy Effects of Plant Polyphenols: Molecular Mechanisms. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21041250"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"756132","DOI":"10.1155\/2012\/756132","article-title":"Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species","volume":"2012","author":"Gomes","year":"2012","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_14","first-page":"211","article-title":"An overview of the effects of polyphenols on cardiac mitochondrial function","volume":"28","author":"Salehi","year":"2019","journal-title":"J. Maz. Univ. Med. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"118341","DOI":"10.1016\/j.lfs.2020.118341","article-title":"Stabilization of telomere by the antioxidant property of polyphenols: Anti-aging potential","volume":"259","author":"Maleki","year":"2020","journal-title":"Life Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3389\/fendo.2018.00790","article-title":"Hallmarks of aging: An autophagic perspective","volume":"9","author":"Barbosa","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.redox.2016.12.001","article-title":"Happily (n) ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence","volume":"11","author":"Weber","year":"2017","journal-title":"Redox Biol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Rolt, A., and Cox, L.S. (2020). Structural basis of the anti-ageing effects of polyphenolics: Mitigation of oxidative stress. BMC Chem., 14.","DOI":"10.1186\/s13065-020-00696-0"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cardiores.2006.10.004","article-title":"Dietary polyphenols: Good, bad, or indifferent for your health?","volume":"73","author":"Halliwell","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.foodchem.2019.01.096","article-title":"Positive and negative effects of polyphenol incorporation in baked foods","volume":"284","author":"Ou","year":"2019","journal-title":"Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.tcb.2018.02.001","article-title":"Hallmarks of cellular senescence","volume":"28","author":"Nehme","year":"2018","journal-title":"Trends Cell Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"10604","DOI":"10.1073\/pnas.0500398102","article-title":"Epigenetic differences arise during the lifetime of monozygotic twins","volume":"102","author":"Fraga","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9175806","DOI":"10.1155\/2017\/9175806","article-title":"Epigenetics and Oxidative Stress in Aging","volume":"2017","author":"Calabria","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e1600584","DOI":"10.1126\/sciadv.1600584","article-title":"Epigenetics and aging","volume":"2","author":"Pal","year":"2016","journal-title":"Sci. Adv."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s40279-013-0114-1","article-title":"Exercise: Putting action into our epigenome","volume":"44","author":"Denham","year":"2014","journal-title":"Sport. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Arora, I., Sharma, M., Sun, L.Y., and Tollefsbol, T.O. (2020). The Epigenetic Link between Polyphenols, Aging and Age-Related Diseases. Genes, 11.","DOI":"10.3390\/genes11091094"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1002\/jcp.24054","article-title":"Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression","volume":"227","author":"Donohoe","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"ref_29","first-page":"741468","article-title":"Diet and aging","volume":"2012","year":"2012","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1093\/carcin\/bgh123","article-title":"Diallyl disulfide (DADS) increases histone acetylation and p21 waf1\/cip1 expression in human colon tumor cell lines","volume":"25","author":"Druesne","year":"2004","journal-title":"Carcinogenesis"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.biopha.2014.12.016","article-title":"Green tea polyphenol EGCG reverse cisplatin resistance of A549\/DDP cell line through candidate genes demethylation","volume":"69","author":"Zhang","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/jcb.21417","article-title":"Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG","volume":"103","author":"Berletch","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/carcin\/bgq285","article-title":"(\u2212)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1\/p21 and p 16 INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells","volume":"32","author":"Nandakumar","year":"2011","journal-title":"Carcinogenesis"},{"key":"ref_34","first-page":"7563","article-title":"Tea polyphenol (\u2212)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines","volume":"63","author":"Fang","year":"2003","journal-title":"Cancer Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00109-019-01759-z","article-title":"Klotho recovery by genistein via promoter histone acetylation and DNA demethylation mitigates renal fibrosis in mice","volume":"97","author":"Li","year":"2019","journal-title":"J. Mol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.jnutbio.2011.10.007","article-title":"Polyphenols in brewed green tea inhibit prostate tumor xenograft growth by localizing to the tumor and decreasing oxidative stress and angiogenesis","volume":"23","author":"Henning","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1016\/j.bcp.2008.02.016","article-title":"Quercetin augments TRAIL-induced apoptotic death: Involvement of the ERK signal transduction pathway","volume":"75","author":"Kim","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1080\/01635581.2012.717682","article-title":"Reactivation of RASSF1A in breast cancer cells by curcumin","volume":"64","author":"Du","year":"2012","journal-title":"Nutr. Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/ptr.5373","article-title":"Curcumin reactivates silenced tumor suppressor gene RAR\u03b2 by reducing DNA methylation","volume":"29","author":"Jiang","year":"2015","journal-title":"Phytother. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bcp.2006.04.018","article-title":"Attenuation of osteoclastogenesis and osteoclast function by apigenin","volume":"72","author":"Bandyopadhyay","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15272\/ajbps.v4i39.612","article-title":"Effect of olive leaf components on the proliferation and viability of hematopoietic stem cells","volume":"4","author":"Samet","year":"2014","journal-title":"Asian J. Biomed. Pharm. Sci."},{"key":"ref_42","unstructured":"Eggler, A.L., and Savinov, S.N. (2013). 