{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T08:54:06Z","timestamp":1781427246340,"version":"3.54.1"},"reference-count":69,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1182 Project C2"],"award-info":[{"award-number":["CRC1182 Project C2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 257\/591-1 FUGG"],"award-info":[{"award-number":["INST 257\/591-1 FUGG"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Christian-Albrechts University Kiel","award":["CRC1182 Project C2"],"award-info":[{"award-number":["CRC1182 Project C2"]}]},{"name":"Christian-Albrechts University Kiel","award":["INST 257\/591-1 FUGG"],"award-info":[{"award-number":["INST 257\/591-1 FUGG"]}]},{"name":"Open Access-Publikationskosten","award":["CRC1182 Project C2"],"award-info":[{"award-number":["CRC1182 Project C2"]}]},{"name":"Open Access-Publikationskosten","award":["INST 257\/591-1 FUGG"],"award-info":[{"award-number":["INST 257\/591-1 FUGG"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Knowing the molecular makeup of an organ system is required for its in-depth understanding. We analyzed the molecular repertoire of the adult tracheal system of the fruit fly Drosophila melanogaster using transcriptome studies to advance our knowledge of the adult insect tracheal system. Comparing this to the larval tracheal system revealed several major differences that likely influence organ function. During the transition from larval to adult tracheal system, a shift in the expression of genes responsible for the formation of cuticular structure occurs. This change in transcript composition manifests in the physical properties of cuticular structures of the adult trachea. Enhanced tonic activation of the immune system is observed in the adult trachea, which encompasses the increased expression of antimicrobial peptides. In addition, modulatory processes are conspicuous, in this case mainly by the increased expression of G protein-coupled receptors in the adult trachea. Finally, all components of a peripheral circadian clock are present in the adult tracheal system, which is not the case in the larval tracheal system. Comparative analysis of driver lines targeting the adult tracheal system revealed that even the canonical tracheal driver line breathless (btl)-Gal4 is not able to target all parts of the adult tracheal system. Here, we have uncovered a specific transcriptome pattern of the adult tracheal system and provide this dataset as a basis for further analyses of the adult insect tracheal system.<\/jats:p>","DOI":"10.3390\/ijms24065628","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T03:14:35Z","timestamp":1678936475000},"page":"5628","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Adult and Larval Tracheal Systems Exhibit Different Molecular Architectures in Drosophila"],"prefix":"10.3390","volume":"24","author":[{"given":"Judith","family":"Bossen","sequence":"first","affiliation":[{"name":"Department Zoology, Molecular Physiology, Kiel University, 24118 Kiel, Germany"},{"name":"German Lung Center (DZL), Airway Research Center North (ARCN), 24118 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Prange","sequence":"additional","affiliation":[{"name":"Department Zoology, Molecular Physiology, Kiel University, 24118 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Philip","family":"K\u00fchle","sequence":"additional","affiliation":[{"name":"Department Zoology, Molecular Physiology, Kiel University, 24118 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"K\u00fcnzel","sequence":"additional","affiliation":[{"name":"Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, 24306 Pl\u00f6n, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Niu","sequence":"additional","affiliation":[{"name":"Department Zoology, Molecular Physiology, Kiel University, 24118 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6744-6811","authenticated-orcid":false,"given":"J\u00f6rg U.","family":"Hammel","sequence":"additional","affiliation":[{"name":"Helmholtz-Zentrum Hereon, Institute of Materials Physics, 21502 Geesthacht, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Krieger","sequence":"additional","affiliation":[{"name":"Department Zoology, Molecular Physiology, Kiel University, 24118 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Knop","sequence":"additional","affiliation":[{"name":"Department Zoology, Molecular Physiology, Kiel University, 24118 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2332-9752","authenticated-orcid":false,"given":"Birte","family":"Ehrhardt","sequence":"additional","affiliation":[{"name":"Research Center Borstel, Priority Research Area Chronic Lung Diseases, Early Life Origins of CLD, 23485 Borstel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Uliczka","sequence":"additional","affiliation":[{"name":"Research Center Borstel, Priority Research Area Chronic Lung Diseases, Early Life Origins of CLD, 23485 Borstel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Krauss-Etschmann","sequence":"additional","affiliation":[{"name":"German Lung Center (DZL), Airway Research Center North (ARCN), 24118 Kiel, Germany"},{"name":"Research Center Borstel, Priority Research Area Chronic Lung Diseases, Early Life Origins of CLD, 23485 Borstel, Germany"},{"name":"Institute for Experimental Medicine, Kiel University, 24118 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Roeder","sequence":"additional","affiliation":[{"name":"Department Zoology, Molecular Physiology, Kiel University, 24118 Kiel, Germany"},{"name":"German Lung Center (DZL), Airway Research Center North (ARCN), 24118 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-4419-5638-5_5","article-title":"A Drosophila Asthma Model\u2014What the Fly Tells Us About Inflammatory Diseases of the Lung","volume":"710","author":"Roeder","year":"2012","journal-title":"Adv. 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