{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:26:23Z","timestamp":1788981983676,"version":"build-2803163510"},"reference-count":51,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MCIN\/Spanish Research Agency (AEI)","award":["PID2019-105995RB-I00"],"award-info":[{"award-number":["PID2019-105995RB-I00"]}]},{"name":"MCIN\/Spanish Research Agency (AEI)","award":["PID2019-106410RB-I00"],"award-info":[{"award-number":["PID2019-106410RB-I00"]}]},{"name":"MCIN\/Spanish Research Agency (AEI)","award":["RD16\/0011\/0025"],"award-info":[{"award-number":["RD16\/0011\/0025"]}]},{"name":"MCIN\/Spanish Research Agency (AEI)","award":["US-1380891"],"award-info":[{"award-number":["US-1380891"]}]},{"name":"Red TerCel ISCIII","award":["PID2019-105995RB-I00"],"award-info":[{"award-number":["PID2019-105995RB-I00"]}]},{"name":"Red TerCel ISCIII","award":["PID2019-106410RB-I00"],"award-info":[{"award-number":["PID2019-106410RB-I00"]}]},{"name":"Red TerCel ISCIII","award":["RD16\/0011\/0025"],"award-info":[{"award-number":["RD16\/0011\/0025"]}]},{"name":"Red TerCel ISCIII","award":["US-1380891"],"award-info":[{"award-number":["US-1380891"]}]},{"name":"Consejer\u00eda de Econom\u00eda, Conocimiento, Empresas y Universidad","award":["PID2019-105995RB-I00"],"award-info":[{"award-number":["PID2019-105995RB-I00"]}]},{"name":"Consejer\u00eda de Econom\u00eda, Conocimiento, Empresas y Universidad","award":["PID2019-106410RB-I00"],"award-info":[{"award-number":["PID2019-106410RB-I00"]}]},{"name":"Consejer\u00eda de Econom\u00eda, Conocimiento, Empresas y Universidad","award":["RD16\/0011\/0025"],"award-info":[{"award-number":["RD16\/0011\/0025"]}]},{"name":"Consejer\u00eda de Econom\u00eda, Conocimiento, Empresas y Universidad","award":["US-1380891"],"award-info":[{"award-number":["US-1380891"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Antiparkinsonian carotid body (CB) cell therapy has been proven to be effective in rodent and nonhuman primate models of Parkinson\u2019s disease (PD), exerting trophic protection and restoration of the dopaminergic nigrostriatal pathway. These neurotrophic actions are mediated through the release of high levels of glial-cell-line-derived neurotrophic factor (GDNF) by the CB transplant. Pilot clinical trials have also shown that CB autotransplantation can improve motor symptoms in PD patients, although its effectiveness is affected by the scarcity of the grafted tissue. Here, we analyzed the antiparkinsonian efficacy of in vitro-expanded CB dopaminergic glomus cells. Intrastriatal xenografts of rat CB neurospheres were shown to protect nigral neurons from degeneration in a chronic MPTP mouse PD model. In addition, grafts performed at the end of the neurotoxic treatment resulted in the repair of striatal dopaminergic terminals through axonal sprouting. Interestingly, both neuroprotective and reparative effects induced by in vitro-expanded CB cells were similar to those previously reported by the use of CB transplants. This action could be explained because stem-cell-derived CB neurospheres produce similar amounts of GDNF compared to native CB tissue. This study provides the first evidence that in vitro-expanded CB cells could be a clinical option for cell therapy in PD.<\/jats:p>","DOI":"10.3390\/ijms24065575","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T05:53:44Z","timestamp":1678859624000},"page":"5575","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Protection and Repair of the Nigrostriatal Pathway with Stem-Cell-Derived Carotid Body Glomus Cell Transplants in Chronic MPTP Parkinsonian Model"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2131-9013","authenticated-orcid":false,"given":"Javier","family":"Villadiego","sequence":"first","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Sevilla, Spain"},{"name":"Departamento de Fisiolog\u00eda M\u00e9dica y Biof\u00edsica, Facultad de Medicina, Universidad de Sevilla, 41009 Sevilla, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana B.","family":"Mu\u00f1oz-Manchado","sequence":"additional","affiliation":[{"name":"Unidad de Biolog\u00eda Celular, Departamento de Anatom\u00eda Patol\u00f3gica, Biolog\u00eda Celular, Histolog\u00eda, Historia de la Ciencia, Medicina Legal y Forense y Toxicolog\u00eda, INiBICA (Instituto de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica de C\u00e1diz), Universidad de C\u00e1diz, 11003 C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Sobrino","sequence":"additional","affiliation":[{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba, Departamento de Biolog\u00eda Celular, Fisiolog\u00eda e Inmunolog\u00eda, Universidad de C\u00f3rdoba, 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5440-5199","authenticated-orcid":false,"given":"Victoria","family":"Bonilla-Henao","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Sevilla, Spain"},{"name":"Departamento de Fisiolog\u00eda M\u00e9dica y Biof\u00edsica, Facultad de Medicina, Universidad de Sevilla, 41009 Sevilla, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nela","family":"Su\u00e1rez-Luna","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Sevilla, Spain"},{"name":"Departamento de Fisiolog\u00eda M\u00e9dica y Biof\u00edsica, Facultad de Medicina, Universidad de Sevilla, 41009 Sevilla, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Ortega-S\u00e1enz","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Sevilla, Spain"},{"name":"Departamento de Fisiolog\u00eda M\u00e9dica y Biof\u00edsica, Facultad de Medicina, Universidad de Sevilla, 41009 Sevilla, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1085-0714","authenticated-orcid":false,"given":"Ricardo","family":"Pardal","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Sevilla, Spain"},{"name":"Departamento de Fisiolog\u00eda M\u00e9dica y Biof\u00edsica, Facultad de Medicina, Universidad de Sevilla, 41009 Sevilla, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"L\u00f3pez-Barneo","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Sevilla, Spain"},{"name":"Departamento de Fisiolog\u00eda M\u00e9dica y Biof\u00edsica, Facultad de Medicina, Universidad de Sevilla, 41009 Sevilla, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Toledo-Aral","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Sevilla, Spain"},{"name":"Departamento de Fisiolog\u00eda M\u00e9dica y Biof\u00edsica, Facultad de Medicina, Universidad de Sevilla, 41009 Sevilla, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28029 Madrid, 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