50 Years of Phytochemistry Research, Springer."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.4103\/1673-5374.332128","article-title":"Phytochemicals as inhibitors of tumor necrosis factor alpha and neuroinflammatory responses in neurodegenerative diseases","volume":"17","author":"Zahedipour","year":"2022","journal-title":"Neural Regen. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.foodchem.2012.02.172","article-title":"Anti-inflammatory activity of lipophilic epigallocatechin gallate (EGCG) derivatives in LPS-stimulated murine macrophages","volume":"134","author":"Zhong","year":"2012","journal-title":"Food Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3892\/ijo.2013.2006","article-title":"(-)-Epigallocatechin-3-gallate blocks nicotine-induced matrix metalloproteinase-9 expression and invasiveness via suppression of NF-\u03baB and AP-1 in endothelial cells","volume":"43","author":"Khoi","year":"2013","journal-title":"Int. J. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Rahimifard, M., Baeeri, M., Bahadar, H., Moini-Nodeh, S., Khalid, M., Haghi-Aminjan, H., Mohammadian, H., and Abdollahi, M. (2020). Therapeutic effects of gallic acid in regulating senescence and diabetes; an in vitro study. Molecules, 25.","DOI":"10.3390\/molecules25245875"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Menicacci, B., Cipriani, C., Margheri, F., Mocali, A., and Giovannelli, L. (2017). Modulation of the senescence-associated inflammatory phenotype in human fibroblasts by olive phenols. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112275"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.phymed.2013.05.002","article-title":"Oleuropein and oleacein may restore biological functions of endothelial progenitor cells impaired by angiotensin II via activation of Nrf2\/heme oxygenase-1 pathway","volume":"20","author":"Parzonko","year":"2013","journal-title":"Phytomedicine"},{"key":"ref_49","first-page":"1905","article-title":"Oleic acid enhances the motility of umbilical cord blood derived mesenchymal stem cells through EphB2-dependent F-actin formation","volume":"1853","author":"Jung","year":"2015","journal-title":"Biochim. Biochim. Et Biophys. Acta (BBA)-Mol. Cell Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1089\/rej.2006.0513","article-title":"The olive constituent oleuropein exhibits proteasome stimulatory properties in vitro and confers life span extension of human embryonic fibroblasts","volume":"10","author":"Katsiki","year":"2007","journal-title":"Rejuvenation Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00198-010-1270-x","article-title":"Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: The effect on differentiation in stem cells derived from bone marrow","volume":"22","year":"2011","journal-title":"Osteoporos. Int."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1089\/109662003772519831","article-title":"Polyphenolics in grape seeds\u2014Biochemistry and functionality","volume":"6","author":"Shi","year":"2003","journal-title":"J. Med. Food"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","article-title":"Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease","volume":"47","author":"Hickson","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ebiom.2018.12.052","article-title":"Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study","volume":"40","author":"Justice","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/jnr.21503","article-title":"Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation","volume":"86","author":"Bureau","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0192-0561(99)00024-7","article-title":"Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-\u03b1 production in murine macrophages","volume":"21","author":"Ghosh","year":"1999","journal-title":"Int. J. Immunopharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/jn\/137.10.2190","article-title":"Dietary flavones and flavonoles are inhibitors of poly (ADP-ribose) polymerase-1 in pulmonary epithelial cells","volume":"137","author":"Geraets","year":"2007","journal-title":"J. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/sj.bjp.0706695","article-title":"Regulation of IL-1-induced selective IL-6 release from human mast cells and inhibition by quercetin","volume":"148","author":"Kempuraj","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5388","DOI":"10.1038\/s41598-020-62292-5","article-title":"Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability","volume":"10","author":"Matsuno","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.fct.2019.02.010","article-title":"Microbial metabolites of proanthocyanidins reduce chemical carcinogen-induced DNA damage in human lung epithelial and fetal hepatic cells in vitro","volume":"125","author":"Thilakarathna","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"65717","DOI":"10.18632\/oncotarget.20084","article-title":"A comparative study of anti-aging properties and mechanism: Resveratrol and caloric restriction","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/0886022X.2022.2029488","article-title":"Resveratrol inhibits the progression of premature senescence partially by regulating v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) and sirtuin 1 (SIRT1)","volume":"44","author":"He","year":"2022","journal-title":"Ren. Fail."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Zheng, M., Bai, Y., Sun, X., Fu, R., Liu, L., Liu, M., Li, Z., and Huang, X. (2022). Resveratrol Reestablishes Mitochondrial Quality Control in Myocardial Ischemia\/Reperfusion Injury through Sirt1\/Sirt3-Mfn2-Parkin-PGC-1\u03b1 Pathway. Molecules, 27.","DOI":"10.3390\/molecules27175545"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nature08197","article-title":"Recent progress in the biology and physiology of sirtuins","volume":"460","author":"Finkel","year":"2009","journal-title":"Nature"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Zhu, X., Liu, Q., Wang, M., Liang, M., Yang, X., Xu, X., Zou, H., and Qiu, J. (2011). Activation of Sirt1 by resveratrol inhibits TNF-\u03b1 induced inflammation in fibroblasts. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027081"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"8786","DOI":"10.1128\/MCB.23.23.8786-8794.2003","article-title":"Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway","volume":"23","author":"Kwak","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.arr.2012.02.001","article-title":"The role of DNA damage and repair in aging through the prism of Koch-like criteria","volume":"12","author":"Moskalev","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev-biochem-062917-012239","article-title":"Nuclear genomic instability and aging","volume":"87","author":"Niedernhofer","year":"2018","journal-title":"Annu. Rev. Biochem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nrm.2017.68","article-title":"Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases","volume":"18","author":"Kubben","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ajhg.2019.06.005","article-title":"DNA damage and associated DNA repair defects in disease and premature aging","volume":"105","author":"Tiwari","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev-genet-120417-031501","article-title":"Somatic mutagenesis in mammals and its implications for human disease and aging","volume":"52","author":"Zhang","year":"2018","journal-title":"Annu. Rev. Genet."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/s13059-019-1919-5","article-title":"The somatic mutation landscape of the human body","volume":"20","author":"Morrison","year":"2019","journal-title":"Genome Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"9014","DOI":"10.1073\/pnas.1902510116","article-title":"Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan","volume":"116","author":"Zhang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nrg.2016.145","article-title":"Mosaicism in health and disease\u2014Clones picking up speed","volume":"18","author":"Forsberg","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Risques, R.A., and Kennedy, S.R. (2018). Aging and the rise of somatic cancer-associated mutations in normal tissues. PLoS Genet., 14.","DOI":"10.1371\/journal.pgen.1007108"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.tig.2011.03.002","article-title":"Somatic mosaicism in healthy human tissues","volume":"27","author":"De","year":"2011","journal-title":"Trends Genet."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"6005","DOI":"10.1073\/pnas.1601311113","article-title":"Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues","volume":"113","author":"Krimmel","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"12484","DOI":"10.1038\/ncomms12484","article-title":"Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults","volume":"7","author":"Young","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s10522-019-09832-3","article-title":"The protective function of non-coding DNA in DNA damage accumulation with age and its roles in age-related diseases","volume":"20","author":"Qiu","year":"2019","journal-title":"Biogerontology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2217\/epi-2017-0103","article-title":"The protective function of noncoding DNA in genome defense of eukaryotic male germ cells","volume":"10","author":"Qiu","year":"2018","journal-title":"Epigenomics"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-cellbio-100617-062653","article-title":"Heterochromatin: Guardian of the genome","volume":"34","author":"Janssen","year":"2018","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e13080","DOI":"10.1111\/acel.13080","article-title":"Measuring biological aging in humans: A quest","volume":"19","author":"Ferrucci","year":"2020","journal-title":"Aging Cell"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Proshkina, E., Shaposhnikov, M., and Moskalev, A. (2020). Genome-Protecting Compounds as Potential Geroprotectors. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124484"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"11","DOI":"10.18388\/abp.2007_3265","article-title":"Oxidative damage to DNA and antioxidant status in aging and age-related diseases","volume":"54","author":"Olinski","year":"2007","journal-title":"Acta Biochim. Pol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/ageing\/afm107","article-title":"Age-related increases in DNA repair and antioxidant protection: A comparison of the Boyd Orr Cohort of elderly subjects with a younger population sample","volume":"36","author":"Humphreys","year":"2007","journal-title":"Age Ageing"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/BF02873438","article-title":"Changes in antioxidant enzyme levels and DNA damage during aging","volume":"13","author":"Reddy","year":"1998","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_87","unstructured":"De Caterina, R., Martinez, A.J., and Kohlmeier, M. (2019). Principles of Nutrigenetics and Nutrigenomics: Fundamentals of Individualized Nutrition, Academic Press."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3945\/an.117.015610","article-title":"Vitamins associated with brain aging, mild cognitive impairment, and alzheimer disease: Biomarkers, epidemiological and experimental evidence, plausible mechanisms, and knowledge gaps","volume":"8","author":"Fenech","year":"2017","journal-title":"Adv. Nutr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1158\/1940-6207.CAPR-10-0137","article-title":"Proanthocyanidins Inhibit Photocarcinogenesis through Enhancement of DNA Repair and Xeroderma Pigmentosum Group A\u2013Dependent MechanismProanthocyanidins Stimulate DNA Repair","volume":"3","author":"Vaid","year":"2010","journal-title":"Cancer Prev. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"49625","DOI":"10.18632\/oncotarget.17867","article-title":"Dietary grape seed proanthocyanidins inactivate regulatory T cells by promoting NER-dependent DNA repair in dendritic cells in UVB-exposed skin","volume":"8","author":"Vaid","year":"2017","journal-title":"Oncotarget"},{"key":"ref_91","first-page":"135","article-title":"Telomere dysfunction in ageing and age-related diseases","volume":"24","author":"Rossiello","year":"2022","journal-title":"Nature"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"15122","DOI":"10.1073\/pnas.1902452116","article-title":"Telomere shortening rate predicts species life span","volume":"116","author":"Whittemore","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10522-018-9748-6","article-title":"Mitochondria, its DNA and telomeres in ageing and human population","volume":"19","author":"Zole","year":"2018","journal-title":"Biogerontology"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1101\/gad.263863.115","article-title":"Human telomerase: Biogenesis, trafficking, recruitment, and activation","volume":"29","author":"Schmidt","year":"2015","journal-title":"Genes Dev."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3892\/or.2021.8135","article-title":"Abnormal function of telomere protein TRF2 induces cell mutation and the effects of environmental tumor-promoting factors (Review)","volume":"46","author":"Wang","year":"2021","journal-title":"Oncol. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nature09787","article-title":"Telomere dysfunction induces metabolic and mitochondrial compromise","volume":"470","author":"Sahin","year":"2011","journal-title":"Nature"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.cmet.2019.03.001","article-title":"Telomere dysfunction induces sirtuin repression that drives telomere-dependent disease","volume":"29","author":"Amano","year":"2019","journal-title":"Cell Metab."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.cell.2020.12.028","article-title":"Telomeres: History, health, and hallmarks of aging","volume":"184","author":"Chakravarti","year":"2021","journal-title":"Cell"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/acel.12411","article-title":"Blockade of senescence-associated microRNA-195 in aged skeletal muscle cells facilitates reprogramming to produce induced pluripotent stem cells","volume":"15","author":"Kondo","year":"2016","journal-title":"Aging Cell"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e103420","DOI":"10.15252\/embj.2019103420","article-title":"Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction","volume":"39","author":"Sun","year":"2020","journal-title":"EMBO J."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"101507","DOI":"10.1016\/j.arr.2021.101507","article-title":"Stress and telomere shortening: Insights from cellular mechanisms","volume":"73","author":"Lin","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"12","DOI":"10.18632\/aging.100886","article-title":"Nutrition and lifestyle in healthy aging: The telomerase challenge","volume":"8","author":"Boccardi","year":"2016","journal-title":"Aging"},{"key":"ref_103","first-page":"327","article-title":"Telomerase RNA component genetic variants interact with the mediterranean diet modifying the inflammatory status and its relationship with aging: CORDIOPREV Study","volume":"73","author":"Corina","year":"2018","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ijcard.2011.07.083","article-title":"Epigallocatechin gallate, the major component of polyphenols in green tea, inhibits telomere attrition mediated cardiomyocyte apoptosis in cardiac hypertrophy","volume":"162","author":"Sheng","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/sj.ejcn.1602489","article-title":"Black tea\u2013helpful or harmful? A review of the evidence","volume":"61","author":"Gardner","year":"2007","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"7501424","DOI":"10.1155\/2021\/7501424","article-title":"Trends in Natural Nutrients for Oxidative Stress and Cell Senescence","volume":"2021","author":"Omidifar","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/biof.1400","article-title":"Effect of resveratrol and pterostilbene on aging and longevity","volume":"44","author":"Li","year":"2018","journal-title":"Biofactors"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1038\/cddis.2009.8","article-title":"Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy","volume":"1","author":"Morselli","year":"2010","journal-title":"Cell Death Dis."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1007\/s11357-012-9489-4","article-title":"Dietary resveratrol prevents Alzheimer\u2019s markers and increases life span in SAMP8","volume":"35","author":"Porquet","year":"2013","journal-title":"Age"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"He, F., Ru, X., and Wen, T. (2020). NRF2, a Transcription Factor for Stress Response and Beyond. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21134777"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"690686","DOI":"10.3389\/fragi.2021.690686","article-title":"An NRF2 Perspective on Stem Cells and Ageing","volume":"2","author":"Dodson","year":"2021","journal-title":"Front. Aging"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.stem.2016.04.015","article-title":"Mitochondrial dynamics impacts stem cell identity and fate decisions by regulating a nuclear transcriptional program","volume":"19","author":"Khacho","year":"2016","journal-title":"Cell Stem Cell"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.jnutbio.2015.08.001","article-title":"The complexity of the Nrf2 pathway: Beyond the antioxidant response","volume":"26","author":"Huang","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1073\/pnas.1417566112","article-title":"Regulation of Nrf2 signaling and longevity in naturally long-lived rodents","volume":"112","author":"Lewis","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/icb\/icq034","article-title":"Nrf2, a guardian of healthspan and gatekeeper of species longevity","volume":"50","author":"Lewis","year":"2010","journal-title":"Integr. Comp. Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/MCO.0b013e32834136f2","article-title":"The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation","volume":"14","author":"Sykiotis","year":"2011","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1101\/gad.13.1.76","article-title":"Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain","volume":"13","author":"Itoh","year":"1999","journal-title":"Genes Dev."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"6635460","DOI":"10.1155\/2021\/6635460","article-title":"The Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging","volume":"2021","author":"Yu","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2654910","DOI":"10.1155\/2019\/2654910","article-title":"Nrf2\/Keap1\/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells","volume":"2019","author":"Yan","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"120111","DOI":"10.1016\/j.lfs.2021.120111","article-title":"Nrf2\/Keap1\/ARE signaling: Towards specific regulation","volume":"291","author":"Ulasov","year":"2022","journal-title":"Life Sci"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"13291","DOI":"10.1074\/jbc.R900010200","article-title":"The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress","volume":"284","author":"Nguyen","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"e1900400","DOI":"10.1002\/cbdv.201900400","article-title":"Recent advances of natural polyphenols activators for Keap1-Nrf2 signaling pathway","volume":"16","author":"Zhou","year":"2019","journal-title":"Chem. Biodivers."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1083\/jcb.201709072","article-title":"Pathways of cellular proteostasis in aging and disease","volume":"217","author":"Klaips","year":"2018","journal-title":"J. Cell Biol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.redox.2017.07.008","article-title":"Proteostasis, oxidative stress and aging","volume":"13","author":"Korovila","year":"2017","journal-title":"Redox Biol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/mas.21381","article-title":"Protein carbonylation as a major hallmark of oxidative damage: Update of analytical strategies","volume":"33","author":"Fedorova","year":"2014","journal-title":"Mass Spectrom. Rev."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"417842","DOI":"10.1155\/2014\/417842","article-title":"Reactive carbonyl species in vivo: Generation and dual biological effects","volume":"2014","author":"Semchyshyn","year":"2014","journal-title":"Sci. World J."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev-biochem-061516-044908","article-title":"Proteasomal and autophagic degradation systems","volume":"86","author":"Dikic","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41580-019-0101-y","article-title":"The proteostasis network and its decline in ageing","volume":"20","author":"Hipp","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1126\/science.1080418","article-title":"Asymmetric inheritance of oxidatively damaged proteins during cytokinesis","volume":"299","author":"Aguilaniu","year":"2003","journal-title":"Science"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1038\/s41598-018-25118-z","article-title":"(Poly) phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis","volume":"8","author":"Macedo","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev-biochem-061516-045115","article-title":"Protein misfolding, amyloid formation, and human disease: A summary of progress over the last decade","volume":"86","author":"Chiti","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Hajieva, P. (2017). The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection. Molecules, 22.","DOI":"10.3390\/molecules22010159"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Pignatti, C., D\u2019Adamo, S., Stefanelli, C., and Flamigni, F. (2020). Nutrients and Pathways that Regulate Health Span and Life Span. Geriatrics, 5.","DOI":"10.3390\/geriatrics5040095"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"126","DOI":"10.2174\/1570159X15666170703113212","article-title":"Effects of resveratrol and other polyphenols on Sirt1: Relevance to brain function during aging","volume":"16","author":"Sarubbo","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"943321","DOI":"10.3389\/fimmu.2022.943321","article-title":"Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism","volume":"13","author":"Cui","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mce.2017.03.031","article-title":"Regulation of stem cell aging by SIRT1-Linking metabolic signaling to epigenetic modifications","volume":"455","author":"Yu","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_137","first-page":"1170","article-title":"SIRT1 is downregulated by autophagy in senescence and ageing","volume":"22","author":"Xu","year":"2020","journal-title":"Nature"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.arr.2018.02.004","article-title":"Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming","volume":"43","author":"Ong","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tcb.2014.04.002","article-title":"NAD+ and sirtuins in aging and disease","volume":"24","author":"Imai","year":"2014","journal-title":"Trends Cell Biol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.arr.2018.05.001","article-title":"Anti-senescence compounds: A potential nutraceutical approach to healthy aging","volume":"46","author":"Baldoni","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"3565127","DOI":"10.1155\/2016\/3565127","article-title":"ROS, cell senescence, and novel molecular mechanisms in aging and age-related diseases","volume":"2016","author":"Davalli","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"24","DOI":"10.5483\/BMBRep.2019.52.1.290","article-title":"Sirtuin signaling in cellular senescence and aging","volume":"52","author":"Lee","year":"2019","journal-title":"BMB Rep."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"D\u2019Angelo, S., Mele, E., Di Filippo, F., Viggiano, A., and Meccariello, R. (2021). Sirt1 activity in the brain: Simultaneous effects on energy homeostasis and reproduction. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18031243"},{"key":"ref_144","first-page":"3212","article-title":"Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1","volume":"17","author":"Zou","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s11481-017-9759-0","article-title":"Chronic silymarin, quercetin and naringenin treatments increase monoamines synthesis and hippocampal Sirt1 levels improving cognition in aged rats","volume":"13","author":"Sarubbo","year":"2018","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.bcp.2012.06.031","article-title":"Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence","volume":"84","author":"Yao","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2147\/CIA.S158513","article-title":"Oxidative stress, aging, and diseases","volume":"13","author":"Liguori","year":"2018","journal-title":"Clin. Interv. Aging"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/1873-3468.12956","article-title":"Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease","volume":"592","author":"Nissanka","year":"2018","journal-title":"FEBS Lett."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.pneurobio.2011.04.013","article-title":"DNA repair deficiency in neurodegeneration","volume":"94","author":"Jeppesen","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Kennedy, S.R., Salk, J.J., Schmitt, M.W., and Loeb, L.A. (2013). Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage. PLoS Genet., 9.","DOI":"10.1371\/journal.pgen.1003794"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"44879","DOI":"10.18632\/oncotarget.9821","article-title":"Mitochondrial dysfunction and oxidative stress in aging and cancer","volume":"7","author":"Kudryavtseva","year":"2016","journal-title":"Oncotarget"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.4161\/cc.19800","article-title":"Oncogene-induced senescence results in marked metabolic and bioenergetic alterations","volume":"11","author":"Quijano","year":"2012","journal-title":"Cell Cycle"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3389\/fcell.2020.00239","article-title":"MitophAging: Mitophagy in aging and disease","volume":"8","author":"Bakula","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.nbd.2018.07.005","article-title":"Autophagy and mitophagy in ALS","volume":"122","author":"Evans","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"ref_155","unstructured":"Pourahmad, J., Salimi, A., and Seydi, E. (2016). Free Radicals and Diseases, Intech Open."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"4946711","DOI":"10.1155\/2021\/4946711","article-title":"Targeting Mitochondrial Biogenesis with Polyphenol Compounds","volume":"2021","author":"Chodari","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Ashkar, F., Bhullar, K.S., and Wu, J. (2022). The Effect of Polyphenols on Kidney Disease: Targeting Mitochondria. Nutrients, 14.","DOI":"10.3390\/nu14153115"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Yessenkyzy, A., and Saliev, T. (2020). Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research. Nutrients, 12.","DOI":"10.3390\/nu12051344"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Naoi, M., Wu, Y., Shamoto-Nagai, M., and Maruyama, W. (2019). Mitochondria in Neuroprotection by Phytochemicals: Bioactive Polyphenols Modulate Mitochondrial Apoptosis System, Function and Structure. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20102451"},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Dilberger, B., and Passon, M. (2019). Polyphenols and Metabolites Enhance Survival in Rodents and Nematodes-Impact of Mitochondria. Nutrients, 11.","DOI":"10.3390\/nu11081886"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"6705621","DOI":"10.1155\/2016\/6705621","article-title":"Resveratrol regulates mitochondrial biogenesis and fission\/fusion to attenuate rotenone-induced neurotoxicity","volume":"2016","author":"Peng","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_162","first-page":"425","article-title":"Modulation of mitochondrial biogenesis: Action of physical activity and phytochemicals","volume":"21","author":"Ferrara","year":"2021","journal-title":"J. Phys. Educ. Sport"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Gherardi, G., Corbioli, G., Ruzza, F., and Rizzuto, R. (2022). CoQ(10) and Resveratrol Effects to Ameliorate Aged-Related Mitochondrial Dysfunctions. Nutrients, 14.","DOI":"10.3390\/nu14204326"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/JES.0b013e3182141f80","article-title":"Mitochondrial protection by resveratrol","volume":"39","author":"Ungvari","year":"2011","journal-title":"Exerc. Sport Sci. Rev."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neuint.2017.02.007","article-title":"Mitophagy in neurodegeneration and aging","volume":"109","author":"Fivenson","year":"2017","journal-title":"Neurochem. Int."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Go\u00f1i, I., and Hern\u00e1ndez-Galiot, A. (2019). Intake of Nutrient and Non-Nutrient Dietary Antioxidants. Contribution of Macromolecular Antioxidant Polyphenols in an Elderly Mediterranean Population. Nutrients, 11.","DOI":"10.3390\/nu11092165"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Louren\u00e7o, S.C., and Mold\u00e3o-Martins, M. (2019). Antioxidants of Natural Plant Origins: From Sources to Food Industry Applications. Molecules, 24.","DOI":"10.3390\/molecules24224132"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Luo, J., Si, H., Jia, Z., and Liu, D. (2021). Dietary Anti-Aging Polyphenols and Potential Mechanisms. Antioxidants, 10.","DOI":"10.3390\/antiox10020283"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Truong, V.L., and Jeong, W.S. (2021). Cellular Defensive Mechanisms of Tea Polyphenols: Structure-Activity Relationship. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179109"},{"key":"ref_170","first-page":"4012603","article-title":"Association between Circulating Antioxidants and Longevity: Insight from Mendelian Randomization Study","volume":"2022","author":"Yu","year":"2022","journal-title":"BioMed Res. Int."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"483","DOI":"10.11613\/BM.2019.030501","article-title":"Hallmarks of senescence and aging","volume":"29","author":"Dodig","year":"2019","journal-title":"Biochem. Med."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1172\/JCI95148","article-title":"Mechanisms and functions of cellular senescence","volume":"128","author":"Herranz","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000129697","article-title":"Senescence, apoptosis or autophagy?","volume":"54","author":"Vicencio","year":"2008","journal-title":"Gerontology"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Yanagi, S., Tsubouchi, H., Miura, A., Matsuo, A., Matsumoto, N., and Nakazato, M. (2017). The impacts of cellular senescence in elderly pneumonia and in age-related lung diseases that increase the risk of respiratory infections. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18030503"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.exger.2010.01.018","article-title":"Quantitative assessment of markers for cell senescence","volume":"45","author":"Lawless","year":"2010","journal-title":"Exp. Gerontol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00125-004-1605-2","article-title":"Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice","volume":"48","author":"Sone","year":"2005","journal-title":"Diabetologia"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nrcardio.2013.30","article-title":"The roles of senescence and telomere shortening in cardiovascular disease","volume":"10","author":"Fyhrquist","year":"2013","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/nm.2014","article-title":"A crucial role for adipose tissue p53 in the regulation of insulin resistance","volume":"15","author":"Minamino","year":"2009","journal-title":"Nat. Med."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.exger.2003.08.007","article-title":"Senescence-associated cell death of human endothelial cells: The role of oxidative stress","volume":"38","author":"Unterluggauer","year":"2003","journal-title":"Exp. Gerontol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1749-6632.1994.tb21787.x","article-title":"The role of oxidative stress in signal transduction changes and cell loss in senescence","volume":"738","author":"Joseph","year":"1994","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Roger, L., Tomas, F., and Gire, V. (2021). Mechanisms and Regulation of Cellular Senescence. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222313173"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1089\/rej.2011.1245","article-title":"A diet rich in olive oil phenolics reduces oxidative stress in the heart of SAMP8 mice by induction of Nrf2-dependent gene expression","volume":"15","author":"Bayram","year":"2012","journal-title":"Rejuvenation Res."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00109-019-01846-1","article-title":"Caloric restriction maintains stem cells through niche and regulates stem cell aging","volume":"98","author":"Maharajan","year":"2020","journal-title":"J. Mol. Med."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3233\/NUA-130016","article-title":"Beneficial effects of olive oil phenols on the aging process: Experimental evidence and possible mechanisms of action","volume":"1","author":"Giovannelli","year":"2012","journal-title":"Nutr. Aging"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez del R\u00edo, L., Guti\u00e9rrez-Casado, E., Varela-L\u00f3pez, A., and Villalba, J.M. (2016). Olive oil and the hallmarks of aging. Molecules, 21.","DOI":"10.3390\/molecules21020163"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Puca, F., and Fedele, M. (2022). Role of Diet in Stem and Cancer Stem Cells. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158108"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.2147\/CIA.S72006","article-title":"Olive oil in the prevention and treatment of osteoporosis after artificial menopause","volume":"9","author":"Liu","year":"2014","journal-title":"Clin. Interv. Aging"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.imbio.2010.06.007","article-title":"Oleic acid modulation of the immune response in wound healing: A new approach for skin repair","volume":"216","author":"Cardoso","year":"2011","journal-title":"Immunobiology"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/s41430-020-00841-x","article-title":"Mediterranean diet and the hallmarks of ageing","volume":"75","author":"Shannon","year":"2021","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.numecd.2017.09.003","article-title":"Aging process, adherence to Mediterranean diet and nutritional status in a large cohort of nonagenarians: Effects on endothelial progenitor cells","volume":"28","author":"Cesari","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3945\/ajcn.110.006866","article-title":"Mediterranean diet reduces endothelial damage and improves the regenerative capacity of endothelium","volume":"93","author":"Marin","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1042\/CS20110477","article-title":"Moderate-to-high-intensity training and a hypocaloric Mediterranean diet enhance endothelial progenitor cells and fitness in subjects with the metabolic syndrome","volume":"123","year":"2012","journal-title":"Clin. Sci."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00018-022-04186-5","article-title":"ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NF\u03baB activation","volume":"79","author":"Kim","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1101\/gad.17276711","article-title":"Control of the senescence-associated secretory phenotype by NF-\u03baB promotes senescence and enhances chemosensitivity","volume":"25","author":"Chien","year":"2011","journal-title":"Genes Dev."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3389\/fimmu.2018.00586","article-title":"Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines","volume":"9","author":"Rea","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Koppula, S., Akther, M., and Haque, M.E. (2021). Potential Nutrients from Natural and Synthetic Sources Targeting Inflammaging\u2014A Review of Literature, Clinical Data and Patents. Nutrients, 13.","DOI":"10.3390\/nu13114058"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.arr.2017.09.001","article-title":"Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition","volume":"40","author":"Calder","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.2174\/138161209789058110","article-title":"An update of the oxidation-inflammation theory of aging: The involvement of the immune system in oxi-inflamm-aging","volume":"15","author":"Miquel","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.arr.2007.09.002","article-title":"Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging","volume":"7","author":"Salminen","year":"2008","journal-title":"Ageing Res. Rev."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Shakoor, H., and Feehan, J. (2021). Immunomodulatory Effects of Dietary Polyphenols. Nutrients, 13.","DOI":"10.3390\/nu13030728"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Yahfoufi, N., Alsadi, N., Jambi, M., and Matar, C. (2018). The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients, 10.","DOI":"10.3390\/nu10111618"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bcp.2016.01.019","article-title":"Resveratrol inhibits inflammatory signaling implicated in ionizing radiation-induced premature ovarian failure through antagonistic crosstalk between silencing information regulator 1 (SIRT1) and poly (ADP-ribose) polymerase 1 (PARP-1)","volume":"103","author":"Said","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exger.2015.02.004","article-title":"Anti-inflammatory effect of resveratrol in old mice liver","volume":"64","author":"Tung","year":"2015","journal-title":"Exp. Gerontol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neurobiolaging.2016.04.007","article-title":"Resveratrol attenuates peripheral and brain inflammation and reduces ischemic brain injury in aged female mice","volume":"44","author":"Jeong","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ejphar.2008.03.008","article-title":"Health effects of quercetin: From antioxidant to nutraceutical","volume":"585","author":"Boots","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/jn\/138.5.885","article-title":"Quercetin from shallots (Allium cepa L. var. aggregatum) is more bioavailable than its glucosides","volume":"138","author":"Wiczkowski","year":"2008","journal-title":"J. Nutr."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2174\/1876396001104010189","article-title":"Beneficial effects of quercetin on obesity and diabetes","volume":"4","author":"Aguirre","year":"2011","journal-title":"Open Nutraceuticals J."},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Liu, S., Liu, J., He, L., Liu, L., Cheng, B., Zhou, F., Cao, D., and He, Y. (2022). A Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health. Molecules, 27.","DOI":"10.3390\/molecules27144400"},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Xu, X.Y., Meng, X., Li, S., and Gan, R.Y. (2018). Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges and Perspectives. Nutrients, 10.","DOI":"10.3390\/nu10101553"},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Kong, W.Y., Ngai, S.C., and Goh, B.H. (2021). Is Curcumin the Answer to Future Chemotherapy Cocktail?. Molecules, 26.","DOI":"10.3390\/molecules26144329"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.2147\/DDDT.S327378","article-title":"Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures","volume":"15","author":"Peng","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Pulido-Moran, M., Moreno-Fernandez, J., Ramirez-Tortosa, C., and Ramirez-Tortosa, M. (2016). Curcumin and Health. Molecules, 21.","DOI":"10.3390\/molecules21030264"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/bph.13621","article-title":"Curcumin, the golden nutraceutical: Multitargeting for multiple chronic diseases","volume":"174","author":"Kunnumakkara","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.3233\/JAD-170071","article-title":"Assessment of Novel Curcumin Derivatives as Potent Inhibitors of Inflammation and Amyloid-\u03b2 Aggregation in Alzheimer\u2019s Disease","volume":"60","author":"Doens","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Hussain, Y., Khan, H., Alotaibi, G., and Khan, F. (2022). How Curcumin Targets Inflammatory Mediators in Diabetes: Therapeutic Insights and Possible Solutions. Molecules, 27.","DOI":"10.3390\/molecules27134058"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.3390\/molecules16064567","article-title":"Curcumin: An anti-inflammatory molecule from a curry spice on the path to cancer treatment","volume":"16","author":"Basnet","year":"2011","journal-title":"Molecules"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2174\/138945011794815356","article-title":"The targets of curcumin","volume":"12","author":"Zhou","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jtcme.2015.10.001","article-title":"Curcumin reverses neurochemical, histological and immuno-histochemical alterations in the model of global brain ischemia","volume":"7","author":"Nobre","year":"2017","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s11481-012-9363-2","article-title":"Neuroprotective effect of curcuminoids against inflammation-mediated dopaminergic neurodegeneration in the MPTP model of Parkinson\u2019s disease","volume":"7","author":"Ojha","year":"2012","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"7386239","DOI":"10.1155\/2020\/7386239","article-title":"Protective Effect of Epigallocatechin-3-Gallate in Hydrogen Peroxide-Induced Oxidative Damage in Chicken Lymphocytes","volume":"2020","author":"Chi","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"6719534","DOI":"10.1155\/2016\/6719534","article-title":"Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results","volume":"2016","author":"Garrido","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Farhan, M. (2022). Green Tea Catechins: Nature\u2019s Way of Preventing and Treating Cancer. Int J Mol Sci, 23.","DOI":"10.3390\/ijms231810713"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.taap.2017.05.016","article-title":"Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1\u03b2 signaling in rheumatoid arthritis synovial fibroblasts","volume":"329","author":"Fechtner","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"7007","DOI":"10.2147\/IJN.S146296","article-title":"In vitro study on anti-inflammatory effects of epigallocatechin-3-gallate-loaded nano-and microscale particles","volume":"12","author":"Wu","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.canlet.2011.02.023","article-title":"Epigallocatechin-3-gallate effectively attenuates skeletal muscle atrophy caused by cancer cachexia","volume":"305","author":"Wang","year":"2011","journal-title":"Cancer Lett."},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Rahman, M.M., and Rahaman, M.S. (2021). Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects. Molecules, 27.","DOI":"10.3390\/molecules27010233"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.3390\/nu6104032","article-title":"Green tea consumption affects cognitive dysfunction in the elderly: A pilot study","volume":"6","author":"Ide","year":"2014","journal-title":"Nutrients"},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Baker, L.D., Manson, J.E., Rapp, S.R., Sesso, H.D., Gaussoin, S.A., Shumaker, S.A., and Espeland, M.A. (2022). Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial. Alzheimer\u2019s Dement.","DOI":"10.1002\/alz.12767"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1080\/09637486.2021.1972411","article-title":"Turmeric root extract supplementation improves pre-frontal cortex oxygenation and blood volume in older males and females: A randomised cross-over, placebo-controlled study","volume":"73","author":"Rezende","year":"2022","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.exger.2014.05.015","article-title":"Safety and metabolic outcomes of resveratrol supplementation in older adults: Results of a twelve-week, placebo-controlled pilot study","volume":"57","author":"Anton","year":"2014","journal-title":"Exp. Gerontol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"111111","DOI":"10.1016\/j.exger.2020.111111","article-title":"Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial","volume":"143","author":"Harper","year":"2021","journal-title":"Exp. Gerontol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/6\/5508\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:54:18Z","timestamp":1760122458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/6\/5508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,14]]},"references-count":231,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["ijms24065508"],"URL":"https:\/\/doi.org\/10.3390\/ijms24065508","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,14]]}}}